Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q924C6 (LOXL4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysyl oxidase homolog 4

EC=1.4.3.-
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene names
Name:Loxl4
Synonyms:Loxc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May modulate the formation of a collagenous extracellular matrix.

Cofactor

Copper By similarity.

Contains 1 lysine tyrosylquinone By similarity.

Subcellular location

Secretedextracellular space Potential.

Post-translational modification

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Sequence similarities

Belongs to the lysyl oxidase family.

Contains 4 SRCR domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 757732Lysyl oxidase homolog 4
PRO_0000018536

Regions

Domain33 – 134102SRCR 1
Domain160 – 288129SRCR 2
Domain312 – 412101SRCR 3
Domain422 – 530109SRCR 4
Region534 – 737204Lysyl-oxidase like

Sites

Metal binding6121Copper Potential
Metal binding6141Copper Potential
Metal binding6161Copper Potential

Amino acid modifications

Modified residue67512',4',5'-topaquinone By similarity
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation6301N-linked (GlcNAc...) Potential
Disulfide bond59 ↔ 123 By similarity
Disulfide bond72 ↔ 133 By similarity
Disulfide bond103 ↔ 113 By similarity
Disulfide bond192 ↔ 277 By similarity
Disulfide bond205 ↔ 287 By similarity
Disulfide bond252 ↔ 262 By similarity
Disulfide bond337 ↔ 401 By similarity
Disulfide bond350 ↔ 411 By similarity
Disulfide bond381 ↔ 391 By similarity
Disulfide bond451 ↔ 516 By similarity
Disulfide bond464 ↔ 529 By similarity
Disulfide bond498 ↔ 508 By similarity
Disulfide bond559 ↔ 565 By similarity
Disulfide bond611 ↔ 659 By similarity
Disulfide bond643 ↔ 649 By similarity
Disulfide bond671 ↔ 681 By similarity
Disulfide bond718 ↔ 732 By similarity
Cross-link639 ↔ 675Lysine tyrosylquinone (Lys-Tyr) By similarity

Experimental info

Sequence conflict391T → A in AAK71933. Ref.1
Sequence conflict1201V → I in AAK71933. Ref.1
Sequence conflict2531L → F in AAK71933. Ref.1
Sequence conflict4441V → G in AAK71933. Ref.1
Sequence conflict6151Y → N in AAK71933. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q924C6 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 45E698867160955C

FASTA75784,779
        10         20         30         40         50         60 
MMWPQPPTFS LFLLLLLSQA PSSRPQSSGT KKLRLVGPTD RPEEGRLEVL HQGQWGTVCD 

        70         80         90        100        110        120 
DDFALQEATV ACRQLGFESA LTWAHSAKYG QGEGPIWLDN VRCLGTEKTL DQCGSNGWGV 

       130        140        150        160        170        180 
SDCRHSEDVG VVCHPRRQHG YHSEKVSNAL GPQGRRLEEV RLKPILASAK RHSPVTEGAV 

       190        200        210        220        230        240 
EVRYDGHWRQ VCDQGWTMNN SRVVCGMLGF PSQTSVNSHY YRKVWNLKMK DPKSRLNSLT 

       250        260        270        280        290        300 
KKNSFWIHRV DCLGTEPHLA KCQVQVAPGR GKLRPACPGG MHAVVSCVAG PHFRRQKPKP 

       310        320        330        340        350        360 
TRKESHAEEL KVRLRSGAQV GEGRVEVLMN RQWGTVCDHR WNLISASVVC RQLGFGSARE 

       370        380        390        400        410        420 
ALFGAQLGQG LGPIHLSEVR CRGYERTLGD CLALEGSQNG CQHANDAAVR CNIPDMGFQN 

       430        440        450        460        470        480 
KVRLAGGRNS EEGVVEVQVE VNGVPRWGTV CSDHWGLTEA MVTCRQLGLG FANFALKDTW 

       490        500        510        520        530        540 
YWQGTPEAKE VVMSGVRCSG TEMALQQCQR HGPVHCSHGP GRFSAGVACM NSAPDLVMNA 

       550        560        570        580        590        600 
QLVQETAYLE DRPLSMLYCA HEENCLSKSA DHMDWPYGYR RLLRFSSQIY NLGRADFRPK 

       610        620        630        640        650        660 
AGRHSWIWHQ CHRHYHSIEV FTHYDLLTLN GSKVAEGHKA SFCLEDTNCP SGVQRRYACA 

       670        680        690        700        710        720 
NFGEQGVAVG CWDTYRHDID CQWVDITDVG PGDYIFQVVV NPTNDVAESD FSNNMIRCRC 

       730        740        750 
KYDGQRVWLH NCHTGDSYRA NAELSLEQEQ RLRNNLI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF338440 mRNA. Translation: AAK71933.1.
AC124552 Genomic DNA. No translation available.
CCDSCCDS29830.1.
RefSeqNP_444313.3. NM_053083.3.
UniGeneMm.178767.

3D structure databases

ProteinModelPortalQ924C6.
SMRQ924C6. Positions 44-133, 310-412, 422-531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ924C6. 1 interaction.

PTM databases

PhosphoSiteQ924C6.

Proteomic databases

PaxDbQ924C6.
PRIDEQ924C6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026190; ENSMUSP00000026190; ENSMUSG00000025185.
ENSMUST00000171432; ENSMUSP00000126686; ENSMUSG00000025185.
GeneID67573.
KEGGmmu:67573.
UCSCuc008hns.2. mouse.

Organism-specific databases

CTD84171.
MGIMGI:1914823. Loxl4.

Phylogenomic databases

eggNOGNOG40770.
GeneTreeENSGT00740000115380.
HOGENOMHOG000220841.
HOVERGENHBG052336.
InParanoidQ924C6.
KOK00280.
OrthoDBEOG7SN8C6.

Gene expression databases

ArrayExpressQ924C6.
BgeeQ924C6.
CleanExMM_LOXL4.
GenevestigatorQ924C6.

Family and domain databases

Gene3D3.10.250.10. 4 hits.
InterProIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTSM00202. SR. 4 hits.
[Graphical view]
SUPFAMSSF56487. SSF56487. 4 hits.
PROSITEPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio324941.
PROQ924C6.
SOURCESearch...

Entry information

Entry nameLOXL4_MOUSE
AccessionPrimary (citable) accession number: Q924C6
Secondary accession number(s): E9PXI3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot