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Q924C6

- LOXL4_MOUSE

UniProt

Q924C6 - LOXL4_MOUSE

Protein

Lysyl oxidase homolog 4

Gene

Loxl4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May modulate the formation of a collagenous extracellular matrix.

    Cofactori

    Copper.By similarity
    Contains 1 lysine tyrosylquinone.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi612 – 6121CopperSequence Analysis
    Metal bindingi614 – 6141CopperSequence Analysis
    Metal bindingi616 – 6161CopperSequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. protein-lysine 6-oxidase activity Source: MGI
    3. scavenger receptor activity Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysyl oxidase homolog 4 (EC:1.4.3.-)
    Alternative name(s):
    Lysyl oxidase-like protein 4
    Lysyl oxidase-related protein C
    Gene namesi
    Name:Loxl4
    Synonyms:Loxc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1914823. Loxl4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: UniProtKB-SubCell
    3. membrane Source: InterPro
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 757732Lysyl oxidase homolog 4PRO_0000018536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi59 ↔ 123PROSITE-ProRule annotation
    Disulfide bondi72 ↔ 133PROSITE-ProRule annotation
    Disulfide bondi103 ↔ 113PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 277PROSITE-ProRule annotation
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi205 ↔ 287PROSITE-ProRule annotation
    Disulfide bondi252 ↔ 262PROSITE-ProRule annotation
    Disulfide bondi337 ↔ 401PROSITE-ProRule annotation
    Disulfide bondi350 ↔ 411PROSITE-ProRule annotation
    Disulfide bondi381 ↔ 391PROSITE-ProRule annotation
    Disulfide bondi451 ↔ 516PROSITE-ProRule annotation
    Disulfide bondi464 ↔ 529PROSITE-ProRule annotation
    Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi559 ↔ 565PROSITE-ProRule annotation
    Disulfide bondi611 ↔ 659PROSITE-ProRule annotation
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Cross-linki639 ↔ 675Lysine tyrosylquinone (Lys-Tyr)By similarity
    Disulfide bondi643 ↔ 649PROSITE-ProRule annotation
    Disulfide bondi671 ↔ 681PROSITE-ProRule annotation
    Modified residuei675 – 67512',4',5'-topaquinoneBy similarity
    Disulfide bondi718 ↔ 732PROSITE-ProRule annotation

    Post-translational modificationi

    The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, LTQ, TPQ

    Proteomic databases

    PaxDbiQ924C6.
    PRIDEiQ924C6.

    PTM databases

    PhosphoSiteiQ924C6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ924C6.
    BgeeiQ924C6.
    CleanExiMM_LOXL4.
    GenevestigatoriQ924C6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ924C6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924C6.
    SMRiQ924C6. Positions 44-133, 310-412, 422-531.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 134102SRCR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini160 – 288129SRCR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini312 – 412101SRCR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini422 – 530109SRCR 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni534 – 737204Lysyl-oxidase likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysyl oxidase family.Curated
    Contains 4 SRCR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG40770.
    GeneTreeiENSGT00740000115380.
    HOGENOMiHOG000220841.
    HOVERGENiHBG052336.
    InParanoidiQ924C6.
    KOiK00280.
    OrthoDBiEOG7SN8C6.

    Family and domain databases

    Gene3Di3.10.250.10. 4 hits.
    InterProiIPR001695. Lysyl_oxidase.
    IPR019828. Lysyl_oxidase_CS.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view]
    PfamiPF01186. Lysyl_oxidase. 1 hit.
    PF00530. SRCR. 4 hits.
    [Graphical view]
    PRINTSiPR00074. LYSYLOXIDASE.
    PR00258. SPERACTRCPTR.
    SMARTiSM00202. SR. 4 hits.
    [Graphical view]
    SUPFAMiSSF56487. SSF56487. 4 hits.
    PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
    PS00420. SRCR_1. 1 hit.
    PS50287. SRCR_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q924C6-1 [UniParc]FASTAAdd to Basket

