Q924A0 (TF7L2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor 7-like 2

Alternative name(s):
HMG box transcription factor 4
T-cell-specific transcription factor 4
Short name=T-cell factor 4
Short name=TCF-4
Short name=mTCF-4

Gene names

Name:	Tcf7l2
Synonyms:	Tcf4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 By similarity. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Ref.7 Ref.10
Subunit structure	Interacts with TGFB1I1. Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promoters, negatively modulating its transcriptional activity By similarity. Interacts with TNIK. Interacts with ZIPK/DAPK3 By similarity. Interacts with XIAP/BIRC4 and TLE3 By similarity. Interacts with DDIT3/CHOP By similarity. Ref.8 Ref.9
Subcellular location	Nucleus › PML body. Note: Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies By similarity.
Tissue specificity	Detected in adult brain and liver, and at lower levels in intestine, with a clear increase from the distal colon to the duodenum. Detected at low levels in heart, lung, kidney, pituitary and testis.
Developmental stage	First detected at E10.5. Highly expressed at E13.5-E16.5 in the central nervous system, in particular in the roof of the mesencephalon, at the ditelencephalic junction and in dorsal thalamus. At E13.5, detected at low levels in gastrointestinal epithelia.
Post-translational modification	Phosphorylated at Thr-178 and/or Thr-189 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway By similarity. Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA By similarity.
Involvement in disease	Constitutive activation and subsequent transactivation of target genes may lead to the maintenance of stem-cell characteristics (cycling and longevity) in cells that should normally undergo terminal differentiation and constitute the primary transforming event in colorectal cancer (CRC).
Sequence similarities	Belongs to the TCF/LEF family. Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Activator Repressor
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone mineralization Inferred from genetic interaction PubMed 19213727. Source: MGI canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 10937998. Source: MGI catenin import into nucleus Inferred from direct assay PubMed 9792805. Source: MGI embryonic digestive tract morphogenesis Inferred from genetic interaction PubMed 15057272. Source: MGI embryonic genitalia morphogenesis Inferred from genetic interaction PubMed 15057272. Source: MGI embryonic hindgut morphogenesis Inferred from genetic interaction PubMed 15057272. Source: MGI face morphogenesis Inferred from genetic interaction PubMed 17699607. Source: MGI myoblast cell fate commitment Inferred from mutant phenotype PubMed 10937998. Source: MGI negative regulation of BMP signaling pathway Inferred from mutant phenotype PubMed 17919533. Source: MGI negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 10937998. Source: MGI negative regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 17919533. Source: MGI negative regulation of organ growth Inferred from mutant phenotype PubMed 17919533. Source: MGI neural tube development Inferred from genetic interaction PubMed 15057272. Source: MGI odontogenesis of dentin-containing tooth Inferred from genetic interaction PubMed 17699607. Source: MGI oligodendrocyte development Inferred from mutant phenotype PubMed 19741146. Source: MGI pituitary gland development Inferred from mutant phenotype PubMed 17919533. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 17919533. Source: MGI positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 19251639. Source: MGI positive regulation of insulin secretion Inferred from mutant phenotype PubMed 19168596. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 21335239. Source: BHF-UCL regulation of insulin secretion involved in cellular response to glucose stimulus Inferred from mutant phenotype PubMed 19168596. Source: MGI regulation of myelination Inferred from mutant phenotype PubMed 19503085. Source: MGI regulation of oligodendrocyte differentiation Inferred from mutant phenotype PubMed 19503085. Source: MGI regulation of skeletal muscle tissue development Inferred from mutant phenotype PubMed 21177349. Source: MGI response to glucose stimulus Inferred from mutant phenotype PubMed 19168596. Source: BHF-UCL secretory granule localization Inferred from mutant phenotype PubMed 19168596. Source: MGI skin development Inferred from genetic interaction PubMed 19718027. Source: MGI somatic stem cell maintenance Inferred from mutant phenotype PubMed 10027409PubMed 19251639Ref.7. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	PML body Inferred from electronic annotation. Source: UniProtKB-SubCell catenin-TCF7L2 complex Inferred from direct assay Ref.1. Source: BHF-UCL cytosol Inferred from direct assay PubMed 15578569. Source: BHF-UCL transcription factor complex Inferred from direct assay PubMed 12861022. Source: MGI
Molecular_function	beta-catenin binding Inferred from direct assay PubMed 19503085PubMed 9784592. Source: MGI chromatin binding Inferred from direct assay PubMed 17727834. Source: MGI sequence-specific DNA binding Inferred from direct assay Ref.1. Source: BHF-UCL sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription regulatory region DNA binding Inferred from direct assay PubMed 20044351. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Traf1	P39428	6	EBI-646713,EBI-520123

