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Protein

FAS-associated factor 1

Gene

Faf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potentiates but cannot initiate FAS-induced apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 1
Gene namesi
Name:Faf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70987. Faf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649FAS-associated factor 1PRO_0000211040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191PhosphoserineCombined sources
Modified residuei579 – 5791PhosphothreonineBy similarity
Modified residuei581 – 5811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ924K2.
PRIDEiQ924K2.

PTM databases

iPTMnetiQ924K2.
PhosphoSiteiQ924K2.

Expressioni

Tissue specificityi

Central nervous system.

Interactioni

Subunit structurei

Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250821. 2 interactions.
STRINGi10116.ENSRNOP00000011765.

Structurei

3D structure databases

ProteinModelPortaliQ924K2.
SMRiQ924K2. Positions 98-190, 324-494, 568-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5757UBAAdd
BLAST
Domaini568 – 64578UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 UBA domain.Curated
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
HOGENOMiHOG000043073.
HOVERGENiHBG002876.
InParanoidiQ924K2.
PhylomeDBiQ924K2.

Family and domain databases

InterProiIPR033043. FAF1.
IPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PANTHERiPTHR23322:SF29. PTHR23322:SF29. 3 hits.
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 3 hits.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG
60 70 80 90 100
ILQSDFGGET MPGPTFDPAS PPAPAPAPSS SAFRPVMPSR QIVERQPRML
110 120 130 140 150
DFRVEYRDRN VDVVLEDSCT VGEIKQILEN ELQIPVPKML LKGWKTGDVE
160 170 180 190 200
DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS HAGALQESLN QNFMLIITHR
210 220 230 240 250
EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP ASATDDSMCL
260 270 280 290 300
AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STVVHMVSDS DGDDFEDASE
310 320 330 340 350
FGVVDGEVFG MASSTMRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV
360 370 380 390 400
FFIGSLEAAF QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV
410 420 430 440 450
SYLSQNFITW AWDLTKDANR ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF
460 470 480 490 500
LIIMGKRSSN EVLNVIQGNT TVDELMMRLM AAMEIFSAQQ QEDIKDEDER
510 520 530 540 550
EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ IRKEQEEERE
560 570 580 590 600
AIRLSLEQAL PPEPEEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD
610 620 630 640
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLLAKE
Length:649
Mass (Da):73,745
Last modified:December 1, 2001 - v1
Checksum:iC4A8086E687F0A3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293459 mRNA. Translation: AAK94676.1.
RefSeqiNP_569090.1. NM_130406.1.
UniGeneiRn.198288.

Genome annotation databases

GeneIDi140657.
KEGGirno:140657.
UCSCiRGD:70987. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293459 mRNA. Translation: AAK94676.1.
RefSeqiNP_569090.1. NM_130406.1.
UniGeneiRn.198288.

3D structure databases

ProteinModelPortaliQ924K2.
SMRiQ924K2. Positions 98-190, 324-494, 568-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250821. 2 interactions.
STRINGi10116.ENSRNOP00000011765.

PTM databases

iPTMnetiQ924K2.
PhosphoSiteiQ924K2.

Proteomic databases

PaxDbiQ924K2.
PRIDEiQ924K2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140657.
KEGGirno:140657.
UCSCiRGD:70987. rat.

Organism-specific databases

CTDi11124.
RGDi70987. Faf1.

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
HOGENOMiHOG000043073.
HOVERGENiHBG002876.
InParanoidiQ924K2.
PhylomeDBiQ924K2.

Miscellaneous databases

PROiQ924K2.

Family and domain databases

InterProiIPR033043. FAF1.
IPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PANTHERiPTHR23322:SF29. PTHR23322:SF29. 3 hits.
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 3 hits.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a cDNA clone encoding Fas-associated factor 1 (FAF1) in rat central nervous system."
    Shin S.W., Lee M.Y., Choe B.K., Oh Y.J., Lee Y.B., Markelonis G.J., Oh T.H.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-581, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAF1_RAT
AccessioniPrimary (citable) accession number: Q924K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.