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Q924M7

- MPI_MOUSE

UniProt

Q924M7 - MPI_MOUSE

Protein

Mannose-6-phosphate isomerase

Gene

Mpi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi110 – 1101ZincBy similarity
    Metal bindingi112 – 1121ZincBy similarity
    Metal bindingi137 – 1371ZincBy similarity
    Metal bindingi276 – 2761ZincBy similarity
    Active sitei295 – 2951By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198715. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00423.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:Mpi
    Synonyms:Mpi1, Pmi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:97075. Mpi.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 423422Mannose-6-phosphate isomerasePRO_0000194237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ924M7.
    PaxDbiQ924M7.
    PRIDEiQ924M7.

    2D gel databases

    REPRODUCTION-2DPAGEQ924M7.

    PTM databases

    PhosphoSiteiQ924M7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ924M7.
    BgeeiQ924M7.
    CleanExiMM_MPI.
    GenevestigatoriQ924M7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ924M7. 1 interaction.
    MINTiMINT-4123108.
    STRINGi10090.ENSMUSP00000034856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924M7.
    SMRiQ924M7. Positions 2-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    GeneTreeiENSGT00390000016075.
    HOGENOMiHOG000241277.
    HOVERGENiHBG000367.
    InParanoidiQ924M7.
    KOiK01809.
    OMAiQGEPWDT.
    OrthoDBiEOG7GTT3M.
    PhylomeDBiQ924M7.
    TreeFamiTF312831.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR10309. PTHR10309. 1 hit.
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSiPR00714. MAN6PISMRASE.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.
    PROSITEiPS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q924M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW    50
    MGTHPRGDAK ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV 100
    LSVDTALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTSFQGLCG 150
    FRPVEEIVTF MKKVPEFQLL IGDDATAQLK ESVGGDTEAM ASALRNCFSH 200
    LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ LHQQHPGDIG 250
    CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP 300
    KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM 350
    EVPSSVTEYK VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA 400
    NESVLLKITV PKDLLIFRAC CLL 423
    Length:423
    Mass (Da):46,575
    Last modified:December 1, 2001 - v1
    Checksum:i3A49506D1249B670
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244360 mRNA. Translation: AAK69388.1.
    BC051163 mRNA. Translation: AAH51163.1.
    CCDSiCCDS40650.1.
    RefSeqiNP_080113.1. NM_025837.2.
    UniGeneiMm.247218.

    Genome annotation databases

    EnsembliENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306.
    GeneIDi110119.
    KEGGimmu:110119.
    UCSCiuc009pvd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244360 mRNA. Translation: AAK69388.1 .
    BC051163 mRNA. Translation: AAH51163.1 .
    CCDSi CCDS40650.1.
    RefSeqi NP_080113.1. NM_025837.2.
    UniGenei Mm.247218.

    3D structure databases

    ProteinModelPortali Q924M7.
    SMRi Q924M7. Positions 2-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q924M7. 1 interaction.
    MINTi MINT-4123108.
    STRINGi 10090.ENSMUSP00000034856.

    PTM databases

    PhosphoSitei Q924M7.

    2D gel databases

    REPRODUCTION-2DPAGE Q924M7.

    Proteomic databases

    MaxQBi Q924M7.
    PaxDbi Q924M7.
    PRIDEi Q924M7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034856 ; ENSMUSP00000034856 ; ENSMUSG00000032306 .
    GeneIDi 110119.
    KEGGi mmu:110119.
    UCSCi uc009pvd.1. mouse.

    Organism-specific databases

    CTDi 4351.
    MGIi MGI:97075. Mpi.

    Phylogenomic databases

    eggNOGi COG1482.
    GeneTreei ENSGT00390000016075.
    HOGENOMi HOG000241277.
    HOVERGENi HBG000367.
    InParanoidi Q924M7.
    KOi K01809.
    OMAi QGEPWDT.
    OrthoDBi EOG7GTT3M.
    PhylomeDBi Q924M7.
    TreeFami TF312831.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .
    Reactomei REACT_198715. Synthesis of GDP-mannose.

    Miscellaneous databases

    NextBioi 363359.
    PROi Q924M7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q924M7.
    Bgeei Q924M7.
    CleanExi MM_MPI.
    Genevestigatori Q924M7.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR10309. PTHR10309. 1 hit.
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSi PR00714. MAN6PISMRASE.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    PROSITEi PS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase."
      Davis J.A., Wu X.H., Wang L., DeRossi C., Westphal V., Wu R., Alton G., Srikrishna G., Freeze H.H.
      Glycobiology 12:435-442(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiMPI_MOUSE
    AccessioniPrimary (citable) accession number: Q924M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3