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Protein

Squalene synthase

Gene

ERG9

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).By similarity

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Squalene synthase (ERG9)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processIsoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandMagnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene namesi
Name:ERG9
ORF Names:UMAG_04374
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 14, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_04374

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674521 – 572Squalene synthaseAdd BLAST572

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5270.UM04374P0

Structurei

3D structure databases

ProteinModelPortaliQ92459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000186940
InParanoidiQ92459
KOiK00801
OrthoDBiEOG092C2IU6

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR006449 Squal_synth-like
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR01559 squal_synth, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSYILLG FTHPSELRAM IGYKVWRDPL NDIKANPQAS GWDRQRMRDC
60 70 80 90 100
WGFLDLTSRS FAAVIKELKG ELSRVICLFY LVLRALDTVE DDMTIPAQRK
110 120 130 140 150
IPLLVNFYKY LEQPGWNFTE SGPNEKDRQL LVEFDKVIAE YQLLDVGYKT
160 170 180 190 200
VISDITAKMG AGMASYIELS AKGPLKVAMW KHFDLYCHFV AGLVGEGLSR
210 220 230 240 250
LFSESKLERP WLGHQLELSN HMGLFLQKTN IIRDYAEDCE EGRYFWPQQC
260 270 280 290 300
WGDDFAKFES QPDVAKGIIE IKPGHFRPAD NELGQRSMYV LSSMLLDAMS
310 320 330 340 350
HATHALDYLA LLKEQSVFNF CAIPQVMAIA TLELMFNNPD VFKKNVKIRK
360 370 380 390 400
GVAVGLILRA VNPRDVAYTF LHYSRKMHAR LSPADPNFTR WSVELARIEQ
410 420 430 440 450
WCETYYPSFI AAASEGKPTD IRANALRSWS ESRRTQALIL KQAKLNGSDA
460 470 480 490 500
STLDAKSVLE AAQNSALDPR DLMTEDERAA QDKRDRDQMV KFFLIILVGM
510 520 530 540 550
VTFMGIVALI TWEIVWWWTM DTPDPLSVYV KHAYYLVKTQ GWSTVKEVLR
560 570
TTRLSFEHVW KHGLTSPPKL EL
Length:572
Mass (Da):65,523
Last modified:December 12, 2006 - v2
Checksum:i26FA62E2CA677C10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71 – 72EL → DV in CAA68054 (Ref. 1) Curated2
Sequence conflicti428S → T in CAA68054 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99718 Genomic DNA Translation: CAA68054.1
CM003153 Genomic DNA Translation: KIS67272.1
RefSeqiXP_011391077.1, XM_011392775.1

Genome annotation databases

EnsemblFungiiKIS67272; KIS67272; UMAG_04374
GeneIDi23564576
KEGGiuma:UMAG_04374

Similar proteinsi

Entry informationi

Entry nameiFDFT_USTMA
AccessioniPrimary (citable) accession number: Q92459
Secondary accession number(s): A0A0D1BZY0, Q4P689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: April 25, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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