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Q924N5

- ACBG1_RAT

UniProt

Q924N5 - ACBG1_RAT

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Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

Acsbg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei547 – 5471ATPBy similarity
Binding sitei562 – 5621ATPBy similarity
Binding sitei698 – 6981ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi279 – 2879ATPBy similarity
Nucleotide bindingi469 – 4746ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: HGNC
  3. very long-chain fatty acid-CoA ligase activity Source: HGNC

GO - Biological processi

  1. long-chain fatty acid metabolic process Source: HGNC
  2. ovarian follicle atresia Source: RGD
  3. response to glucocorticoid Source: Ensembl
  4. very long-chain fatty acid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Gonadotropin-regulated long chain acyl CoA synthetase
Short name:
GR-LACS
Gene namesi
Name:Acsbg1
Synonyms:Grlacs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi708557. Acsbg1.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Long-chain-fatty-acid--CoA ligase ACSBG1PRO_0000315811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei655 – 6551PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ924N5.
PRIDEiQ924N5.

2D gel databases

World-2DPAGE0004:Q924N5.

PTM databases

PhosphoSiteiQ924N5.

Expressioni

Tissue specificityi

Present in testis, at a lower level in brain, and at a very low level in ovary. Not detected in other tissues. tested. Present in Leydig cells of the adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells (at protein level).2 Publications

Inductioni

Down-regulated by gonadotropin.1 Publication

Gene expression databases

GenevestigatoriQ924N5.

Interactioni

Protein-protein interaction databases

BioGridi251236. 1 interaction.
STRINGi10116.ENSRNOP00000016104.

Structurei

3D structure databases

ProteinModelPortaliQ924N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ924N5.
KOiK15013.
OMAiINSAGKN.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ924N5.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRSSEAGYC CLSRDSNMPD SRDDQQQGAS MGTSPDNSQT SSLIDGRTLS
60 70 80 90 100
KESPSHGLEL SAPEKARAAS LDASEEALWT TRADGRVRLR LEPFCTQLPY
110 120 130 140 150
TVHQMFYEAL DKYGNLSALG FKRKDKWERI SYYQYYLIAR KVAKGFLKLG
160 170 180 190 200
LERAHSVAIL GFNSPEWFFS AVGTVFAGGI VTGIYTTSSP EACQYIAHDC
210 220 230 240 250
RANVIVVDTQ KQLEKILKIW KDLPHLKAVV IYQEPPPKKM ANVYTMEELI
260 270 280 290 300
ELGQEVPEEA LDAIIDTQQP NQCCVLVYTS GTTGNPKGVM LSQDNITWTA
310 320 330 340 350
RYGSQAGDIQ PAEVQQEVVV SYLPLSHIAA QIYDLWTGIQ WGAQVCFADP
360 370 380 390 400
DALKGTLVNT LREVEPTSHM GVPRVWEKIM ERIQEVAAQS GFIRRKMLLW
410 420 430 440 450
AMSVTLEQNL TCPSNDLKPF TSRLADYLVL ARVRQALGFA KCQKNFYGAA
460 470 480 490 500
PMTAETQRFF LGLNIRLYAG YGLSESTGPH FMSSPYNYRL YSSGRVVPGC
510 520 530 540 550
RVKLVNQDAD GIGEICLWGR TIFMGYLNME DKTHEAIDSE GWLHTGDMGR
560 570 580 590 600
LDDDGFLYIT GRLKELIITA GGENVPPVPI EEAVKMELPI ISSAMLIGDQ
610 620 630 640 650
RKFLSMLLTL KCTLNPETSE PTDNLTEQAV EFCQRVGSKA STVSEIVGQK
660 670 680 690 700
DEAVYQAIHE GIQRVNANAA ARPYHIQKWA ILERDFSISG GELGPTMKLK
710 720
RLTVLEKYKD IIDSFYQEQK Q
Length:721
Mass (Da):80,519
Last modified:December 1, 2001 - v1
Checksum:i600DC8F87546DA32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208125 mRNA. Translation: AAG35729.1.
RefSeqiNP_599216.1. NM_134389.1.
UniGeneiRn.17672.

Genome annotation databases

EnsembliENSRNOT00000016104; ENSRNOP00000016104; ENSRNOG00000011381.
GeneIDi171410.
KEGGirno:171410.
UCSCiRGD:708557. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208125 mRNA. Translation: AAG35729.1 .
RefSeqi NP_599216.1. NM_134389.1.
UniGenei Rn.17672.

3D structure databases

ProteinModelPortali Q924N5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251236. 1 interaction.
STRINGi 10116.ENSRNOP00000016104.

PTM databases

PhosphoSitei Q924N5.

2D gel databases

World-2DPAGE 0004:Q924N5.

Proteomic databases

PaxDbi Q924N5.
PRIDEi Q924N5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016104 ; ENSRNOP00000016104 ; ENSRNOG00000011381 .
GeneIDi 171410.
KEGGi rno:171410.
UCSCi RGD:708557. rat.

Organism-specific databases

CTDi 23205.
RGDi 708557. Acsbg1.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000101725.
HOGENOMi HOG000230004.
HOVERGENi HBG054660.
InParanoidi Q924N5.
KOi K15013.
OMAi INSAGKN.
OrthoDBi EOG7B5WVB.
PhylomeDBi Q924N5.
TreeFami TF354286.

Enzyme and pathway databases

BRENDAi 6.2.1.3. 3474.

Miscellaneous databases

NextBioi 622288.
PROi Q924N5.

Gene expression databases

Genevestigatori Q924N5.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase."
    Tang P.-Z., Tsai-Morris C.-H., Dufau M.L.
    Proc. Natl. Acad. Sci. U.S.A. 98:6581-6586(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  2. "Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain. Identification of novel forms in the brain."
    Li J., Sheng Y., Tang P.-Z., Tsai-Morris C.-H., Dufau M.L.
    J. Steroid Biochem. Mol. Biol. 98:207-217(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACBG1_RAT
AccessioniPrimary (citable) accession number: Q924N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3