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Protein

Metastasis-associated protein MTA3

Gene

Mta3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri377 – 40428GATA-type; atypicalAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of G2/M transition of mitotic cell cycle Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_334621. HDACs deacetylate histones.
REACT_350574. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA3
Gene namesi
Name:Mta3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2151172. Mta3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cohesin complex Source: MGI
  • cytoplasm Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • NuRD complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Metastasis-associated protein MTA3PRO_0000083499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521PhosphothreonineBy similarity
Modified residuei516 – 5161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ924K8.
PaxDbiQ924K8.
PRIDEiQ924K8.

PTM databases

PhosphoSiteiQ924K8.

Expressioni

Tissue specificityi

Expressed in heart, brain, spleen, lung, liver and kidney.

Gene expression databases

BgeeiQ924K8.
CleanExiMM_MTA3.
ExpressionAtlasiQ924K8. baseline and differential.
GenevisibleiQ924K8. MM.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6 (By similarity). Interacts with NACC2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi228046. 11 interactions.
IntActiQ924K8. 4 interactions.
MINTiMINT-4102500.
STRINGi10090.ENSMUSP00000068931.

Structurei

Secondary structure

1
591
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi272 – 28413Combined sources
Helixi289 – 2946Combined sources
Beta strandi298 – 3003Combined sources
Helixi302 – 31312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRGNMR-A267-323[»]
ProteinModelPortaliQ924K8.
SMRiQ924K8. Positions 148-323, 376-418.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ924K8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 147147BAHPROSITE-ProRule annotationAdd
BLAST
Domaini148 – 258111ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 31753SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri377 – 40428GATA-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG252834.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ924K8.
OMAiITDYVYF.
PhylomeDBiQ924K8.
TreeFamiTF106444.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD
60 70 80 90 100
ISNTLIMLAD KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL
110 120 130 140 150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSV KTLLADKGEI
160 170 180 190 200
RVGPKYQADI PDMLPEDSDE REQSKLEVKV WDPNSPLTDR QIDQFLVVAR
210 220 230 240 250
AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL YRHGYDLSSA
260 270 280 290 300
ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK
310 320 330 340 350
SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS
360 370 380 390 400
SNGKAGTVNG AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL
410 420 430 440 450
CATCWLYWKK YGGLKMPTQS DEEKSPSPTA EDPRARSHMS RQALQGMPVR
460 470 480 490 500
NTGSPKSAVK TRQAFFLRTT YFTKIARQVC KSTLRLRQAA RRPFVAINYA
510 520 530 540 550
AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK KPNVIRSPPS
560 570 580 590
LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R
Length:591
Mass (Da):67,077
Last modified:December 1, 2001 - v1
Checksum:iABA5CB9E86FCE7E2
GO
Isoform 2 (identifier: Q924K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-512: YADRHAE → CKTLFNS
     513-591: Missing.

Show »
Length:512
Mass (Da):58,310
Checksum:i2BA89DB28A94C1D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661E → EG in AAH22124 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei506 – 5127YADRHAE → CKTLFNS in isoform 2. 1 PublicationVSP_001605
Alternative sequencei513 – 59179Missing in isoform 2. 1 PublicationVSP_001606Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288138 mRNA. Translation: AAK83045.1.
BC022124 mRNA. Translation: AAH22124.1.
CCDSiCCDS28997.1. [Q924K8-1]
RefSeqiNP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2. [Q924K8-1]
UniGeneiMm.277668.
Mm.443827.

Genome annotation databases

EnsembliENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817. [Q924K8-1]
GeneIDi116871.
UCSCiuc012axw.1. mouse. [Q924K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288138 mRNA. Translation: AAK83045.1.
BC022124 mRNA. Translation: AAH22124.1.
CCDSiCCDS28997.1. [Q924K8-1]
RefSeqiNP_001164525.1. NM_001171054.1.
NP_473423.1. NM_054082.2. [Q924K8-1]
UniGeneiMm.277668.
Mm.443827.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRGNMR-A267-323[»]
ProteinModelPortaliQ924K8.
SMRiQ924K8. Positions 148-323, 376-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228046. 11 interactions.
IntActiQ924K8. 4 interactions.
MINTiMINT-4102500.
STRINGi10090.ENSMUSP00000068931.

PTM databases

PhosphoSiteiQ924K8.

Proteomic databases

MaxQBiQ924K8.
PaxDbiQ924K8.
PRIDEiQ924K8.

Protocols and materials databases

DNASUi116871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817. [Q924K8-1]
GeneIDi116871.
UCSCiuc012axw.1. mouse. [Q924K8-1]

Organism-specific databases

CTDi57504.
MGIiMGI:2151172. Mta3.

Phylogenomic databases

eggNOGiNOG252834.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ924K8.
OMAiITDYVYF.
PhylomeDBiQ924K8.
TreeFamiTF106444.

Enzyme and pathway databases

ReactomeiREACT_334621. HDACs deacetylate histones.
REACT_350574. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

EvolutionaryTraceiQ924K8.
NextBioi369242.
PROiQ924K8.
SOURCEiSearch...

Gene expression databases

BgeeiQ924K8.
CleanExiMM_MTA3.
ExpressionAtlasiQ924K8. baseline and differential.
GenevisibleiQ924K8. MM.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3."
    Simpson A., Uitto J., Rodeck U., Mahoney M.G.
    Gene 273:29-39(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 267-323.

Entry informationi

Entry nameiMTA3_MOUSE
AccessioniPrimary (citable) accession number: Q924K8
Secondary accession number(s): Q8VC18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.