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Protein

Aquaporin-3

Gene

AQP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).By similarity

GO - Molecular functioni

  1. glycerol channel activity Source: BHF-UCL
  2. transporter activity Source: ProtInc
  3. urea transmembrane transporter activity Source: GO_Central
  4. water channel activity Source: BHF-UCL

GO - Biological processi

  1. carbohydrate transmembrane transport Source: GO_Central
  2. cellular water homeostasis Source: GO_Central
  3. excretion Source: ProtInc
  4. ion transmembrane transport Source: GO_Central
  5. odontogenesis Source: UniProtKB
  6. positive regulation of immune system process Source: BHF-UCL
  7. regulation of keratinocyte differentiation Source: BHF-UCL
  8. renal water absorption Source: Ensembl
  9. response to calcium ion Source: BHF-UCL
  10. response to retinoic acid Source: BHF-UCL
  11. response to vitamin D Source: BHF-UCL
  12. transmembrane transport Source: Reactome
  13. transport Source: ProtInc
  14. urea transmembrane transport Source: GO_Central
  15. water transport Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-3
Short name:
AQP-3
Alternative name(s):
Aquaglyceroporin-3
Gene namesi
Name:AQP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:636. AQP3.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein
Note: In collecting ducts of kidney.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Topological domaini50 – 534ExtracellularSequence Analysis
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Topological domaini75 – 10935CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 15727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Topological domaini179 – 18810CytoplasmicSequence Analysis
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Topological domaini210 – 24435ExtracellularSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST
Topological domaini266 – 29227CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. cell-cell junction Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. integral component of membrane Source: BHF-UCL
  5. integral component of plasma membrane Source: GO_Central
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi607457. phenotype.
PharmGKBiPA24921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Aquaporin-3PRO_0000063943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ92482.
PRIDEiQ92482.

Expressioni

Tissue specificityi

Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

Inductioni

Up-regulated by magnesium.1 Publication

Gene expression databases

BgeeiQ92482.
CleanExiHS_AQP3.
GenevestigatoriQ92482.

Organism-specific databases

HPAiHPA014924.

Interactioni

Protein-protein interaction databases

BioGridi106856. 3 interactions.
IntActiQ92482. 1 interaction.
STRINGi9606.ENSP00000297991.

Structurei

3D structure databases

ProteinModelPortaliQ92482.
SMRiQ92482. Positions 24-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 853NPA 1
Motifi215 – 2173NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ92482.
KOiK09876.
OMAiLDMINGF.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ92482.
TreeFamiTF313173.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023275. Aquaporin_3.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02015. AQUAPORIN3.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92482-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR
60 70 80 90 100
GTHGGFLTIN LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK
110 120 130 140 150
LPIYTLAQTL GAFLGAGIVF GLYYDAIWHF ADNQLFVSGP NGTAGIFATY
160 170 180 190 200
PSGHLDMING FFDQFIGTAS LIVCVLAIVD PYNNPVPRGL EAFTVGLVVL
210 220 230 240 250
VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ HWWWVPIVSP
260 270 280 290
LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI
Length:292
Mass (Da):31,544
Last modified:November 1, 1997 - v2
Checksum:iA9555E9576EABA9C
GO
Isoform 2 (identifier: Q92482-2) [UniParc]FASTAAdd to Basket

Also known as: delta5

The sequence of this isoform differs from the canonical sequence as follows:
     165-281: FIGTASLIVC...PPPSNEEENV → DRPALVVGAH...FPLDLAQIAP
     282-292: Missing.

Note: Due to a polymorphism at the 5'-splice donor site of intron 5, leading to exon 5 skipping and premature termination of translation. This is the molecular basis of the GIL blood group.

Show »
Length:281
Mass (Da):29,987
Checksum:iC46894A001707CC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → G in BAF84897. (PubMed:14702039)Curated
Sequence conflicti137 – 1371V → A in CAG46822. 1 PublicationCurated

Polymorphismi

AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in GIL-negative individuals that lack functional AQP3.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431V → M.1 Publication
Corresponds to variant rs34942735 [ dbSNP | Ensembl ].
VAR_025089

