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Q924M7 (MPI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannose-6-phosphate isomerase

EC=5.3.1.8
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name=PMI
Gene names
Name:Mpi
Synonyms:Mpi1, Pmi
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subcellular location

Cytoplasm Ref.1.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 423422Mannose-6-phosphate isomerase
PRO_0000194237

Sites

Active site2951 By similarity
Metal binding1101Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1371Zinc By similarity
Metal binding2761Zinc By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q924M7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3A49506D1249B670

FASTA42346,575
        10         20         30         40         50         60 
MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW MGTHPRGDAK 

        70         80         90        100        110        120 
ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV LSVDTALSIQ AHPNKELAEK 

       130        140        150        160        170        180 
LHLQAPEHYP DANHKPEMAI ALTSFQGLCG FRPVEEIVTF MKKVPEFQLL IGDDATAQLK 

       190        200        210        220        230        240 
ESVGGDTEAM ASALRNCFSH LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ 

       250        260        270        280        290        300 
LHQQHPGDIG CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP 

       310        320        330        340        350        360 
KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM EVPSSVTEYK 

       370        380        390        400        410        420 
VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA NESVLLKITV PKDLLIFRAC 


CLL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase."
Davis J.A., Wu X.H., Wang L., DeRossi C., Westphal V., Wu R., Alton G., Srikrishna G., Freeze H.H.
Glycobiology 12:435-442(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF244360 mRNA. Translation: AAK69388.1.
BC051163 mRNA. Translation: AAH51163.1.
RefSeqNP_080113.1. NM_025837.2.
UniGeneMm.247218.

3D structure databases

ProteinModelPortalQ924M7.
SMRQ924M7. Positions 2-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ924M7. 1 interaction.
MINTMINT-4123108.
STRING10090.ENSMUSP00000034856.

PTM databases

PhosphoSiteQ924M7.

2D gel databases

REPRODUCTION-2DPAGEQ924M7.

Proteomic databases

PaxDbQ924M7.
PRIDEQ924M7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306.
GeneID110119.
KEGGmmu:110119.
UCSCuc009pvd.1. mouse.

Organism-specific databases

CTD4351.
MGIMGI:97075. Mpi.

Phylogenomic databases

eggNOGCOG1482.
GeneTreeENSGT00390000016075.
HOGENOMHOG000241277.
HOVERGENHBG000367.
InParanoidQ924M7.
KOK01809.
OMAFKVLCAD.
OrthoDBEOG7GTT3M.
PhylomeDBQ924M7.
TreeFamTF312831.

Enzyme and pathway databases

UniPathwayUPA00126; UER00423.

Gene expression databases

ArrayExpressQ924M7.
BgeeQ924M7.
CleanExMM_MPI.
GenevestigatorQ924M7.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR10309. PTHR10309. 1 hit.
PfamPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSPR00714. MAN6PISMRASE.
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR00218. manA. 1 hit.
PROSITEPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio363359.
PROQ924M7.
SOURCESearch...

Entry information

Entry nameMPI_MOUSE
AccessionPrimary (citable) accession number: Q924M7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot