Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urocortin-3

Gene

Ucn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • digestion Source: InterPro
  • neuropeptide signaling pathway Source: MGI
  • response to stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-3
Alternative name(s):
Urocortin III
Short name:
Ucn III
Gene namesi
Name:Ucn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1932970. Ucn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 12198PRO_0000006247Add
BLAST
Chaini123 – 16038Urocortin-3PRO_0000006248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei160 – 1601Isoleucine amideSequence analysis

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiQ924A4.
PRIDEiQ924A4.

PTM databases

PhosphoSiteiQ924A4.

Expressioni

Tissue specificityi

Expressed in some areas of the brain including the hypothalamus, amygdala, and brainstem, but is not evident in the cerebellum, pituitary, or cerebral cortex; it is also expressed peripherally in small intestine and skin.1 Publication

Gene expression databases

BgeeiQ924A4.
CleanExiMM_UCN3.
ExpressionAtlasiQ924A4. baseline and differential.
GenevisibleiQ924A4. MM.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI

Protein-protein interaction databases

BioGridi219919. 2 interactions.
STRINGi10090.ENSMUSP00000049678.

Structurei

3D structure databases

ProteinModelPortaliQ924A4.
SMRiQ924A4. Positions 123-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ00. Eukaryota.
ENOG410YJR9. LUCA.
GeneTreeiENSGT00390000001251.
HOGENOMiHOG000230495.
HOVERGENiHBG036243.
InParanoidiQ924A4.
KOiK05257.
OMAiQRTKFTL.
OrthoDBiEOG7VHT06.
PhylomeDBiQ924A4.
TreeFamiTF330723.

Family and domain databases

InterProiIPR000187. CRF.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPTYFLLP LLLLLGGPRT SLSHKFYNTG PVFSCLNTAL SEVKKNKLED
60 70 80 90 100
VPLLSKKSFG HLPTQDPSGE EDDNQTHLQI KRTFSGAAGG NGAGSTRYRY
110 120 130 140 150
QSQAQHKGKL YPDKPKSDRG TKFTLSLDVP TNIMNILFNI DKAKNLRAKA
160
AANAQLMAQI GKKK
Length:164
Mass (Da):18,063
Last modified:December 1, 2001 - v1
Checksum:i93A77CB93DA56E5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361944 Genomic DNA. Translation: AAK67318.1.
CCDSiCCDS26217.1.
RefSeqiNP_112540.2. NM_031250.5.
UniGeneiMm.313662.

Genome annotation databases

EnsembliENSMUST00000058610; ENSMUSP00000049678; ENSMUSG00000044988.
GeneIDi83428.
KEGGimmu:83428.
UCSCiuc007pjh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361944 Genomic DNA. Translation: AAK67318.1.
CCDSiCCDS26217.1.
RefSeqiNP_112540.2. NM_031250.5.
UniGeneiMm.313662.

3D structure databases

ProteinModelPortaliQ924A4.
SMRiQ924A4. Positions 123-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219919. 2 interactions.
STRINGi10090.ENSMUSP00000049678.

PTM databases

PhosphoSiteiQ924A4.

Proteomic databases

PaxDbiQ924A4.
PRIDEiQ924A4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058610; ENSMUSP00000049678; ENSMUSG00000044988.
GeneIDi83428.
KEGGimmu:83428.
UCSCiuc007pjh.2. mouse.

Organism-specific databases

CTDi114131.
MGIiMGI:1932970. Ucn3.

Phylogenomic databases

eggNOGiENOG410IZ00. Eukaryota.
ENOG410YJR9. LUCA.
GeneTreeiENSGT00390000001251.
HOGENOMiHOG000230495.
HOVERGENiHBG036243.
InParanoidiQ924A4.
KOiK05257.
OMAiQRTKFTL.
OrthoDBiEOG7VHT06.
PhylomeDBiQ924A4.
TreeFamiTF330723.

Miscellaneous databases

NextBioi350542.
PROiQ924A4.
SOURCEiSearch...

Gene expression databases

BgeeiQ924A4.
CleanExiMM_UCN3.
ExpressionAtlasiQ924A4. baseline and differential.
GenevisibleiQ924A4. MM.

Family and domain databases

InterProiIPR000187. CRF.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor."
    Lewis K., Li C., Perrin M.H., Blount A., Kunitake K., Donaldson C., Vaughan J., Reyes T.M., Gulyas J., Fischer W., Bilezikjian L., Rivier J., Sawchenko P.E., Vale W.W.
    Proc. Natl. Acad. Sci. U.S.A. 98:7570-7575(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SYNTHESIS OF UCN III, TISSUE SPECIFICITY.

Entry informationi

Entry nameiUCN3_MOUSE
AccessioniPrimary (citable) accession number: Q924A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.