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Q924S3 (Q924S3_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Itga2 RGD 621632
OrganismRattus norvegicus (Rat) EMBL BAB62267.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length325 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.

Sequence similarities

Belongs to the integrin alpha chain family. RuleBase RU003762

Ontologies

Keywords
   Biological processCell adhesion RuleBase RU003762
   Cellular componentMembrane
   DomainTransmembrane RuleBase RU003762
   Molecular functionIntegrin RuleBase RU003762 EMBL BAB62267.1
Receptor RuleBase RU003762
Gene Ontology (GO)
   Biological_processcell adhesion

Traceable author statement PubMed 12941079. Source: RGD

cell proliferation

Inferred from expression pattern PubMed 12856576. Source: RGD

cellular component movement

Inferred from expression pattern PubMed 8969864. Source: RGD

cellular response to hormone stimulus

Inferred from expression pattern PubMed 11341970PubMed 11746505. Source: RGD

detection of mechanical stimulus involved in sensory perception of pain

Inferred from mutant phenotype PubMed 18234883. Source: RGD

establishment of protein localization

Inferred from direct assay PubMed 10972675. Source: RGD

hepatocyte differentiation

Inferred from expression pattern PubMed 16458388. Source: RGD

hypotonic response

Inferred from mutant phenotype PubMed 18234883. Source: RGD

integrin-mediated signaling pathway

Traceable author statement PubMed 12941079. Source: RGD

mammary gland development

Inferred from expression pattern PubMed 11341970. Source: RGD

positive regulation of DNA binding

Inferred from mutant phenotype PubMed 19239475. Source: RGD

positive regulation of alkaline phosphatase activity

Inferred from mutant phenotype PubMed 10867645. Source: RGD

positive regulation of cell adhesion

Inferred from mutant phenotype PubMed 19394307. Source: RGD

positive regulation of cell projection organization

Inferred from mutant phenotype PubMed 9878098. Source: RGD

positive regulation of collagen binding

Inferred from mutant phenotype PubMed 19394307. Source: RGD

positive regulation of collagen biosynthetic process

Inferred from mutant phenotype PubMed 10867645. Source: RGD

positive regulation of epithelial cell migration

Inferred from mutant phenotype PubMed 19394307. Source: RGD

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 18234883. Source: RGD

positive regulation of leukocyte migration

Inferred from mutant phenotype PubMed 10688841. Source: RGD

positive regulation of phagocytosis, engulfment

Inferred from mutant phenotype PubMed 9284952. Source: RGD

positive regulation of positive chemotaxis

Inferred from mutant phenotype PubMed 9529384. Source: RGD

positive regulation of smooth muscle cell migration

Inferred from mutant phenotype PubMed 19239475. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 19239475. Source: RGD

positive regulation of smooth muscle contraction

Inferred from mutant phenotype PubMed 16263112. Source: RGD

positive regulation of translation

Inferred from mutant phenotype PubMed 10867645. Source: RGD

positive regulation of transmission of nerve impulse

Inferred from mutant phenotype PubMed 15501602. Source: RGD

response to L-ascorbic acid

Inferred from expression pattern PubMed 9275042. Source: RGD

response to amine

Inferred from expression pattern PubMed 9252524. Source: RGD

response to drug

Inferred from expression pattern PubMed 12941079. Source: RGD

response to hypoxia

Inferred from expression pattern PubMed 16284587. Source: RGD

response to mechanical stimulus

Inferred from expression pattern PubMed 12856576. Source: RGD

response to muscle activity

Inferred from expression pattern PubMed 11934598. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 12851778. Source: RGD

skin morphogenesis

Inferred from mutant phenotype PubMed 17118629. Source: RGD

wound healing

Inferred from expression pattern PubMed 9388237. Source: RGD

   Cellular_componentaxon

Inferred from direct assay PubMed 15501602. Source: RGD

axon terminus

Inferred from direct assay PubMed 15501602. Source: RGD

cell outer membrane

Inferred from direct assay PubMed 9252524. Source: RGD

cell projection

Inferred from direct assay PubMed 12851778. Source: RGD

cell surface

Inferred from direct assay PubMed 15037024. Source: RGD

extracellular space

Traceable author statement PubMed 12941079. Source: RGD

focal adhesion

Inferred from direct assay PubMed 11746505. Source: RGD

integral component of membrane

Traceable author statement PubMed 12941079. Source: RGD

integrin complex

Traceable author statement PubMed 12941079. Source: RGD

nucleus

Inferred from direct assay PubMed 12851778. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 9388237. Source: RGD

   Molecular_functioncell adhesion molecule binding

Traceable author statement PubMed 12941079. Source: RGD

collagen binding

Traceable author statement PubMed 12941079. Source: RGD

integrin binding

Inferred from mutant phenotype PubMed 17118629. Source: RGD

laminin binding

Inferred from mutant phenotype PubMed 10082128. Source: RGD

protein complex binding

Inferred from direct assay PubMed 18234883PubMed 19027888. Source: RGD

protein heterodimerization activity

Inferred from direct assay PubMed 9388237. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAB62267.1

Sequences

Sequence LengthMass (Da)Tools
Q924S3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BAB76926EFD1B96F

FASTA32535,866
        10         20         30         40         50         60 
PVDGTEVTCQ IGSSQKSVTC DVGYPALKSE QQVTFTINLD FNLQNLQNQA AINFQAFSES 

        70         80         90        100        110        120 
QETNKADNSV SLIVPLLYDA ELHLTRSTNI NFYEISSDEN APSVINSVED IGPEFIFSLK 

       130        140        150        160        170        180 
ITAGSAPVSM ASVTIHIPLH TKEKNPLLYL TGIQTDKAGD ISCRAEINPL NLPHTASPVS 

       190        200        210        220        230        240 
FKSENFRHMK ELDCKTTSCS NVSCWLKDLH MKAEYFINVT TRVWNRTFAA STFQTVQLTA 

       250        260        270        280        290        300 
AAEIDTHNPQ LFVIEENAVT IPLMIMKPTE KAEVPTGVII GSIIAGILLL LAMVAGLWKL 

       310        320 
GFFKRQYKKM GQNPDETDET TELNS 

« Hide

References

[1]"Rat alpha2 integrin cDNA."
Tateno C., Asahina K., Yoshizato K.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB067445 mRNA. Translation: BAB62267.1.
UniGeneRn.83597.

3D structure databases

ProteinModelPortalQ924S3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000015940.

Proteomic databases

PaxDbQ924S3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD621632. Itga2.

Phylogenomic databases

eggNOGNOG237277.
HOGENOMHOG000059610.
InParanoidQ924S3.
PhylomeDBQ924S3.

Gene expression databases

GenevestigatorQ924S3.

Family and domain databases

InterProIPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PROSITEPS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ924S3_RAT
AccessionPrimary (citable) accession number: Q924S3
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)