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Protein

Kremen protein 1

Gene

Kremen1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.By similarity

GO - Biological processi

  • cell communication Source: GO_Central
  • muscle organ development Source: RGD
  • nervous system development Source: RGD
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kremen protein 1
Alternative name(s):
Dickkopf receptor
Kringle domain-containing transmembrane protein 1
Kringle-containing protein marking the eye and the nose
Gene namesi
Name:Kremen1
Synonyms:Kremen
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620789. Kremen1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 392ExtracellularSequence analysisAdd BLAST372
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 473CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002156620 – 473Kremen protein 1Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 114By similarity
Disulfide bondi55 ↔ 95By similarity
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 109By similarity
Disulfide bondi122 ↔ 186By similarity
Disulfide bondi147 ↔ 167By similarity
Disulfide bondi151 ↔ 169By similarity
Disulfide bondi190 ↔ 198By similarity
Disulfide bondi214 ↔ 240By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924S4.
PRIDEiQ924S4.

Interactioni

Subunit structurei

Forms a ternary complex with DKK1 and LRP6. Interacts with LRP6 in a DKK1-dependent manner. Interacts with DKK1 and RSPO1 (via FU repeats).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013543.

Structurei

3D structure databases

ProteinModelPortaliQ924S4.
SMRiQ924S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 114KringlePROSITE-ProRule annotationAdd BLAST84
Domaini116 – 210WSCPROSITE-ProRule annotationAdd BLAST95
Domaini214 – 321CUBPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni414 – 473Essential for apopototic activityBy similarityAdd BLAST60

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR07. Eukaryota.
ENOG41112QM. LUCA.
HOGENOMiHOG000070150.
HOVERGENiHBG052290.
InParanoidiQ924S4.
PhylomeDBiQ924S4.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiView protein in InterPro
IPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
PfamiView protein in Pfam
PF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
PIRSFiPIRSF036961. Kremen. 1 hit.
SMARTiView protein in SMART
SM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiView protein in PROSITE
PS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPAARLAL LSAAALTLAA RPAPGPRPSP ECFTANGADY RGTQSWTALQ
60 70 80 90 100
GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH
110 120 130 140 150
EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF
160 170 180 190 200
CRSQRFKFAG MESGYACFCG NNPDYWKHGE AASTECNNVC FGDHTQPCGG
210 220 230 240 250
DGRIILFDTL VGACGGNYSS MAAVVYSPDF PDTYATGRVC YWTIRVPGAS
260 270 280 290 300
RIHFNFTIFD IRDSADMVEL LDGYTHRVLV RFDGRSRPPL SFNVSLDFVI
310 320 330 340 350
LYFFSDRINQ AQGFAVLYQA TKEEPPQERP AINQTLAEVI TEQANLSVSA
360 370 380 390 400
AHSSKVLYVI TSSPSHPPQT VPGSHSWVPS VGASGHRVEG WTVYGLATLL
410 420 430 440 450
ILTVTAVVAK ILLHVTFKSH RVTASGDLRD CRQPGTSGEI WTIFYEPSTT
460 470
ISIFKKKLKG QSQQDDRNPL VSD
Length:473
Mass (Da):51,869
Last modified:December 1, 2001 - v1
Checksum:i9B510857DF856F08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065090 mRNA. Translation: BAB62003.1.
RefSeqiNP_446101.1. NM_053649.1.
UniGeneiRn.90021.

Genome annotation databases

GeneIDi114107.
KEGGirno:114107.
UCSCiRGD:620789. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKREM1_RAT
AccessioniPrimary (citable) accession number: Q924S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome