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Protein

LETM1 domain-containing protein 1

Gene

Letmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein 1
Alternative name(s):
Cervical cancer receptor
MCC-32
Gene namesi
Name:Letmd1
Synonyms:Mccr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915864. Letmd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 137137CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 360202Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360LETM1 domain-containing protein 1PRO_0000310420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ924L1.
MaxQBiQ924L1.
PaxDbiQ924L1.
PRIDEiQ924L1.

PTM databases

iPTMnetiQ924L1.
PhosphoSiteiQ924L1.

Expressioni

Gene expression databases

BgeeiQ924L1.
CleanExiMM_LETMD1.
GenevisibleiQ924L1. MM.

Interactioni

Subunit structurei

Interacts with BRI3BP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037546.

Structurei

3D structure databases

ProteinModelPortaliQ924L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 360183Letm1 RBDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 110110Required and sufficient for mitochondrial importBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
GeneTreeiENSGT00390000018328.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiQ924L1.
OMAiMVGYAFF.
OrthoDBiEOG7WT420.
PhylomeDBiQ924L1.
TreeFamiTF314047.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSRVCWAR AALWGSTVAP GPFVTRRLQL GRSGPAWRAP RSSKLHLSPK
60 70 80 90 100
ADVKNLISYV VTKTRAINGS YHRFLGRHFP RFYALYTTFM KGIQMLWADG
110 120 130 140 150
KKARRIKADM WKQNLKFHQL SYREMEHLRQ FRRDITKCLF VGLISIPPFA
160 170 180 190 200
NYLVFLLMYL FPRQLLVKHF WTPKQQIDFL DVYHGLRRRS HSEVITHLRR
210 220 230 240 250
ASTFVSHEKL RRQLTDLCTK VQSGTHPAAQ DVLALRDCFS TYPLGFSQLQ
260 270 280 290 300
ASQMRALSQA MLLTPYLPPP LLRQRLKSHT TVIHQLDRAL AKLGIGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIADD RCRAWLGEWL HISCSLKEPE LSLLLHNVVL
360
LSTNYLETRR
Length:360
Mass (Da):41,701
Last modified:December 1, 2001 - v1
Checksum:i4689BC4F3D2A0BBD
GO
Isoform 2 (identifier: Q924L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Show »
Length:271
Mass (Da):31,627
Checksum:i872AA941E4B7C146
GO
Isoform 3 (identifier: Q924L1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:203
Mass (Da):23,404
Checksum:iDD083332E4B059BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201P → T in BAE41093 (PubMed:16141072).Curated
Sequence conflicti207 – 2071H → Q in AAM90666 (Ref. 2) Curated
Sequence conflicti316 – 3161H → N in BAE32758 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 157157Missing in isoform 3. 1 PublicationVSP_029280Add
BLAST
Alternative sequencei1 – 8989Missing in isoform 2. 2 PublicationsVSP_029281Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287293 mRNA. Translation: AAK83032.1.
AF401483 mRNA. Translation: AAM90666.1.
AK045256 mRNA. Translation: BAC32283.1.
AK080221 mRNA. Translation: BAC37851.1.
AK154676 mRNA. Translation: BAE32758.1.
AK169341 mRNA. Translation: BAE41093.1.
BC021361 mRNA. Translation: AAH21361.1.
CCDSiCCDS27838.1. [Q924L1-1]
RefSeqiNP_598854.1. NM_134093.2. [Q924L1-1]
XP_006521384.1. XM_006521321.2. [Q924L1-2]
XP_006521385.1. XM_006521322.1. [Q924L1-3]
XP_006521386.1. XM_006521323.2. [Q924L1-3]
UniGeneiMm.275272.

Genome annotation databases

EnsembliENSMUST00000037001; ENSMUSP00000037546; ENSMUSG00000037353. [Q924L1-1]
GeneIDi68614.
KEGGimmu:68614.
UCSCiuc007xrg.2. mouse. [Q924L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287293 mRNA. Translation: AAK83032.1.
AF401483 mRNA. Translation: AAM90666.1.
AK045256 mRNA. Translation: BAC32283.1.
AK080221 mRNA. Translation: BAC37851.1.
AK154676 mRNA. Translation: BAE32758.1.
AK169341 mRNA. Translation: BAE41093.1.
BC021361 mRNA. Translation: AAH21361.1.
CCDSiCCDS27838.1. [Q924L1-1]
RefSeqiNP_598854.1. NM_134093.2. [Q924L1-1]
XP_006521384.1. XM_006521321.2. [Q924L1-2]
XP_006521385.1. XM_006521322.1. [Q924L1-3]
XP_006521386.1. XM_006521323.2. [Q924L1-3]
UniGeneiMm.275272.

3D structure databases

ProteinModelPortaliQ924L1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037546.

PTM databases

iPTMnetiQ924L1.
PhosphoSiteiQ924L1.

Proteomic databases

EPDiQ924L1.
MaxQBiQ924L1.
PaxDbiQ924L1.
PRIDEiQ924L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037001; ENSMUSP00000037546; ENSMUSG00000037353. [Q924L1-1]
GeneIDi68614.
KEGGimmu:68614.
UCSCiuc007xrg.2. mouse. [Q924L1-1]

Organism-specific databases

CTDi25875.
MGIiMGI:1915864. Letmd1.

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
GeneTreeiENSGT00390000018328.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiQ924L1.
OMAiMVGYAFF.
OrthoDBiEOG7WT420.
PhylomeDBiQ924L1.
TreeFamiTF314047.

Miscellaneous databases

NextBioi327560.
PROiQ924L1.
SOURCEiSearch...

Gene expression databases

BgeeiQ924L1.
CleanExiMM_LETMD1.
GenevisibleiQ924L1. MM.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cervical cancer receptor."
    Hwang J.H., Kim J.W., Hwang S.Y.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C3H/He.
  2. "Identification of a mouse cDNA (MCC) homologous to human HCCR-1 and HCCR-2 gene."
    Kim J.W.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: FVB/NJ.
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Aorta, Embryo and Vein.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  5. "Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization."
    Ko J., Lee Y.H., Hwang S.Y., Lee Y.S., Shin S.M., Hwang J.H., Kim J., Kim Y.W., Jang S.-W., Ryoo Z.Y., Kim I.-K., Namkoong S.E., Kim J.W.
    Oncogene 22:4679-4689(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart and Kidney.

Entry informationi

Entry nameiLTMD1_MOUSE
AccessioniPrimary (citable) accession number: Q924L1
Secondary accession number(s): Q3TF05
, Q3U3M7, Q8BLG9, Q8K1F7, Q8VDS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.