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Q92459 (FDFT_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Squalene synthase

Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene names
Name:ERG9
ORF Names:UM04374
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol By similarity.

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subunit structure

Monomer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Squalene synthase
PRO_0000067452

Regions

Transmembrane316 – 33621Helical; Potential
Transmembrane492 – 51221Helical; Potential

Experimental info

Sequence conflict71 – 722EL → DV in CAA68054. Ref.1
Sequence conflict4281S → T in CAA68054. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92459 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: 26FA62E2CA677C10

FASTA57265,523
        10         20         30         40         50         60 
MGLLSYILLG FTHPSELRAM IGYKVWRDPL NDIKANPQAS GWDRQRMRDC WGFLDLTSRS 

        70         80         90        100        110        120 
FAAVIKELKG ELSRVICLFY LVLRALDTVE DDMTIPAQRK IPLLVNFYKY LEQPGWNFTE 

       130        140        150        160        170        180 
SGPNEKDRQL LVEFDKVIAE YQLLDVGYKT VISDITAKMG AGMASYIELS AKGPLKVAMW 

       190        200        210        220        230        240 
KHFDLYCHFV AGLVGEGLSR LFSESKLERP WLGHQLELSN HMGLFLQKTN IIRDYAEDCE 

       250        260        270        280        290        300 
EGRYFWPQQC WGDDFAKFES QPDVAKGIIE IKPGHFRPAD NELGQRSMYV LSSMLLDAMS 

       310        320        330        340        350        360 
HATHALDYLA LLKEQSVFNF CAIPQVMAIA TLELMFNNPD VFKKNVKIRK GVAVGLILRA 

       370        380        390        400        410        420 
VNPRDVAYTF LHYSRKMHAR LSPADPNFTR WSVELARIEQ WCETYYPSFI AAASEGKPTD 

       430        440        450        460        470        480 
IRANALRSWS ESRRTQALIL KQAKLNGSDA STLDAKSVLE AAQNSALDPR DLMTEDERAA 

       490        500        510        520        530        540 
QDKRDRDQMV KFFLIILVGM VTFMGIVALI TWEIVWWWTM DTPDPLSVYV KHAYYLVKTQ 

       550        560        570 
GWSTVKEVLR TTRLSFEHVW KHGLTSPPKL EL 

« Hide

References

« Hide 'large scale' references
[1]"Squalene synthase in plant pathogenic fungi."
Corran A.J.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IMI 103761.
[2]"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. expand/collapse author list , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 521 / FGSC 9021.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99718 Genomic DNA. Translation: CAA68054.1.
AACP01000154 Genomic DNA. Translation: EAK85649.1.
RefSeqXP_760521.1. XM_755428.1.

3D structure databases

ProteinModelPortalQ92459.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM04374.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM04374T0; UM04374P0; UM04374.
GeneID3632482.
KEGGuma:UM04374.1.

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000186940.
KOK00801.
OMATDIAREM.
OrthoDBEOG7GJ6P5.

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_USTMA
AccessionPrimary (citable) accession number: Q92459
Secondary accession number(s): Q4P689
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways