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Protein

Protein capicua homolog

Gene

Cic

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which may play a role in development of the central nervous system (CNS).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1107 – 117569HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

  • lung alveolus development Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein capicua homolog
Gene namesi
Name:Cic
Synonyms:Kiaa0306
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918972. Cic.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: GO_Central
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25102510Protein capicua homologPRO_0000048599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei774 – 7741PhosphoserineCombined sources
Modified residuei778 – 7781PhosphoserineCombined sources
Modified residuei1053 – 10531PhosphoserineCombined sources
Modified residuei1080 – 10801PhosphoserineBy similarity
Modified residuei1184 – 11841PhosphoserineBy similarity
Modified residuei1269 – 12691PhosphoserineBy similarity
Modified residuei1338 – 13381PhosphoserineCombined sources
Modified residuei1343 – 13431PhosphoserineCombined sources
Modified residuei1403 – 14031PhosphoserineCombined sources
Modified residuei1604 – 16041PhosphoserineBy similarity
Modified residuei1625 – 16251PhosphoserineCombined sources
Modified residuei1644 – 16441PhosphoserineBy similarity
Modified residuei2169 – 21691N6-acetyllysineCombined sources
Modified residuei2192 – 21921PhosphothreonineCombined sources
Modified residuei2195 – 21951PhosphoserineBy similarity
Modified residuei2253 – 22531PhosphoserineBy similarity
Modified residuei2275 – 22751PhosphoserineCombined sources
Modified residuei2280 – 22801PhosphoserineBy similarity
Modified residuei2284 – 22841PhosphoserineCombined sources
Modified residuei2291 – 22911PhosphoserineBy similarity
Modified residuei2299 – 22991PhosphoserineCombined sources
Modified residuei2300 – 23001PhosphothreonineBy similarity
Modified residuei2304 – 23041PhosphoserineCombined sources
Modified residuei2311 – 23111PhosphoserineCombined sources
Modified residuei2497 – 24971PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ924A2.
MaxQBiQ924A2.
PaxDbiQ924A2.
PeptideAtlasiQ924A2.
PRIDEiQ924A2.

PTM databases

iPTMnetiQ924A2.
PhosphoSiteiQ924A2.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are present in cerebellum (at protein level).1 Publication

Developmental stagei

Expressed postnatally in the hippocampus, neocortex, olfactory bulb and cerebellum. Expressed in the hippocampus from P0 to P15. Expressed in the posterior region of the neocortex at P4, the anterior region at P9, and is then lost by P15. Expressed in the cerebellum from P0, specifically within the external granule layer (EGL) which contains granule cell precursors. By P7 expression is distributed throughout the EGL and is reduced in the inner granule cell layer (IGL) where granule cells finally differentiate. Expression in the IGL continues to diminish up to P15, when granule cell neurogenesis is complete.2 Publications

Gene expression databases

BgeeiENSMUSG00000005442.
CleanExiMM_CIC.
ExpressionAtlasiQ924A2. baseline and differential.
GenevisibleiQ924A2. MM.

Interactioni

Subunit structurei

Isoforms 1 and 2 interact with ATXN1. Interacts with ATXN1L.2 Publications

Protein-protein interaction databases

BioGridi214881. 1 interaction.
DIPiDIP-60650N.
IntActiQ924A2. 1 interaction.
MINTiMINT-4122947.
STRINGi10090.ENSMUSP00000005578.

