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Protein

Alpha-protein kinase 3

Gene

Alpk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Role in cardiomyocyte differentiation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle cell development Source: MGI
  • heart development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 3 (EC:2.7.11.-)
Alternative name(s):
Myocytic induction/differentiation originator
Short name:
Midori
Gene namesi
Name:Alpk3Imported
Synonyms:Kiaa1330
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2151224. Alpk3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002915311 – 1678Alpha-protein kinase 3Add BLAST1678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineCombined sources1
Modified residuei1197PhosphoserineCombined sources1
Disulfide bondi1271 ↔ 1321PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ924C5.
PRIDEiQ924C5.

PTM databases

iPTMnetiQ924C5.
PhosphoSitePlusiQ924C5.

Expressioni

Tissue specificityi

Expressed in the heart and skeletal muscle of adult mice.1 Publication

Developmental stagei

First detected in the cardiac crescent at 7.5 dpc when the developing heart became visible and remains through to 10.5 dpc.1 Publication

Gene expression databases

CleanExiMM_ALPK3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102971.

Structurei

3D structure databases

ProteinModelPortaliQ924C5.
SMRiQ924C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 173Ig-like 1Sequence analysisAdd BLAST97
Domaini1249 – 1337Ig-like 2Sequence analysisAdd BLAST89
Domaini1365 – 1598Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation
Contains 2 Ig-like (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
HOGENOMiHOG000169775.
HOVERGENiHBG074162.
InParanoidiQ924C5.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRRAAGRG WGLGGRAGAG GDSEDDGPVW TPGPASRNYL LSVRPEASLS
60 70 80 90 100
SNRLSHPSSG RSTFCSIIAQ LTEETQPLFE TTLKSRAVSE DSDVRFTCIV
110 120 130 140 150
TGYPEPEVTW YKDDIELDRY CGLPKYEITH QGNRHTLQLY RCQEEDAAIY
160 170 180 190 200
QASARNTKGI VSCSGVLEVG TMTEYKIHQR WFAKLKRKAA AKMREIEQSW
210 220 230 240 250
KHGKEASGEA DTLLLRKISP DRFQRKRRLS GVEEAVLSTP VREMEEGSSA
260 270 280 290 300
AWQEGETESA QHPGLGLINS FAPGEAPTNG EPAPENGEDE ERGLLTYICE
310 320 330 340 350
VMELGPQNSP PKESGAKKKR KDEESKPGEQ KLELEKAEGS QCSSENVVPS
360 370 380 390 400
TDKPNSSRRE KSTDTQPAQT QPRGRVARGP GIESTRKTAS VLGIQDKVQD
410 420 430 440 450
VPAPAPAPAP APAPAPAPVP VPAPTPVPSR SSEQVYFSLK DMFMETTRAG
460 470 480 490 500
RSQEEEKPPP PSTRVAGESP PGKTPVKSRL EKVPMVSSQP TSSMVPPPIK
510 520 530 540 550
PLNRKRFAPP KSKVESTTTS LSSQTSESMA QSLGKALPSA STQVPTPPAR
560 570 580 590 600
RRHGTRDSPL QGQTSHKTPG EALESPATVA PTKSANSSSD TVSVDHDSSG
610 620 630 640 650
NQGATEPMDT ETQEDGRTLV DGRTGSRKKT HTDGKLQVDG RTQETEHKTE
660 670 680 690 700
HTLSPRTQAG EKDVVTQGSE RPQSDRSSWK NLVTQRRVDM QVGQMQAGER
710 720 730 740 750
WQQDPGDARI QEEEKETQSA AGSIPVAFET QSEQLSMASL SSLPGALKGS
760 770 780 790 800
PSGCPRESQA IECFEKSTEA PCVQERSDLM LRSEEAAFRS HEDGLLGPPS
810 820 830 840 850
GNRTYPTQLP PEGHSEHLGG QTHQRSEQED SLSQCPKKEQ PQEPLHVGLS
860 870 880 890 900
GGHSTGLSQE VPAMPSLPGT GLTSSLQEEL PGTAASLHTN TDVPLPSRDQ
910 920 930 940 950
DFPSSAPTLQ LGPGSPTQSH PPEAMTTSSE GACAKEPNVD GRSSGTRSCD
960 970 980 990 1000
PGLIDSLKNY LLLLLKLSSP ETSEARAESQ EVADTGGLTS SSTLVPTMEV
1010 1020 1030 1040 1050
AGLSPRTSRR ILERVENNHL VQSAQTLLLS PCTSRRLTGL LDREVQAGQQ
1060 1070 1080 1090 1100
ALAAAQCSRG PCPTPLTIPA IVVGEEGSAG EDSEERTSQE SDKKGLLGEV
1110 1120 1130 1140 1150
EGHTVESRTQ EPCQEEAMPG EALTGLPAAT PEELALGARR KRFLPKVRAG
1160 1170 1180 1190 1200
SDGEANKAEE RESPTVSPRG PRKGLTPGSP GTPGRERRSP TQARKASMLE
1210 1220 1230 1240 1250
VPGAEEEPAT GDLVSRSKDS GLDSEPAVDE GKQEALAKQR KAKDLLKAPQ
1260 1270 1280 1290 1300
VIRKIRVEQF PDSSGSLKLW CQFFNIVSDS VLTWAKDQHP VGEVNRSAGD
1310 1320 1330 1340 1350
EGPAALAIVQ ASPTDCGVYR CTIQNEHGSA STDFCLSPEV LSGFISREEG
1360 1370 1380 1390 1400
EVGEEIEMTP MVFAKGLADS GCWGDKLFGR LVSEELRGGG HGLQKASRAK
1410 1420 1430 1440 1450
VIYGLEPIFE SGRTCIIKVS SLLVFGPSSE TSLLGRNYDV TIQGCKIQNM
1460 1470 1480 1490 1500
SREYCKIFAA EARAASGFGE VPEIIPLYLI YRPANNIPYA TLEEDLGKPL
1510 1520 1530 1540 1550
QTYCSRQWGC AGAPAAASSS EALQKCQTFQ HWLYQWTNGS FLVTDLTGAD
1560 1570 1580 1590 1600
WKMTDVQIAT KLRGYQGLKE SCFPALLDQF ASSHQCNTYC DMLGLKPLKG
1610 1620 1630 1640 1650
PEAAHPQAKA KGSKSPSAGR KGSQLSPQPQ KKGLPSPQGS RKSAPSSRAT
1660 1670
LQASQAATVQ LLGQPPVQDG SSKAQSMR
Length:1,678
Mass (Da):180,199
Last modified:December 1, 2001 - v1
Checksum:iFB80D50C7F34E4A7
GO

