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Protein

C-type lectin domain family 2 member B

Gene

CLEC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member B
Alternative name(s):
Activation-induced C-type lectin
C-type lectin superfamily member 2
IFN-alpha-2b-inducing-related protein 1
Gene namesi
Name:CLEC2B
Synonyms:AICL, CLECSF2, IFNRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2053. CLEC2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2518Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 149124ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26582.

Polymorphism and mutation databases

BioMutaiCLEC2B.
DMDMi33860149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149C-type lectin domain family 2 member BPRO_0000046611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi63 ↔ 144PROSITE-ProRule annotation
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi123 ↔ 136PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ92478.
PaxDbiQ92478.
PRIDEiQ92478.

Expressioni

Tissue specificityi

Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.

Gene expression databases

BgeeiQ92478.
CleanExiHS_CLEC2B.
ExpressionAtlasiQ92478. baseline and differential.
GenevisibleiQ92478. HS.

Organism-specific databases

HPAiHPA008194.

Interactioni

Protein-protein interaction databases

BioGridi115300. 1 interaction.
DIPiDIP-58612N.
STRINGi9606.ENSP00000228438.

Structurei

3D structure databases

ProteinModelPortaliQ92478.
SMRiQ92478. Positions 32-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 145104C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000059595.
InParanoidiQ92478.
KOiK10071.
OMAiWICRKKI.
OrthoDBiEOG7JHM7B.
PhylomeDBiQ92478.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKHKKCFI IVGVLITTNI ITLIVKLTRD SQSLCPYDWI GFQNKCYYFS
60 70 80 90 100
KEEGDWNSSK YNCSTQHADL TIIDNIEEMN FLRRYKCSSD HWIGLKMAKN
110 120 130 140
RTGQWVDGAT FTKSFGMRGS EGCAYLSDDG AATARCYTER KWICRKRIH
Length:149
Mass (Da):17,307
Last modified:August 15, 2003 - v2
Checksum:i0B4FED23424F6C55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791M → T in AAH05254 (PubMed:15489334).Curated
Sequence conflicti107 – 1071D → H in CAA65480 (PubMed:9038101).Curated
Sequence conflicti132 – 1376ATARCY → TTAQIQ (Ref. 6) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96719 mRNA. Translation: CAA65480.1.
AB015628 mRNA. Translation: BAA76495.1.
AK313916 mRNA. Translation: BAG36638.1.
CH471094 Genomic DNA. Translation: EAW96127.1.
BC005254 mRNA. Translation: AAH05254.1.
AY142147 mRNA. Translation: AAN46677.1.
CCDSiCCDS8605.1.
RefSeqiNP_005118.2. NM_005127.2.
UniGeneiHs.85201.

Genome annotation databases

EnsembliENST00000228438; ENSP00000228438; ENSG00000110852.
GeneIDi9976.
KEGGihsa:9976.
UCSCiuc001qwn.4. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69 homolog

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96719 mRNA. Translation: CAA65480.1.
AB015628 mRNA. Translation: BAA76495.1.
AK313916 mRNA. Translation: BAG36638.1.
CH471094 Genomic DNA. Translation: EAW96127.1.
BC005254 mRNA. Translation: AAH05254.1.
AY142147 mRNA. Translation: AAN46677.1.
CCDSiCCDS8605.1.
RefSeqiNP_005118.2. NM_005127.2.
UniGeneiHs.85201.

3D structure databases

ProteinModelPortaliQ92478.
SMRiQ92478. Positions 32-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115300. 1 interaction.
DIPiDIP-58612N.
STRINGi9606.ENSP00000228438.

Polymorphism and mutation databases

BioMutaiCLEC2B.
DMDMi33860149.

Proteomic databases

MaxQBiQ92478.
PaxDbiQ92478.
PRIDEiQ92478.

Protocols and materials databases

DNASUi9976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228438; ENSP00000228438; ENSG00000110852.
GeneIDi9976.
KEGGihsa:9976.
UCSCiuc001qwn.4. human.

Organism-specific databases

CTDi9976.
GeneCardsiCLEC2B.
HGNCiHGNC:2053. CLEC2B.
HPAiHPA008194.
MIMi603242. gene.
neXtProtiNX_Q92478.
PharmGKBiPA26582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000059595.
InParanoidiQ92478.
KOiK10071.
OMAiWICRKKI.
OrthoDBiEOG7JHM7B.
PhylomeDBiQ92478.
TreeFamiTF351467.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCLEC2B. human.
GeneWikiiCLEC2B.
GenomeRNAii9976.
NextBioi37678.
PROiQ92478.
SOURCEiSearch...

Gene expression databases

BgeeiQ92478.
CleanExiHS_CLEC2B.
ExpressionAtlasiQ92478. baseline and differential.
GenevisibleiQ92478. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "AICL, a new activation induced antigen encoded by the human NK gene complex."
    Hamann J., Montgomery K.T., Lau S., Kucherlapati R., van Lier R.A.W.
    Immunogenetics 45:295-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."
    Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.
    Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder.
  6. "Study on gene response of IFN inducing."
    Li Q., Zhao H., Wang L., Liu L., Dong C., Dong S., Wang J.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-137.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLC2B_HUMAN
AccessioniPrimary (citable) accession number: Q92478
Secondary accession number(s): B2R9U1
, Q8IZE9, Q9BS74, Q9UQB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: August 15, 2003
Last modified: March 16, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.