Structurei

3D structure databases

ProteinModelPortaliQ924A2.
SMRiQ924A2. Positions 1108-1175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni935 – 95319Interaction with ATXN1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 7742Glu-richAdd
BLAST
Compositional biasi339 – 441103Pro-richAdd
BLAST
Compositional biasi612 – 1045434Pro-richAdd
BLAST
Compositional biasi1415 – 2202788Pro-richAdd
BLAST
Compositional biasi2426 – 250378Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITBG. Eukaryota.
ENOG4111S7E. LUCA.
GeneTreeiENSGT00530000063757.
HOVERGENiHBG081174.
InParanoidiQ924A2.
KOiK20225.
OMAiTKPAAYK.
OrthoDBiEOG091G16LO.
PhylomeDBiQ924A2.
TreeFamiTF323412.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR032147. DUF4819.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF16090. DUF4819. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924A2-4) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPMKKACPG LAGSASGSKS PPATRAKALR RRGAGEGDKP EEEEEAQPQE
60 70 80 90 100
QAGPEEAEEG EEEEAERDPG AEGTHPELQP NDPTPGLTED PKGDGEAGRW
110 120 130 140 150
EPSLSRKTAT FKSRAPKKKY VEEHGTGNVG VVGAPEERER TPEDASALGV
160 170 180 190 200
PPRPPTSTRS SSTDTASEHS ADLEDEPPEA CGPGPWPSTG TSEGYDLRQL
210 220 230 240 250
RSQRVLARRG DGLFLPAVVR QVRRSQDLGV QFPGDRALTF YEGVPGGGVD
260 270 280 290 300
VVLDVTPPPG ALMVGTAVCT CVEPGVAAYR EGVVVEVATK PAAYKVRLSP
310 320 330 340 350
GPSSHAGPPG TLPQAQQTLH REPEEAVWVT RSSLRLLRPP WEPGALLRKH
360 370 380 390 400
PAGPEEEQAE PGPALPPCPS SVEPKQPEDA EVSNISFGSN LGTRCEEGEE
410 420 430 440 450
KHPPSLGTPV LLPLPPPQLL SPPPKSPAFG GPGRPSEQPS PCQEGSQGGS
460 470 480 490 500
RSSSVASLEK GAAPAARART PLTAAQQKYK KGDVVCTPNG IRKKFNGKQW
510 520 530 540 550
RRLCSRDGCM KESQRRGYCS RHLSMRTKEM EGLADSGPGG TGRPAGVAAR
560 570 580 590 600
EGSTEFDWGD ETSRDSEASS VAARGDSRPR LVAPADLSRF EFDECEAAVM
610 620 630 640 650
LVSLGSSRSG TPSFSPVSTQ SPFSPAPSPS PSPLFGFRPA NFSPINASPV
660 670 680 690 700
IQRTAVRSRH LSASTPKAGV LTPPDLGPHP PPPAPRERHS SGILPTFQTN
710 720 730 740 750
LTFTVPISPG RRKTELLPHP GTLGASGAGG GGAAPDFPKS DSLDSGVDSV
760 770 780 790 800
SHTPTPSTPA GFRAVSPAVP FSRSRQPSPL LLLPPPAGLT SDPGPSVRRV
810 820 830 840 850
PAVQRDSPVI VRNPDVPLPS KFPGEVGTAG EARAGGPGRS CRETPVPPGV
860 870 880 890 900
ASGKPGLPPP LPAPVPITVP PAAPTAVAQP MPTLGLASSP FQPVAFHPSP
910 920 930 940 950
AALLPVLVPS SYPSHPAPKK EVIMGRPGTV WTNVEPRSVA VFPWHSLVPF
960 970 980 990 1000
LAPSQPDPSV QPSEAQQPAS HPVASNQSKE PAESAAVAHE QPPGGTGGAD
1010 1020 1030 1040 1050
PGRPPGAVCP ESPGPGPPLT LGGVDPGKSL PPTTEEEAPG PPGEPRLDSE
1060 1070 1080 1090 1100
TESDHDDAFL SIMSPEIQLP LPPGKRRTQS LSALPKERDS SSEKDGRSPN
