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Q924N5

- ACBG1_RAT

UniProt

Q924N5 - ACBG1_RAT

Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

Acsbg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.1 Publication

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei547 – 5471ATPBy similarity
    Binding sitei562 – 5621ATPBy similarity
    Binding sitei698 – 6981ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi279 – 2879ATPBy similarity
    Nucleotide bindingi469 – 4746ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: HGNC
    3. very long-chain fatty acid-CoA ligase activity Source: HGNC

    GO - Biological processi

    1. long-chain fatty acid metabolic process Source: HGNC
    2. ovarian follicle atresia Source: RGD
    3. response to glucocorticoid Source: Ensembl
    4. very long-chain fatty acid metabolic process Source: HGNC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.2.1.3. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 1
    Gonadotropin-regulated long chain acyl CoA synthetase
    Short name:
    GR-LACS
    Gene namesi
    Name:Acsbg1
    Synonyms:Grlacs
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi708557. Acsbg1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    3. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Long-chain-fatty-acid--CoA ligase ACSBG1PRO_0000315811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei655 – 6551PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ924N5.
    PRIDEiQ924N5.

    2D gel databases

    World-2DPAGE0004:Q924N5.

    PTM databases

    PhosphoSiteiQ924N5.

    Expressioni

    Tissue specificityi

    Present in testis, at a lower level in brain, and at a very low level in ovary. Not detected in other tissues. tested. Present in Leydig cells of the adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells (at protein level).2 Publications

    Inductioni

    Down-regulated by gonadotropin.1 Publication

    Gene expression databases

    GenevestigatoriQ924N5.

    Interactioni

    Protein-protein interaction databases

    BioGridi251236. 1 interaction.
    STRINGi10116.ENSRNOP00000016104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    HOGENOMiHOG000230004.
    HOVERGENiHBG054660.
    InParanoidiQ924N5.
    KOiK15013.
    OMAiINSAGKN.
    OrthoDBiEOG7B5WVB.
    PhylomeDBiQ924N5.
    TreeFamiTF354286.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q924N5-1 [UniParc]FASTAAdd to Basket

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    MPRSSEAGYC CLSRDSNMPD SRDDQQQGAS MGTSPDNSQT SSLIDGRTLS    50
    KESPSHGLEL SAPEKARAAS LDASEEALWT TRADGRVRLR LEPFCTQLPY 100
    TVHQMFYEAL DKYGNLSALG FKRKDKWERI SYYQYYLIAR KVAKGFLKLG 150
    LERAHSVAIL GFNSPEWFFS AVGTVFAGGI VTGIYTTSSP EACQYIAHDC 200
    RANVIVVDTQ KQLEKILKIW KDLPHLKAVV IYQEPPPKKM ANVYTMEELI 250
    ELGQEVPEEA LDAIIDTQQP NQCCVLVYTS GTTGNPKGVM LSQDNITWTA 300
    RYGSQAGDIQ PAEVQQEVVV SYLPLSHIAA QIYDLWTGIQ WGAQVCFADP 350
    DALKGTLVNT LREVEPTSHM GVPRVWEKIM ERIQEVAAQS GFIRRKMLLW 400
    AMSVTLEQNL TCPSNDLKPF TSRLADYLVL ARVRQALGFA KCQKNFYGAA 450
    PMTAETQRFF LGLNIRLYAG YGLSESTGPH FMSSPYNYRL YSSGRVVPGC 500
    RVKLVNQDAD GIGEICLWGR TIFMGYLNME DKTHEAIDSE GWLHTGDMGR 550
    LDDDGFLYIT GRLKELIITA GGENVPPVPI EEAVKMELPI ISSAMLIGDQ 600
    RKFLSMLLTL KCTLNPETSE PTDNLTEQAV EFCQRVGSKA STVSEIVGQK 650
    DEAVYQAIHE GIQRVNANAA ARPYHIQKWA ILERDFSISG GELGPTMKLK 700
    RLTVLEKYKD IIDSFYQEQK Q 721
    Length:721
    Mass (Da):80,519
    Last modified:December 1, 2001 - v1
    Checksum:i600DC8F87546DA32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208125 mRNA. Translation: AAG35729.1.
    RefSeqiNP_599216.1. NM_134389.1.
    UniGeneiRn.17672.

    Genome annotation databases

    EnsembliENSRNOT00000016104; ENSRNOP00000016104; ENSRNOG00000011381.
    GeneIDi171410.
    KEGGirno:171410.
    UCSCiRGD:708557. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208125 mRNA. Translation: AAG35729.1 .
    RefSeqi NP_599216.1. NM_134389.1.
    UniGenei Rn.17672.

    3D structure databases

    ProteinModelPortali Q924N5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 251236. 1 interaction.
    STRINGi 10116.ENSRNOP00000016104.

    PTM databases

    PhosphoSitei Q924N5.

    2D gel databases

    World-2DPAGE 0004:Q924N5.

    Proteomic databases

    PaxDbi Q924N5.
    PRIDEi Q924N5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016104 ; ENSRNOP00000016104 ; ENSRNOG00000011381 .
    GeneIDi 171410.
    KEGGi rno:171410.
    UCSCi RGD:708557. rat.

    Organism-specific databases

    CTDi 23205.
    RGDi 708557. Acsbg1.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    HOGENOMi HOG000230004.
    HOVERGENi HBG054660.
    InParanoidi Q924N5.
    KOi K15013.
    OMAi INSAGKN.
    OrthoDBi EOG7B5WVB.
    PhylomeDBi Q924N5.
    TreeFami TF354286.

    Enzyme and pathway databases

    BRENDAi 6.2.1.3. 3474.

    Miscellaneous databases

    NextBioi 622288.
    PROi Q924N5.

    Gene expression databases

    Genevestigatori Q924N5.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase."
      Tang P.-Z., Tsai-Morris C.-H., Dufau M.L.
      Proc. Natl. Acad. Sci. U.S.A. 98:6581-6586(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    2. "Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain. Identification of novel forms in the brain."
      Li J., Sheng Y., Tang P.-Z., Tsai-Morris C.-H., Dufau M.L.
      J. Steroid Biochem. Mol. Biol. 98:207-217(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiACBG1_RAT
    AccessioniPrimary (citable) accession number: Q924N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3