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    MMWPQPPTFS LFLLLLLSQA PSSRPQSSGT KKLRLVGPTD RPEEGRLEVL    50
    HQGQWGTVCD DDFALQEATV ACRQLGFESA LTWAHSAKYG QGEGPIWLDN 100
    VRCLGTEKTL DQCGSNGWGV SDCRHSEDVG VVCHPRRQHG YHSEKVSNAL 150
    GPQGRRLEEV RLKPILASAK RHSPVTEGAV EVRYDGHWRQ VCDQGWTMNN 200
    SRVVCGMLGF PSQTSVNSHY YRKVWNLKMK DPKSRLNSLT KKNSFWIHRV 250
    DCLGTEPHLA KCQVQVAPGR GKLRPACPGG MHAVVSCVAG PHFRRQKPKP 300
    TRKESHAEEL KVRLRSGAQV GEGRVEVLMN RQWGTVCDHR WNLISASVVC 350
    RQLGFGSARE ALFGAQLGQG LGPIHLSEVR CRGYERTLGD CLALEGSQNG 400
    CQHANDAAVR CNIPDMGFQN KVRLAGGRNS EEGVVEVQVE VNGVPRWGTV 450
    CSDHWGLTEA MVTCRQLGLG FANFALKDTW YWQGTPEAKE VVMSGVRCSG 500
    TEMALQQCQR HGPVHCSHGP GRFSAGVACM NSAPDLVMNA QLVQETAYLE 550
    DRPLSMLYCA HEENCLSKSA DHMDWPYGYR RLLRFSSQIY NLGRADFRPK 600
    AGRHSWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP 650
    SGVQRRYACA NFGEQGVAVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV 700
    NPTNDVAESD FSNNMIRCRC KYDGQRVWLH NCHTGDSYRA NAELSLEQEQ 750
    RLRNNLI 757
    Length:757
    Mass (Da):84,779
    Last modified:July 27, 2011 - v2
    Checksum:i45E698867160955C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391T → A in AAK71933. (PubMed:11292829)Curated
    Sequence conflicti120 – 1201V → I in AAK71933. (PubMed:11292829)Curated
    Sequence conflicti253 – 2531L → F in AAK71933. (PubMed:11292829)Curated
    Sequence conflicti444 – 4441V → G in AAK71933. (PubMed:11292829)Curated
    Sequence conflicti615 – 6151Y → N in AAK71933. (PubMed:11292829)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338440 mRNA. Translation: AAK71933.1.
    AC124552 Genomic DNA. No translation available.
    CCDSiCCDS29830.1.
    RefSeqiNP_444313.3. NM_053083.3.
    UniGeneiMm.178767.

    Genome annotation databases

    EnsembliENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185.
    ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
    GeneIDi67573.
    KEGGimmu:67573.
    UCSCiuc008hns.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338440 mRNA. Translation: AAK71933.1 .
    AC124552 Genomic DNA. No translation available.
    CCDSi CCDS29830.1.
    RefSeqi NP_444313.3. NM_053083.3.
    UniGenei Mm.178767.

    3D structure databases

    ProteinModelPortali Q924C6.
    SMRi Q924C6. Positions 44-133, 310-412, 422-531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q924C6. 1 interaction.

    PTM databases

    PhosphoSitei Q924C6.

    Proteomic databases

    PaxDbi Q924C6.
    PRIDEi Q924C6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026190 ; ENSMUSP00000026190 ; ENSMUSG00000025185 .
    ENSMUST00000171432 ; ENSMUSP00000126686 ; ENSMUSG00000025185 .
    GeneIDi 67573.
    KEGGi mmu:67573.
    UCSCi uc008hns.2. mouse.

    Organism-specific databases

    CTDi 84171.
    MGIi MGI:1914823. Loxl4.

    Phylogenomic databases

    eggNOGi NOG40770.
    GeneTreei ENSGT00740000115380.
    HOGENOMi HOG000220841.
    HOVERGENi HBG052336.
    InParanoidi Q924C6.
    KOi K00280.
    OrthoDBi EOG7SN8C6.

    Miscellaneous databases

    NextBioi 324941.
    PROi Q924C6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q924C6.
    Bgeei Q924C6.
    CleanExi MM_LOXL4.
    Genevestigatori Q924C6.

    Family and domain databases

    Gene3Di 3.10.250.10. 4 hits.
    InterProi IPR001695. Lysyl_oxidase.
    IPR019828. Lysyl_oxidase_CS.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view ]
    Pfami PF01186. Lysyl_oxidase. 1 hit.
    PF00530. SRCR. 4 hits.
    [Graphical view ]
    PRINTSi PR00074. LYSYLOXIDASE.
    PR00258. SPERACTRCPTR.
    SMARTi SM00202. SR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF56487. SSF56487. 4 hits.
    PROSITEi PS00926. LYSYL_OXIDASE. 1 hit.
    PS00420. SRCR_1. 1 hit.
    PS50287. SRCR_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage."
      Ito H., Akiyama H., Iguchi H., Iyama K., Miyamoto M., Ohsawa K., Nakamura T.
      J. Biol. Chem. 276:24023-24029(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiLOXL4_MOUSE
    AccessioniPrimary (citable) accession number: Q924C6
    Secondary accession number(s): E9PXI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3