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Protein

Chloride anion exchanger

Gene

Slc26a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-RNO-427601. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride anion exchanger
Alternative name(s):
Down-regulated in adenoma
Short name:
Protein DRA
Solute carrier family 26 member 3
Gene namesi
Name:Slc26a3
Synonyms:Dra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620623. Slc26a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 17530ExtracellularSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence analysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence analysisAdd
BLAST
Transmembranei702 – 72221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • brush border membrane Source: RGD
  • integral component of plasma membrane Source: InterPro
  • membrane Source: UniProtKB
  • sperm midpiece Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Chloride anion exchangerPRO_0000080163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ924C9.
PRIDEiQ924C9.

PTM databases

iPTMnetiQ924C9.
PhosphoSiteiQ924C9.

Expressioni

Gene expression databases

GenevisibleiQ924C9. RN.

Interactioni

Subunit structurei

Interacts with PDZK1, CFTR, SLC26A6 and SLC9A3R1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009473.

Structurei

3D structure databases

ProteinModelPortaliQ924C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini518 – 713196STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ924C9.
KOiK14078.
OMAiQETIGDC.
OrthoDBiEOG76T9QT.
PhylomeDBiQ924C9.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030321. SLC26A3.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF19. PTHR11814:SF19. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEAIGNQYV VARPVYSTKA FGEEFKKTYG HHKTFLDHLK GCCSCSSQKA
60 70 80 90 100
KKIALSLFPI ASWLPAYKIK EWLLSDIVSG ISTGLVAVLQ GLAFALLVNI
110 120 130 140 150
PPAYGLYAAF FPVITYFFLG TSRHISVGPF PVLSMMVGVV VTRVASGSDT
160 170 180 190 200
SPALSSSSAE NDSMIEEKVM VAASVTVLSG IIQLLLGVLQ IGFVVIYLSE
210 220 230 240 250
SLISGFTTAA AIHVLVSQLK FMLQLTVPAH SDPFSIFKVL ESVFSQIQKT
260 270 280 290 300
NIADLVTSVI ILVVVFVVKE INQRYRSKLP VPIPIELIMT VIATGISYGC
310 320 330 340 350
NFEQRFGVAV VGNMSLGFQP PITPSVEVFQ DTIGDCFGIA IVGFAVAFSV
360 370 380 390 400
ASVYSLKYDY PIDGNQELIA LGVSNIFTGA FKGFAGSTAL SRSGVQESTG
410 420 430 440 450
GKTQVAGLLS AVIVLIVIVA IGFLLQPLQK SVLAALALGN LKGMLMQFAE
460 470 480 490 500
IGRLWKKDKY DCLIWIMTFI FAIVLGLGLG LAASVAFQLL TIVFRTQFPK
510 520 530 540 550
CSTLANVGRS NIYKNKKNYA DVYEPEGVKI FRCPSPIYFA NIGFFKQKLI
560 570 580 590 600
DAVGFNPLRI LRKRNKALKK IRKLQKQGLI QVTPKGFICT SDGFKDSDEE
610 620 630 640 650
LDNNQIEELD QPINTTDLPF EIDWNADLPL NITIPKISLH SLILDFSAVS
660 670 680 690 700
FLDISSMRGL RTILQEFIRI KVDVYIVGTD DDFIDKLARC EFFDDEVTDS
710 720 730 740 750
IFFLTIHDAI LHIWMKKDYS TSKFNSSQEK ERKFDFTINT NGGLRNRECQ

VPVETKF
Length:757
Mass (Da):83,369
Last modified:December 1, 2001 - v1
Checksum:i195D867306ED8ECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337809 mRNA. Translation: AAK83221.1.
RefSeqiNP_446207.1. NM_053755.2.
UniGeneiRn.81026.

Genome annotation databases

EnsembliENSRNOT00000009473; ENSRNOP00000009473; ENSRNOG00000006878.
GeneIDi114629.
KEGGirno:114629.
UCSCiRGD:620623. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337809 mRNA. Translation: AAK83221.1.
RefSeqiNP_446207.1. NM_053755.2.
UniGeneiRn.81026.

3D structure databases

ProteinModelPortaliQ924C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009473.

PTM databases

iPTMnetiQ924C9.
PhosphoSiteiQ924C9.

Proteomic databases

PaxDbiQ924C9.
PRIDEiQ924C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009473; ENSRNOP00000009473; ENSRNOG00000006878.
GeneIDi114629.
KEGGirno:114629.
UCSCiRGD:620623. rat.

Organism-specific databases

CTDi1811.
RGDi620623. Slc26a3.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ924C9.
KOiK14078.
OMAiQETIGDC.
OrthoDBiEOG76T9QT.
PhylomeDBiQ924C9.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-RNO-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiQ924C9.

Gene expression databases

GenevisibleiQ924C9. RN.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030321. SLC26A3.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF19. PTHR11814:SF19. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of down-regulated in adenoma (DRA) mRNA from rat colon."
    Ye H.J., Binder H.J., Rajendran V.M.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiS26A3_RAT
AccessioniPrimary (citable) accession number: Q924C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.