ID Q924D5_MOUSE Unreviewed; 478 AA. AC Q924D5; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 24-JAN-2024, entry version 111. DE RecName: Full=Calcitonin receptor {ECO:0000256|ARBA:ARBA00017333}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAK56134.1}; RN [1] {ECO:0000313|EMBL:AAK56134.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=129 {ECO:0000313|EMBL:AAK56134.1}; RX PubMed=11309373; DOI=10.1074/jbc.M007104200; RA Anusaksathien O., Laplace C., Li X., Ren Y., Peng L., Goldring S.R., RA Galson D.L.; RT "Tissue-specific and ubiquitous promoters direct the expression of RT alternatively spliced transcripts from the calcitonin receptor gene."; RL J. Biol. Chem. 276:22663-22674(2001). CC -!- SUBUNIT: Interacts with GPRASP2. {ECO:0000256|ARBA:ARBA00011681}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|ARBA:ARBA00005314}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AH010783; AAK56134.1; -; Genomic_DNA. DR EMBL; AF333474; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333475; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333476; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333477; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333478; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333479; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333481; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333482; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333483; AAK56134.1; JOINED; Genomic_DNA. DR EMBL; AF333484; AAK56134.1; JOINED; Genomic_DNA. DR AlphaFoldDB; Q924D5; -. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro. DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:UniProt. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR CDD; cd15274; 7tmB1_calcitonin_R; 1. DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam. DR InterPro; IPR017981; GPCR_2-like_7TM. DR InterPro; IPR001688; GPCR_2_calcitonin_rcpt. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR PANTHER; PTHR45620:SF8; CALCITONIN RECEPTOR; 1. DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF02793; HRM; 1. DR PRINTS; PR00361; CALCITONINR. DR PRINTS; PR01350; CTRFAMILY. DR PRINTS; PR00249; GPCRSECRETIN. DR SMART; SM00008; HormR; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR SUPFAM; SSF111418; Hormone receptor domain; 1. DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAK56134.1}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|ARBA:ARBA00023224}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..478 FT /note="Calcitonin receptor" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004320948" FT TRANSMEM 147..173 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 185..203 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 234..254 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 261..284 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 296..320 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 341..362 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 374..394 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 54..138 FT /note="G-protein coupled receptors family 2 profile 1" FT /evidence="ECO:0000259|PROSITE:PS50227" FT DOMAIN 148..395 FT /note="G-protein coupled receptors family 2 profile 2" FT /evidence="ECO:0000259|PROSITE:PS50261" SQ SEQUENCE 478 AA; 55808 MW; 1DF08EA37A4D852D CRC64; MRFLLVNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD AQYKCYDRIH QLPSYEGEGL YCNRTWDGWM CWDDTPAGAT AYQHCPDYFP DFDTAEKVSK YCDENGEWFR HPDSNRTWSN YTLCNAFTSE KLQNAYVLYY LALVGHSLSI AALVASMLIF WIFKNLSCQR VTLHKHMFLT YILNSIIIII HLVEVVPNGD LVRRDPISCK VLHFLHQYMM SCNYFWMLCE GIYLHTLIVM AVFTDEQRLR WYYLLGWGFP IVPTIIHAIT RALYYNDNCW LSAETHLLYI IHGPVMVALV VNFFFLLNIV RVLVTKMRQT HEAESYMYLK AVKATMVLVP LLGIQFVVFP WRPSNKVLGK IYDYLMHSLI HFQGFFVATI YCFCNHEVQV TLKRQWTQFK IQWSQRWGRR RPTNRVVSAP RAVAFAEPDG LPIYICHQEP RNPPISNNEG EESTEMIPMN VIQQDASA //