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q924A0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q924A0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: S → SSFLSS
     417-459: EHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL → GEKKSAFATYKVKAAASAHPLQMEAY

Isoform 3 (identifier: Q924A0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     237-240: Missing.

Isoform 4 (identifier: Q924A0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     417-433: Missing.
     457-459: CSL → ADANTPKKCR...PLSLVTKSLE

Isoform 5 (identifier: Q924A0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: V → VQSPLPCCTQGHACPHFYTPSDFTVSTQVFRDTKSSHSLQKVGEPWYLE
     270-459: Missing.

Isoform 6 (identifier: Q924A0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     270-459: Missing.

Isoform 7 (identifier: Q924A0-7)

The sequence of this isoform differs from the canonical sequence as follows:
     127-127: T → TLHFQSGSTHYSAYKTIEHQIAIQ
     237-240: Missing.
     270-459: Missing.

Isoform 8 (identifier: Q924A0-8)

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: S → SSFLSS
     417-459: EHSECFLNPC...QNNWCGPCSL → GERGESGRWR...LGSLFCLCVF

Note: May result from the retention of an intron in the cDNA.

Isoform 9 (identifier: Q924A0-9)

Also known as: dnTcf7l2 exon1b/c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: MPQLNGGGGD...ARSPSPAHIV → M

