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Protein

C-type lectin domain family 2 member B

Gene

CLEC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member B
Alternative name(s):
Activation-induced C-type lectin
C-type lectin superfamily member 2
IFN-alpha-2b-inducing-related protein 1
Gene namesi
Name:CLEC2B
Synonyms:AICL, CLECSF2, IFNRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2053. CLEC2B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini26 – 149ExtracellularSequence analysisAdd BLAST124

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9976.
OpenTargetsiENSG00000110852.
PharmGKBiPA26582.

Polymorphism and mutation databases

BioMutaiCLEC2B.
DMDMi33860149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466111 – 149C-type lectin domain family 2 member BAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi63 ↔ 144PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi123 ↔ 136PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ92478.
PaxDbiQ92478.
PeptideAtlasiQ92478.
PRIDEiQ92478.

PTM databases

iPTMnetiQ92478.
PhosphoSitePlusiQ92478.

Expressioni

Tissue specificityi

Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.

Gene expression databases

BgeeiENSG00000110852.
CleanExiHS_CLEC2B.
ExpressionAtlasiQ92478. baseline and differential.
GenevisibleiQ92478. HS.

Organism-specific databases

HPAiHPA008194.

Interactioni

Protein-protein interaction databases

BioGridi115300. 1 interactor.
DIPiDIP-58612N.
STRINGi9606.ENSP00000228438.

Structurei

3D structure databases

ProteinModelPortaliQ92478.
SMRiQ92478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 145C-type lectinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000059595.
InParanoidiQ92478.
KOiK10071.
OMAiWICRKKI.
OrthoDBiEOG091G0N3M.
PhylomeDBiQ92478.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKHKKCFI IVGVLITTNI ITLIVKLTRD SQSLCPYDWI GFQNKCYYFS
60 70 80 90 100
KEEGDWNSSK YNCSTQHADL TIIDNIEEMN FLRRYKCSSD HWIGLKMAKN
110 120 130 140
RTGQWVDGAT FTKSFGMRGS EGCAYLSDDG AATARCYTER KWICRKRIH
Length:149
Mass (Da):17,307
Last modified:August 15, 2003 - v2
Checksum:i0B4FED23424F6C55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79M → T in AAH05254 (PubMed:15489334).Curated1
Sequence conflicti107D → H in CAA65480 (PubMed:9038101).Curated1
Sequence conflicti132 – 137ATARCY → TTAQIQ (Ref. 6) Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96719 mRNA. Translation: CAA65480.1.
AB015628 mRNA. Translation: BAA76495.1.
AK313916 mRNA. Translation: BAG36638.1.
CH471094 Genomic DNA. Translation: EAW96127.1.
BC005254 mRNA. Translation: AAH05254.1.
AY142147 mRNA. Translation: AAN46677.1.
CCDSiCCDS8605.1.
RefSeqiNP_005118.2. NM_005127.2.
UniGeneiHs.85201.

Genome annotation databases

EnsembliENST00000228438; ENSP00000228438; ENSG00000110852.
GeneIDi9976.
KEGGihsa:9976.
UCSCiuc001qwn.4. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69 homolog

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96719 mRNA. Translation: CAA65480.1.
AB015628 mRNA. Translation: BAA76495.1.
AK313916 mRNA. Translation: BAG36638.1.
CH471094 Genomic DNA. Translation: EAW96127.1.
BC005254 mRNA. Translation: AAH05254.1.
AY142147 mRNA. Translation: AAN46677.1.
CCDSiCCDS8605.1.
RefSeqiNP_005118.2. NM_005127.2.
UniGeneiHs.85201.

3D structure databases

ProteinModelPortaliQ92478.
SMRiQ92478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115300. 1 interactor.
DIPiDIP-58612N.
STRINGi9606.ENSP00000228438.

PTM databases

iPTMnetiQ92478.
PhosphoSitePlusiQ92478.

Polymorphism and mutation databases

BioMutaiCLEC2B.
DMDMi33860149.

Proteomic databases

MaxQBiQ92478.
PaxDbiQ92478.
PeptideAtlasiQ92478.
PRIDEiQ92478.

Protocols and materials databases

DNASUi9976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228438; ENSP00000228438; ENSG00000110852.
GeneIDi9976.
KEGGihsa:9976.
UCSCiuc001qwn.4. human.

Organism-specific databases

CTDi9976.
DisGeNETi9976.
GeneCardsiCLEC2B.
HGNCiHGNC:2053. CLEC2B.
HPAiHPA008194.
MIMi603242. gene.
neXtProtiNX_Q92478.
OpenTargetsiENSG00000110852.
PharmGKBiPA26582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000059595.
InParanoidiQ92478.
KOiK10071.
OMAiWICRKKI.
OrthoDBiEOG091G0N3M.
PhylomeDBiQ92478.
TreeFamiTF351467.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCLEC2B. human.
GeneWikiiCLEC2B.
GenomeRNAii9976.
PROiQ92478.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110852.
CleanExiHS_CLEC2B.
ExpressionAtlasiQ92478. baseline and differential.
GenevisibleiQ92478. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC2B_HUMAN
AccessioniPrimary (citable) accession number: Q92478
Secondary accession number(s): B2R9U1
, Q8IZE9, Q9BS74, Q9UQB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: August 15, 2003
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.