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Q924C6

- LOXL4_MOUSE

UniProt

Q924C6 - LOXL4_MOUSE

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Protein
Lysyl oxidase homolog 4
Gene
Loxl4, Loxc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May modulate the formation of a collagenous extracellular matrix.

Cofactori

Copper By similarity.
Contains 1 lysine tyrosylquinone By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi612 – 6121Copper Reviewed prediction
Metal bindingi614 – 6141Copper Reviewed prediction
Metal bindingi616 – 6161Copper Reviewed prediction

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. protein-lysine 6-oxidase activity Source: MGI
  3. scavenger receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 4 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene namesi
Name:Loxl4
Synonyms:Loxc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1914823. Loxl4.

Subcellular locationi

Secretedextracellular space Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: UniProtKB-SubCell
  3. membrane Source: InterPro
  4. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 757732Lysyl oxidase homolog 4
PRO_0000018536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 123 By similarity
Disulfide bondi72 ↔ 133 By similarity
Disulfide bondi103 ↔ 113 By similarity
Disulfide bondi192 ↔ 277 By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi205 ↔ 287 By similarity
Disulfide bondi252 ↔ 262 By similarity
Disulfide bondi337 ↔ 401 By similarity
Disulfide bondi350 ↔ 411 By similarity
Disulfide bondi381 ↔ 391 By similarity
Disulfide bondi451 ↔ 516 By similarity
Disulfide bondi464 ↔ 529 By similarity
Disulfide bondi498 ↔ 508 By similarity
Disulfide bondi559 ↔ 565 By similarity
Disulfide bondi611 ↔ 659 By similarity
Glycosylationi630 – 6301N-linked (GlcNAc...) Reviewed prediction
Cross-linki639 ↔ 675Lysine tyrosylquinone (Lys-Tyr) By similarity
Disulfide bondi643 ↔ 649 By similarity
Disulfide bondi671 ↔ 681 By similarity
Modified residuei675 – 67512',4',5'-topaquinone By similarity
Disulfide bondi718 ↔ 732 By similarity

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

PaxDbiQ924C6.
PRIDEiQ924C6.

PTM databases

PhosphoSiteiQ924C6.

Expressioni

Gene expression databases

ArrayExpressiQ924C6.
BgeeiQ924C6.
CleanExiMM_LOXL4.
GenevestigatoriQ924C6.

Interactioni

Protein-protein interaction databases

IntActiQ924C6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ924C6.
SMRiQ924C6. Positions 44-133, 310-412, 422-531.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 134102SRCR 1
Add
BLAST
Domaini160 – 288129SRCR 2
Add
BLAST
Domaini312 – 412101SRCR 3
Add
BLAST
Domaini422 – 530109SRCR 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni534 – 737204Lysyl-oxidase like
Add
BLAST

Sequence similaritiesi

Belongs to the lysyl oxidase family.
Contains 4 SRCR domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG40770.
GeneTreeiENSGT00740000115380.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ924C6.
KOiK00280.
OrthoDBiEOG7SN8C6.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924C6-1 [UniParc]FASTAAdd to Basket

« Hide

MMWPQPPTFS LFLLLLLSQA PSSRPQSSGT KKLRLVGPTD RPEEGRLEVL    50
HQGQWGTVCD DDFALQEATV ACRQLGFESA LTWAHSAKYG QGEGPIWLDN 100
VRCLGTEKTL DQCGSNGWGV SDCRHSEDVG VVCHPRRQHG YHSEKVSNAL 150
GPQGRRLEEV RLKPILASAK RHSPVTEGAV EVRYDGHWRQ VCDQGWTMNN 200
SRVVCGMLGF PSQTSVNSHY YRKVWNLKMK DPKSRLNSLT KKNSFWIHRV 250
DCLGTEPHLA KCQVQVAPGR GKLRPACPGG MHAVVSCVAG PHFRRQKPKP 300
TRKESHAEEL KVRLRSGAQV GEGRVEVLMN RQWGTVCDHR WNLISASVVC 350
RQLGFGSARE ALFGAQLGQG LGPIHLSEVR CRGYERTLGD CLALEGSQNG 400
CQHANDAAVR CNIPDMGFQN KVRLAGGRNS EEGVVEVQVE VNGVPRWGTV 450
CSDHWGLTEA MVTCRQLGLG FANFALKDTW YWQGTPEAKE VVMSGVRCSG 500
TEMALQQCQR HGPVHCSHGP GRFSAGVACM NSAPDLVMNA QLVQETAYLE 550
DRPLSMLYCA HEENCLSKSA DHMDWPYGYR RLLRFSSQIY NLGRADFRPK 600
AGRHSWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP 650
SGVQRRYACA NFGEQGVAVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV 700
NPTNDVAESD FSNNMIRCRC KYDGQRVWLH NCHTGDSYRA NAELSLEQEQ 750
RLRNNLI 757
Length:757
Mass (Da):84,779
Last modified:July 27, 2011 - v2
Checksum:i45E698867160955C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391T → A in AAK71933. 1 Publication
Sequence conflicti120 – 1201V → I in AAK71933. 1 Publication
Sequence conflicti253 – 2531L → F in AAK71933. 1 Publication
Sequence conflicti444 – 4441V → G in AAK71933. 1 Publication
Sequence conflicti615 – 6151Y → N in AAK71933. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF338440 mRNA. Translation: AAK71933.1.
AC124552 Genomic DNA. No translation available.
CCDSiCCDS29830.1.
RefSeqiNP_444313.3. NM_053083.3.
UniGeneiMm.178767.

Genome annotation databases

EnsembliENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185.
ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
GeneIDi67573.
KEGGimmu:67573.
UCSCiuc008hns.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF338440 mRNA. Translation: AAK71933.1 .
AC124552 Genomic DNA. No translation available.
CCDSi CCDS29830.1.
RefSeqi NP_444313.3. NM_053083.3.
UniGenei Mm.178767.

3D structure databases

ProteinModelPortali Q924C6.
SMRi Q924C6. Positions 44-133, 310-412, 422-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q924C6. 1 interaction.

PTM databases

PhosphoSitei Q924C6.

Proteomic databases

PaxDbi Q924C6.
PRIDEi Q924C6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026190 ; ENSMUSP00000026190 ; ENSMUSG00000025185 .
ENSMUST00000171432 ; ENSMUSP00000126686 ; ENSMUSG00000025185 .
GeneIDi 67573.
KEGGi mmu:67573.
UCSCi uc008hns.2. mouse.

Organism-specific databases

CTDi 84171.
MGIi MGI:1914823. Loxl4.

Phylogenomic databases

eggNOGi NOG40770.
GeneTreei ENSGT00740000115380.
HOGENOMi HOG000220841.
HOVERGENi HBG052336.
InParanoidi Q924C6.
KOi K00280.
OrthoDBi EOG7SN8C6.

Miscellaneous databases

NextBioi 324941.
PROi Q924C6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q924C6.
Bgeei Q924C6.
CleanExi MM_LOXL4.
Genevestigatori Q924C6.

Family and domain databases

Gene3Di 3.10.250.10. 4 hits.
InterProi IPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view ]
Pfami PF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view ]
PRINTSi PR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTi SM00202. SR. 4 hits.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 4 hits.
PROSITEi PS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage."
    Ito H., Akiyama H., Iguchi H., Iyama K., Miyamoto M., Ohsawa K., Nakamura T.
    J. Biol. Chem. 276:24023-24029(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLOXL4_MOUSE
AccessioniPrimary (citable) accession number: Q924C6
Secondary accession number(s): E9PXI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi