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Protein
Submitted name:

Calcitonin receptor isoform Cla-2

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Calcitonin receptor isoform Cla-2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei147 – 173HelicalSequence analysisAdd BLAST27
Transmembranei185 – 203HelicalSequence analysisAdd BLAST19
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei261 – 284HelicalSequence analysisAdd BLAST24
Transmembranei296 – 320HelicalSequence analysisAdd BLAST25
Transmembranei341 – 362HelicalSequence analysisAdd BLAST22
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500432094825 – 478Sequence analysisAdd BLAST454

Structurei

3D structure databases

ProteinModelPortaliQ924D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 138G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST85
Domaini148 – 395G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST248

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG102129.

Family and domain databases

CDDicd15274. 7tmB1_calcitonin_R. 1 hit.
Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PANTHERiPTHR12011:SF389. PTHR12011:SF389. 1 hit.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q924D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLLVNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD
60 70 80 90 100
AQYKCYDRIH QLPSYEGEGL YCNRTWDGWM CWDDTPAGAT AYQHCPDYFP
110 120 130 140 150
DFDTAEKVSK YCDENGEWFR HPDSNRTWSN YTLCNAFTSE KLQNAYVLYY
160 170 180 190 200
LALVGHSLSI AALVASMLIF WIFKNLSCQR VTLHKHMFLT YILNSIIIII
210 220 230 240 250
HLVEVVPNGD LVRRDPISCK VLHFLHQYMM SCNYFWMLCE GIYLHTLIVM
260 270 280 290 300
AVFTDEQRLR WYYLLGWGFP IVPTIIHAIT RALYYNDNCW LSAETHLLYI
310 320 330 340 350
IHGPVMVALV VNFFFLLNIV RVLVTKMRQT HEAESYMYLK AVKATMVLVP
360 370 380 390 400
LLGIQFVVFP WRPSNKVLGK IYDYLMHSLI HFQGFFVATI YCFCNHEVQV
410 420 430 440 450
TLKRQWTQFK IQWSQRWGRR RPTNRVVSAP RAVAFAEPDG LPIYICHQEP
460 470
RNPPISNNEG EESTEMIPMN VIQQDASA
Length:478
Mass (Da):55,808
Last modified:December 1, 2001 - v1
Checksum:i1DF08EA37A4D852D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH010783
, AF333474, AF333475, AF333476, AF333477, AF333478, AF333479, AF333481, AF333482, AF333483, AF333484 Genomic DNA. Translation: AAK56134.1.
UniGeneiMm.4642.

Similar proteinsi

Entry informationi

Entry nameiQ924D5_MOUSE
AccessioniPrimary (citable) accession number: Q924D5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)