Metastasis-associated protein MTA3 - Mus musculus (Mouse)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Preferred order of sections

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

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Q924K8 (MTA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 89. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Metastasis-associated protein MTA3

Gene names

Name:

Mta3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Sequence length	591 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Function	Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels By similarity.
Subunit structure	Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD) By similarity.
Subcellular location	Nucleus. Cytoplasm Ref.1.
Tissue specificity	Expressed in heart, brain, spleen, lung, liver and kidney.
Sequence similarities	Contains 1 BAH domain. Contains 1 ELM2 domain. Contains 1 GATA-type zinc finger. Contains 1 SANT domain.

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: MGI nucleus Inferred from direct assay Ref.1. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 591

591

Metastasis-associated protein MTA3

PRO_0000083499

Domain

1 – 147

147

BAH

Domain

148 – 258

111

ELM2

Domain

265 – 317

SANT

Zinc finger

377 – 404

GATA-type; atypical

Alternative sequence

506 – 512

YADRHAE → CKTLFNS in isoform 2.

VSP_001605

Alternative sequence

513 – 591

Missing in isoform 2.

VSP_001606

Sequence conflict

166

E → EG in AAH22124. Ref.2

591

Helix Strand Turn

Details...

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: ABA5CB9E86FCE7E2 Show »	FASTA	591	67,077
10 20 30 40 50 60 MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD ISNTLIMLAD 70 80 90 100 110 120 KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL PATHIRGKCS VALLNETESV 130 140 150 160 170 180 LSYLDKEDTF FYSLVYDPSV KTLLADKGEI RVGPKYQADI PDMLPEDSDE REQSKLEVKV 190 200 210 220 230 240 WDPNSPLTDR QIDQFLVVAR AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL 250 260 270 280 290 300 YRHGYDLSSA ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK 310 320 330 340 350 360 SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS SNGKAGTVNG 370 380 390 400 410 420 AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL CATCWLYWKK YGGLKMPTQS 430 440 450 460 470 480 DEEKSPSPTA EDPRARSHMS RQALQGMPVR NTGSPKSAVK TRQAFFLRTT YFTKIARQVC 490 500 510 520 530 540 KSTLRLRQAA RRPFVAINYA AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK 550 560 570 580 590 KPNVIRSPPS LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R « Hide
Isoform 2 [UniParc]. Checksum: 2BA89DB28A94C1D9 Show »	FASTA	512	58,310
10 20 30 40 50 60 MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD ISNTLIMLAD 70 80 90 100 110 120 KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL PATHIRGKCS VALLNETESV 130 140 150 160 170 180 LSYLDKEDTF FYSLVYDPSV KTLLADKGEI RVGPKYQADI PDMLPEDSDE REQSKLEVKV 190 200 210 220 230 240 WDPNSPLTDR QIDQFLVVAR AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL 250 260 270 280 290 300 YRHGYDLSSA ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK 310 320 330 340 350 360 SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS SNGKAGTVNG 370 380 390 400 410 420 AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL CATCWLYWKK YGGLKMPTQS 430 440 450 460 470 480 DEEKSPSPTA EDPRARSHMS RQALQGMPVR NTGSPKSAVK TRQAFFLRTT YFTKIARQVC 490 500 510 KSTLRLRQAA RRPFVAINYA AIRAECKTLF NS « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3." Simpson A., Uitto J., Rodeck U., Mahoney M.G. Gene 273:29-39(2001) [PubMed: 11483358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION. Strain: 129/Sv.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Liver.
[3]	"Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 267-323.
+	Additional computationally mapped references.

EMBL
GenBank
DDBJ

AF288138 mRNA. Translation: AAK83045.1.
BC022124 mRNA. Translation: AAH22124.1.

IPI

IPI00125745.
IPI00221805.

RefSeq

NP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2.

UniGene

Mm.277668.

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CRG	NMR	-	A	267-323	[»]

ProteinModelPortal

Q924K8.

SMR

Q924K8. Positions 5-145, 267-323, 374-418.

ModBase

Search...

IntAct

Q924K8. 1 interaction.

STRING

Q924K8.

PhosphoSite

Q924K8.

PRIDE

Q924K8.

StructuralBiologyKnowledgebase

Search...

Ensembl

ENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817.

GeneID

116871.

KEGG

mmu:116871.

UCSC

uc012axw.1. mouse.

CTD

57504.

MGI

MGI:2151172. Mta3.

GeneTree

ENSGT00580000081398.

HOGENOM

HBG403019.

HOVERGEN

HBG002598.

InParanoid

Q924K8.

OMA

PINYAAI.

OrthoDB

EOG4QZ7KJ.

PhylomeDB

Q924K8.

ArrayExpress

Q924K8.

Bgee

Q924K8.

CleanEx

MM_MTA3.

Genevestigator

Q924K8.

GermOnline

ENSMUSG00000055817. Mus musculus.

InterPro

IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT_DNA-bd.
IPR017884. SANT_eukarya.
IPR000679. Znf_GATA.
[Graphical view]

K11660.

Pfam

PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]

SMART

SM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS00344. GATA_ZN_FINGER_1. False negative.
PS50114. GATA_ZN_FINGER_2. False negative.
PS51293. SANT. 1 hit.
[Graphical view]

ProtoNet

Search...

NextBio

369242.

SOURCE

Search...

Entry name

MTA3_MOUSE

Accession

Primary (citable) accession number: Q924K8
Secondary accession number(s): Q8VC18

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q924K8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q924K8-2)

The sequence of this isoform differs from the canonical sequence as follows:
506-512: YADRHAE → CKTLFNS
513-591: Missing.