Note: Dominant negative form which cannot bind CTNNB1. Expression is VAX2-dependent.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	Transcription factor 7-like 2		PRO_0000048624
Regions
	DNA binding	327 – 395	69	HMG box
	Region	1 – 53	53	CTNNB1-binding
	Region	178 – 372	195	Mediates interaction with MAD2L2 By similarity
	Motif	402 – 408	7	Nuclear localization signal Potential
	Compositional bias	155 – 294	140	Pro-rich
Amino acid modifications
	Modified residue	178	1	Phosphothreonine; by NLK By similarity
	Modified residue	189	1	Phosphothreonine; by NLK By similarity
	Cross-link	297		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Natural variations
	Alternative sequence	1 – 161	161	MPQLN…PAHIV → M in isoform 9.		VSP_043205
	Alternative sequence	127	1	T → TLHFQSGSTHYSAYKTIEHQ IAIQ in isoform 7.		VSP_006973
	Alternative sequence	161	1	V → VQSPLPCCTQGHACPHFYTP SDFTVSTQVFRDTKSSHSLQ KVGEPWYLE in isoform 5.		VSP_006974
	Alternative sequence	237 – 240	4	Missing in isoform 3 and isoform 7.		VSP_006975
	Alternative sequence	268	1	S → SSFLSS in isoform 2 and isoform 8.		VSP_006976
	Alternative sequence	270 – 459	190	Missing in isoform 5, isoform 6 and isoform 7.		VSP_006977
	Alternative sequence	417 – 459	43	EHSEC…GPCSL → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 2.		VSP_006979
	Alternative sequence	417 – 459	43	EHSEC…GPCSL → GERGESGRWRLEDHSYVRLP SGGGRRNPRPGHCGEPILGS LFCLCVF in isoform 8.		VSP_006980
	Alternative sequence	417 – 433	17	Missing in isoform 4.		VSP_006978
	Alternative sequence	457 – 459	3	CSL → ADANTPKKCRALFGLDRQTL WCKPCRRKKKCVRYIQGEGS CLSPPSSDGSLLDSPPPSPH LLGSPPQDAKSQTEQTQPLS LSLKPDPLAHLSMMPPPPAL LLAEAAHGKASALCPNGALD LPPAALQPSMVPSSSLAQPS TSSLHSHNSLAGTQPQPLSL VTKSLE in isoform 4.		VSP_006981
Experimental info
	Sequence conflict	57	1	D → N in AAD16967. Ref.2
	Sequence conflict	57	1	D → N in AAK77488. Ref.3
	Sequence conflict	57	1	D → N in AAK77489. Ref.3
	Sequence conflict	57	1	D → N in AAK77490. Ref.3
	Sequence conflict	236	1	W → R in AAL58534. Ref.4
	Sequence conflict	410	1	K → Q in AAD16968. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 25, 2003. Version 2. Checksum: 43BC307DC258E83F	FASTA	459	51,217
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL 190 200 210 220 230 240 ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ 250 260 270 280 290 300 QGQPVYPITT GGFRHPYPTA LTVNASMSRF PPHMVPPHHT LHTTGIPHPA IVTPTVKQES 310 320 330 340 350 360 SQSDVGSLHS SKHQDSKKEE EKKKPHIKKP LNAFMLYMKE MRAKVVAECT LKESAAINQI 370 380 390 400 410 420 LGRRWHALSR EEQAKYYELA RKERQLHMQL YPGWSARDNY GKKKKRKRDK QPGETNEHSE 430 440 450 CFLNPCLSLP PITDLSAPKK CRARFGLDQQ NNWCGPCSL
	Isoform 2 [UniParc]. Checksum: EDD7D6F4E01EBF2D	FASTA	447	49,746
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL 190 200 210 220 230 240 ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ 250 260 270 280 290 300 QGQPVYPITT GGFRHPYPTA LTVNASMSSF LSSRFPPHMV PPHHTLHTTG IPHPAIVTPT 310 320 330 340 350 360 VKQESSQSDV GSLHSSKHQD SKKEEEKKKP HIKKPLNAFM LYMKEMRAKV VAECTLKESA 370 380 390 400 410 420 AINQILGRRW HALSREEQAK YYELARKERQ LHMQLYPGWS ARDNYGKKKK RKRDKQPGET 430 440 NGEKKSAFAT YKVKAAASAH PLQMEAY
	Isoform 3 [UniParc]. Checksum: CAAC8E5E0E20C558	FASTA	455	50,779
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL 190 200 210 220 230 240 ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWQGQP 250 260 270 280 290 300 VYPITTGGFR HPYPTALTVN ASMSRFPPHM VPPHHTLHTT GIPHPAIVTP TVKQESSQSD 310 320 330 340 350 360 VGSLHSSKHQ DSKKEEEKKK PHIKKPLNAF MLYMKEMRAK VVAECTLKES AAINQILGRR 370 380 390 400 410 420 WHALSREEQA KYYELARKER QLHMQLYPGW SARDNYGKKK KRKRDKQPGE TNEHSECFLN 430 440 450 PCLSLPPITD LSAPKKCRAR FGLDQQNNWC GPCSL
	Isoform 4 [UniParc]. Checksum: 5E99A68C93632464	FASTA	605	66,406
