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Protein

Aryl-hydrocarbon-interacting protein-like 1

Gene

Aipl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be important in protein trafficking and/or protein folding and stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
  • phototransduction, visible light Source: MGI
  • protein farnesylation Source: MGI
  • regulation of cGMP metabolic process Source: MGI
  • retina homeostasis Source: MGI
  • visual perception Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl-hydrocarbon-interacting protein-like 1
Gene namesi
Name:Aipl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2148800 Aipl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753441 – 328Aryl-hydrocarbon-interacting protein-like 1Add BLAST328

Proteomic databases

PaxDbiQ924K1
PRIDEiQ924K1

PTM databases

PhosphoSitePlusiQ924K1

Expressioni

Gene expression databases

BgeeiENSMUSG00000040554
ExpressionAtlasiQ924K1 baseline and differential
GenevisibleiQ924K1 MM

Interactioni

Subunit structurei

Interacts with NUB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ924K1, 1 interactor
STRINGi10090.ENSMUSP00000036279

Structurei

3D structure databases

ProteinModelPortaliQ924K1
SMRiQ924K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 145PPIase FKBP-typeAdd BLAST93
Repeati178 – 211TPR 1Add BLAST34
Repeati230 – 263TPR 2Add BLAST34
Repeati264 – 297TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545 Eukaryota
ENOG410YGYV LUCA
GeneTreeiENSGT00390000001289
HOGENOMiHOG000007366
HOVERGENiHBG004198
InParanoidiQ924K1
KOiK17767
OMAiETWNLSN
OrthoDBiEOG091G0C69
TreeFamiTF314507

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031209 AIPL1
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11242:SF2 PTHR11242:SF2, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q924K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSLLLNVE GVKKTILHGG TGELPSFITG SRVTFHFRTM KCDDERTVID
60 70 80 90 100
DSKQVGQPMS IIIGNMFKLE VWETLLTSMR LGEVAEFWCD TIHTGVYPML
110 120 130 140 150
SRSLRQVAEG KDPTSWHVHT CGLANMFAYH TLGYEDLDEL QKEPQPLVFL
160 170 180 190 200
IELLQVEAPN EYQRETWNLN NEERMQAVPL LHGEGNRLYK LGRYDQAATK
210 220 230 240 250
YQEAIVCLRN LQTKEKPWEV EWLKLEKMIN TLILNYCQCL LKKEEYYEVL
260 270 280 290 300
EHTSDILRHH PGIVKAYYMR ARAHAEVWNA EEAKADLEKV LELEPSMRKA
310 320
VLRELRLLES RLADKQEEER QRCRSMLG
Length:328
Mass (Da):38,212
Last modified:July 27, 2011 - v2
Checksum:i36AA409151209D39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26S → N in AAK77956 (PubMed:11420621).Curated1
Sequence conflicti44D → E in AAK77956 (PubMed:11420621).Curated1
Sequence conflicti151I → Y in AAK77956 (PubMed:11420621).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296412 mRNA Translation: AAK77956.1
BX321917 Genomic DNA Translation: CAI25580.1
CH466596 Genomic DNA Translation: EDL12655.1
CCDSiCCDS24976.1
RefSeqiNP_444475.2, NM_053245.2
UniGeneiMm.95707

Genome annotation databases

EnsembliENSMUST00000048207; ENSMUSP00000036279; ENSMUSG00000040554
GeneIDi114230
KEGGimmu:114230
UCSCiuc007jxy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAIPL1_MOUSE
AccessioniPrimary (citable) accession number: Q924K1
Secondary accession number(s): Q5RI54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health