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Q924M7

- MPI_MOUSE

UniProt

Q924M7 - MPI_MOUSE

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Protein

Mannose-6-phosphate isomerase

Gene

Mpi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101ZincBy similarity
Metal bindingi112 – 1121ZincBy similarity
Metal bindingi137 – 1371ZincBy similarity
Metal bindingi276 – 2761ZincBy similarity
Active sitei295 – 2951By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: MGI
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198715. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:Mpi
Synonyms:Mpi1, Pmi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:97075. Mpi.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 423422Mannose-6-phosphate isomerasePRO_0000194237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ924M7.
PaxDbiQ924M7.
PRIDEiQ924M7.

2D gel databases

REPRODUCTION-2DPAGEQ924M7.

PTM databases

PhosphoSiteiQ924M7.

Expressioni

Gene expression databases

BgeeiQ924M7.
CleanExiMM_MPI.
ExpressionAtlasiQ924M7. baseline.
GenevestigatoriQ924M7.

Interactioni

Protein-protein interaction databases

IntActiQ924M7. 1 interaction.
MINTiMINT-4123108.
STRINGi10090.ENSMUSP00000034856.

Structurei

3D structure databases

ProteinModelPortaliQ924M7.
SMRiQ924M7. Positions 2-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
GeneTreeiENSGT00390000016075.
HOGENOMiHOG000241277.
HOVERGENiHBG000367.
InParanoidiQ924M7.
KOiK01809.
OMAiQGEPWDT.
OrthoDBiEOG7GTT3M.
PhylomeDBiQ924M7.
TreeFamiTF312831.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW
60 70 80 90 100
MGTHPRGDAK ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV
110 120 130 140 150
LSVDTALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTSFQGLCG
160 170 180 190 200
FRPVEEIVTF MKKVPEFQLL IGDDATAQLK ESVGGDTEAM ASALRNCFSH
210 220 230 240 250
LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ LHQQHPGDIG
260 270 280 290 300
CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP
310 320 330 340 350
KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM
360 370 380 390 400
EVPSSVTEYK VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA
410 420
NESVLLKITV PKDLLIFRAC CLL
Length:423
Mass (Da):46,575
Last modified:December 1, 2001 - v1
Checksum:i3A49506D1249B670
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244360 mRNA. Translation: AAK69388.1.
BC051163 mRNA. Translation: AAH51163.1.
CCDSiCCDS40650.1.
RefSeqiNP_080113.1. NM_025837.2.
UniGeneiMm.247218.

Genome annotation databases

EnsembliENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306.
GeneIDi110119.
KEGGimmu:110119.
UCSCiuc009pvd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244360 mRNA. Translation: AAK69388.1 .
BC051163 mRNA. Translation: AAH51163.1 .
CCDSi CCDS40650.1.
RefSeqi NP_080113.1. NM_025837.2.
UniGenei Mm.247218.

3D structure databases

ProteinModelPortali Q924M7.
SMRi Q924M7. Positions 2-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q924M7. 1 interaction.
MINTi MINT-4123108.
STRINGi 10090.ENSMUSP00000034856.

PTM databases

PhosphoSitei Q924M7.

2D gel databases

REPRODUCTION-2DPAGE Q924M7.

Proteomic databases

MaxQBi Q924M7.
PaxDbi Q924M7.
PRIDEi Q924M7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034856 ; ENSMUSP00000034856 ; ENSMUSG00000032306 .
GeneIDi 110119.
KEGGi mmu:110119.
UCSCi uc009pvd.1. mouse.

Organism-specific databases

CTDi 4351.
MGIi MGI:97075. Mpi.

Phylogenomic databases

eggNOGi COG1482.
GeneTreei ENSGT00390000016075.
HOGENOMi HOG000241277.
HOVERGENi HBG000367.
InParanoidi Q924M7.
KOi K01809.
OMAi QGEPWDT.
OrthoDBi EOG7GTT3M.
PhylomeDBi Q924M7.
TreeFami TF312831.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .
Reactomei REACT_198715. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi 363359.
PROi Q924M7.
SOURCEi Search...

Gene expression databases

Bgeei Q924M7.
CleanExi MM_MPI.
ExpressionAtlasi Q924M7. baseline.
Genevestigatori Q924M7.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase."
    Davis J.A., Wu X.H., Wang L., DeRossi C., Westphal V., Wu R., Alton G., Srikrishna G., Freeze H.H.
    Glycobiology 12:435-442(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiMPI_MOUSE
AccessioniPrimary (citable) accession number: Q924M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3