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Protein

Lon protease homolog, mitochondrial

Gene

Lonp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.UniRule annotation2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei845UniRule annotation1
Active sitei888UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi513 – 520ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cellular protein complex assembly Source: RGD
  • cellular response to oxidative stress Source: Ensembl
  • misfolded or incompletely synthesized protein catabolic process Source: GO_Central
  • mitochondrion organization Source: RGD
  • oxidation-dependent protein catabolic process Source: Ensembl
  • protein homooligomerization Source: Ensembl
  • proteolysis Source: RGD
  • response to aluminum ion Source: RGD
  • response to hormone Source: RGD
  • response to hypoxia Source: RGD

Keywordsi

Molecular functionDNA-binding, Hydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog, mitochondrialUniRule annotation (EC:3.4.21.-UniRule annotation)
Alternative name(s):
Lon protease-like proteinUniRule annotation
Short name:
LONPUniRule annotation
Mitochondrial ATP-dependent protease LonUniRule annotation
Serine protease 15UniRule annotation
Gene namesi
Name:Lonp1
Synonyms:Lon, Prss15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621598. Lonp1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • membrane Source: Ensembl
  • mitochondrial matrix Source: RGD
  • mitochondrial nucleoid Source: Ensembl
  • mitochondrion Source: RGD
  • nucleoplasm Source: Ensembl

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 65MitochondrionUniRule annotationAdd BLAST65
ChainiPRO_000025496266 – 950Lon protease homolog, mitochondrialAdd BLAST885

Proteomic databases

PaxDbiQ924S5.
PRIDEiQ924S5.

PTM databases

iPTMnetiQ924S5.
PhosphoSitePlusiQ924S5.

Expressioni

Inductioni

By hypoxia or ER stress.1 Publication

Gene expression databases

BgeeiENSRNOG00000046502.
GenevisibleiQ924S5. RN.

Interactioni

Subunit structurei

Homohexamer or homoheptamer. Organized in a ring with a central cavity. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ924S5. 1 interactor.
STRINGi10116.ENSRNOP00000066618.

Structurei

3D structure databases

ProteinModelPortaliQ924S5.
SMRiQ924S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 358Lon N-terminalPROSITE-ProRule annotationAdd BLAST247
Domaini749 – 939Lon proteolyticPROSITE-ProRule annotationAdd BLAST191

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
GeneTreeiENSGT00530000063553.
HOVERGENiHBG000798.
InParanoidiQ924S5.
KOiK08675.
OMAiMEMIDMS.
OrthoDBiEOG091G01TN.
PhylomeDBiQ924S5.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_03120. lonm_euk. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR008269. Lon_proteolytic.
IPR027065. Lon_Prtase.
IPR003111. Lon_substr-bd.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERiPTHR43718. PTHR43718. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiView protein in PROSITE
PS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTGYVRL WAAARCWVLR RPLLAVTGGR VPSASGSWLR RGCRVCDTST
60 70 80 90 100
PWGGRVPMGG GQWRGLWDAG SRGGSDETSE GGVEDGATAS SGEGPVVTAL
110 120 130 140 150
APMTVPDVFP HLPLIAISRN PVFPRFIKIV EVKNKKLVEL LRRKVRLAQP
160 170 180 190 200
YVGVFLKRDD NNESDVVESL DEIYHTGTFA QIHEMQDLGD KLRMIVTGHR
210 220 230 240 250
RIHISRQLEV EPEGLEPEAE NKQKSRRKLK RGKKEVGDEL GAKPQLEMVT
260 270 280 290 300
EATSDTSKEV LMVEVENVAH EDFQVTEEVK ALTAEIVKTI RDIIALNPLY
310 320 330 340 350
RESVLQMMQA GQRVVDNPIY LSDMGAALTG AESHELQDVL EETNILKRLY
360 370 380 390 400
KALSLLKKEF ELSKLQQRLG REVEEKIKQT HRKYLLQEQL KIIKKELGLE
410 420 430 440 450
KDDKDAIEEK FRERLKELVV PKHVMDVVDE ELSKLALLDN HSSEFNVTRN
460 470 480 490 500
YLDWLTSIPW GRQSDENLDL ARAQSVLEED HYGMEDVKKR VLEFIAVSQL
510 520 530 540 550
RGSTQGKILC FHGPPGVGKT SIARSIARAL GREYFRFSVG GMTDVAEIKG
560 570 580 590 600
HRRTYVGAMP GKIIQCLKKT KTENPLVLID EVDKIGRGYQ GDPSSALLEL
610 620 630 640 650
LDPEQNANFL DHYLDVPVDL SKVLFICTAN VTDTIPEPLR DRMEMINVSG
660 670 680 690 700
YVAQEKLAIA ERYLVPQART LCGLDESKAQ LSATVLTLLI KQYCRESGVR
710 720 730 740 750
NLQKQVEKVL RKAAYKIVSG EAQTVHVTPE NLQDFVGKPV FTVERMYDVT
760 770 780 790 800
PPGVVMGLAW TAMGGSTLFV ETSLRRPQPS GSKEDKDGSL EVTGQLGDVM
810 820 830 840 850
KESARIAYTF ARAFLMEQDP ENDFLVTSHI HLHVPEGATP KDGPSAGCTI
860 870 880 890 900
VTALLSLALG QPVLQNLAMT GEVSLTGKVL PVGGIKEKTI AAKRAGVTCI
910 920 930 940 950
ILPAENRKDF SDLAPFITEG LEVHFVEHYR DIFRIAFPLR EHQEALAVER
Length:950
Mass (Da):105,793
Last modified:December 1, 2001 - v1
Checksum:iD505C3D851B6F0E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB064323 mRNA. Translation: BAB62423.1.
RefSeqiNP_596895.1. NM_133404.1.
UniGeneiRn.146805.

Genome annotation databases

EnsembliENSRNOT00000074253; ENSRNOP00000066618; ENSRNOG00000046502.
GeneIDi170916.
KEGGirno:170916.

Similar proteinsi

Entry informationi

Entry nameiLONM_RAT
AccessioniPrimary (citable) accession number: Q924S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families