Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LETM1 domain-containing protein 1

Gene

Letmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein 1
Alternative name(s):
Cervical cancer receptor
MCC-32
Gene namesi
Name:Letmd1
Synonyms:Mccr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915864. Letmd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 137CytoplasmicSequence analysisAdd BLAST137
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 360Mitochondrial intermembraneSequence analysisAdd BLAST202

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104201 – 360LETM1 domain-containing protein 1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ924L1.
PeptideAtlasiQ924L1.
PRIDEiQ924L1.

PTM databases

iPTMnetiQ924L1.
PhosphoSitePlusiQ924L1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037353.
CleanExiMM_LETMD1.
GenevisibleiQ924L1. MM.

Interactioni

Subunit structurei

Interacts with BRI3BP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037546.

Structurei

3D structure databases

ProteinModelPortaliQ924L1.
SMRiQ924L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 360Letm1 RBDPROSITE-ProRule annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 110Required and sufficient for mitochondrial importBy similarityAdd BLAST110

Sequence similaritiesi

Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
GeneTreeiENSGT00390000018328.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiQ924L1.
OMAiMVGYAFF.
OrthoDBiEOG091G0GD0.
PhylomeDBiQ924L1.
TreeFamiTF314047.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSRVCWAR AALWGSTVAP GPFVTRRLQL GRSGPAWRAP RSSKLHLSPK
60 70 80 90 100
ADVKNLISYV VTKTRAINGS YHRFLGRHFP RFYALYTTFM KGIQMLWADG
110 120 130 140 150
KKARRIKADM WKQNLKFHQL SYREMEHLRQ FRRDITKCLF VGLISIPPFA
160 170 180 190 200
NYLVFLLMYL FPRQLLVKHF WTPKQQIDFL DVYHGLRRRS HSEVITHLRR
210 220 230 240 250
ASTFVSHEKL RRQLTDLCTK VQSGTHPAAQ DVLALRDCFS TYPLGFSQLQ
260 270 280 290 300
ASQMRALSQA MLLTPYLPPP LLRQRLKSHT TVIHQLDRAL AKLGIGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIADD RCRAWLGEWL HISCSLKEPE LSLLLHNVVL
360
LSTNYLETRR
Length:360
Mass (Da):41,701
Last modified:December 1, 2001 - v1
Checksum:i4689BC4F3D2A0BBD
GO
Isoform 2 (identifier: Q924L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Show »
Length:271
Mass (Da):31,627
Checksum:i872AA941E4B7C146
GO
Isoform 3 (identifier: Q924L1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:203
Mass (Da):23,404
Checksum:iDD083332E4B059BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → T in BAE41093 (PubMed:16141072).Curated1
Sequence conflicti207H → Q in AAM90666 (Ref. 2) Curated1
Sequence conflicti316H → N in BAE32758 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292801 – 157Missing in isoform 3. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0292811 – 89Missing in isoform 2. 2 PublicationsAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287293 mRNA. Translation: AAK83032.1.
AF401483 mRNA. Translation: AAM90666.1.
AK045256 mRNA. Translation: BAC32283.1.
AK080221 mRNA. Translation: BAC37851.1.
AK154676 mRNA. Translation: BAE32758.1.
AK169341 mRNA. Translation: BAE41093.1.
BC021361 mRNA. Translation: AAH21361.1.
CCDSiCCDS27838.1. [Q924L1-1]
RefSeqiNP_598854.1. NM_134093.2. [Q924L1-1]
XP_006521384.1. XM_006521321.3. [Q924L1-2]
XP_006521385.1. XM_006521322.1. [Q924L1-3]
XP_006521386.1. XM_006521323.3. [Q924L1-3]
XP_017172228.1. XM_017316739.1. [Q924L1-3]
UniGeneiMm.275272.

Genome annotation databases

EnsembliENSMUST00000037001; ENSMUSP00000037546; ENSMUSG00000037353. [Q924L1-1]
GeneIDi68614.
KEGGimmu:68614.
UCSCiuc007xrg.2. mouse. [Q924L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287293 mRNA. Translation: AAK83032.1.
AF401483 mRNA. Translation: AAM90666.1.
AK045256 mRNA. Translation: BAC32283.1.
AK080221 mRNA. Translation: BAC37851.1.
AK154676 mRNA. Translation: BAE32758.1.
AK169341 mRNA. Translation: BAE41093.1.
BC021361 mRNA. Translation: AAH21361.1.
CCDSiCCDS27838.1. [Q924L1-1]
RefSeqiNP_598854.1. NM_134093.2. [Q924L1-1]
XP_006521384.1. XM_006521321.3. [Q924L1-2]
XP_006521385.1. XM_006521322.1. [Q924L1-3]
XP_006521386.1. XM_006521323.3. [Q924L1-3]
XP_017172228.1. XM_017316739.1. [Q924L1-3]
UniGeneiMm.275272.

3D structure databases

ProteinModelPortaliQ924L1.
SMRiQ924L1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037546.

PTM databases

iPTMnetiQ924L1.
PhosphoSitePlusiQ924L1.

Proteomic databases

PaxDbiQ924L1.
PeptideAtlasiQ924L1.
PRIDEiQ924L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037001; ENSMUSP00000037546; ENSMUSG00000037353. [Q924L1-1]
GeneIDi68614.
KEGGimmu:68614.
UCSCiuc007xrg.2. mouse. [Q924L1-1]

Organism-specific databases

CTDi25875.
MGIiMGI:1915864. Letmd1.

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
GeneTreeiENSGT00390000018328.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiQ924L1.
OMAiMVGYAFF.
OrthoDBiEOG091G0GD0.
PhylomeDBiQ924L1.
TreeFamiTF314047.

Miscellaneous databases

PROiQ924L1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037353.
CleanExiMM_LETMD1.
GenevisibleiQ924L1. MM.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTMD1_MOUSE
AccessioniPrimary (citable) accession number: Q924L1
Secondary accession number(s): Q3TF05
, Q3U3M7, Q8BLG9, Q8K1F7, Q8VDS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.