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Protein

Metastasis-associated protein MTA3

Gene

Mta3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri377 – 404GATA-type; atypicalAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of G2/M transition of mitotic cell cycle Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA3
Gene namesi
Name:Mta3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2151172. Mta3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cohesin complex Source: MGI
  • cytoplasm Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
  • NuRD complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834991 – 591Metastasis-associated protein MTA3Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei425PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei452PhosphothreonineBy similarity1
Modified residuei516PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ924K8.
PaxDbiQ924K8.
PeptideAtlasiQ924K8.
PRIDEiQ924K8.

PTM databases

iPTMnetiQ924K8.
PhosphoSitePlusiQ924K8.

Expressioni

Tissue specificityi

Expressed in heart, brain, spleen, lung, liver and kidney.

Gene expression databases

BgeeiENSMUSG00000055817.
CleanExiMM_MTA3.
ExpressionAtlasiQ924K8. baseline and differential.
GenevisibleiQ924K8. MM.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6 (By similarity). Interacts with NACC2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi228046. 12 interactors.
DIPiDIP-61664N.
IntActiQ924K8. 4 interactors.
MINTiMINT-4102500.
STRINGi10090.ENSMUSP00000068931.

Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi272 – 284Combined sources13
Helixi289 – 294Combined sources6
Beta strandi298 – 300Combined sources3
Helixi302 – 313Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRGNMR-A267-323[»]
ProteinModelPortaliQ924K8.
SMRiQ924K8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ924K8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 147BAHPROSITE-ProRule annotationAdd BLAST147
Domaini148 – 258ELM2PROSITE-ProRule annotationAdd BLAST111
Domaini265 – 317SANTPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri377 – 404GATA-type; atypicalAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3554. Eukaryota.
ENOG410XSAJ. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ924K8.
KOiK11660.
OMAiKHNYDLS.
OrthoDBiEOG091G04Z4.
PhylomeDBiQ924K8.
TreeFamiTF106444.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD
60 70 80 90 100
ISNTLIMLAD KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL
110 120 130 140 150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSV KTLLADKGEI
160 170 180 190 200
RVGPKYQADI PDMLPEDSDE REQSKLEVKV WDPNSPLTDR QIDQFLVVAR
210 220 230 240 250
AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL YRHGYDLSSA
260 270 280 290 300
ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK
310 320 330 340 350
SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS
360 370 380 390 400
SNGKAGTVNG AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL
410 420 430 440 450
CATCWLYWKK YGGLKMPTQS DEEKSPSPTA EDPRARSHMS RQALQGMPVR
460 470 480 490 500
NTGSPKSAVK TRQAFFLRTT YFTKIARQVC KSTLRLRQAA RRPFVAINYA
510 520 530 540 550
AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK KPNVIRSPPS
560 570 580 590
LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R
Length:591
Mass (Da):67,077
Last modified:December 1, 2001 - v1
Checksum:iABA5CB9E86FCE7E2
GO
Isoform 2 (identifier: Q924K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-512: YADRHAE → CKTLFNS
     513-591: Missing.

Show »
Length:512
Mass (Da):58,310
Checksum:i2BA89DB28A94C1D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166E → EG in AAH22124 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001605506 – 512YADRHAE → CKTLFNS in isoform 2. 1 Publication7
Alternative sequenceiVSP_001606513 – 591Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288138 mRNA. Translation: AAK83045.1.
BC022124 mRNA. Translation: AAH22124.1.
CCDSiCCDS28997.1. [Q924K8-1]
RefSeqiNP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2. [Q924K8-1]
UniGeneiMm.277668.
Mm.443827.

Genome annotation databases

EnsembliENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817. [Q924K8-1]
GeneIDi116871.
KEGGimmu:116871.
UCSCiuc012axw.1. mouse. [Q924K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288138 mRNA. Translation: AAK83045.1.
BC022124 mRNA. Translation: AAH22124.1.
CCDSiCCDS28997.1. [Q924K8-1]
RefSeqiNP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2. [Q924K8-1]
UniGeneiMm.277668.
Mm.443827.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRGNMR-A267-323[»]
ProteinModelPortaliQ924K8.
SMRiQ924K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228046. 12 interactors.
DIPiDIP-61664N.
IntActiQ924K8. 4 interactors.
MINTiMINT-4102500.
STRINGi10090.ENSMUSP00000068931.

PTM databases

iPTMnetiQ924K8.
PhosphoSitePlusiQ924K8.

Proteomic databases

EPDiQ924K8.
PaxDbiQ924K8.
PeptideAtlasiQ924K8.
PRIDEiQ924K8.

Protocols and materials databases

DNASUi116871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817. [Q924K8-1]
GeneIDi116871.
KEGGimmu:116871.
UCSCiuc012axw.1. mouse. [Q924K8-1]

Organism-specific databases

CTDi57504.
MGIiMGI:2151172. Mta3.

Phylogenomic databases

eggNOGiKOG3554. Eukaryota.
ENOG410XSAJ. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ924K8.
KOiK11660.
OMAiKHNYDLS.
OrthoDBiEOG091G04Z4.
PhylomeDBiQ924K8.
TreeFamiTF106444.

Miscellaneous databases

EvolutionaryTraceiQ924K8.
PROiQ924K8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055817.
CleanExiMM_MTA3.
ExpressionAtlasiQ924K8. baseline and differential.
GenevisibleiQ924K8. MM.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTA3_MOUSE
AccessioniPrimary (citable) accession number: Q924K8
Secondary accession number(s): Q8VC18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.