Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q924C6

- LOXL4_MOUSE

UniProt

Q924C6 - LOXL4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysyl oxidase homolog 4

Gene

Loxl4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May modulate the formation of a collagenous extracellular matrix.

Cofactori

Copper.By similarity
Contains 1 lysine tyrosylquinone.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi612 – 6121CopperSequence Analysis
Metal bindingi614 – 6141CopperSequence Analysis
Metal bindingi616 – 6161CopperSequence Analysis

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. protein-lysine 6-oxidase activity Source: MGI
  3. scavenger receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 4 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene namesi
Name:Loxl4
Synonyms:Loxc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1914823. Loxl4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. membrane Source: InterPro
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 757732Lysyl oxidase homolog 4PRO_0000018536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 123PROSITE-ProRule annotation
Disulfide bondi72 ↔ 133PROSITE-ProRule annotation
Disulfide bondi103 ↔ 113PROSITE-ProRule annotation
Disulfide bondi192 ↔ 277PROSITE-ProRule annotation
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi205 ↔ 287PROSITE-ProRule annotation
Disulfide bondi252 ↔ 262PROSITE-ProRule annotation
Disulfide bondi337 ↔ 401PROSITE-ProRule annotation
Disulfide bondi350 ↔ 411PROSITE-ProRule annotation
Disulfide bondi381 ↔ 391PROSITE-ProRule annotation
Disulfide bondi451 ↔ 516PROSITE-ProRule annotation
Disulfide bondi464 ↔ 529PROSITE-ProRule annotation
Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
Disulfide bondi559 ↔ 565PROSITE-ProRule annotation
Disulfide bondi611 ↔ 659PROSITE-ProRule annotation
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
Cross-linki639 ↔ 675Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi643 ↔ 649PROSITE-ProRule annotation
Disulfide bondi671 ↔ 681PROSITE-ProRule annotation
Modified residuei675 – 67512',4',5'-topaquinoneBy similarity
Disulfide bondi718 ↔ 732PROSITE-ProRule annotation

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

MaxQBiQ924C6.
PaxDbiQ924C6.
PRIDEiQ924C6.

PTM databases

PhosphoSiteiQ924C6.

Expressioni

Gene expression databases

BgeeiQ924C6.
CleanExiMM_LOXL4.
ExpressionAtlasiQ924C6. baseline and differential.
GenevestigatoriQ924C6.

Interactioni

Protein-protein interaction databases

IntActiQ924C6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ924C6.
SMRiQ924C6. Positions 44-133, 310-412, 422-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 134102SRCR 1PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 288129SRCR 2PROSITE-ProRule annotationAdd
BLAST
Domaini312 – 412101SRCR 3PROSITE-ProRule annotationAdd
BLAST
Domaini422 – 530109SRCR 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni534 – 737204Lysyl-oxidase likeAdd
BLAST

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated
Contains 4 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG40770.
GeneTreeiENSGT00760000119251.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ924C6.
KOiK00280.
OrthoDBiEOG7SN8C6.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924C6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMWPQPPTFS LFLLLLLSQA PSSRPQSSGT KKLRLVGPTD RPEEGRLEVL
60 70 80 90 100
HQGQWGTVCD DDFALQEATV ACRQLGFESA LTWAHSAKYG QGEGPIWLDN
110 120 130 140 150
VRCLGTEKTL DQCGSNGWGV SDCRHSEDVG VVCHPRRQHG YHSEKVSNAL
160 170 180 190 200
GPQGRRLEEV RLKPILASAK RHSPVTEGAV EVRYDGHWRQ VCDQGWTMNN
210 220 230 240 250
SRVVCGMLGF PSQTSVNSHY YRKVWNLKMK DPKSRLNSLT KKNSFWIHRV
260 270 280 290 300
DCLGTEPHLA KCQVQVAPGR GKLRPACPGG MHAVVSCVAG PHFRRQKPKP
310 320 330 340 350
TRKESHAEEL KVRLRSGAQV GEGRVEVLMN RQWGTVCDHR WNLISASVVC
360 370 380 390 400
RQLGFGSARE ALFGAQLGQG LGPIHLSEVR CRGYERTLGD CLALEGSQNG
410 420 430 440 450
CQHANDAAVR CNIPDMGFQN KVRLAGGRNS EEGVVEVQVE VNGVPRWGTV
460 470 480 490 500
CSDHWGLTEA MVTCRQLGLG FANFALKDTW YWQGTPEAKE VVMSGVRCSG
510 520 530 540 550
TEMALQQCQR HGPVHCSHGP GRFSAGVACM NSAPDLVMNA QLVQETAYLE
560 570 580 590 600
DRPLSMLYCA HEENCLSKSA DHMDWPYGYR RLLRFSSQIY NLGRADFRPK
610 620 630 640 650
AGRHSWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP
660 670 680 690 700
SGVQRRYACA NFGEQGVAVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV
710 720 730 740 750
NPTNDVAESD FSNNMIRCRC KYDGQRVWLH NCHTGDSYRA NAELSLEQEQ

