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Q924S1

- PLCD_RAT

UniProt

Q924S1 - PLCD_RAT

Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Gene

Agpat4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.By similarity

    Catalytic activityi

    Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_194934. Synthesis of PA.
    UniPathwayiUPA00557; UER00613.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC:2.3.1.51)
    Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 4
    Short name:
    1-AGP acyltransferase 4
    Short name:
    1-AGPAT 4
    Lysophosphatidic acid acyltransferase delta
    Short name:
    LPAAT-delta
    Gene namesi
    Name:Agpat4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi619916. Agpat4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3783781-acyl-sn-glycerol-3-phosphate acyltransferase deltaPRO_0000208199Add
    BLAST

    Proteomic databases

    PRIDEiQ924S1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ924S1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024213.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924S1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi96 – 1016HXXXXD motif

    Domaini

    The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0204.
    GeneTreeiENSGT00530000062943.
    HOGENOMiHOG000006110.
    HOVERGENiHBG008205.
    InParanoidiQ924S1.
    KOiK13523.
    OMAiPEKYFFL.
    OrthoDBiEOG7H7928.
    PhylomeDBiQ924S1.
    TreeFamiTF314065.

    Family and domain databases

    InterProiIPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PfamiPF01553. Acyltransferase. 1 hit.
    [Graphical view]
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q924S1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIGLLKSQ FLCHLVFCYV FIASGLIVNA IQLCTLVIWP INKQLFRKIN    50
    ARLCYCVSSQ LVMLLEWWSG TECTIYTDPK ASPHYGKENA IVVLNHKFEI 100
    DFLCGWSLAE RLGILGNSKV LAKKELAYVP IIGWMWYFVE MIFCTRKWEQ 150
    DRQTVAKSLL HLRDYPEKYL FLIHCEGTRF TEKKHQISMQ VAQAKGLPSL 200
    KHHLLPRTKG FAITVKCLRD VVPAVYDCTL NFRNNENPTL LGVLNGKKYH 250
    ADCYVRRIPM EDIPEDEDKC SAWLHKLYQE KDAFQEEYYR TGVFPETPWV 300
    PPRRPWSLVN WLFWASLLLY PFFQFLVSMV SSGSSVTLAS LVLIFCMASM 350
    GVRWMIGVTE IDKGSAYGNI DNKRKQTD 378
    Length:378
    Mass (Da):43,794
    Last modified:December 1, 2001 - v1
    Checksum:i389AA01B7327AE2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067572 mRNA. Translation: BAB62290.1.
    BC086992 mRNA. Translation: AAH86992.1.
    RefSeqiNP_596897.1. NM_133406.1.
    XP_006227919.1. XM_006227857.1.
    UniGeneiRn.41595.

    Genome annotation databases

    EnsembliENSRNOT00000024213; ENSRNOP00000024213; ENSRNOG00000017731.
    GeneIDi170919.
    KEGGirno:170919.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067572 mRNA. Translation: BAB62290.1 .
    BC086992 mRNA. Translation: AAH86992.1 .
    RefSeqi NP_596897.1. NM_133406.1.
    XP_006227919.1. XM_006227857.1.
    UniGenei Rn.41595.

    3D structure databases

    ProteinModelPortali Q924S1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024213.

    Proteomic databases

    PRIDEi Q924S1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024213 ; ENSRNOP00000024213 ; ENSRNOG00000017731 .
    GeneIDi 170919.
    KEGGi rno:170919.

    Organism-specific databases

    CTDi 56895.
    RGDi 619916. Agpat4.

    Phylogenomic databases

    eggNOGi COG0204.
    GeneTreei ENSGT00530000062943.
    HOGENOMi HOG000006110.
    HOVERGENi HBG008205.
    InParanoidi Q924S1.
    KOi K13523.
    OMAi PEKYFFL.
    OrthoDBi EOG7H7928.
    PhylomeDBi Q924S1.
    TreeFami TF314065.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00613 .
    Reactomei REACT_194934. Synthesis of PA.

    Miscellaneous databases

    NextBioi 621403.
    PROi Q924S1.

    Gene expression databases

    Genevestigatori Q924S1.

    Family and domain databases

    InterProi IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    Pfami PF01553. Acyltransferase. 1 hit.
    [Graphical view ]
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rattus norvegicus mRNA for lysophosphatidic acid acyltransferase-delta, complete cds."
      Li W., Suzuki T.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiPLCD_RAT
    AccessioniPrimary (citable) accession number: Q924S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3