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Protein

Inositol-1-monophosphatase

Gene

Impa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol monophosphatase 1 (Impa1), Inositol-1-monophosphatase (Impa2), Inositol monophosphatase 2 (Impa2), Inositol monophosphatase 3 (Impad1), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa2)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00823; UER00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphataseUniRule annotation (EC:3.1.3.25UniRule annotation)
Gene namesi
Name:Impa1Imported
ORF Names:mCG_1639Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1933158. Impa1.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSMUSG00000027531.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the inositol monophosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.
HOVERGENiHBG052123.
KOiK01092.
OMAiNNYAEFC.
OrthoDBiEOG091G0D21.
TreeFamiTF313194.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiView protein in InterPro
IPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiView protein in Pfam
PF00459. Inositol_P. 1 hit.
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiView protein in PROSITE
PS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q924B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV
60 70 80 90 100
EKMLMSSIKE KYPCHSFIGE ESVAAGEKTV FTEQPTWVID PIDGTTNFVH
110 120 130 140 150
RFPFVAVSIG FLVNKEMEFG IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ
160 170 180 190 200
QEDITKSLLV TELGSSRKPE TLRIVLSNME KLCSIPIHGI RSVGTAAVNM
210 220 230 240 250
CLVATGGADA YYEMGIHCWD MAGAGIIVTE AGGVLMDVTG GPFDLMSRRI
260 270
IAANSITLAK RIAKEIEIIP LQRDDES
Length:277
Mass (Da):30,429
Last modified:December 1, 2001 - v1
Checksum:iFB6915DCD7F477F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123726 Genomic DNA. No translation available.
BC055722 mRNA. Translation: AAH55722.1.
AH010671, AF353728 Genomic DNA. Translation: AAK39515.1.
AK078406 mRNA. Translation: BAC37259.1.
AK083238 mRNA. Translation: BAC38823.1.
AK145472 mRNA. Translation: BAE26456.1.
AK147778 mRNA. Translation: BAE28132.1.
AK152774 mRNA. Translation: BAE31486.1.
AK160203 mRNA. Translation: BAE35691.1.
AK160467 mRNA. Translation: BAE35806.1.
AK168457 mRNA. Translation: BAE40356.1.
CH466577 Genomic DNA. Translation: EDL05164.1.
CH466577 Genomic DNA. Translation: EDL05166.1.
RefSeqiNP_001297362.1. NM_001310433.1.
NP_061352.2. NM_018864.6.
UniGeneiMm.183042.

Genome annotation databases

EnsembliENSMUST00000065938; ENSMUSP00000068174; ENSMUSG00000027531.
GeneIDi55980.
KEGGimmu:55980.
UCSCiuc008opo.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ924B0_MOUSE
AccessioniPrimary (citable) accession number: Q924B0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported