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Q924S3

- Q924S3_RAT

UniProt

Q924S3 - Q924S3_RAT

Protein
Submitted name:

Alpha 2 integrin

Gene

Itga2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: RGD
    2. collagen binding Source: RGD
    3. integrin binding Source: RGD
    4. laminin binding Source: RGD
    5. protein complex binding Source: RGD
    6. protein heterodimerization activity Source: RGD

    GO - Biological processi

    1. cell adhesion Source: RGD
    2. cell proliferation Source: RGD
    3. cellular component movement Source: RGD
    4. cellular response to hormone stimulus Source: RGD
    5. detection of mechanical stimulus involved in sensory perception of pain Source: RGD
    6. establishment of protein localization Source: RGD
    7. hepatocyte differentiation Source: RGD
    8. hypotonic response Source: RGD
    9. integrin-mediated signaling pathway Source: RGD
    10. mammary gland development Source: RGD
    11. positive regulation of alkaline phosphatase activity Source: RGD
    12. positive regulation of cell adhesion Source: RGD
    13. positive regulation of cell projection organization Source: RGD
    14. positive regulation of collagen binding Source: RGD
    15. positive regulation of collagen biosynthetic process Source: RGD
    16. positive regulation of DNA binding Source: RGD
    17. positive regulation of epithelial cell migration Source: RGD
    18. positive regulation of inflammatory response Source: RGD
    19. positive regulation of leukocyte migration Source: RGD
    20. positive regulation of phagocytosis, engulfment Source: RGD
    21. positive regulation of positive chemotaxis Source: RGD
    22. positive regulation of smooth muscle cell migration Source: RGD
    23. positive regulation of smooth muscle cell proliferation Source: RGD
    24. positive regulation of smooth muscle contraction Source: RGD
    25. positive regulation of translation Source: RGD
    26. positive regulation of transmission of nerve impulse Source: RGD
    27. response to amine Source: RGD
    28. response to drug Source: RGD
    29. response to hypoxia Source: RGD
    30. response to L-ascorbic acid Source: RGD
    31. response to mechanical stimulus Source: RGD
    32. response to muscle activity Source: RGD
    33. response to organic cyclic compound Source: RGD
    34. skin morphogenesis Source: RGD
    35. wound healing Source: RGD

    Keywords - Molecular functioni

    IntegrinUniRule annotationImported, ReceptorUniRule annotation

    Keywords - Biological processi

    Cell adhesionUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha 2 integrinImported
    Gene namesi
    Name:Itga2Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621632. Itga2.

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. axon Source: RGD
    2. axon terminus Source: RGD
    3. cell outer membrane Source: RGD
    4. cell projection Source: RGD
    5. cell surface Source: RGD
    6. extracellular space Source: RGD
    7. focal adhesion Source: RGD
    8. integral component of membrane Source: RGD
    9. integrin complex Source: RGD
    10. nucleus Source: RGD
    11. perinuclear region of cytoplasm Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PaxDbiQ924S3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ924S3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015940.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924S3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiNOG237277.
    HOGENOMiHOG000059610.
    InParanoidiQ924S3.
    PhylomeDBiQ924S3.

    Family and domain databases

    InterProiIPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PROSITEiPS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q924S3-1 [UniParc]FASTAAdd to Basket

    « Hide

    PVDGTEVTCQ IGSSQKSVTC DVGYPALKSE QQVTFTINLD FNLQNLQNQA    50
    AINFQAFSES QETNKADNSV SLIVPLLYDA ELHLTRSTNI NFYEISSDEN 100
    APSVINSVED IGPEFIFSLK ITAGSAPVSM ASVTIHIPLH TKEKNPLLYL 150
    TGIQTDKAGD ISCRAEINPL NLPHTASPVS FKSENFRHMK ELDCKTTSCS 200
    NVSCWLKDLH MKAEYFINVT TRVWNRTFAA STFQTVQLTA AAEIDTHNPQ 250
    LFVIEENAVT IPLMIMKPTE KAEVPTGVII GSIIAGILLL LAMVAGLWKL 300
    GFFKRQYKKM GQNPDETDET TELNS 325
    Length:325
    Mass (Da):35,866
    Last modified:December 1, 2001 - v1
    Checksum:iBAB76926EFD1B96F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067445 mRNA. Translation: BAB62267.1.
    UniGeneiRn.83597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067445 mRNA. Translation: BAB62267.1 .
    UniGenei Rn.83597.

    3D structure databases

    ProteinModelPortali Q924S3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015940.

    Proteomic databases

    PaxDbi Q924S3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 621632. Itga2.

    Phylogenomic databases

    eggNOGi NOG237277.
    HOGENOMi HOG000059610.
    InParanoidi Q924S3.
    PhylomeDBi Q924S3.

    Gene expression databases

    Genevestigatori Q924S3.

    Family and domain databases

    InterProi IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PROSITEi PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat alpha2 integrin cDNA."
      Tateno C., Asahina K., Yoshizato K.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ924S3_RAT
    AccessioniPrimary (citable) accession number: Q924S3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)