Reviewed, UniProtKB/Swiss-Prot Q924S1 (PLCD_RAT)

Names and origin

Protein names

Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    EC=2.3.1.51
Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 4
      Short name=1-AGP acyltransferase 4
      Short name=1-AGPAT 4
    Lysophosphatidic acid acyltransferase delta
      Short name=LPAAT-delta

Gene names

Name:

Agpat4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	1-acyl-sn-glycerol-3-phosphate acyltransferase delta		PRO_0000208199
Regions
	Transmembrane	11 – 31	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	311 – 331	21	Potential
	Transmembrane	338 – 358	21	Potential
	Motif	96 – 101	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q924S1-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 389AA01B7327AE2B	FASTA	378	43,794
	10 20 30 40 50 60 MDLIGLLKSQ FLCHLVFCYV FIASGLIVNA IQLCTLVIWP INKQLFRKIN ARLCYCVSSQ 70 80 90 100 110 120 LVMLLEWWSG TECTIYTDPK ASPHYGKENA IVVLNHKFEI DFLCGWSLAE RLGILGNSKV 130 140 150 160 170 180 LAKKELAYVP IIGWMWYFVE MIFCTRKWEQ DRQTVAKSLL HLRDYPEKYL FLIHCEGTRF 190 200 210 220 230 240 TEKKHQISMQ VAQAKGLPSL KHHLLPRTKG FAITVKCLRD VVPAVYDCTL NFRNNENPTL 250 260 270 280 290 300 LGVLNGKKYH ADCYVRRIPM EDIPEDEDKC SAWLHKLYQE KDAFQEEYYR TGVFPETPWV 310 320 330 340 350 360 PPRRPWSLVN WLFWASLLLY PFFQFLVSMV SSGSSVTLAS LVLIFCMASM GVRWMIGVTE 370 IDKGSAYGNI DNKRKQTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rattus norvegicus mRNA for lysophosphatidic acid acyltransferase-delta, complete cds." Li W., Suzuki T. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB067572 mRNA. Translation: BAB62290.1. BC086992 mRNA. Translation: AAH86992.1.
IPI	IPI00205071.
RefSeq	NP_596897.1.
UniGene	Rn.41595
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q924S1.
Genome annotation databases
Ensembl	ENSRNOT00000024213; ENSRNOP00000024213; ENSRNOG00000017731; Rattus norvegicus. [Genome view]
GeneID	170919.
KEGG	rno:170919.
UCSC	NM_133406. rat.
Organism-specific databases
CTD	170919.
RGD	619916. Agpat4.
Phylogenomic databases
eggNOG	roNOG06478.
HOVERGEN	Q924S1.
InParanoid	Q924S1.
OMA	WMWYFLE.
OrthoDB	EOG9DFS6X.
PhylomeDB	Q924S1.
Enzyme and pathway databases
BRENDA	2.3.1.51. 248.
Gene expression databases
ArrayExpress	Q924S1.
Genevestigator	Q924S1.
GermOnline	ENSRNOG00000017731. Rattus norvegicus.
Family and domain databases
InterPro	IPR002123. Acyltransferase. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	621403.

Entry information

Entry name

PLCD_RAT

Accession

Primary (citable) accession number: Q924S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)