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Q924S7

- SPRE2_MOUSE

UniProt

Q924S7 - SPRE2_MOUSE

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Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

Spred2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.1 Publication

GO - Molecular functioni

  1. protein kinase binding Source: BHF-UCL
  2. protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  3. stem cell factor receptor binding Source: MGI

GO - Biological processi

  1. inactivation of MAPK activity Source: MGI
  2. multicellular organismal development Source: InterPro
  3. negative regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
  4. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  5. regulation of protein deacetylation Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 2
Short name:
Spred-2
Gene namesi
Name:Spred2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2150019. Spred2.

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesicle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Cytoplasm 1 Publication
Note: Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Sprouty-related, EVH1 domain-containing protein 2PRO_0000076911Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination (By similarity).By similarity
Ubiquitinated; leading to degradation by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ924S7.
PaxDbiQ924S7.
PRIDEiQ924S7.

PTM databases

PhosphoSiteiQ924S7.

Expressioni

Tissue specificityi

Predominantly expressed in lung, liver and testis. In testis, it is specially found in mature spermatids projecting into the lumen of the seminiferous. Strongly expressed in glandular epithelia. Also expressed in embryonic tissues such as heart, lung, liver and brain.2 Publications

Gene expression databases

BgeeiQ924S7.
CleanExiMM_SPRED2.
ExpressionAtlasiQ924S7. baseline and differential.
GenevestigatoriQ924S7.

Interactioni

Subunit structurei

Interacts with ras.1 Publication

Protein-protein interaction databases

BioGridi227830. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ924S7.
SMRiQ924S7. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 122118WH1PROSITE-ProRule annotationAdd
BLAST
Domaini197 – 25256KBDPROSITE-ProRule annotationAdd
BLAST
Domaini300 – 408109SPRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KBD domain.PROSITE-ProRule annotation
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
Contains 1 WH1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG277322.
GeneTreeiENSGT00730000110272.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ924S7.
KOiK04703.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924S7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE
60 70 80 90 100
GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL
110 120 130 140 150
TFQSPADARA FDRGVRKAIE DLIEGSTTSS STLHNEAELG DDDVFTTATD
160 170 180 190 200
SSSNSSQKRE PTTRTISSPT SCEHRKIYTL DPYPMDHYHP DQRLPRSYPQ
210 220 230 240 250
VTFPEDDEEI VRINPREKIW MTGYEDYRHA PVRGKYLDTT EDADSYVRFA
260 270 280 290 300
KGEVPKHEYT YPYVDSSDFG FGEDPKGSVI KTQPPRAKSR RRKENGERSR
310 320 330 340 350
CVYCRDMFNH EENRRGHCQD APDAVRTCIR RVSCMWCADS MLYHCMSDPE
360 370 380 390 400
GDYTDPCSCD TSDEKFCLRW MALIALSFLA PCMCCYLPLR ACHRCGVMCR
410
CCGGKHKAAA
Length:410
Mass (Da):46,794
Last modified:December 1, 2001 - v1
Checksum:i8A652D06CE8D3BB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB063496 mRNA. Translation: BAB62849.1.
AK036430 mRNA. Translation: BAC29425.1.
BC066013 mRNA. Translation: AAH66013.1.
CCDSiCCDS24454.1.
RefSeqiNP_277058.1. NM_033523.4.
UniGeneiMm.266627.

Genome annotation databases

EnsembliENSMUST00000093298; ENSMUSP00000090987; ENSMUSG00000045671.
GeneIDi114716.
KEGGimmu:114716.
UCSCiuc007icr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB063496 mRNA. Translation: BAB62849.1 .
AK036430 mRNA. Translation: BAC29425.1 .
BC066013 mRNA. Translation: AAH66013.1 .
CCDSi CCDS24454.1.
RefSeqi NP_277058.1. NM_033523.4.
UniGenei Mm.266627.

3D structure databases

ProteinModelPortali Q924S7.
SMRi Q924S7. Positions 1-124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 227830. 1 interaction.

PTM databases

PhosphoSitei Q924S7.

Proteomic databases

MaxQBi Q924S7.
PaxDbi Q924S7.
PRIDEi Q924S7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000093298 ; ENSMUSP00000090987 ; ENSMUSG00000045671 .
GeneIDi 114716.
KEGGi mmu:114716.
UCSCi uc007icr.1. mouse.

Organism-specific databases

CTDi 200734.
MGIi MGI:2150019. Spred2.

Phylogenomic databases

eggNOGi NOG277322.
GeneTreei ENSGT00730000110272.
HOGENOMi HOG000220886.
HOVERGENi HBG057556.
InParanoidi Q924S7.
KOi K04703.

Miscellaneous databases

ChiTaRSi SPRED2. mouse.
NextBioi 368741.
PROi Q924S7.
SOURCEi Search...

Gene expression databases

Bgeei Q924S7.
CleanExi MM_SPRED2.
ExpressionAtlasi Q924S7. baseline and differential.
Genevestigatori Q924S7.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view ]
PROSITEi PS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH RAS, TISSUE SPECIFICITY, FUNCTION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Expression and subcellular localization of Spred proteins in mouse and human tissues."
    Engelhardt C.M., Bundschu K., Messerschmitt M., Renne T., Walter U., Reinhard M., Schuh K.
    Histochem. Cell Biol. 122:527-538(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPRE2_MOUSE
AccessioniPrimary (citable) accession number: Q924S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3