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL 190 200 210 220 230 240 ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ 250 260 270 280 290 300 QGQPVYPITT GGFRHPYPTA LTVNASMSRF PPHMVPPHHT LHTTGIPHPA IVTPTVKQES 310 320 330 340 350 360 SQSDVGSLHS SKHQDSKKEE EKKKPHIKKP LNAFMLYMKE MRAKVVAECT LKESAAINQI 370 380 390 400 410 420 LGRRWHALSR EEQAKYYELA RKERQLHMQL YPGWSARDNY GKKKKRKRDK QPGETNDLSA 430 440 450 460 470 480 PKKCRARFGL DQQNNWCGPA DANTPKKCRA LFGLDRQTLW CKPCRRKKKC VRYIQGEGSC 490 500 510 520 530 540 LSPPSSDGSL LDSPPPSPHL LGSPPQDAKS QTEQTQPLSL SLKPDPLAHL SMMPPPPALL 550 560 570 580 590 600 LAEAAHGKAS ALCPNGALDL PPAALQPSMV PSSSLAQPST SSLHSHNSLA GTQPQPLSLV TKSLE
	Isoform 5 [UniParc]. Checksum: 37F33F08CAF073EF	FASTA	317	34,803
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VQSPLPCCTQ GHACPHFYTP 190 200 210 220 230 240 SDFTVSTQVF RDTKSSHSLQ KVGEPWYLES NKVPVVQHPH HVHPLTPLIT YSNEHFTPGN 250 260 270 280 290 300 PPPHLPADVD PKTGIPRPPH PPDISPYYPL SPGTVGQIPH PLGWLVPQQG QPVYPITTGG 310 FRHPYPTALT VNASMSR
	Isoform 6 [UniParc]. Checksum: 2D77D77415FF4833	FASTA	269	29,379
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL 190 200 210 220 230 240 ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ 250 260 QGQPVYPITT GGFRHPYPTA LTVNASMSR
	Isoform 7 [UniParc]. Checksum: 62778EB672DF0785	FASTA	288	31,583
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTLHF QSGSTHYSAY KTIEHQIAIQ YLQMKWPLLD VQAGSLQSRQ TLKDARSPSP 190 200 210 220 230 240 AHIVSNKVPV VQHPHHVHPL TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS 250 260 270 280 PYYPLSPGTV GQIPHPLGWQ GQPVYPITTG GFRHPYPTAL TVNASMSR
	Isoform 8 [UniParc]. Checksum: A0E7D915D2EC4D0B	FASTA	468	52,160
	10 20 30 40 50 60 MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQDSSS 70 80 90 100 110 120 DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 130 140 150 160 170 180 LSPTARTYLQ MKWPLLDVQA GSLQSRQTLK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL 190 200 210 220 230 240 ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ 250 260 270 280 290 300 QGQPVYPITT GGFRHPYPTA LTVNASMSSF LSSRFPPHMV PPHHTLHTTG IPHPAIVTPT 310 320 330 340 350 360 VKQESSQSDV GSLHSSKHQD SKKEEEKKKP HIKKPLNAFM LYMKEMRAKV VAECTLKESA 370 380 390 400 410 420 AINQILGRRW HALSREEQAK YYELARKERQ LHMQLYPGWS ARDNYGKKKK RKRDKQPGET 430 440 450 460 NGERGESGRW RLEDHSYVRL PSGGGRRNPR PGHCGEPILG SLFCLCVF
	Isoform 9 (dnTcf7l2 exon1b/c) [UniParc]. Checksum: E046B2B2BBB11219	FASTA	299	33,726
	10 20 30 40 50 60 MSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY 70 80 90 100 110 120 PLSPGTVGQI PHPLGWLVPQ QGQPVYPITT GGFRHPYPTA LTVNASMSRF PPHMVPPHHT 130 140 150 160 170 180 LHTTGIPHPA IVTPTVKQES SQSDVGSLHS SKHQDSKKEE EKKKPHIKKP LNAFMLYMKE 190 200 210 220 230 240 MRAKVVAECT LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL YPGWSARDNY 250 260 270 280 290 GKKKKRKRDK QPGETNEHSE CFLNPCLSLP PITDLSAPKK CRARFGLDQQ NNWCGPCSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse." Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H. Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Embryo.
[2]	"A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation." Lee Y.J., Swencki B., Shoichet S., Shivdasani R.A. J. Biol. Chem. 274:1566-1572(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4). Strain: ICR. Tissue: Fetal intestine.
[3]	"Identification of members of the Wnt signaling pathway in the embryonic pituitary gland." Douglas K.R., Brinkmeier M.L., Kennell J.A., Eswara P., Harrison T.A., Patrianakos A.I., Sprecher B.S., Potok M.A., Lyons R.H. Jr., MacDougald O.A., Camper S.A. Mamm. Genome 12:843-851(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 6 AND 7), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 5). Strain: C57BL/6J and CD-1. Tissue: Pituitary.
