Q924I3 (CCRL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 11
Short name=C-C CKR-11
Short name=CC-CKR-11
Short name=CCR-11

Alternative name(s):
CC chemokine receptor-like 1
Short name=CCRL1
CCX CKR

Gene names

Name:	Ccrl1
Synonyms:	Ccr11

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for CCL19, CCL21A and CCL25. Receptor for CCL2, CCL8 and CCL13 By similarity. Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Expressed in lung, heart, spleen, skeletal muscle, testis, astrocytes and microglia. Ref.1 Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	C-C chemokine receptor type 11		PRO_0000069297
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 62	21	Helical; Name=1; Potential
	Topological domain	63 – 77	15	Cytoplasmic Potential
	Transmembrane	78 – 99	22	Helical; Name=2; Potential
	Topological domain	100 – 114	15	Extracellular Potential
	Transmembrane	115 – 135	21	Helical; Name=3; Potential
	Topological domain	136 – 154	19	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 199	24	Extracellular Potential
	Transmembrane	200 – 220	21	Helical; Name=5; Potential
	Topological domain	221 – 240	20	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Helical; Name=6; Potential
	Topological domain	262 – 289	28	Extracellular Potential
	Transmembrane	290 – 310	21	Helical; Name=7; Potential
	Topological domain	311 – 350	40	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	50	1	V → M in BAC27061. Ref.4
	Sequence conflict	287	1	V → L in AAL68400. Ref.2
	Sequence conflict	287	1	V → L in AAL68962. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q924I3 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C5F7D9DC949CECCF	FASTA	350	39,531
	10 20 30 40 50 60 MALELNQSAE YYYEENEMNY THDYSQYEVI CIKEEVRQFA KVFLPAFFTV AFVTGLAGNS 70 80 90 100 110 120 VVVAIYAYYK KQRTKTDVYI LNLAVADLLL LITLPFWAVN AVHGWILGKM MCKVTSALYT 130 140 150 160 170 180 VNFVSGMQFL ACISIDRYWA ITKAPSQSGA GRPCWIICCC VWMAAILLSI PQLVFYTVNQ 190 200 210 220 230 240 NARCTPIFPH HLGTSLKASI QMLEIGIGFV VPFLIMGVCY ASTARALIKM PNIKKSRPLR 250 260 270 280 290 300 VLLAVVVVFI VTQLPYNVVK FCQAIDAIYL LITSCDMSKR MDVAIQVTES IALFHSCLNP 310 320 330 340 350 ILYVFMGASF KNYIMKVAKK YGSWRRQRQN VEEIPFDSEG PTEPTSSFTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Astrocytes express functional chemokine receptors." Dorf M.E., Berman M.A., Tanabe S., Heesen M., Luo Y. J. Neuroimmunol. 111:109-121(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c.
[2]	"Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR." Townson J.R., Nibbs R.J. Eur. J. Immunol. 32:1230-1241(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN CHEMOKINES BINDING, TISSUE SPECIFICITY.
[3]	"RANTES and eotaxin stimulate chemotaxis, chemokine/cytokine synthesis, and receptor modulation in murine astrocytes." Luo Y., Berman M.A., Fischer F.R., Abromson-Leeman S.R., Kuziel W.A., Gerard C., Dorf M.E. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head and Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF306532 mRNA. Translation: AAK81712.1. AY072796 mRNA. Translation: AAL68400.1. AY072938 mRNA. Translation: AAL68962.1. AK030643 mRNA. Translation: BAC27061.1. AK042430 mRNA. Translation: BAC31258.1.
IPI	IPI00154072.
RefSeq	NP_663746.2. NM_145700.2.
UniGene	Mm.269254.
3D structure databases
ProteinModelPortal	Q924I3.
SMR	Q924I3. Positions 39-322.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q924I3.
Proteomic databases
PRIDE	Q924I3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000076147; ENSMUSP00000075507; ENSMUSG00000079355.
GeneID	252837.
KEGG	mmu:252837.
UCSC	uc009rhh.2. mouse.
Organism-specific databases
CTD	51554.
MGI	MGI:2181676. Ccrl1.
Phylogenomic databases
eggNOG	NOG148788.
GeneTree	ENSGT00690000101668.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q924I3.
KO	K04186.
OMA	LEICIGF.
OrthoDB	EOG48KRBK.
Gene expression databases
Bgee	Q924I3.
CleanEx	MM_CCRL1.
Genevestigator	Q924I3.
GermOnline	ENSMUSG00000041748. Mus musculus.
Family and domain databases
InterPro	IPR005383. Chemokine_CCR11. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01558. CHEMOKINER11. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	387341.
SOURCE	Search...

Entry information

Entry name

CCRL1_MOUSE

Accession

Primary (citable) accession number: Q924I3
Secondary accession number(s): Q8C0M1, Q8QZW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program