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Protein

Mitogen-activated protein kinase kinase kinase kinase 3

Gene

Map4k3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase kinase 3 (EC:2.7.11.1)
Alternative name(s):
Germinal center kinase-related protein kinase
Short name:
GLK
MAPK/ERK kinase kinase kinase 3
Short name:
MEK kinase kinase 3
Short name:
MEKKK 3
Gene namesi
Name:Map4k3
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621280 Map4k3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862791 – 873Mitogen-activated protein kinase kinase kinase kinase 3Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei329PhosphoserineBy similarity1
Modified residuei377PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ924I2
PRIDEiQ924I2

PTM databases

iPTMnetiQ924I2
PhosphoSitePlusiQ924I2

Interactioni

Subunit structurei

Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.1 Publication

Protein-protein interaction databases

BioGridi251030, 1 interactor
MINTiQ924I2
STRINGi10116.ENSRNOP00000010366

Structurei

3D structure databases

ProteinModelPortaliQ924I2
SMRiQ924I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 273Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini535 – 846CNHPROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0576 Eukaryota
ENOG410XP9G LUCA
HOGENOMiHOG000230824
HOVERGENiHBG036702
InParanoidiQ924I2
KOiK04406

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR021160 MAPKKKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF038172 MAPKKKK, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q924I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE
60 70 80 90 100
PGEDFAVVQQ EIIMMKDCKH ANIVAYFGSY LRRDKLWICM EFCGGGSLQD
110 120 130 140 150
IYHVTGPLSE LQIAYVSRET LQGLYYLHSK GKMHRDIKGA NILLTDNGHV
160 170 180 190 200
KLADFGVSAQ ITATIAKRKS FIGTPYWMAP EVAAVERKGG YNQLCDLWAV
210 220 230 240 250
GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKL KWSNSFHHFV
260 270 280 290 300
KMALTKNPKK RPTAEKLLQH PFVTQPLTRS LAIELLDKVN NPDHSTYHDF
310 320 330 340 350
DDDDPEPLVA VPHRIPSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH
360 370 380 390 400
ELDLQLEYGQ GHQSNYFLGG NKSLLKSVEE ELHQRGHVAH LEDDEGDDDD
410 420 430 440 450
SKHSTLKAKV PPPLPPKPKS ISIPQDTHSS EDSNQGTIKR CPSSGSPAKP
460 470 480 490 500
SHVPPRPPPP RLPPQKPAVL GNGVSSFQLN GERDGSVHQQ QSEQRGTNLS
510 520 530 540 550
RKEKKDVPKP ISNGLPPTPK VHMGACFSKV FNGCPLKIHC ATSWINPDTR
560 570 580 590 600
DQYLIFGAEE GIYTLNLNEL HETSMEQLFP RRCTWLYVMN NCLLSVSGKA
610 620 630 640 650
SQLYSHNLPG LFDYARQMQK LPVAIPAHKL PDRILPRKFA VSAKIPETKW
660 670 680 690 700
CQKCCVVRNP YTGHKYLCGA LQTSIVLLEW VEPMQKFMLI KHIEFPMPCP
710 720 730 740 750
LRMFEMLVVP EQEYPLVCVG VSRGRDFNQV VRFETVNPNS TSSWFTESDT
760 770 780 790 800
PQTNVTHVTQ LERDTILVCL DCCIKIVNLQ GRLKSSRKLS SELTFDFQIE
810 820 830 840 850
SIVCLQDSVL AFWKHGMQGR SFRSNEVTQE ISDNTRIFRL LGSDRVVVLE
860 870
SRPTDNPTAN SNLYILAGHE NSY
Length:873
Mass (Da):98,679
Last modified:July 10, 2007 - v2
Checksum:i2EF27843498FA81D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AI112857 mRNA No translation available.
AF312224 mRNA Translation: AAK53214.1
RefSeqiNP_596898.1, NM_133407.1
UniGeneiRn.93345

Genome annotation databases

GeneIDi170920
KEGGirno:170920
UCSCiRGD:621280 rat

Similar proteinsi

Entry informationi

Entry nameiM4K3_RAT
AccessioniPrimary (citable) accession number: Q924I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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