1110 1120 1130 1140 1150
KREKDHIRRP MNAFMIFSKR HRALVHQRHP NQDNRTVSKI LGEWWYALGP
1160 1170 1180 1190 1200
KEKQKYHDLA FQVKEAHFKA HPDWKWCNKD RKKSSSEAKP ASLGLAGGHK
1210 1220 1230 1240 1250
ETRERSMSET GTAAAPGVSS ELLSVAAQTL LSSDTKVPGS GPCGAERLHA
1260 1270 1280 1290 1300
VGAPGSARPR AFSHSGVHSL DGGEVDSQAL QELTQMVSGP ASYSGPKPSP
1310 1320 1330 1340 1350
QYGAPGSFAA PGEGGTLATS GRPPLLPSRA SRSQRAASED MTSDEERMVI
1360 1370 1380 1390 1400
CEEEGDDDVI ADDSFGTTDI DLKCKERVTD SESGDSSGED PEGNKGFGRK
1410 1420 1430 1440 1450
VFSPVIRSSF THCRPTLDPE PPGPPDPPAA FSKGYGPTPS SSSSPASTSV
1460 1470 1480 1490 1500
SVSTSFSLGS GTFKTQESGQ GSTAVPLRPP PPGAGGPATP SKATRFPPTD
1510 1520 1530 1540 1550
SATFRRKRPE SVGSLEAPGP SVIAAPPSGG GNLLQTLVLP PSKEDREGTR
1560 1570 1580 1590 1600
VPSAPAPPLA YGAPAAPLCR PAATMVTNVV RPVSSTPVPI ASKPFPTSGR
1610 1620 1630 1640 1650
AEASSNDIAG ARTEMGTGSR VPGGSPMGVS LVYSDKKSAA AATSPAPHLV
1660 1670 1680 1690 1700
AGPLLGTVGK APATVTNLLV GTPGYGAPAS PAVQFIAQGA PGSATPAGSG
1710 1720 1730 1740 1750
ASTGSGPNGP VPLGILQPGA LGKAGGITQV QYILPTLPQQ LQVAPAPAPA
1760 1770 1780 1790 1800
PGTKAAAPSG PAPTTSIRFT LPPGTSTNGK VLAATAPTAG IPILQSVPSA
1810 1820 1830 1840 1850
PPPKAQSVSP VQATPSGGSA QLLPGKVLVP LAAPSMSVRG GGAGQPLPLV
1860 1870 1880 1890 1900
SSPFSVPVQN GAQQPSKIIQ LTPVPVSTPS GLVPPLSPAT MPGPTSQPQK
1910 1920 1930 1940 1950
VLLPSSTRIT YVQSAGGHTL PLGTSSACSQ TGTVTSYGPT SSVALGFTSL
1960 1970 1980 1990 2000
GPSGPAFVQP LLSGQAPLLA PGQVGVSPVP SPQLPPACTA SGGPVITAFY
2010 2020 2030 2040 2050
PGSPAPTSAP LGPPSQAPPS LVYTVATSTT PPAATILPKG PPASATATPA
2060 2070 2080 2090 2100
PTSPFPSATG SMTYSLVAPK AQRPSPKAPQ KVKAAIASIP VGSFESGTTG
2110 2120 2130 2140 2150
RPGSTPRQSS DSGVAREPAA PESELEGQPT PPAPPPPTET WPPTARSSPP
2160 2170 2180 2190 2200
PPLPAEERPG TKGPETASKF PSSSSDWRVP GLGLESRGEP PTPPSPAPAT
2210 2220 2230 2240 2250
GPSGSSSGSS EGSSGRAAGD TPERKEVTSS GKKMKVRPPP LKKTFDSVDK
2260 2270 2280 2290 2300
VLSEVDFEER FAELPEFRPE EVLPSPTLQS LATSPRAILG SYRKKRKNST
2310 2320 2330 2340 2350
DLDSAPEDPT SPKRKMRRRS SCSSEPNTPK SAKCEGDIFT FDRTGTETED
2360 2370 2380 2390 2400
VLGELEYEKV PYSSLRRTLD QRRALVMQLF QDHGFFPSAQ ATAAFQARYA
2410 2420 2430 2440 2450
DIFPSKVCLQ LKIREVRQKI MQAATPTEQP PGAEAPLPGP PPTGMAATPV
2460 2470 2480 2490 2500
PTPSPAGGPD PTSPGSDSGT AQVAPPLPPP PEPGPGQPGW EGAPQPSPPP
2510
SGPSTAATGR
Length:2,510
Mass (Da):258,130
Last modified:June 12, 2007 - v2
Checksum:i092C6CA3CC71B6D9
GO
Isoform 2 (identifier: Q924A2-2) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     1-907: Missing.
     908-929: VPSSYPSHPAPKKEVIMGRPGT → MYSAHRPLIPASGAASRGLGMF
     2250-2250: K → NR