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei165 – 281117FIGTA…EEENV → DRPALVVGAHRVPTPGLHCG CLRVPADDRLPPGAAPTLQR GRECEAGPCEAQGADLSGKG HLPLRCPGLEHPLTVQGHSQ EAPLHDPPFQAKELPIYPHP TKTAPSGFPLDLAQIAP in isoform 2. 1 PublicationVSP_003229Add
BLAST
Alternative sequencei282 – 29211Missing in isoform 2. 1 PublicationVSP_003230Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001325 mRNA. Translation: BAA19237.1.
AJ493597 mRNA. Translation: CAD38526.1.
CR541991 mRNA. Translation: CAG46788.1.
CR542025 mRNA. Translation: CAG46822.1.
BT007199 mRNA. Translation: AAP35863.1.
AK292208 mRNA. Translation: BAF84897.1.
AK315760 mRNA. Translation: BAG38113.1.
DQ083949 Genomic DNA. Translation: AAY68214.1.
AL356218 Genomic DNA. Translation: CAI13311.1.
CH471071 Genomic DNA. Translation: EAW58500.1.
CH471071 Genomic DNA. Translation: EAW58504.1.
BC013566 mRNA. Translation: AAH13566.1.
CCDSiCCDS6542.1. [Q92482-1]
PIRiA57119.
RefSeqiNP_004916.1. NM_004925.4. [Q92482-1]
UniGeneiHs.234642.

Genome annotation databases

EnsembliENST00000297991; ENSP00000297991; ENSG00000165272. [Q92482-1]
GeneIDi360.
KEGGihsa:360.
UCSCiuc003zsx.3. human. [Q92482-1]
uc010mju.3. human. [Q92482-2]

Polymorphism databases

DMDMi2497938.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001325 mRNA. Translation: BAA19237.1.
AJ493597 mRNA. Translation: CAD38526.1.
CR541991 mRNA. Translation: CAG46788.1.
CR542025 mRNA. Translation: CAG46822.1.
BT007199 mRNA. Translation: AAP35863.1.
AK292208 mRNA. Translation: BAF84897.1.
AK315760 mRNA. Translation: BAG38113.1.
DQ083949 Genomic DNA. Translation: AAY68214.1.
AL356218 Genomic DNA. Translation: CAI13311.1.
CH471071 Genomic DNA. Translation: EAW58500.1.
CH471071 Genomic DNA. Translation: EAW58504.1.
BC013566 mRNA. Translation: AAH13566.1.
CCDSiCCDS6542.1. [Q92482-1]
PIRiA57119.
RefSeqiNP_004916.1. NM_004925.4. [Q92482-1]
UniGeneiHs.234642.

3D structure databases

ProteinModelPortaliQ92482.
SMRiQ92482. Positions 24-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106856. 3 interactions.
IntActiQ92482. 1 interaction.
STRINGi9606.ENSP00000297991.

Chemistry

GuidetoPHARMACOLOGYi690.

Polymorphism databases

DMDMi2497938.

Proteomic databases

PaxDbiQ92482.
PRIDEiQ92482.

Protocols and materials databases

DNASUi360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297991; ENSP00000297991; ENSG00000165272. [Q92482-1]
GeneIDi360.
KEGGihsa:360.
UCSCiuc003zsx.3. human. [Q92482-1]
uc010mju.3. human. [Q92482-2]

Organism-specific databases

CTDi360.
GeneCardsiGC09M033431.
HGNCiHGNC:636. AQP3.
HPAiHPA014924.
MIMi600170. gene.
607457. phenotype.
neXtProtiNX_Q92482.
PharmGKBiPA24921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0580.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiQ92482.
KOiK09876.
OMAiLDMINGF.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ92482.
TreeFamiTF313173.

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

ChiTaRSiAQP3. human.
GeneWikiiAquaporin_3.
GenomeRNAii360.
NextBioi1505.
PROiQ92482.
SOURCEiSearch...

Gene expression databases

BgeeiQ92482.
CleanExiHS_AQP3.
GenevestigatoriQ92482.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023275. Aquaporin_3.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02015. AQUAPORIN3.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and chromosomal localization of a human water channel (AQP3) gene."
    Ishibashi K., Sasaki S., Saito F., Ikeuchi T., Marumo F.
    Genomics 27:352-354(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. Ishibashi K.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 91; 96 AND 186.
  3. "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL."
    Roudier N., Ripoche P., Gane P., Le Pennec P.Y., Daniels G., Cartron J.-P., Bailly P.
    J. Biol. Chem. 277:45854-45859(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GIL BLOOD GROUP SYSTEM.
    Tissue: Blood.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Esophagus and Trachea.
  7. SeattleSNPs variation discovery resource
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-43.
  8. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  11. "Regulation of aquaporin 3 expression by magnesium ion."
    Okahira M., Kubota M., Iguchi K., Usui S., Hirano K.
    Eur. J. Pharmacol. 588:26-32(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiAQP3_HUMAN
AccessioniPrimary (citable) accession number: Q92482
Secondary accession number(s): A8K843
, B2RE16, D3DRL3, O00108, Q6FGT2, Q6FGW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 4, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.