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Protein

Protein boule-like

Gene

Boll

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).By similarity

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
  3. translation activator activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. meiotic nuclear division Source: MGI
  3. multicellular organismal development Source: UniProtKB-KW
  4. positive regulation of translational initiation Source: MGI
  5. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein boule-like
Gene namesi
Name:Boll
Synonyms:Boule
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1922638. Boll.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Protein boule-likePRO_0000081496Add
BLAST

Proteomic databases

PaxDbiQ924M5.
PRIDEiQ924M5.

PTM databases

PhosphoSiteiQ924M5.

Expressioni

Tissue specificityi

Testis specific. Not expressed in early embryos, primoridal germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.1 Publication

Developmental stagei

First expressed in stage III spermatocytes and peaks in late pachytene or diplotene stage spermatocytes. Expressed in secondary spermatocytes and early spermatids, then decreases until it is undetectable in spermatids.1 Publication

Gene expression databases

BgeeiQ924M5.
CleanExiMM_BOLL.
ExpressionAtlasiQ924M5. baseline and differential.
GenevestigatoriQ924M5.

Interactioni

Subunit structurei

Interacts with DAZ1 and DAZL.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084868.

Structurei

3D structure databases

ProteinModelPortaliQ924M5.
SMRiQ924M5. Positions 28-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 11078RRMPROSITE-ProRule annotationAdd
BLAST
Domaini164 – 19431DAZ-likeAdd
BLAST

Sequence similaritiesi

Belongs to the RRM DAZ family.Curated
Contains 1 DAZ-like domain.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG260394.
GeneTreeiENSGT00530000063480.
HOGENOMiHOG000095250.
HOVERGENiHBG048761.
InParanoidiQ924M5.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTDSLSPSP NPVSPVPLNN PTSGPRYGTV IPNRIFVGGI DFKTNENDLR
60 70 80 90 100
KFFSQYGSVK EVKIVNDRAG VSKGYGFITF ETQEDAQKIL QEAEKLNYKD
110 120 130 140 150
KKLNIGPAIR KQQVGIPRSS LMPAAGTMYL TTSTGYPYTY HNGVAYFHTP
160 170 180 190 200
EVTSVPPSWP SRSISSSPVM VAQPVYQQPA YHYQAPAQCL PGQWQWGVPQ
210 220 230 240 250
SPASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS VPEPYSDHGV
260 270 280
QAAYHQVYAS SAIAMPAPMM QPEPIKVRSL F
Length:281
Mass (Da):30,856
Last modified:March 1, 2004 - v2
Checksum:i42C32EA6B0C21D10
GO
Isoform 2 (identifier: Q924M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → METESRAQSTNQT
     119-120: SS → MY
     121-281: Missing.

Show »
Length:132
Mass (Da):14,768
Checksum:i9308BC3C19A2E798
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → EFRCCRTESRAQSTNQT (PubMed:11390979).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → METESRAQSTNQT in isoform 2. 1 PublicationVSP_009447
Alternative sequencei119 – 1202SS → MY in isoform 2. 1 PublicationVSP_009448
Alternative sequencei121 – 281161Missing in isoform 2. 1 PublicationVSP_009449Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272859 mRNA. Translation: AAK69026.1.
AK016125 mRNA. Translation: BAB30121.1.
BY103870 mRNA. No translation available.
RefSeqiNP_001106838.1. NM_001113367.1.
NP_083543.2. NM_029267.3.
UniGeneiMm.483408.

Genome annotation databases

EnsembliENSMUST00000159398; ENSMUSP00000123814; ENSMUSG00000025977. [Q924M5-2]
GeneIDi75388.
KEGGimmu:75388.
UCSCiuc007bam.1. mouse. [Q924M5-2]
uc011wlb.1. mouse. [Q924M5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272859 mRNA. Translation: AAK69026.1.
AK016125 mRNA. Translation: BAB30121.1.
BY103870 mRNA. No translation available.
RefSeqiNP_001106838.1. NM_001113367.1.
NP_083543.2. NM_029267.3.
UniGeneiMm.483408.

3D structure databases

ProteinModelPortaliQ924M5.
SMRiQ924M5. Positions 28-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084868.

PTM databases

PhosphoSiteiQ924M5.

Proteomic databases

PaxDbiQ924M5.
PRIDEiQ924M5.

Protocols and materials databases

DNASUi75388.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159398; ENSMUSP00000123814; ENSMUSG00000025977. [Q924M5-2]
GeneIDi75388.
KEGGimmu:75388.
UCSCiuc007bam.1. mouse. [Q924M5-2]
uc011wlb.1. mouse. [Q924M5-1]

Organism-specific databases

CTDi66037.
MGIiMGI:1922638. Boll.

Phylogenomic databases

eggNOGiNOG260394.
GeneTreeiENSGT00530000063480.
HOGENOMiHOG000095250.
HOVERGENiHBG048761.
InParanoidiQ924M5.

Miscellaneous databases

NextBioi342892.
PROiQ924M5.
SOURCEiSearch...

Gene expression databases

BgeeiQ924M5.
CleanExiMM_BOLL.
ExpressionAtlasiQ924M5. baseline and differential.
GenevestigatoriQ924M5.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans."
    Xu E.Y., Moore F.L., Reijo Pera R.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:7414-7419(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-46 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiBOLL_MOUSE
AccessioniPrimary (citable) accession number: Q924M5
Secondary accession number(s): Q9D4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: February 4, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.