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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

sodB

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Manganese1
Metal bindingi77Manganese1
Metal bindingi163Manganese1
Metal bindingi167Manganese1

GO - Molecular functioni

  • IgE binding Source: AspGD
  • manganese ion binding Source: AspGD
  • superoxide dismutase activity Source: UniProtKB-EC

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Alternative name(s):
Allergen: Asp f 6
Gene namesi
Name:sodB
ORF Names:AFUA_1G14550
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu1g14550

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3124 Asp f 6.0101
76 Asp f 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000032881? – 210Superoxide dismutase [Mn], mitochondrial
Transit peptidei1 – ?MitochondrionBy similarity

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi5085.CADAFUBP00001380

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni14 – 20Combined sources7
Helixi23 – 31Combined sources9
Helixi33 – 53Combined sources21
Helixi57 – 82Combined sources26
Helixi87 – 89Combined sources3
Helixi94 – 96Combined sources3
Helixi98 – 108Combined sources11
Helixi111 – 124Combined sources14
Beta strandi127 – 137Combined sources11
Beta strandi142 – 148Combined sources7
Beta strandi155 – 163Combined sources9
Helixi166 – 168Combined sources3
Helixi170 – 173Combined sources4
Helixi177 – 184Combined sources8
Helixi185 – 187Combined sources3
Helixi190 – 199Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKCX-ray2.00A/B/X/Y1-210[»]
ProteinModelPortaliQ92450
SMRiQ92450
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92450

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000013583
InParanoidiQ92450
KOiK04564
OMAiYEGWKGE
OrthoDBiEOG092C4NQ6

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQYTLPPL PYPYDALQPY ISQQIMELHH KKHHQTYVNG LNAALEAQKK
60 70 80 90 100
AAEANDVPKL VSVQQAIKFN GGGHINHSLF WKNLAPEKSG GGKIDQAPVL
110 120 130 140 150
KAAIEQRWGS FDKFKDAFNT TLLGIQGSGW GWLVTDGPKG KLDITTTHDQ
160 170 180 190 200
DPVTGAAPVF GVDMWEHAYY LQYLNDKASY AKGIWNVINW AEAENRYIAG
210
DKGGHPFMKL
Length:210
Mass (Da):23,390
Last modified:December 6, 2005 - v3
Checksum:iCE701E7086E414FC
GO

Sequence cautioni

The sequence AAB60779 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55N → T in AAB60779 (PubMed:8691141).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53561 mRNA Translation: AAB60779.1 Different initiation.
AAHF01000004 Genomic DNA Translation: EAL90786.1
RefSeqiXP_752824.1, XM_747731.1

Genome annotation databases

EnsemblFungiiCADAFUAT00007458; CADAFUAP00007458; CADAFUAG00007458
GeneIDi3509846
KEGGiafm:AFUA_1G14550

Entry informationi

Entry nameiSODM_ASPFU
AccessioniPrimary (citable) accession number: Q92450
Secondary accession number(s): Q4WRZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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