Lysyl oxidase homolog 4 precursor - Mus musculus (Mouse)

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Q924C6 (LOXL4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Lysyl oxidase homolog 4
EC=1.4.3.-

Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C

Gene names

Name:	Loxl4
Synonyms:	Loxc

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	757 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May modulate the formation of a collagenous extracellular matrix.
Cofactor	Copper By similarity. Contains 1 lysine tyrosylquinone By similarity.
Subcellular location	Secreted › extracellular space Potential.
Post-translational modification	The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Sequence similarities	Belongs to the lysyl oxidase family. Contains 4 SRCR domains.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
PTM	Disulfide bond Glycoprotein LTQ TPQ
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from direct assay Ref.1. Source: MGI extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro protein-lysine 6-oxidase activity Inferred from direct assay Ref.1. Source: MGI scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

Potential

Chain

26 – 757

732

Lysyl oxidase homolog 4

PRO_0000018536

Regions

Domain

33 – 134

102

SRCR 1

Domain

160 – 288

129

SRCR 2

Domain

312 – 412

101

SRCR 3

Domain

422 – 530

109

SRCR 4

Region

534 – 737

204

Lysyl-oxidase like

Sites

Metal binding

612

Copper Potential

Metal binding

614

Copper Potential

Metal binding

616

Copper Potential

Amino acid modifications

Modified residue

675

2',4',5'-topaquinone By similarity

Glycosylation

199

N-linked (GlcNAc...) Potential

Glycosylation

630

N-linked (GlcNAc...) Potential

Disulfide bond

59 ↔ 123

By similarity

Disulfide bond

72 ↔ 133

By similarity

Disulfide bond

103 ↔ 113

By similarity

Disulfide bond

192 ↔ 277

By similarity

Disulfide bond

205 ↔ 287

By similarity

Disulfide bond

252 ↔ 262

By similarity

Disulfide bond

337 ↔ 401

By similarity

Disulfide bond

350 ↔ 411

By similarity

Disulfide bond

381 ↔ 391

By similarity

Disulfide bond

451 ↔ 516

By similarity

Disulfide bond

464 ↔ 529

By similarity

Disulfide bond

498 ↔ 508

By similarity

Disulfide bond

559 ↔ 565

By similarity

Disulfide bond

611 ↔ 659

By similarity

Disulfide bond

643 ↔ 649

By similarity

Disulfide bond

671 ↔ 681

By similarity

Disulfide bond

718 ↔ 732

By similarity

Cross-link

639 ↔ 675

Lysine tyrosylquinone (Lys-Tyr) By similarity

Experimental info

Sequence conflict

T → A in AAK71933. Ref.1

Sequence conflict

120

V → I in AAK71933. Ref.1

Sequence conflict

253

L → F in AAK71933. Ref.1

Sequence conflict

444

V → G in AAK71933. Ref.1

Sequence conflict

615

Y → N in AAK71933. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q924C6 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 45E698867160955C
Show »

FASTA

757

84,779

        10         20         30         40         50         60 
MMWPQPPTFS LFLLLLLSQA PSSRPQSSGT KKLRLVGPTD RPEEGRLEVL HQGQWGTVCD 

        70         80         90        100        110        120 
DDFALQEATV ACRQLGFESA LTWAHSAKYG QGEGPIWLDN VRCLGTEKTL DQCGSNGWGV 

       130        140        150        160        170        180 
SDCRHSEDVG VVCHPRRQHG YHSEKVSNAL GPQGRRLEEV RLKPILASAK RHSPVTEGAV 

       190        200        210        220        230        240 
EVRYDGHWRQ VCDQGWTMNN SRVVCGMLGF PSQTSVNSHY YRKVWNLKMK DPKSRLNSLT 

       250        260        270        280        290        300 
KKNSFWIHRV DCLGTEPHLA KCQVQVAPGR GKLRPACPGG MHAVVSCVAG PHFRRQKPKP 

       310        320        330        340        350        360 
TRKESHAEEL KVRLRSGAQV GEGRVEVLMN RQWGTVCDHR WNLISASVVC RQLGFGSARE 

       370        380        390        400        410        420 
ALFGAQLGQG LGPIHLSEVR CRGYERTLGD CLALEGSQNG CQHANDAAVR CNIPDMGFQN 

       430        440        450        460        470        480 
KVRLAGGRNS EEGVVEVQVE VNGVPRWGTV CSDHWGLTEA MVTCRQLGLG FANFALKDTW 

       490        500        510        520        530        540 
YWQGTPEAKE VVMSGVRCSG TEMALQQCQR HGPVHCSHGP GRFSAGVACM NSAPDLVMNA 

       550        560        570        580        590        600 
QLVQETAYLE DRPLSMLYCA HEENCLSKSA DHMDWPYGYR RLLRFSSQIY NLGRADFRPK 

       610        620        630        640        650        660 
AGRHSWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP SGVQRRYACA 

       670        680        690        700        710        720 
NFGEQGVAVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV NPTNDVAESD FSNNMIRCRC 

       730        740        750 
KYDGQRVWLH NCHTGDSYRA NAELSLEQEQ RLRNNLI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage." Ito H., Akiyama H., Iguchi H., Iyama K., Miyamoto M., Ohsawa K., Nakamura T. J. Biol. Chem. 276:24023-24029(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF338440 mRNA. Translation: AAK71933.1. AC124552 Genomic DNA. No translation available.
IPI	IPI00125444.
RefSeq	NP_444313.3. NM_053083.3.
UniGene	Mm.178767.
3D structure databases
ProteinModelPortal	Q924C6.
SMR	Q924C6. Positions 44-133, 310-412, 422-531.
ModBase	Search...
PTM databases
PhosphoSite	Q924C6.
Proteomic databases
PaxDb	Q924C6.
PRIDE	Q924C6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185. ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
GeneID	67573.
KEGG	mmu:67573.
Organism-specific databases
CTD	84171.
MGI	MGI:1914823. Loxl4.
Phylogenomic databases
eggNOG	NOG40770.
GeneTree	ENSGT00690000101879.
HOGENOM	HOG000220841.
HOVERGEN	HBG052336.
InParanoid	Q924C6.
KO	K00280.
OrthoDB	EOG4C5CHS.
Gene expression databases
ArrayExpress	Q924C6.
Bgee	Q924C6.
CleanEx	MM_LOXL4.
Genevestigator	Q924C6.
GermOnline	ENSMUSG00000025185. Mus musculus.
Family and domain databases
InterPro	IPR001695. Lysyl_oxidase. IPR019828. Lysyl_oxidase_CS. IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF01186. Lysyl_oxidase. 1 hit. PF00530. SRCR. 4 hits. [Graphical view]
PRINTS	PR00074. LYSYLOXIDASE. PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 4 hits. [Graphical view]
SUPFAM	SSF56487. Srcr_receptor. 4 hits.
PROSITE	PS00926. LYSYL_OXIDASE. 1 hit. PS00420. SRCR_1. 1 hit. PS50287. SRCR_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	324941.
SOURCE	Search...

Entry information

Entry name

LOXL4_MOUSE

Accession

Primary (citable) accession number: Q924C6
Secondary accession number(s): E9PXI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents