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Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Gene

Agpat4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.By similarity

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
  3. Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 1 (Cds1), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1483166 Synthesis of PA
UniPathwayiUPA00557; UER00613

Names & Taxonomyi

Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC:2.3.1.51)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 4
Short name:
1-AGP acyltransferase 4
Short name:
1-AGPAT 4
Lysophosphatidic acid acyltransferase delta
Short name:
LPAAT-delta
Gene namesi
Name:Agpat4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619916 Agpat4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002081991 – 3781-acyl-sn-glycerol-3-phosphate acyltransferase deltaAdd BLAST378

Proteomic databases

PaxDbiQ924S1
PRIDEiQ924S1

Expressioni

Gene expression databases

BgeeiENSRNOG00000017731
ExpressionAtlasiQ924S1 baseline and differential
GenevisibleiQ924S1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024213

Structurei

3D structure databases

ProteinModelPortaliQ924S1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 101HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1505 Eukaryota
COG0204 LUCA
GeneTreeiENSGT00890000139404
HOGENOMiHOG000006110
HOVERGENiHBG008205
InParanoidiQ924S1
KOiK13523
PhylomeDBiQ924S1
TreeFamiTF314065

Family and domain databases

InterProiView protein in InterPro
IPR032098 Acyltransf_C
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF16076 Acyltransf_C, 1 hit
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit

Sequencei

Sequence statusi: Complete.

Q924S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIGLLKSQ FLCHLVFCYV FIASGLIVNA IQLCTLVIWP INKQLFRKIN
60 70 80 90 100
ARLCYCVSSQ LVMLLEWWSG TECTIYTDPK ASPHYGKENA IVVLNHKFEI
110 120 130 140 150
DFLCGWSLAE RLGILGNSKV LAKKELAYVP IIGWMWYFVE MIFCTRKWEQ
160 170 180 190 200
DRQTVAKSLL HLRDYPEKYL FLIHCEGTRF TEKKHQISMQ VAQAKGLPSL
210 220 230 240 250
KHHLLPRTKG FAITVKCLRD VVPAVYDCTL NFRNNENPTL LGVLNGKKYH
260 270 280 290 300
ADCYVRRIPM EDIPEDEDKC SAWLHKLYQE KDAFQEEYYR TGVFPETPWV
310 320 330 340 350
PPRRPWSLVN WLFWASLLLY PFFQFLVSMV SSGSSVTLAS LVLIFCMASM
360 370
GVRWMIGVTE IDKGSAYGNI DNKRKQTD
Length:378
Mass (Da):43,794
Last modified:December 1, 2001 - v1
Checksum:i389AA01B7327AE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067572 mRNA Translation: BAB62290.1
BC086992 mRNA Translation: AAH86992.1
RefSeqiNP_596897.1, NM_133406.1
XP_006227919.1, XM_006227857.3
UniGeneiRn.41595

Genome annotation databases

EnsembliENSRNOT00000024213; ENSRNOP00000024213; ENSRNOG00000017731
GeneIDi170919
KEGGirno:170919

Similar proteinsi

Entry informationi

Entry nameiPLCD_RAT
AccessioniPrimary (citable) accession number: Q924S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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