Show »
Length:1,604
Mass (Da):163,753
Checksum:i348B7AE0567C32EA
GO

Sequence cautioni

The sequence BAC41408 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1089 – 10891D → E in BAE27978 (PubMed:16141072).Curated
Sequence conflicti1963 – 19631S → SA in AAK73516 (PubMed:12393275).Curated
Sequence conflicti2059 – 20591T → TA in AAK73516 (PubMed:12393275).Curated
Sequence conflicti2115 – 21151A → P in BAB23472 (PubMed:16141072).Curated
Sequence conflicti2156 – 21561E → G in BAE27978 (PubMed:16141072).Curated
Sequence conflicti2212 – 22121G → V in BAE27813 (PubMed:16141072).Curated
Sequence conflicti2364 – 23641S → L in BAB23472 (PubMed:16141072).Curated
Sequence conflicti2401 – 24011D → N in BAB23472 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 907907Missing in isoform 2. 3 PublicationsVSP_026140Add
BLAST
Alternative sequencei908 – 92922VPSSY…GRPGT → MYSAHRPLIPASGAASRGLG MF in isoform 2. 3 PublicationsVSP_026141Add
BLAST
Alternative sequencei2250 – 22501K → NR in isoform 2. 3 PublicationsVSP_039804

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363690 mRNA. Translation: AAK73516.1.
AK004685 mRNA. Translation: BAB23472.1.
AK147276 mRNA. Translation: BAE27813.1.
AK147535 mRNA. Translation: BAE27978.1.
AC156992 Genomic DNA. No translation available.
BC040463 mRNA. Translation: AAH40463.1.
BC058665 mRNA. Translation: AAH58665.1.
AB093224 mRNA. Translation: BAC41408.1. Sequence problems.
CCDSiCCDS52146.1. [Q924A2-2]
CCDS80678.1. [Q924A2-4]
RefSeqiNP_001289740.1. NM_001302811.1. [Q924A2-4]
NP_082158.2. NM_027882.4. [Q924A2-2]
UniGeneiMm.28833.

Genome annotation databases

EnsembliENSMUST00000163320; ENSMUSP00000126659; ENSMUSG00000005442. [Q924A2-2]
ENSMUST00000169266; ENSMUSP00000132351; ENSMUSG00000005442. [Q924A2-4]
GeneIDi71722.
KEGGimmu:71722.
UCSCiuc009fsa.3. mouse. [Q924A2-4]
uc009fsc.3. mouse. [Q924A2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363690 mRNA. Translation: AAK73516.1.
AK004685 mRNA. Translation: BAB23472.1.
AK147276 mRNA. Translation: BAE27813.1.
AK147535 mRNA. Translation: BAE27978.1.
AC156992 Genomic DNA. No translation available.
BC040463 mRNA. Translation: AAH40463.1.
BC058665 mRNA. Translation: AAH58665.1.
AB093224 mRNA. Translation: BAC41408.1. Sequence problems.
CCDSiCCDS52146.1. [Q924A2-2]
CCDS80678.1. [Q924A2-4]
RefSeqiNP_001289740.1. NM_001302811.1. [Q924A2-4]
NP_082158.2. NM_027882.4. [Q924A2-2]
UniGeneiMm.28833.

3D structure databases

ProteinModelPortaliQ924A2.
SMRiQ924A2. Positions 1108-1175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214881. 1 interaction.
DIPiDIP-60650N.
IntActiQ924A2. 1 interaction.
MINTiMINT-4122947.
STRINGi10090.ENSMUSP00000005578.

PTM databases

iPTMnetiQ924A2.
PhosphoSiteiQ924A2.

Proteomic databases

EPDiQ924A2.
MaxQBiQ924A2.
PaxDbiQ924A2.
PeptideAtlasiQ924A2.
PRIDEiQ924A2.

Protocols and materials databases

DNASUi71722.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163320; ENSMUSP00000126659; ENSMUSG00000005442. [Q924A2-2]
ENSMUST00000169266; ENSMUSP00000132351; ENSMUSG00000005442. [Q924A2-4]
GeneIDi71722.
KEGGimmu:71722.
UCSCiuc009fsa.3. mouse. [Q924A2-4]
uc009fsc.3. mouse. [Q924A2-2]

Organism-specific databases

CTDi23152.
MGIiMGI:1918972. Cic.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ITBG. Eukaryota.
ENOG4111S7E. LUCA.
GeneTreeiENSGT00530000063757.
HOVERGENiHBG081174.
InParanoidiQ924A2.
KOiK20225.
OMAiTKPAAYK.
OrthoDBiEOG091G16LO.
PhylomeDBiQ924A2.
TreeFamiTF323412.

Miscellaneous databases

PROiQ924A2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005442.
CleanExiMM_CIC.
ExpressionAtlasiQ924A2. baseline and differential.
GenevisibleiQ924A2. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR032147. DUF4819.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF16090. DUF4819. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIC_MOUSE
AccessioniPrimary (citable) accession number: Q924A2
Secondary accession number(s): Q3UH79
, Q3UHP4, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 12, 2007
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.