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Q924K8

- MTA3_MOUSE

UniProt

Q924K8 - MTA3_MOUSE

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Protein

Metastasis-associated protein MTA3

Gene

Mta3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri377 – 40428GATA-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of cell proliferation Source: MGI
  2. positive regulation of G2/M transition of mitotic cell cycle Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA3
Gene namesi
Name:Mta3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2151172. Mta3.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cohesin complex Source: MGI
  2. cytoplasm Source: MGI
  3. nucleus Source: MGI
  4. NuRD complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Metastasis-associated protein MTA3PRO_0000083499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521PhosphothreonineBy similarity
Modified residuei454 – 4541PhosphoserineBy similarity
Modified residuei516 – 5161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ924K8.
PaxDbiQ924K8.
PRIDEiQ924K8.

PTM databases

PhosphoSiteiQ924K8.

Expressioni

Tissue specificityi

Expressed in heart, brain, spleen, lung, liver and kidney.

Gene expression databases

BgeeiQ924K8.
CleanExiMM_MTA3.
ExpressionAtlasiQ924K8. baseline and differential.
GenevestigatoriQ924K8.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6 By similarity. Interacts with NACC2 By similarity.By similarity

Protein-protein interaction databases

BioGridi228046. 11 interactions.
IntActiQ924K8. 4 interactions.
MINTiMINT-4102500.

Structurei

Secondary structure

1
591
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi272 – 28413
Helixi289 – 2946
Beta strandi298 – 3003
Helixi302 – 31312

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRGNMR-A267-323[»]
ProteinModelPortaliQ924K8.
SMRiQ924K8. Positions 148-323.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ924K8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 147147BAHPROSITE-ProRule annotationAdd
BLAST
Domaini148 – 258111ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 31753SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri377 – 40428GATA-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG252834.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ924K8.
KOiK11660.
OMAiHMSRQAT.
PhylomeDBiQ924K8.
TreeFamiTF106444.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q924K8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD
60 70 80 90 100
ISNTLIMLAD KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL
110 120 130 140 150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSV KTLLADKGEI
160 170 180 190 200
RVGPKYQADI PDMLPEDSDE REQSKLEVKV WDPNSPLTDR QIDQFLVVAR
210 220 230 240 250
AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL YRHGYDLSSA
260 270 280 290 300
ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK
310 320 330 340 350
SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS
360 370 380 390 400
SNGKAGTVNG AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL
410 420 430 440 450
CATCWLYWKK YGGLKMPTQS DEEKSPSPTA EDPRARSHMS RQALQGMPVR
460 470 480 490 500
NTGSPKSAVK TRQAFFLRTT YFTKIARQVC KSTLRLRQAA RRPFVAINYA
510 520 530 540 550
AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK KPNVIRSPPS
560 570 580 590
LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R
Length:591
Mass (Da):67,077
Last modified:December 1, 2001 - v1
Checksum:iABA5CB9E86FCE7E2
GO
Isoform 2 (identifier: Q924K8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-512: YADRHAE → CKTLFNS
     513-591: Missing.

Show »
Length:512
Mass (Da):58,310
Checksum:i2BA89DB28A94C1D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661E → EG in AAH22124. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei506 – 5127YADRHAE → CKTLFNS in isoform 2. 1 PublicationVSP_001605
Alternative sequencei513 – 59179Missing in isoform 2. 1 PublicationVSP_001606Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288138 mRNA. Translation: AAK83045.1.
BC022124 mRNA. Translation: AAH22124.1.
CCDSiCCDS28997.1. [Q924K8-1]
RefSeqiNP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2. [Q924K8-1]
UniGeneiMm.277668.
Mm.443827.

Genome annotation databases

EnsembliENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817. [Q924K8-1]
GeneIDi116871.
KEGGimmu:116871.
UCSCiuc012axw.1. mouse. [Q924K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288138 mRNA. Translation: AAK83045.1 .
BC022124 mRNA. Translation: AAH22124.1 .
CCDSi CCDS28997.1. [Q924K8-1 ]
RefSeqi NP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2. [Q924K8-1 ]
UniGenei Mm.277668.
Mm.443827.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CRG NMR - A 267-323 [» ]
ProteinModelPortali Q924K8.
SMRi Q924K8. Positions 148-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228046. 11 interactions.
IntActi Q924K8. 4 interactions.
MINTi MINT-4102500.

PTM databases

PhosphoSitei Q924K8.

Proteomic databases

MaxQBi Q924K8.
PaxDbi Q924K8.
PRIDEi Q924K8.

Protocols and materials databases

DNASUi 116871.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067826 ; ENSMUSP00000068931 ; ENSMUSG00000055817 . [Q924K8-1 ]
GeneIDi 116871.
KEGGi mmu:116871.
UCSCi uc012axw.1. mouse. [Q924K8-1 ]

Organism-specific databases

CTDi 57504.
MGIi MGI:2151172. Mta3.

Phylogenomic databases

eggNOGi NOG252834.
GeneTreei ENSGT00580000081398.
HOGENOMi HOG000045387.
HOVERGENi HBG002598.
InParanoidi Q924K8.
KOi K11660.
OMAi HMSRQAT.
PhylomeDBi Q924K8.
TreeFami TF106444.

Miscellaneous databases

ChiTaRSi MTA3. mouse.
EvolutionaryTracei Q924K8.
NextBioi 369242.
PROi Q924K8.
SOURCEi Search...

Gene expression databases

Bgeei Q924K8.
CleanExi MM_MTA3.
ExpressionAtlasi Q924K8. baseline and differential.
Genevestigatori Q924K8.

Family and domain databases

InterProi IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view ]
Pfami PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view ]
SMARTi SM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3."
    Simpson A., Uitto J., Rodeck U., Mahoney M.G.
    Gene 273:29-39(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 267-323.

Entry informationi

Entry nameiMTA3_MOUSE
AccessioniPrimary (citable) accession number: Q924K8
Secondary accession number(s): Q8VC18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3