Sequence cautioni

The sequence BAD90441 differs from that shown. Reason: Frameshift at positions 644 and 653.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1297S → R in BAD90441 (Ref. 2) Curated1
Sequence conflicti1646S → G in BAC34907 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338872 mRNA. Translation: AAK60496.1.
AK220384 Transcribed RNA. Translation: BAD90441.1. Frameshift.
AK052268 mRNA. Translation: BAC34907.1.
UniGeneiMm.475768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338872 mRNA. Translation: AAK60496.1.
AK220384 Transcribed RNA. Translation: BAD90441.1. Frameshift.
AK052268 mRNA. Translation: BAC34907.1.
UniGeneiMm.475768.

3D structure databases

ProteinModelPortaliQ924C5.
SMRiQ924C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102971.

PTM databases

iPTMnetiQ924C5.
PhosphoSitePlusiQ924C5.

Proteomic databases

PaxDbiQ924C5.
PRIDEiQ924C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2151224. Alpk3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
HOGENOMiHOG000169775.
HOVERGENiHBG074162.
InParanoidiQ924C5.

Miscellaneous databases

PROiQ924C5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ALPK3.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALPK3_MOUSE
AccessioniPrimary (citable) accession number: Q924C5
Secondary accession number(s): Q5DTY6, Q8C7A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.