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Protein

Aryl-hydrocarbon-interacting protein-like 1

Gene

Aipl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be important in protein trafficking and/or protein folding and stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
  • phototransduction, visible light Source: MGI
  • protein farnesylation Source: MGI
  • protein folding Source: InterPro
  • regulation of cGMP metabolic process Source: MGI
  • retina homeostasis Source: MGI
  • visual perception Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl-hydrocarbon-interacting protein-like 1
Gene namesi
Name:Aipl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2148800. Aipl1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • photoreceptor inner segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753441 – 328Aryl-hydrocarbon-interacting protein-like 1Add BLAST328

Proteomic databases

PaxDbiQ924K1.
PRIDEiQ924K1.

PTM databases

PhosphoSitePlusiQ924K1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040554.
ExpressionAtlasiQ924K1. baseline and differential.
GenevisibleiQ924K1. MM.

Interactioni

Subunit structurei

Interacts with NUB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ924K1. 1 interactor.
STRINGi10090.ENSMUSP00000036279.

Structurei

3D structure databases

ProteinModelPortaliQ924K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 145PPIase FKBP-typeAdd BLAST93
Repeati178 – 211TPR 1Add BLAST34
Repeati230 – 263TPR 2Add BLAST34
Repeati264 – 297TPR 3Add BLAST34

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
GeneTreeiENSGT00390000001289.
HOGENOMiHOG000007366.
HOVERGENiHBG004198.
InParanoidiQ924K1.
KOiK17767.
OMAiVIEHCNE.
OrthoDBiEOG091G0C69.
TreeFamiTF314507.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031209. AIPL1.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF2. PTHR11242:SF2. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSLLLNVE GVKKTILHGG TGELPSFITG SRVTFHFRTM KCDDERTVID
60 70 80 90 100
DSKQVGQPMS IIIGNMFKLE VWETLLTSMR LGEVAEFWCD TIHTGVYPML
110 120 130 140 150
SRSLRQVAEG KDPTSWHVHT CGLANMFAYH TLGYEDLDEL QKEPQPLVFL
160 170 180 190 200
IELLQVEAPN EYQRETWNLN NEERMQAVPL LHGEGNRLYK LGRYDQAATK
210 220 230 240 250
YQEAIVCLRN LQTKEKPWEV EWLKLEKMIN TLILNYCQCL LKKEEYYEVL
260 270 280 290 300
EHTSDILRHH PGIVKAYYMR ARAHAEVWNA EEAKADLEKV LELEPSMRKA
310 320
VLRELRLLES RLADKQEEER QRCRSMLG
Length:328
Mass (Da):38,212
Last modified:July 27, 2011 - v2
Checksum:i36AA409151209D39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26S → N in AAK77956 (PubMed:11420621).Curated1
Sequence conflicti44D → E in AAK77956 (PubMed:11420621).Curated1
Sequence conflicti151I → Y in AAK77956 (PubMed:11420621).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296412 mRNA. Translation: AAK77956.1.
BX321917 Genomic DNA. Translation: CAI25580.1.
CH466596 Genomic DNA. Translation: EDL12655.1.
CCDSiCCDS24976.1.
RefSeqiNP_444475.2. NM_053245.2.
UniGeneiMm.95707.

Genome annotation databases

EnsembliENSMUST00000048207; ENSMUSP00000036279; ENSMUSG00000040554.
GeneIDi114230.
KEGGimmu:114230.
UCSCiuc007jxy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296412 mRNA. Translation: AAK77956.1.
BX321917 Genomic DNA. Translation: CAI25580.1.
CH466596 Genomic DNA. Translation: EDL12655.1.
CCDSiCCDS24976.1.
RefSeqiNP_444475.2. NM_053245.2.
UniGeneiMm.95707.

3D structure databases

ProteinModelPortaliQ924K1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ924K1. 1 interactor.
STRINGi10090.ENSMUSP00000036279.

PTM databases

PhosphoSitePlusiQ924K1.

Proteomic databases

PaxDbiQ924K1.
PRIDEiQ924K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048207; ENSMUSP00000036279; ENSMUSG00000040554.
GeneIDi114230.
KEGGimmu:114230.
UCSCiuc007jxy.2. mouse.

Organism-specific databases

CTDi23746.
MGIiMGI:2148800. Aipl1.

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
GeneTreeiENSGT00390000001289.
HOGENOMiHOG000007366.
HOVERGENiHBG004198.
InParanoidiQ924K1.
KOiK17767.
OMAiVIEHCNE.
OrthoDBiEOG091G0C69.
TreeFamiTF314507.

Miscellaneous databases

PROiQ924K1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040554.
ExpressionAtlasiQ924K1. baseline and differential.
GenevisibleiQ924K1. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031209. AIPL1.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF2. PTHR11242:SF2. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIPL1_MOUSE
AccessioniPrimary (citable) accession number: Q924K1
Secondary accession number(s): Q5RI54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.