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Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

Acsbg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei547ATPBy similarity1
Binding sitei562ATPBy similarity1
Binding sitei698ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi279 – 287ATPBy similarity9
Nucleotide bindingi469 – 474ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • long-chain fatty acid metabolic process Source: RGD
  • ovarian follicle atresia Source: RGD
  • response to glucocorticoid Source: RGD
  • very long-chain fatty acid metabolic process Source: HGNC

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3 5301
ReactomeiR-RNO-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Gonadotropin-regulated long chain acyl CoA synthetase
Short name:
GR-LACS
Gene namesi
Name:Acsbg1
Synonyms:Grlacs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi708557 Acsbg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158111 – 721Long-chain-fatty-acid--CoA ligase ACSBG1Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei655PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ924N5
PRIDEiQ924N5

2D gel databases

World-2DPAGEi0004:Q924N5

PTM databases

iPTMnetiQ924N5
PhosphoSitePlusiQ924N5

Expressioni

Tissue specificityi

Present in testis, at a lower level in brain, and at a very low level in ovary. Not detected in other tissues. tested. Present in Leydig cells of the adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells (at protein level).2 Publications

Inductioni

Down-regulated by gonadotropin.1 Publication

Gene expression databases

BgeeiENSRNOG00000011381
ExpressionAtlasiQ924N5 baseline and differential
GenevisibleiQ924N5 RN

Interactioni

Protein-protein interaction databases

BioGridi251236, 2 interactors
STRINGi10116.ENSRNOP00000016104

Structurei

3D structure databases

ProteinModelPortaliQ924N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00690000101725
HOGENOMiHOG000230004
HOVERGENiHBG054660
InParanoidiQ924N5
KOiK15013
PhylomeDBiQ924N5
TreeFamiTF354286

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q924N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSSEAGYC CLSRDSNMPD SRDDQQQGAS MGTSPDNSQT SSLIDGRTLS
60 70 80 90 100
KESPSHGLEL SAPEKARAAS LDASEEALWT TRADGRVRLR LEPFCTQLPY
110 120 130 140 150
TVHQMFYEAL DKYGNLSALG FKRKDKWERI SYYQYYLIAR KVAKGFLKLG
160 170 180 190 200
LERAHSVAIL GFNSPEWFFS AVGTVFAGGI VTGIYTTSSP EACQYIAHDC
210 220 230 240 250
RANVIVVDTQ KQLEKILKIW KDLPHLKAVV IYQEPPPKKM ANVYTMEELI
260 270 280 290 300
ELGQEVPEEA LDAIIDTQQP NQCCVLVYTS GTTGNPKGVM LSQDNITWTA
310 320 330 340 350
RYGSQAGDIQ PAEVQQEVVV SYLPLSHIAA QIYDLWTGIQ WGAQVCFADP
360 370 380 390 400
DALKGTLVNT LREVEPTSHM GVPRVWEKIM ERIQEVAAQS GFIRRKMLLW
410 420 430 440 450
AMSVTLEQNL TCPSNDLKPF TSRLADYLVL ARVRQALGFA KCQKNFYGAA
460 470 480 490 500
PMTAETQRFF LGLNIRLYAG YGLSESTGPH FMSSPYNYRL YSSGRVVPGC
510 520 530 540 550
RVKLVNQDAD GIGEICLWGR TIFMGYLNME DKTHEAIDSE GWLHTGDMGR
560 570 580 590 600
LDDDGFLYIT GRLKELIITA GGENVPPVPI EEAVKMELPI ISSAMLIGDQ
610 620 630 640 650
RKFLSMLLTL KCTLNPETSE PTDNLTEQAV EFCQRVGSKA STVSEIVGQK
660 670 680 690 700
DEAVYQAIHE GIQRVNANAA ARPYHIQKWA ILERDFSISG GELGPTMKLK
710 720
RLTVLEKYKD IIDSFYQEQK Q
Length:721
Mass (Da):80,519
Last modified:December 1, 2001 - v1
Checksum:i600DC8F87546DA32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208125 mRNA Translation: AAG35729.1
RefSeqiNP_599216.1, NM_134389.1
UniGeneiRn.17672

Genome annotation databases

EnsembliENSRNOT00000016104; ENSRNOP00000016104; ENSRNOG00000011381
GeneIDi171410
KEGGirno:171410
UCSCiRGD:708557 rat

Similar proteinsi

Entry informationi

Entry nameiACBG1_RAT
AccessioniPrimary (citable) accession number: Q924N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health