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Protein

Kremen protein 1

Gene

Kremen1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).By similarity

GO - Biological processi

  • muscle organ development Source: RGD
  • nervous system development Source: RGD
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kremen protein 1
Alternative name(s):
Dickkopf receptor
Kringle domain-containing transmembrane protein 1
Kringle-containing protein marking the eye and the nose
Gene namesi
Name:Kremen1
Synonyms:Kremen
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620789. Kremen1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 392372ExtracellularSequence analysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence analysisAdd
BLAST
Topological domaini414 – 47360CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 473454Kremen protein 1PRO_0000021566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 114By similarity
Disulfide bondi55 ↔ 95By similarity
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi84 ↔ 109By similarity
Disulfide bondi214 ↔ 240By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence analysis
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924S4.
PRIDEiQ924S4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013543.

Structurei

3D structure databases

ProteinModelPortaliQ924S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 11484KringlePROSITE-ProRule annotationAdd
BLAST
Domaini116 – 21095WSCPROSITE-ProRule annotationAdd
BLAST
Domaini214 – 321108CUBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 WSC domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR07. Eukaryota.
ENOG41112QM. LUCA.
HOGENOMiHOG000070150.
HOVERGENiHBG052290.
InParanoidiQ924S4.
PhylomeDBiQ924S4.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PIRSFiPIRSF036961. Kremen. 1 hit.
SMARTiSM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPAARLAL LSAAALTLAA RPAPGPRPSP ECFTANGADY RGTQSWTALQ
60 70 80 90 100
GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH
110 120 130 140 150
EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF
160 170 180 190 200
CRSQRFKFAG MESGYACFCG NNPDYWKHGE AASTECNNVC FGDHTQPCGG
210 220 230 240 250
DGRIILFDTL VGACGGNYSS MAAVVYSPDF PDTYATGRVC YWTIRVPGAS
260 270 280 290 300
RIHFNFTIFD IRDSADMVEL LDGYTHRVLV RFDGRSRPPL SFNVSLDFVI
310 320 330 340 350
LYFFSDRINQ AQGFAVLYQA TKEEPPQERP AINQTLAEVI TEQANLSVSA
360 370 380 390 400
AHSSKVLYVI TSSPSHPPQT VPGSHSWVPS VGASGHRVEG WTVYGLATLL
410 420 430 440 450
ILTVTAVVAK ILLHVTFKSH RVTASGDLRD CRQPGTSGEI WTIFYEPSTT
460 470
ISIFKKKLKG QSQQDDRNPL VSD
Length:473
Mass (Da):51,869
Last modified:December 1, 2001 - v1
Checksum:i9B510857DF856F08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065090 mRNA. Translation: BAB62003.1.
RefSeqiNP_446101.1. NM_053649.1.
UniGeneiRn.90021.

Genome annotation databases

GeneIDi114107.
KEGGirno:114107.
UCSCiRGD:620789. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065090 mRNA. Translation: BAB62003.1.
RefSeqiNP_446101.1. NM_053649.1.
UniGeneiRn.90021.

3D structure databases

ProteinModelPortaliQ924S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013543.

Proteomic databases

PaxDbiQ924S4.
PRIDEiQ924S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114107.
KEGGirno:114107.
UCSCiRGD:620789. rat.

Organism-specific databases

CTDi83999.
RGDi620789. Kremen1.

Phylogenomic databases

eggNOGiENOG410IR07. Eukaryota.
ENOG41112QM. LUCA.
HOGENOMiHOG000070150.
HOVERGENiHBG052290.
InParanoidiQ924S4.
PhylomeDBiQ924S4.

Miscellaneous databases

NextBioi618285.
PROiQ924S4.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PIRSFiPIRSF036961. Kremen. 1 hit.
SMARTiSM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Nakamura T., Nakamura T.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKREM1_RAT
AccessioniPrimary (citable) accession number: Q924S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.