[4]	"A novel isoform of the HMG transcription factor Tcf4." Bayarsaihan D. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9). Strain: C57BL/6J. Tissue: Head.
[6]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[7]	"Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4." Korinek V., Barker N., Moerer P., van Donselaar E., Huls G., Peters P.J., Clevers H. Nat. Genet. 19:379-383(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"HIC-5 is a novel repressor of lymphoid enhancer factor/T-cell factor-driven transcription." Ghogomu S.M., van Venrooy S., Ritthaler M., Wedlich D., Gradl D. J. Biol. Chem. 281:1755-1764(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TGFB1I1.
[9]	"The kinase TNIK is an essential activator of Wnt target genes." Mahmoudi T., Li V.S.W., Ng S.S., Taouatas N., Vries R.G.J., Mohammed S., Heck A.J., Clevers H. EMBO J. 28:3329-3340(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TNIK AND CTNNB1.
[10]	"A novel mechanism for the transcriptional regulation of Wnt signaling in development." Vacik T., Stubbs J.L., Lemke G. Genes Dev. 25:1783-1795(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223070 mRNA. Translation: CAA11071.1. AF107298 mRNA. Translation: AAD16967.1. AF107299 mRNA. Translation: AAD16968.1. AF363722 Genomic DNA. Translation: AAK77485.1. AF363722 Genomic DNA. Translation: AAK77486.1. AF363724 mRNA. Translation: AAK77488.1. AF363725 mRNA. Translation: AAK77489.1. AF363726 mRNA. Translation: AAK77490.1. AY072035 mRNA. Translation: AAL58534.1. AK048536 mRNA. Translation: BAC33366.1. AC118695 Genomic DNA. No translation available. AC137148 Genomic DNA. No translation available. AC157916 Genomic DNA. No translation available.
IPI	IPI00129307. IPI00224936. IPI00224938. IPI00224939. IPI00224941. IPI00830945. IPI00831494. IPI00831648. IPI00918384.
RefSeq	NP_001136390.1. NM_001142918.1. NP_001136393.1. NM_001142921.1. NP_001136396.1. NM_001142924.1.
UniGene	Mm.139815.
3D structure databases
ProteinModelPortal	Q924A0.
SMR	Q924A0. Positions 12-49, 326-401.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-40920N.
IntAct	Q924A0. 1 interaction.
MINT	MINT-421706.
PTM databases
PhosphoSite	Q924A0.
Proteomic databases
PRIDE	Q924A0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000111646; ENSMUSP00000107273; ENSMUSG00000024985. ENSMUST00000111649; ENSMUSP00000107276; ENSMUSG00000024985. ENSMUST00000111651; ENSMUSP00000107278; ENSMUSG00000024985. ENSMUST00000111652; ENSMUSP00000107279; ENSMUSG00000024985. ENSMUST00000111659; ENSMUSP00000107287; ENSMUSG00000024985.
GeneID	21416.
KEGG	mmu:21416.
UCSC	uc008hya.2. mouse. uc008hyb.2. mouse. uc008hyh.2. mouse. uc008hyk.2. mouse. uc008hyl.2. mouse.
Organism-specific databases
CTD	6934.
MGI	MGI:1202879. Tcf7l2.
Phylogenomic databases
eggNOG	NOG252916.
GeneTree	ENSGT00390000009964.
HOGENOM	HOG000116032.
HOVERGEN	HBG000419.
KO	K04491.
OrthoDB	EOG43XV3J.
Gene expression databases
ArrayExpress	Q924A0.
Bgee	Q924A0.
CleanEx	MM_TCF4.
Genevestigator	Q924A0.
GermOnline	ENSMUSG00000024985. Mus musculus.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR013558. CTNNB1-bd_N. IPR009071. HMG_box_dom. IPR024940. TCF/LEF. [Graphical view]
PANTHER	PTHR10373. PTHR10373. 1 hit.
Pfam	PF08347. CTNNB1_binding. 1 hit. PF00505. HMG_box. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TCF7L2. mouse.
NextBio	300716.
SOURCE	Search...

Entry information

Entry name

TF7L2_MOUSE

Accession

Primary (citable) accession number: Q924A0
Secondary accession number(s): O70574 , Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A1, Q9Z0V3, Q9Z0V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 25, 2003
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program