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Protein

Transmembrane protein 14C

Gene

Tmem14c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14C
Alternative name(s):
p11
Gene namesi
Name:Tmem14c
Synonyms:Cdtw1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621692. Tmem14c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 115114Transmembrane protein 14CPRO_0000221175Add
BLAST

Proteomic databases

PaxDbiQ924P2.
PRIDEiQ924P2.

PTM databases

PhosphoSiteiQ924P2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061240.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
HOVERGENiHBG054211.
InParanoidiQ924P2.
PhylomeDBiQ924P2.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKDSGPLVP LHYYGFGYAA LVATGGIIGY AKAGSVPSLA AGLFFGGLAG
60 70 80 90 100
LGAYQLSQDP RNVWVFLATS GTLAGIMGMR FYNSGKFMPA GLIAGASLLM
110
VAPGVAKIQE ITTMP
Length:115
Mass (Da):11,776
Last modified:December 1, 2001 - v1
Checksum:i6761C77ED520597B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083396 mRNA. Translation: AAK84687.1.
RefSeqiNP_599222.2. NM_134395.2.
UniGeneiRn.114642.

Genome annotation databases

GeneIDi171432.
KEGGirno:171432.
UCSCiRGD:621692. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083396 mRNA. Translation: AAK84687.1.
RefSeqiNP_599222.2. NM_134395.2.
UniGeneiRn.114642.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061240.

PTM databases

PhosphoSiteiQ924P2.

Proteomic databases

PaxDbiQ924P2.
PRIDEiQ924P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171432.
KEGGirno:171432.
UCSCiRGD:621692. rat.

Organism-specific databases

CTDi51522.
RGDi621692. Tmem14c.

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
HOVERGENiHBG054211.
InParanoidiQ924P2.
PhylomeDBiQ924P2.

Miscellaneous databases

PROiQ924P2.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a novel gene up-regulated by stroke."
    Chopp M., Dou D., Tsang W., Wang L.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiTM14C_RAT
AccessioniPrimary (citable) accession number: Q924P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.