RLRNNLI
Length:757
Mass (Da):84,779
Last modified:July 27, 2011 - v2
Checksum:i45E698867160955C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391T → A in AAK71933. (PubMed:11292829)Curated
Sequence conflicti120 – 1201V → I in AAK71933. (PubMed:11292829)Curated
Sequence conflicti253 – 2531L → F in AAK71933. (PubMed:11292829)Curated
Sequence conflicti444 – 4441V → G in AAK71933. (PubMed:11292829)Curated
Sequence conflicti615 – 6151Y → N in AAK71933. (PubMed:11292829)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF338440 mRNA. Translation: AAK71933.1.
AC124552 Genomic DNA. No translation available.
CCDSiCCDS29830.1.
RefSeqiNP_444313.3. NM_053083.3.
UniGeneiMm.178767.

Genome annotation databases

EnsembliENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185.
ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
GeneIDi67573.
KEGGimmu:67573.
UCSCiuc008hns.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF338440 mRNA. Translation: AAK71933.1 .
AC124552 Genomic DNA. No translation available.
CCDSi CCDS29830.1.
RefSeqi NP_444313.3. NM_053083.3.
UniGenei Mm.178767.

3D structure databases

ProteinModelPortali Q924C6.
SMRi Q924C6. Positions 44-133, 310-412, 422-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q924C6. 1 interaction.

PTM databases

PhosphoSitei Q924C6.

Proteomic databases

MaxQBi Q924C6.
PaxDbi Q924C6.
PRIDEi Q924C6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026190 ; ENSMUSP00000026190 ; ENSMUSG00000025185 .
ENSMUST00000171432 ; ENSMUSP00000126686 ; ENSMUSG00000025185 .
GeneIDi 67573.
KEGGi mmu:67573.
UCSCi uc008hns.2. mouse.

Organism-specific databases

CTDi 84171.
MGIi MGI:1914823. Loxl4.

Phylogenomic databases

eggNOGi NOG40770.
GeneTreei ENSGT00760000119251.
HOGENOMi HOG000220841.
HOVERGENi HBG052336.
InParanoidi Q924C6.
KOi K00280.
OrthoDBi EOG7SN8C6.

Miscellaneous databases

NextBioi 324941.
PROi Q924C6.
SOURCEi Search...

Gene expression databases

Bgeei Q924C6.
CleanExi MM_LOXL4.
ExpressionAtlasi Q924C6. baseline and differential.
Genevestigatori Q924C6.

Family and domain databases

Gene3Di 3.10.250.10. 4 hits.
InterProi IPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view ]
Pfami PF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view ]
PRINTSi PR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTi SM00202. SR. 4 hits.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 4 hits.
PROSITEi PS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage."
    Ito H., Akiyama H., Iguchi H., Iyama K., Miyamoto M., Ohsawa K., Nakamura T.
    J. Biol. Chem. 276:24023-24029(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLOXL4_MOUSE
AccessioniPrimary (citable) accession number: Q924C6
Secondary accession number(s): E9PXI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3