Reviewed,
UniProtKB/Swiss-Prot Q924S1 (PLCD_RAT)
Last modified
January 19, 2010.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta EC=2.3.1.51 Alternative name(s): 1-acylglycerol-3-phosphate O-acyltransferase 4 Short name=1-AGP acyltransferase 4 Short name=1-AGPAT 4 Lysophosphatidic acid acyltransferase delta Short name=LPAAT-delta | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 378 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity. |
| Catalytic activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Pathway | |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity. |
| Sequence similarities | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phospholipid biosynthesis |
| Cellular component | Membrane |
| Domain | Transmembrane |
| Molecular function | Acyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 378 | 378 | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta | PRO_0000208199 | |||||
Regions | |||||||||
| Transmembrane | 11 – 31 | 21 | Potential | ||||||
| Transmembrane | 125 – 145 | 21 | Potential | ||||||
| Transmembrane | 311 – 331 | 21 | Potential | ||||||
| Transmembrane | 338 – 358 | 21 | Potential | ||||||
| Motif | 96 – 101 | 6 | HXXXXD motif | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Rattus norvegicus mRNA for lysophosphatidic acid acyltransferase-delta, complete cds." Li W., Suzuki T. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB067572 mRNA. Translation: BAB62290.1. BC086992 mRNA. Translation: AAH86992.1. |
| IPI | IPI00205071. |
| RefSeq | NP_596897.1. |
| UniGene | Rn.41595 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q924S1. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000024213; ENSRNOP00000024213; ENSRNOG00000017731; Rattus norvegicus. [Genome view] |
| GeneID | 170919. |
| KEGG | rno:170919. |
| UCSC | NM_133406. rat. |
Organism-specific databases | |
| CTD | 170919. |
| RGD | 619916. Agpat4. |
Phylogenomic databases | |
| eggNOG | roNOG06478. |
| HOVERGEN | Q924S1. |
| InParanoid | Q924S1. |
| OMA | WMWYFLE. |
| OrthoDB | EOG9DFS6X. |
| PhylomeDB | Q924S1. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.51. 248. |
Gene expression databases | |
| ArrayExpress | Q924S1. |
| Genevestigator | Q924S1. |
| GermOnline | ENSRNOG00000017731. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR002123. Acyltransferase. [Graphical view] |
| Pfam | PF01553. Acyltransferase. 1 hit. [Graphical view] |
| SMART | SM00563. PlsC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 621403. |
Entry information
| Entry name | PLCD_RAT | ||||||||
| Accession | Primary (citable) accession number: Q924S1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


