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Q924S1

- PLCD_RAT

UniProt

Q924S1 - PLCD_RAT

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Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Gene

Agpat4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.By similarity

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

Pathwayi

GO - Molecular functioni

  1. 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_194934. Synthesis of PA.
REACT_232174. Triglyceride Biosynthesis.
UniPathwayiUPA00557; UER00613.

Names & Taxonomyi

Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC:2.3.1.51)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 4
Short name:
1-AGP acyltransferase 4
Short name:
1-AGPAT 4
Lysophosphatidic acid acyltransferase delta
Short name:
LPAAT-delta
Gene namesi
Name:Agpat4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi619916. Agpat4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3783781-acyl-sn-glycerol-3-phosphate acyltransferase deltaPRO_0000208199Add
BLAST

Proteomic databases

PRIDEiQ924S1.

Expressioni

Gene expression databases

GenevestigatoriQ924S1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024213.

Structurei

3D structure databases

ProteinModelPortaliQ924S1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi96 – 1016HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0204.
GeneTreeiENSGT00530000062943.
HOGENOMiHOG000006110.
HOVERGENiHBG008205.
InParanoidiQ924S1.
KOiK13523.
OMAiPEKYFFL.
OrthoDBiEOG7H7928.
PhylomeDBiQ924S1.
TreeFamiTF314065.

Family and domain databases

InterProiIPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924S1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIGLLKSQ FLCHLVFCYV FIASGLIVNA IQLCTLVIWP INKQLFRKIN
60 70 80 90 100
ARLCYCVSSQ LVMLLEWWSG TECTIYTDPK ASPHYGKENA IVVLNHKFEI
110 120 130 140 150
DFLCGWSLAE RLGILGNSKV LAKKELAYVP IIGWMWYFVE MIFCTRKWEQ
160 170 180 190 200
DRQTVAKSLL HLRDYPEKYL FLIHCEGTRF TEKKHQISMQ VAQAKGLPSL
210 220 230 240 250
KHHLLPRTKG FAITVKCLRD VVPAVYDCTL NFRNNENPTL LGVLNGKKYH
260 270 280 290 300
ADCYVRRIPM EDIPEDEDKC SAWLHKLYQE KDAFQEEYYR TGVFPETPWV
310 320 330 340 350
PPRRPWSLVN WLFWASLLLY PFFQFLVSMV SSGSSVTLAS LVLIFCMASM
360 370
GVRWMIGVTE IDKGSAYGNI DNKRKQTD
Length:378
Mass (Da):43,794
Last modified:December 1, 2001 - v1
Checksum:i389AA01B7327AE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067572 mRNA. Translation: BAB62290.1.
BC086992 mRNA. Translation: AAH86992.1.
RefSeqiNP_596897.1. NM_133406.1.
XP_006227919.1. XM_006227857.2.
UniGeneiRn.41595.

Genome annotation databases

EnsembliENSRNOT00000024213; ENSRNOP00000024213; ENSRNOG00000017731.
GeneIDi170919.
KEGGirno:170919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067572 mRNA. Translation: BAB62290.1 .
BC086992 mRNA. Translation: AAH86992.1 .
RefSeqi NP_596897.1. NM_133406.1.
XP_006227919.1. XM_006227857.2.
UniGenei Rn.41595.

3D structure databases

ProteinModelPortali Q924S1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024213.

Proteomic databases

PRIDEi Q924S1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024213 ; ENSRNOP00000024213 ; ENSRNOG00000017731 .
GeneIDi 170919.
KEGGi rno:170919.

Organism-specific databases

CTDi 56895.
RGDi 619916. Agpat4.

Phylogenomic databases

eggNOGi COG0204.
GeneTreei ENSGT00530000062943.
HOGENOMi HOG000006110.
HOVERGENi HBG008205.
InParanoidi Q924S1.
KOi K13523.
OMAi PEKYFFL.
OrthoDBi EOG7H7928.
PhylomeDBi Q924S1.
TreeFami TF314065.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00613 .
Reactomei REACT_194934. Synthesis of PA.
REACT_232174. Triglyceride Biosynthesis.

Miscellaneous databases

NextBioi 621403.
PROi Q924S1.

Gene expression databases

Genevestigatori Q924S1.

Family and domain databases

InterProi IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
Pfami PF01553. Acyltransferase. 1 hit.
[Graphical view ]
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rattus norvegicus mRNA for lysophosphatidic acid acyltransferase-delta, complete cds."
    Li W., Suzuki T.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiPLCD_RAT
AccessioniPrimary (citable) accession number: Q924S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3