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Protein
Submitted name:

GABA type B receptor 1f

Gene

Gabbr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • G-protein coupled GABA receptor activity Source: Ensembl Source: RGD
  • transcription factor binding Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • gamma-aminobutyric acid signaling pathway Source: Ensembl
  • negative regulation of adenylate cyclase activity Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of dopamine secretion Source: RGD
  • negative regulation of epinephrine secretion Source: RGD
  • negative regulation of gamma-aminobutyric acid secretion Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • osteoblast differentiation Source: RGD
  • positive regulation of glutamate secretion Source: RGD
  • positive regulation of growth hormone secretion Source: RGD
  • regulation of cAMP biosynthetic process Source: RGD
  • regulation of glutamate secretion Source: RGD
  • response to ethanol Source: RGD
  • response to nicotine Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_278318. Activation of G protein gated Potassium channels.
REACT_287906. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339234. G alpha (i) signalling events.
REACT_345363. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_352928. GABA B receptor activation.

Names & Taxonomyi

Protein namesi
Submitted name:
GABA type B receptor 1fImported
Submitted name:
Gamma-aminobutyric acid (GABA) B receptor 1, isoform CRA_aImported
Submitted name:
Gamma-aminobutyric acid type B receptor subunit 1Imported
Gene namesi
Name:Gabbr1Imported
ORF Names:rCG_58602Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi621537. Gabbr1.

Subcellular locationi

GO - Cellular componenti

  • axolemma Source: RGD
  • cytoplasm Source: Ensembl
  • dendritic shaft Source: RGD
  • dendritic spine Source: RGD
  • endoplasmic reticulum membrane Source: RGD
  • extracellular space Source: RGD
  • G-protein coupled receptor heterodimeric complex Source: Ensembl
  • intracellular membrane-bounded organelle Source: RGD
  • membrane raft Source: RGD
  • mitochondrial membrane Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • postsynaptic membrane Source: Ensembl
  • presynaptic membrane Source: Ensembl
  • synaptic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047788.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063129.
HOGENOMiHOG000016575.
HOVERGENiHBG051688.
OMAiTGFTLAY.
OrthoDBiEOG7D2FCV.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
IPR002456. GPCR_3_GABA_rcpt_B1.
IPR028082. Peripla_BP_I.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PRINTSiPR01177. GABAB1RECPTR.
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLVPLF LRPLGAGGAQ TPNATSEGCQ IIHPPWEGGI RYRGLTRDQV
60 70 80 90 100
KAINFLPVDY EIEYVCRGER EVVGPKVRKC LANGSWTDMD TPSRCVRICS
110 120 130 140 150
KSYLTLENGK VFLTGGDLPA LDGARVEFRC DPDFHLVGSS RSVCSQGQWS
160 170 180 190 200
TPKPHCQERR AVYIGALFPM SGGWPGGQAC QPAVEMALED VNSRRDILPD
210 220 230 240 250
YELKLIHHDS KCDPGQATKY LYELLYNDPI KIILMPGCSS VSTLVAEAAR
260 270 280 290 300
MWNLIVLSYG SSSPALSNRQ RFPTFFRTHP SATLHNPTRV KLFEKWGWKK
310 320 330 340 350
IATIQQTTEV FTSTLDDLEE RVKEAGIEIT FRQSFFSDPA VPVKNLKRQD
360 370 380 390 400
ARIIVGLFYE TEARKVFCEV YKERLFGKKY VWFLIGWYAD NWFKTYDPSI
410 420 430 440 450
NCTVEEMTEA VEGHITTEIV MLNPANTRSI SNMTSQEFVE KLTKRLKRHP
460 470 480 490 500
EETGGFQEAP LAYDAIWALA LALNKTSGGG GRSGVRLEDF NYNNQTITDQ
510 520 530 540 550
IYRAMNSSSF EGVSGHVVFD ASGSRMAWTL IEQLQGGSYK KIGYYDSTKD
560 570 580 590 600
DLSWSKTDKW IGGSPPADQT LVIKTFRFLS QKLFISVSVL SSLGIVLAVV
610 620 630 640 650
CLSFNIYNSH VRYIQNSQPN LNNLTAVGCS LALAAVFPLG LDGYHIGRSQ
660 670 680 690 700
FPFVCQARLW LLGLGFSLGY GSMFTKIWWV HTVFTKKEEK KEWRKTLEPW
710 720 730 740 750
KLYATVGLLV GMDVLTLAIW QIVDPLHRTI ETFAKEEPKE DIDVSILPQL
760 770 780 790 800
EHCSSKKMNT WLGELWSFAV SSDVQRRATV GGDSPICVWP APESIFYGYK
810 820 830 840 850
GLLLLLGIFL AYETKSVSTE KINDHRAVGM AIYNVAVLCL ITAPVTMILS
860 870 880 890 900
SQQDAAFAFA SLAIVFSSYI TLVVLFVPKM RRLITRGEWQ SETQDTMKTG
910 920 930 940 950
SSTNNNEEEK SRLLEKENRE LEKIIAEKEE RVSELRHQLQ SRQQLRSRRH
960 970 980
PPTPPDPSGG LPRGPSEPPD RLSCDGSRVH LLYK
Length:984
Mass (Da):110,742
Last modified:December 1, 2001 - v1
Checksum:iA93012CFA296FBDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044304 Genomic DNA. No translation available.
AABR07072806 Genomic DNA. No translation available.
AC108572 Genomic DNA. No translation available.
AF283276 mRNA. Translation: AAK69540.1.
CH474093 Genomic DNA. Translation: EDL84628.1.
RefSeqiXP_008770922.1. XM_008772700.1.
UniGeneiRn.30059.

Genome annotation databases

EnsembliENSRNOT00000040232; ENSRNOP00000047788; ENSRNOG00000000774.
GeneIDi81657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044304 Genomic DNA. No translation available.
AABR07072806 Genomic DNA. No translation available.
AC108572 Genomic DNA. No translation available.
AF283276 mRNA. Translation: AAK69540.1.
CH474093 Genomic DNA. Translation: EDL84628.1.
RefSeqiXP_008770922.1. XM_008772700.1.
UniGeneiRn.30059.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040232; ENSRNOP00000047788; ENSRNOG00000000774.
GeneIDi81657.

Organism-specific databases

CTDi2550.
RGDi621537. Gabbr1.

Phylogenomic databases

GeneTreeiENSGT00530000063129.
HOGENOMiHOG000016575.
HOVERGENiHBG051688.
OMAiTGFTLAY.
OrthoDBiEOG7D2FCV.

Enzyme and pathway databases

ReactomeiREACT_278318. Activation of G protein gated Potassium channels.
REACT_287906. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339234. G alpha (i) signalling events.
REACT_345363. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_352928. GABA B receptor activation.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
IPR002456. GPCR_3_GABA_rcpt_B1.
IPR028082. Peripla_BP_I.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PRINTSiPR01177. GABAB1RECPTR.
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and tissue distribution of a novel isoform of the rat GABA(B)R1 receptor subunit."
    Wei K., Eubanks J.H., Francis J., Jia Z., Snead O.C. 3rd
    NeuroReport 12:833-837(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ924M0_RAT
AccessioniPrimary (citable) accession number: Q924M0
Secondary accession number(s): F7FE05
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.