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Q924K8

- MTA3_MOUSE

UniProt

Q924K8 - MTA3_MOUSE

Protein

Metastasis-associated protein MTA3

Gene

Mta3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri377 – 40428GATA-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of cell proliferation Source: MGI
    2. positive regulation of G2/M transition of mitotic cell cycle Source: MGI

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metastasis-associated protein MTA3
    Gene namesi
    Name:Mta3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2151172. Mta3.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cohesin complex Source: MGI
    2. cytoplasm Source: MGI
    3. nucleus Source: MGI
    4. NuRD complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Metastasis-associated protein MTA3PRO_0000083499Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei452 – 4521PhosphothreonineBy similarity
    Modified residuei454 – 4541PhosphoserineBy similarity
    Modified residuei516 – 5161PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ924K8.
    PRIDEiQ924K8.

    PTM databases

    PhosphoSiteiQ924K8.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, spleen, lung, liver and kidney.

    Gene expression databases

    ArrayExpressiQ924K8.
    BgeeiQ924K8.
    CleanExiMM_MTA3.
    GenevestigatoriQ924K8.

    Interactioni

    Subunit structurei

    Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6 By similarity. Interacts with NACC2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi228046. 11 interactions.
    IntActiQ924K8. 4 interactions.
    MINTiMINT-4102500.

    Structurei

    Secondary structure

    1
    591
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi272 – 28413
    Helixi289 – 2946
    Beta strandi298 – 3003
    Helixi302 – 31312

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CRGNMR-A267-323[»]
    ProteinModelPortaliQ924K8.
    SMRiQ924K8. Positions 148-323, 374-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ924K8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 147147BAHPROSITE-ProRule annotationAdd
    BLAST
    Domaini148 – 258111ELM2PROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 31753SANTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAH domain.PROSITE-ProRule annotation
    Contains 1 ELM2 domain.PROSITE-ProRule annotation
    Contains 1 GATA-type zinc finger.Curated
    Contains 1 SANT domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri377 – 40428GATA-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252834.
    GeneTreeiENSGT00580000081398.
    HOGENOMiHOG000045387.
    HOVERGENiHBG002598.
    InParanoidiQ924K8.
    KOiK11660.
    OMAiHMSRQAT.
    PhylomeDBiQ924K8.
    TreeFamiTF106444.

    Family and domain databases

    InterProiIPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view]
    SMARTiSM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q924K8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD    50
    ISNTLIMLAD KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL 100
    PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSV KTLLADKGEI 150
    RVGPKYQADI PDMLPEDSDE REQSKLEVKV WDPNSPLTDR QIDQFLVVAR 200
    AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL YRHGYDLSSA 250
    ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK 300
    SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS 350
    SNGKAGTVNG AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL 400
    CATCWLYWKK YGGLKMPTQS DEEKSPSPTA EDPRARSHMS RQALQGMPVR 450
    NTGSPKSAVK TRQAFFLRTT YFTKIARQVC KSTLRLRQAA RRPFVAINYA 500
    AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK KPNVIRSPPS 550
    LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R 591
    Length:591
    Mass (Da):67,077
    Last modified:December 1, 2001 - v1
    Checksum:iABA5CB9E86FCE7E2
    GO
    Isoform 2 (identifier: Q924K8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         506-512: YADRHAE → CKTLFNS
         513-591: Missing.

    Show »
    Length:512
    Mass (Da):58,310
    Checksum:i2BA89DB28A94C1D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti166 – 1661E → EG in AAH22124. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei506 – 5127YADRHAE → CKTLFNS in isoform 2. 1 PublicationVSP_001605
    Alternative sequencei513 – 59179Missing in isoform 2. 1 PublicationVSP_001606Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288138 mRNA. Translation: AAK83045.1.
    BC022124 mRNA. Translation: AAH22124.1.
    CCDSiCCDS28997.1. [Q924K8-1]
    RefSeqiNP_001164525.1. NM_001171054.1.
    NP_473423.1. NM_054082.2. [Q924K8-1]
    UniGeneiMm.277668.
    Mm.443827.

    Genome annotation databases

    EnsembliENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817. [Q924K8-1]
    GeneIDi116871.
    KEGGimmu:116871.
    UCSCiuc012axw.1. mouse. [Q924K8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288138 mRNA. Translation: AAK83045.1 .
    BC022124 mRNA. Translation: AAH22124.1 .
    CCDSi CCDS28997.1. [Q924K8-1 ]
    RefSeqi NP_001164525.1. NM_001171054.1.
    NP_473423.1. NM_054082.2. [Q924K8-1 ]
    UniGenei Mm.277668.
    Mm.443827.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CRG NMR - A 267-323 [» ]
    ProteinModelPortali Q924K8.
    SMRi Q924K8. Positions 148-323, 374-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228046. 11 interactions.
    IntActi Q924K8. 4 interactions.
    MINTi MINT-4102500.

    PTM databases

    PhosphoSitei Q924K8.

    Proteomic databases

    PaxDbi Q924K8.
    PRIDEi Q924K8.

    Protocols and materials databases

    DNASUi 116871.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067826 ; ENSMUSP00000068931 ; ENSMUSG00000055817 . [Q924K8-1 ]
    GeneIDi 116871.
    KEGGi mmu:116871.
    UCSCi uc012axw.1. mouse. [Q924K8-1 ]

    Organism-specific databases

    CTDi 57504.
    MGIi MGI:2151172. Mta3.

    Phylogenomic databases

    eggNOGi NOG252834.
    GeneTreei ENSGT00580000081398.
    HOGENOMi HOG000045387.
    HOVERGENi HBG002598.
    InParanoidi Q924K8.
    KOi K11660.
    OMAi HMSRQAT.
    PhylomeDBi Q924K8.
    TreeFami TF106444.

    Miscellaneous databases

    ChiTaRSi MTA3. mouse.
    EvolutionaryTracei Q924K8.
    NextBioi 369242.
    PROi Q924K8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q924K8.
    Bgeei Q924K8.
    CleanExi MM_MTA3.
    Genevestigatori Q924K8.

    Family and domain databases

    InterProi IPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view ]
    SMARTi SM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3."
      Simpson A., Uitto J., Rodeck U., Mahoney M.G.
      Gene 273:29-39(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    3. "Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 267-323.

    Entry informationi

    Entry nameiMTA3_MOUSE
    AccessioniPrimary (citable) accession number: Q924K8
    Secondary accession number(s): Q8VC18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3