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Q924S3

- Q924S3_RAT

UniProt

Q924S3 - Q924S3_RAT

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Protein
Submitted name: Alpha 2 integrin
Gene
Itga2
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cell adhesion molecule binding Source: RGD
  2. collagen binding Source: RGD
  3. integrin binding Source: RGD
  4. laminin binding Source: RGD
  5. protein complex binding Source: RGD
  6. protein heterodimerization activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: RGD
  2. cell proliferation Source: RGD
  3. cellular component movement Source: RGD
  4. cellular response to hormone stimulus Source: RGD
  5. detection of mechanical stimulus involved in sensory perception of pain Source: RGD
  6. establishment of protein localization Source: RGD
  7. hepatocyte differentiation Source: RGD
  8. hypotonic response Source: RGD
  9. integrin-mediated signaling pathway Source: RGD
  10. mammary gland development Source: RGD
  11. positive regulation of DNA binding Source: RGD
  12. positive regulation of alkaline phosphatase activity Source: RGD
  13. positive regulation of cell adhesion Source: RGD
  14. positive regulation of cell projection organization Source: RGD
  15. positive regulation of collagen binding Source: RGD
  16. positive regulation of collagen biosynthetic process Source: RGD
  17. positive regulation of epithelial cell migration Source: RGD
  18. positive regulation of inflammatory response Source: RGD
  19. positive regulation of leukocyte migration Source: RGD
  20. positive regulation of phagocytosis, engulfment Source: RGD
  21. positive regulation of positive chemotaxis Source: RGD
  22. positive regulation of smooth muscle cell migration Source: RGD
  23. positive regulation of smooth muscle cell proliferation Source: RGD
  24. positive regulation of smooth muscle contraction Source: RGD
  25. positive regulation of translation Source: RGD
  26. positive regulation of transmission of nerve impulse Source: RGD
  27. response to L-ascorbic acid Source: RGD
  28. response to amine Source: RGD
  29. response to drug Source: RGD
  30. response to hypoxia Source: RGD
  31. response to mechanical stimulus Source: RGD
  32. response to muscle activity Source: RGD
  33. response to organic cyclic compound Source: RGD
  34. skin morphogenesis Source: RGD
  35. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationImported, ReceptorUniRule annotation

Keywords - Biological processi

Cell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha 2 integrinImported
Gene namesi
Name:Itga2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621632. Itga2.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: RGD
  2. axon terminus Source: RGD
  3. cell outer membrane Source: RGD
  4. cell projection Source: RGD
  5. cell surface Source: RGD
  6. extracellular space Source: RGD
  7. focal adhesion Source: RGD
  8. integral component of membrane Source: RGD
  9. integrin complex Source: RGD
  10. nucleus Source: RGD
  11. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ924S3.

Expressioni

Gene expression databases

GenevestigatoriQ924S3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015940.

Structurei

3D structure databases

ProteinModelPortaliQ924S3.

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiNOG237277.
HOGENOMiHOG000059610.
InParanoidiQ924S3.
PhylomeDBiQ924S3.

Family and domain databases

InterProiIPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PROSITEiPS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q924S3-1 [UniParc]FASTAAdd to Basket

« Hide

PVDGTEVTCQ IGSSQKSVTC DVGYPALKSE QQVTFTINLD FNLQNLQNQA    50
AINFQAFSES QETNKADNSV SLIVPLLYDA ELHLTRSTNI NFYEISSDEN 100
APSVINSVED IGPEFIFSLK ITAGSAPVSM ASVTIHIPLH TKEKNPLLYL 150
TGIQTDKAGD ISCRAEINPL NLPHTASPVS FKSENFRHMK ELDCKTTSCS 200
NVSCWLKDLH MKAEYFINVT TRVWNRTFAA STFQTVQLTA AAEIDTHNPQ 250
LFVIEENAVT IPLMIMKPTE KAEVPTGVII GSIIAGILLL LAMVAGLWKL 300
GFFKRQYKKM GQNPDETDET TELNS 325
Length:325
Mass (Da):35,866
Last modified:December 1, 2001 - v1
Checksum:iBAB76926EFD1B96F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB067445 mRNA. Translation: BAB62267.1.
UniGeneiRn.83597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB067445 mRNA. Translation: BAB62267.1 .
UniGenei Rn.83597.

3D structure databases

ProteinModelPortali Q924S3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015940.

Proteomic databases

PaxDbi Q924S3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 621632. Itga2.

Phylogenomic databases

eggNOGi NOG237277.
HOGENOMi HOG000059610.
InParanoidi Q924S3.
PhylomeDBi Q924S3.

Gene expression databases

Genevestigatori Q924S3.

Family and domain databases

InterProi IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PROSITEi PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat alpha2 integrin cDNA."
    Tateno C., Asahina K., Yoshizato K.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ924S3_RAT
AccessioniPrimary (citable) accession number: Q924S3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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