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Q924M5 (BOLL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein boule-like
Gene names
Name:Boll
Synonyms:Boule
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation By similarity.

Subunit structure

Interacts with DAZ1 and DAZL By similarity.

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Testis specific. Not expressed in early embryos, primoridal germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis. Ref.1

Developmental stage

First expressed in stage III spermatocytes and peaks in late pachytene or diplotene stage spermatocytes. Expressed in secondary spermatocytes and early spermatids, then decreases until it is undetectable in spermatids. Ref.1

Sequence similarities

Belongs to the RRM DAZ family.

Contains 1 DAZ-like domain.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
Translation regulation
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   LigandRNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q924M5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q924M5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → METESRAQSTNQT
     119-120: SS → MY
     121-281: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Protein boule-like
PRO_0000081496

Regions

Domain33 – 11078RRM
Domain164 – 19431DAZ-like

Natural variations

Alternative sequence11M → METESRAQSTNQT in isoform 2.
VSP_009447
Alternative sequence119 – 1202SS → MY in isoform 2.
VSP_009448
Alternative sequence121 – 281161Missing in isoform 2.
VSP_009449

Experimental info

Sequence conflict11M → EFRCCRTESRAQSTNQT Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 42C32EA6B0C21D10

FASTA28130,856
        10         20         30         40         50         60 
MQTDSLSPSP NPVSPVPLNN PTSGPRYGTV IPNRIFVGGI DFKTNENDLR KFFSQYGSVK 

        70         80         90        100        110        120 
EVKIVNDRAG VSKGYGFITF ETQEDAQKIL QEAEKLNYKD KKLNIGPAIR KQQVGIPRSS 

       130        140        150        160        170        180 
LMPAAGTMYL TTSTGYPYTY HNGVAYFHTP EVTSVPPSWP SRSISSSPVM VAQPVYQQPA 

       190        200        210        220        230        240 
YHYQAPAQCL PGQWQWGVPQ SPASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS 

       250        260        270        280 
VPEPYSDHGV QAAYHQVYAS SAIAMPAPMM QPEPIKVRSL F 

« Hide

Isoform 2 [UniParc].

Checksum: 9308BC3C19A2E798
Show »

FASTA13214,768

References

« Hide 'large scale' references
[1]"A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans."
Xu E.Y., Moore F.L., Reijo Pera R.A.
Proc. Natl. Acad. Sci. U.S.A. 98:7414-7419(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-46 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF272859 mRNA. Translation: AAK69026.1.
AK016125 mRNA. Translation: BAB30121.1.
BY103870 mRNA. No translation available.
RefSeqNP_001106838.1. NM_001113367.1.
NP_083543.2. NM_029267.3.
UniGeneMm.483408.

3D structure databases

ProteinModelPortalQ924M5.
SMRQ924M5. Positions 22-119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000084868.

PTM databases

PhosphoSiteQ924M5.

Proteomic databases

PaxDbQ924M5.
PRIDEQ924M5.

Protocols and materials databases

DNASU75388.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000159398; ENSMUSP00000123814; ENSMUSG00000025977. [Q924M5-2]
GeneID75388.
KEGGmmu:75388.
UCSCuc007bam.1. mouse. [Q924M5-2]
uc011wlb.1. mouse. [Q924M5-1]

Organism-specific databases

CTD66037.
MGIMGI:1922638. Boll.

Phylogenomic databases

eggNOGNOG260394.
GeneTreeENSGT00530000063480.
HOGENOMHOG000095250.
HOVERGENHBG048761.
InParanoidQ924M5.

Gene expression databases

BgeeQ924M5.
CleanExMM_BOLL.
GenevestigatorQ924M5.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio342892.
PROQ924M5.
SOURCESearch...

Entry information

Entry nameBOLL_MOUSE
AccessionPrimary (citable) accession number: Q924M5
Secondary accession number(s): Q9D4V2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: June 11, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot