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Protein

Proton-coupled amino acid transporter 1

Gene

Slc36a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neutral amino acid/proton symporter. Probably involved in the efflux of lysosomal proteolysis products such as L-proline, L-alanine and glycine from the cell. May play a role in specifying sites for exocytosis in neurons.1 Publication2 Publications

GO - Molecular functioni

GO - Biological processi

  • glycine transport Source: GO_Central
  • neutral amino acid transport Source: UniProtKB
  • proline transport Source: Ensembl
  • proton transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-428559. Proton-coupled neutral amino acid transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 1
Short name:
Proton/amino acid transporter 1
Alternative name(s):
Lysosomal amino acid transporter 1
Short name:
LYAAT-1
Neutral amino acid/proton symporter
Solute carrier family 36 member 1
Gene namesi
Name:Slc36a1
Synonyms:Lyaat1, Pat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619801. Slc36a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50CytoplasmicSequence analysisAdd BLAST50
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 77ExtracellularSequence analysis6
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 140CytoplasmicSequence analysisAdd BLAST42
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 189ExtracellularSequence analysisAdd BLAST28
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 214CytoplasmicSequence analysis4
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 256ExtracellularSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 288CytoplasmicSequence analysisAdd BLAST11
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 341ExtracellularSequence analysisAdd BLAST32
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 371CytoplasmicSequence analysis9
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 396ExtracellularSequence analysis4
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Topological domaini418 – 438CytoplasmicSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 475ExtracellularSequence analysisAdd BLAST16

GO - Cellular componenti

  • endoplasmic reticulum Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938271 – 475Proton-coupled amino acid transporter 1Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi179 ↔ 328By similarity
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924A5.
PRIDEiQ924A5.

Expressioni

Tissue specificityi

Widely expressed and predominantly expressed in brain. Within the brain, expression restricted to neurons and not detected in glial cells. Abundant in regions rich in neurons using glutamate and GABA such as Purkinje cells in the cerebellum and pyramidal cells in the hippocampus.2 Publications

Gene expression databases

BgeeiENSRNOG00000012356.
GenevisibleiQ924A5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016755.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ924A5.
KOiK14209.
OMAiSHWGRRI.
PhylomeDBiQ924A5.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQRLRNED YHDYSSTDVS PEESPSEGLG SFSPGSYQRL GENSSMTWFQ
60 70 80 90 100
TLIHLLKGNI GTGLLGLPLA VKNAGLLLGP LSLLVIGIVA VHCMGILVKC
110 120 130 140 150
AHHLCRRLNK PFLDYGDTVM YGLECSPSTW IRNHSHWGRR IVDFFLVVTQ
160 170 180 190 200
LGFCCVYFVF LADNFKQVIE AANGTTTNCN NNETVILTPT MDSRLYMLTF
210 220 230 240 250
LPFLVLLSFI RNLRILSIFS LLANISMFVS LIMIYQFIVQ RIPDPSHLPL
260 270 280 290 300
VAPWKTYPLF FGTAIFAFEG IGVVLPLENK MKDSQKFPLI LYLGMAIITV
310 320 330 340 350
LYISLGSLGY LQFGADIKGS ITLNLPNCWL YQSVKLLYSI GIFFTYALQF
360 370 380 390 400
YVAAEIIIPA IVSRVPERFE LVVDLSARTA MVCVTCVLAV LIPRLDLVIS
410 420 430 440 450
LVGSVSSSAL ALIIPPLLEV TTYYGEGISP LTITKDALIS ILGFVGFVVG
460 470
TYESLWELIQ PSHSDSSTNS TSAFI
Length:475
Mass (Da):52,569
Last modified:December 1, 2001 - v1
Checksum:iD3D04A489AD1D23C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108L → M no nucleotide entry (PubMed:12598615).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361239 mRNA. Translation: AAK67316.1.
RefSeqiNP_569099.1. NM_130415.1.
XP_008765881.1. XM_008767659.1.
UniGeneiRn.76305.

Genome annotation databases

EnsembliENSRNOT00000016755; ENSRNOP00000016755; ENSRNOG00000012356.
ENSRNOT00000087763; ENSRNOP00000074412; ENSRNOG00000012356.
GeneIDi155205.
KEGGirno:155205.
UCSCiRGD:619801. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361239 mRNA. Translation: AAK67316.1.
RefSeqiNP_569099.1. NM_130415.1.
XP_008765881.1. XM_008767659.1.
UniGeneiRn.76305.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016755.

Proteomic databases

PaxDbiQ924A5.
PRIDEiQ924A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016755; ENSRNOP00000016755; ENSRNOG00000012356.
ENSRNOT00000087763; ENSRNOP00000074412; ENSRNOG00000012356.
GeneIDi155205.
KEGGirno:155205.
UCSCiRGD:619801. rat.

Organism-specific databases

CTDi206358.
RGDi619801. Slc36a1.

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ924A5.
KOiK14209.
OMAiSHWGRRI.
PhylomeDBiQ924A5.
TreeFamiTF314873.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-428559. Proton-coupled neutral amino acid transporters.

Miscellaneous databases

PROiQ924A5.

Gene expression databases

BgeeiENSRNOG00000012356.
GenevisibleiQ924A5. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS36A1_RAT
AccessioniPrimary (citable) accession number: Q924A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.