Q924S3 (Q924S3_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alpha 2 integrin EMBL BAB62267.1

Gene names

Name:

Itga2 RGD 621632

Organism

Rattus norvegicus (Rat) EMBL BAB62267.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	325 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.
Sequence similarities	Belongs to the integrin alpha chain family. RuleBase RU003762

Ontologies

Keywords
Biological process	Cell adhesion RuleBase RU003762
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003762
Molecular function	Integrin RuleBase RU003762 EMBL BAB62267.1 Receptor RuleBase RU003762
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement PubMed 12941079. Source: RGD cell proliferation Inferred from expression pattern PubMed 12856576. Source: RGD cellular component movement Inferred from expression pattern PubMed 8969864. Source: RGD cellular response to hormone stimulus Inferred from expression pattern PubMed 11341970PubMed 11746505. Source: RGD detection of mechanical stimulus involved in sensory perception of pain Inferred from mutant phenotype PubMed 18234883. Source: RGD establishment of protein localization Inferred from direct assay PubMed 10972675. Source: RGD hepatocyte differentiation Inferred from expression pattern PubMed 16458388. Source: RGD hypotonic response Inferred from mutant phenotype PubMed 18234883. Source: RGD integrin-mediated signaling pathway Traceable author statement PubMed 12941079. Source: RGD mammary gland development Inferred from expression pattern PubMed 11341970. Source: RGD positive regulation of DNA binding Inferred from mutant phenotype PubMed 19239475. Source: RGD positive regulation of alkaline phosphatase activity Inferred from mutant phenotype PubMed 10867645. Source: RGD positive regulation of cell adhesion Inferred from mutant phenotype PubMed 19394307. Source: RGD positive regulation of cell projection organization Inferred from mutant phenotype PubMed 9878098. Source: RGD positive regulation of collagen binding Inferred from mutant phenotype PubMed 19394307. Source: RGD positive regulation of collagen biosynthetic process Inferred from mutant phenotype PubMed 10867645. Source: RGD positive regulation of epithelial cell migration Inferred from mutant phenotype PubMed 19394307. Source: RGD positive regulation of inflammatory response Inferred from mutant phenotype PubMed 18234883. Source: RGD positive regulation of leukocyte migration Inferred from mutant phenotype PubMed 10688841. Source: RGD positive regulation of phagocytosis, engulfment Inferred from mutant phenotype PubMed 9284952. Source: RGD positive regulation of positive chemotaxis Inferred from mutant phenotype PubMed 9529384. Source: RGD positive regulation of smooth muscle cell migration Inferred from mutant phenotype PubMed 19239475. Source: RGD positive regulation of smooth muscle cell proliferation Inferred from mutant phenotype PubMed 19239475. Source: RGD positive regulation of smooth muscle contraction Inferred from mutant phenotype PubMed 16263112. Source: RGD positive regulation of translation Inferred from mutant phenotype PubMed 10867645. Source: RGD positive regulation of transmission of nerve impulse Inferred from mutant phenotype PubMed 15501602. Source: RGD response to L-ascorbic acid Inferred from expression pattern PubMed 9275042. Source: RGD response to amine stimulus Inferred from expression pattern PubMed 9252524. Source: RGD response to drug Inferred from expression pattern PubMed 12941079. Source: RGD response to hypoxia Inferred from expression pattern PubMed 16284587. Source: RGD response to muscle activity Inferred from expression pattern PubMed 11934598. Source: RGD response to organic cyclic compound Inferred from expression pattern PubMed 12851778. Source: RGD skin morphogenesis Inferred from mutant phenotype PubMed 17118629. Source: RGD tissue homeostasis Inferred from mutant phenotype PubMed 17118629. Source: RGD wound healing Inferred from expression pattern PubMed 9388237. Source: RGD
Cellular_component	axon terminus Inferred from direct assay PubMed 15501602. Source: RGD cell outer membrane Inferred from direct assay PubMed 9252524. Source: RGD cell surface Inferred from direct assay PubMed 15037024. Source: RGD extracellular space Traceable author statement PubMed 12941079. Source: RGD focal adhesion Inferred from direct assay PubMed 11746505. Source: RGD integrin complex Traceable author statement PubMed 12941079. Source: RGD nucleus Inferred from direct assay PubMed 12851778. Source: RGD perinuclear region of cytoplasm Inferred from direct assay PubMed 9388237. Source: RGD
Molecular_function	cell adhesion molecule binding Traceable author statement PubMed 12941079. Source: RGD collagen binding Traceable author statement PubMed 12941079. Source: RGD integrin binding Inferred from mutant phenotype PubMed 17118629. Source: RGD laminin binding Inferred from mutant phenotype PubMed 10082128. Source: RGD protein heterodimerization activity Inferred from direct assay PubMed 9388237. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAB62267.1

Sequences

	Sequence		Length	Mass (Da)
	Q924S3 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BAB76926EFD1B96F	FASTA	325	35,866
	10 20 30 40 50 60 PVDGTEVTCQ IGSSQKSVTC DVGYPALKSE QQVTFTINLD FNLQNLQNQA AINFQAFSES 70 80 90 100 110 120 QETNKADNSV SLIVPLLYDA ELHLTRSTNI NFYEISSDEN APSVINSVED IGPEFIFSLK 130 140 150 160 170 180 ITAGSAPVSM ASVTIHIPLH TKEKNPLLYL TGIQTDKAGD ISCRAEINPL NLPHTASPVS 190 200 210 220 230 240 FKSENFRHMK ELDCKTTSCS NVSCWLKDLH MKAEYFINVT TRVWNRTFAA STFQTVQLTA 250 260 270 280 290 300 AAEIDTHNPQ LFVIEENAVT IPLMIMKPTE KAEVPTGVII GSIIAGILLL LAMVAGLWKL 310 320 GFFKRQYKKM GQNPDETDET TELNS

References

[1]	"Rat alpha2 integrin cDNA." Tateno C., Asahina K., Yoshizato K. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB067445 mRNA. Translation: BAB62267.1.
IPI	IPI00367939.
UniGene	Rn.83597.
3D structure databases
ProteinModelPortal	Q924S3.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000015940. Q924S3.
Proteomic databases
PaxDb	Q924S3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	621632. Itga2.
Phylogenomic databases
eggNOG	NOG237277.
HOGENOM	HOG000059610.
InParanoid	Q924S3.
OrthoDB	EOG45B1DV.
Gene expression databases
Genevestigator	Q924S3.
Family and domain databases
InterPro	IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. [Graphical view]
Pfam	PF00357. Integrin_alpha. 1 hit. PF08441. Integrin_alpha2. 1 hit. [Graphical view]
PROSITE	PS00242. INTEGRIN_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q924S3_RAT

Accession

Primary (citable) accession number: Q924S3

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)