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Q924M5

- BOLL_MOUSE

UniProt

Q924M5 - BOLL_MOUSE

Protein

Protein boule-like

Gene

Boll

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. regulation of translation Source: UniProtKB-KW
    4. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein boule-like
    Gene namesi
    Name:Boll
    Synonyms:Boule
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1922638. Boll.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Protein boule-likePRO_0000081496Add
    BLAST

    Proteomic databases

    PaxDbiQ924M5.
    PRIDEiQ924M5.

    PTM databases

    PhosphoSiteiQ924M5.

    Expressioni

    Tissue specificityi

    Testis specific. Not expressed in early embryos, primoridal germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.1 Publication

    Developmental stagei

    First expressed in stage III spermatocytes and peaks in late pachytene or diplotene stage spermatocytes. Expressed in secondary spermatocytes and early spermatids, then decreases until it is undetectable in spermatids.1 Publication

    Gene expression databases

    BgeeiQ924M5.
    CleanExiMM_BOLL.
    GenevestigatoriQ924M5.

    Interactioni

    Subunit structurei

    Interacts with DAZ1 and DAZL.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000084868.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924M5.
    SMRiQ924M5. Positions 22-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 11078RRMPROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 19431DAZ-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRM DAZ family.Curated
    Contains 1 DAZ-like domain.Curated
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG260394.
    GeneTreeiENSGT00530000063480.
    HOGENOMiHOG000095250.
    HOVERGENiHBG048761.
    InParanoidiQ924M5.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q924M5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTDSLSPSP NPVSPVPLNN PTSGPRYGTV IPNRIFVGGI DFKTNENDLR    50
    KFFSQYGSVK EVKIVNDRAG VSKGYGFITF ETQEDAQKIL QEAEKLNYKD 100
    KKLNIGPAIR KQQVGIPRSS LMPAAGTMYL TTSTGYPYTY HNGVAYFHTP 150
    EVTSVPPSWP SRSISSSPVM VAQPVYQQPA YHYQAPAQCL PGQWQWGVPQ 200
    SPASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS VPEPYSDHGV 250
    QAAYHQVYAS SAIAMPAPMM QPEPIKVRSL F 281
    Length:281
    Mass (Da):30,856
    Last modified:March 1, 2004 - v2
    Checksum:i42C32EA6B0C21D10
    GO
    Isoform 2 (identifier: Q924M5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → METESRAQSTNQT
         119-120: SS → MY
         121-281: Missing.

    Show »
    Length:132
    Mass (Da):14,768
    Checksum:i9308BC3C19A2E798
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → EFRCCRTESRAQSTNQT(PubMed:11390979)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → METESRAQSTNQT in isoform 2. 1 PublicationVSP_009447
    Alternative sequencei119 – 1202SS → MY in isoform 2. 1 PublicationVSP_009448
    Alternative sequencei121 – 281161Missing in isoform 2. 1 PublicationVSP_009449Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272859 mRNA. Translation: AAK69026.1.
    AK016125 mRNA. Translation: BAB30121.1.
    BY103870 mRNA. No translation available.
    RefSeqiNP_001106838.1. NM_001113367.1.
    NP_083543.2. NM_029267.3.
    UniGeneiMm.483408.

    Genome annotation databases

    EnsembliENSMUST00000159398; ENSMUSP00000123814; ENSMUSG00000025977. [Q924M5-2]
    GeneIDi75388.
    KEGGimmu:75388.
    UCSCiuc007bam.1. mouse. [Q924M5-2]
    uc011wlb.1. mouse. [Q924M5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272859 mRNA. Translation: AAK69026.1 .
    AK016125 mRNA. Translation: BAB30121.1 .
    BY103870 mRNA. No translation available.
    RefSeqi NP_001106838.1. NM_001113367.1.
    NP_083543.2. NM_029267.3.
    UniGenei Mm.483408.

    3D structure databases

    ProteinModelPortali Q924M5.
    SMRi Q924M5. Positions 22-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000084868.

    PTM databases

    PhosphoSitei Q924M5.

    Proteomic databases

    PaxDbi Q924M5.
    PRIDEi Q924M5.

    Protocols and materials databases

    DNASUi 75388.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000159398 ; ENSMUSP00000123814 ; ENSMUSG00000025977 . [Q924M5-2 ]
    GeneIDi 75388.
    KEGGi mmu:75388.
    UCSCi uc007bam.1. mouse. [Q924M5-2 ]
    uc011wlb.1. mouse. [Q924M5-1 ]

    Organism-specific databases

    CTDi 66037.
    MGIi MGI:1922638. Boll.

    Phylogenomic databases

    eggNOGi NOG260394.
    GeneTreei ENSGT00530000063480.
    HOGENOMi HOG000095250.
    HOVERGENi HBG048761.
    InParanoidi Q924M5.

    Miscellaneous databases

    NextBioi 342892.
    PROi Q924M5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q924M5.
    CleanExi MM_BOLL.
    Genevestigatori Q924M5.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans."
      Xu E.Y., Moore F.L., Reijo Pera R.A.
      Proc. Natl. Acad. Sci. U.S.A. 98:7414-7419(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-46 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiBOLL_MOUSE
    AccessioniPrimary (citable) accession number: Q924M5
    Secondary accession number(s): Q9D4V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3