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Protein

Lysyl oxidase homolog 4

Gene

Loxl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the formation of a collagenous extracellular matrix.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi612CopperSequence analysis1
Metal bindingi614CopperSequence analysis1
Metal bindingi616CopperSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 4 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene namesi
Name:Loxl4
Synonyms:Loxc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914823. Loxl4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: UniProtKB-SubCell
  • membrane Source: InterPro
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001853626 – 757Lysyl oxidase homolog 4Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 123PROSITE-ProRule annotation
Disulfide bondi72 ↔ 133PROSITE-ProRule annotation
Disulfide bondi103 ↔ 113PROSITE-ProRule annotation
Disulfide bondi192 ↔ 277PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi205 ↔ 287PROSITE-ProRule annotation
Disulfide bondi252 ↔ 262PROSITE-ProRule annotation
Disulfide bondi337 ↔ 401PROSITE-ProRule annotation
Disulfide bondi350 ↔ 411PROSITE-ProRule annotation
Disulfide bondi381 ↔ 391PROSITE-ProRule annotation
Disulfide bondi451 ↔ 516PROSITE-ProRule annotation
Disulfide bondi464 ↔ 529PROSITE-ProRule annotation
Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
Disulfide bondi559 ↔ 565PROSITE-ProRule annotation
Disulfide bondi611 ↔ 659PROSITE-ProRule annotation
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Cross-linki639 ↔ 675Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi643 ↔ 649PROSITE-ProRule annotation
Disulfide bondi671 ↔ 681PROSITE-ProRule annotation
Modified residuei6752',4',5'-topaquinoneBy similarity1
Disulfide bondi718 ↔ 732PROSITE-ProRule annotation

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

MaxQBiQ924C6.
PaxDbiQ924C6.
PRIDEiQ924C6.

PTM databases

iPTMnetiQ924C6.
PhosphoSitePlusiQ924C6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025185.
CleanExiMM_LOXL4.
ExpressionAtlasiQ924C6. baseline and differential.
GenevisibleiQ924C6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ924C6. 1 interactor.
STRINGi10090.ENSMUSP00000125803.

Structurei

3D structure databases

ProteinModelPortaliQ924C6.
SMRiQ924C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 134SRCR 1PROSITE-ProRule annotationAdd BLAST102
Domaini160 – 288SRCR 2PROSITE-ProRule annotationAdd BLAST129
Domaini312 – 412SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini422 – 530SRCR 4PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni534 – 737Lysyl-oxidase likeAdd BLAST204

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated
Contains 4 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE2X. Eukaryota.
ENOG410XSN1. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ924C6.
KOiK00280.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWPQPPTFS LFLLLLLSQA PSSRPQSSGT KKLRLVGPTD RPEEGRLEVL
60 70 80 90 100
HQGQWGTVCD DDFALQEATV ACRQLGFESA LTWAHSAKYG QGEGPIWLDN
110 120 130 140 150
VRCLGTEKTL DQCGSNGWGV SDCRHSEDVG VVCHPRRQHG YHSEKVSNAL
160 170 180 190 200
GPQGRRLEEV RLKPILASAK RHSPVTEGAV EVRYDGHWRQ VCDQGWTMNN
210 220 230 240 250
SRVVCGMLGF PSQTSVNSHY YRKVWNLKMK DPKSRLNSLT KKNSFWIHRV
260 270 280 290 300
DCLGTEPHLA KCQVQVAPGR GKLRPACPGG MHAVVSCVAG PHFRRQKPKP
310 320 330 340 350
TRKESHAEEL KVRLRSGAQV GEGRVEVLMN RQWGTVCDHR WNLISASVVC
360 370 380 390 400
RQLGFGSARE ALFGAQLGQG LGPIHLSEVR CRGYERTLGD CLALEGSQNG
410 420 430 440 450
CQHANDAAVR CNIPDMGFQN KVRLAGGRNS EEGVVEVQVE VNGVPRWGTV
460 470 480 490 500
CSDHWGLTEA MVTCRQLGLG FANFALKDTW YWQGTPEAKE VVMSGVRCSG
510 520 530 540 550
TEMALQQCQR HGPVHCSHGP GRFSAGVACM NSAPDLVMNA QLVQETAYLE
560 570 580 590 600
DRPLSMLYCA HEENCLSKSA DHMDWPYGYR RLLRFSSQIY NLGRADFRPK
610 620 630 640 650
AGRHSWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP
660 670 680 690 700
SGVQRRYACA NFGEQGVAVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV
710 720 730 740 750
NPTNDVAESD FSNNMIRCRC KYDGQRVWLH NCHTGDSYRA NAELSLEQEQ

RLRNNLI
Length:757
Mass (Da):84,779
Last modified:July 27, 2011 - v2
Checksum:i45E698867160955C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39T → A in AAK71933 (PubMed:11292829).Curated1
Sequence conflicti120V → I in AAK71933 (PubMed:11292829).Curated1
Sequence conflicti253L → F in AAK71933 (PubMed:11292829).Curated1
Sequence conflicti444V → G in AAK71933 (PubMed:11292829).Curated1
Sequence conflicti615Y → N in AAK71933 (PubMed:11292829).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338440 mRNA. Translation: AAK71933.1.
AC124552 Genomic DNA. No translation available.
CCDSiCCDS29830.1.
RefSeqiNP_444313.3. NM_053083.3.
UniGeneiMm.178767.

Genome annotation databases

EnsembliENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185.
ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
GeneIDi67573.
KEGGimmu:67573.
UCSCiuc008hns.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338440 mRNA. Translation: AAK71933.1.
AC124552 Genomic DNA. No translation available.
CCDSiCCDS29830.1.
RefSeqiNP_444313.3. NM_053083.3.
UniGeneiMm.178767.

3D structure databases

ProteinModelPortaliQ924C6.
SMRiQ924C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ924C6. 1 interactor.
STRINGi10090.ENSMUSP00000125803.

PTM databases

iPTMnetiQ924C6.
PhosphoSitePlusiQ924C6.

Proteomic databases

MaxQBiQ924C6.
PaxDbiQ924C6.
PRIDEiQ924C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185.
ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
GeneIDi67573.
KEGGimmu:67573.
UCSCiuc008hns.2. mouse.

Organism-specific databases

CTDi84171.
MGIiMGI:1914823. Loxl4.

Phylogenomic databases

eggNOGiENOG410IE2X. Eukaryota.
ENOG410XSN1. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ924C6.
KOiK00280.

Miscellaneous databases

PROiQ924C6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025185.
CleanExiMM_LOXL4.
ExpressionAtlasiQ924C6. baseline and differential.
GenevisibleiQ924C6. MM.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOXL4_MOUSE
AccessioniPrimary (citable) accession number: Q924C6
Secondary accession number(s): E9PXI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.