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Protein
Submitted name:

Alpha 2 integrin

Gene

Itga2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cell adhesion molecule binding Source: RGD
  2. collagen binding Source: RGD
  3. integrin binding Source: RGD
  4. laminin binding Source: RGD
  5. protein complex binding Source: RGD
  6. protein heterodimerization activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: RGD
  2. cell proliferation Source: RGD
  3. cellular component movement Source: RGD
  4. cellular response to estradiol stimulus Source: RGD
  5. cellular response to mechanical stimulus Source: RGD
  6. cellular response to organic cyclic compound Source: RGD
  7. detection of mechanical stimulus involved in sensory perception of pain Source: RGD
  8. establishment of protein localization Source: RGD
  9. female pregnancy Source: RGD
  10. focal adhesion assembly Source: RGD
  11. hepatocyte differentiation Source: RGD
  12. hypotonic response Source: RGD
  13. integrin-mediated signaling pathway Source: RGD
  14. mammary gland development Source: RGD
  15. positive regulation of alkaline phosphatase activity Source: RGD
  16. positive regulation of cell adhesion Source: RGD
  17. positive regulation of cell projection organization Source: RGD
  18. positive regulation of collagen binding Source: RGD
  19. positive regulation of collagen biosynthetic process Source: RGD
  20. positive regulation of DNA binding Source: RGD
  21. positive regulation of epithelial cell migration Source: RGD
  22. positive regulation of inflammatory response Source: RGD
  23. positive regulation of leukocyte migration Source: RGD
  24. positive regulation of phagocytosis, engulfment Source: RGD
  25. positive regulation of positive chemotaxis Source: RGD
  26. positive regulation of smooth muscle cell migration Source: RGD
  27. positive regulation of smooth muscle cell proliferation Source: RGD
  28. positive regulation of smooth muscle contraction Source: RGD
  29. positive regulation of translation Source: RGD
  30. positive regulation of transmission of nerve impulse Source: RGD
  31. response to amine Source: RGD
  32. response to drug Source: RGD
  33. response to hypoxia Source: RGD
  34. response to L-ascorbic acid Source: RGD
  35. response to muscle activity Source: RGD
  36. response to organic cyclic compound Source: RGD
  37. response to parathyroid hormone Source: RGD
  38. skin morphogenesis Source: RGD
  39. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationImported, ReceptorUniRule annotation

Keywords - Biological processi

Cell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha 2 integrinImported
Gene namesi
Name:Itga2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621632. Itga2.

Subcellular locationi

Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. axon Source: RGD
  2. axon terminus Source: RGD
  3. cell projection Source: RGD
  4. cell surface Source: RGD
  5. extracellular space Source: RGD
  6. focal adhesion Source: RGD
  7. integral component of membrane Source: RGD
  8. integrin complex Source: RGD
  9. nucleus Source: RGD
  10. perinuclear region of cytoplasm Source: RGD
  11. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ924S3.

Expressioni

Gene expression databases

GenevestigatoriQ924S3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015940.

Structurei

3D structure databases

ProteinModelPortaliQ924S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiNOG237277.
HOGENOMiHOG000059610.
PhylomeDBiQ924S3.

Family and domain databases

InterProiIPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PROSITEiPS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q924S3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PVDGTEVTCQ IGSSQKSVTC DVGYPALKSE QQVTFTINLD FNLQNLQNQA
60 70 80 90 100
AINFQAFSES QETNKADNSV SLIVPLLYDA ELHLTRSTNI NFYEISSDEN
110 120 130 140 150
APSVINSVED IGPEFIFSLK ITAGSAPVSM ASVTIHIPLH TKEKNPLLYL
160 170 180 190 200
TGIQTDKAGD ISCRAEINPL NLPHTASPVS FKSENFRHMK ELDCKTTSCS
210 220 230 240 250
NVSCWLKDLH MKAEYFINVT TRVWNRTFAA STFQTVQLTA AAEIDTHNPQ
260 270 280 290 300
LFVIEENAVT IPLMIMKPTE KAEVPTGVII GSIIAGILLL LAMVAGLWKL
310 320
GFFKRQYKKM GQNPDETDET TELNS
Length:325
Mass (Da):35,866
Last modified:December 1, 2001 - v1
Checksum:iBAB76926EFD1B96F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067445 mRNA. Translation: BAB62267.1.
UniGeneiRn.83597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067445 mRNA. Translation: BAB62267.1.
UniGeneiRn.83597.

3D structure databases

ProteinModelPortaliQ924S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015940.

Proteomic databases

PaxDbiQ924S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi621632. Itga2.

Phylogenomic databases

eggNOGiNOG237277.
HOGENOMiHOG000059610.
PhylomeDBiQ924S3.

Gene expression databases

GenevestigatoriQ924S3.

Family and domain databases

InterProiIPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PROSITEiPS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat alpha2 integrin cDNA."
    Tateno C., Asahina K., Yoshizato K.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ924S3_RAT
AccessioniPrimary (citable) accession number: Q924S3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.