Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn], mitochondrial

Gene

sodB

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Manganese1
Metal bindingi77Manganese1
Metal bindingi163Manganese1
Metal bindingi167Manganese1

GO - Molecular functioni

  • IgE binding Source: ASPGD
  • manganese ion binding Source: ASPGD
  • superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Alternative name(s):
Allergen: Asp f 6
Gene namesi
Name:sodB
ORF Names:AFUA_1G14550
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:Afu1g14550.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3124. Asp f 6.0101.
76. Asp f 6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000032881? – 210Superoxide dismutase [Mn], mitochondrial
Transit peptidei1 – ?MitochondrionBy similarity

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

  • IgE binding Source: ASPGD

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni14 – 20Combined sources7
Helixi23 – 31Combined sources9
Helixi33 – 53Combined sources21
Helixi57 – 82Combined sources26
Helixi87 – 89Combined sources3
Helixi94 – 96Combined sources3
Helixi98 – 108Combined sources11
Helixi111 – 124Combined sources14
Beta strandi127 – 137Combined sources11
Beta strandi142 – 148Combined sources7
Beta strandi155 – 163Combined sources9
Helixi166 – 168Combined sources3
Helixi170 – 173Combined sources4
Helixi177 – 184Combined sources8
Helixi185 – 187Combined sources3
Helixi190 – 199Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKCX-ray2.00A/B/X/Y1-210[»]
ProteinModelPortaliQ92450.
SMRiQ92450.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92450.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000013583.
InParanoidiQ92450.
KOiK04564.
OMAiKAAYVDN.
OrthoDBiEOG092C4NQ6.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQYTLPPL PYPYDALQPY ISQQIMELHH KKHHQTYVNG LNAALEAQKK
60 70 80 90 100
AAEANDVPKL VSVQQAIKFN GGGHINHSLF WKNLAPEKSG GGKIDQAPVL
110 120 130 140 150
KAAIEQRWGS FDKFKDAFNT TLLGIQGSGW GWLVTDGPKG KLDITTTHDQ
160 170 180 190 200
DPVTGAAPVF GVDMWEHAYY LQYLNDKASY AKGIWNVINW AEAENRYIAG
210
DKGGHPFMKL
Length:210
Mass (Da):23,390
Last modified:December 6, 2005 - v3
Checksum:iCE701E7086E414FC
GO

Sequence cautioni

The sequence AAB60779 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55N → T in AAB60779 (PubMed:8691141).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53561 mRNA. Translation: AAB60779.1. Different initiation.
AAHF01000004 Genomic DNA. Translation: EAL90786.1.
RefSeqiXP_752824.1. XM_747731.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00007458; CADAFUAP00007458; CADAFUAG00007458.
GeneIDi3509846.
KEGGiafm:AFUA_1G14550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53561 mRNA. Translation: AAB60779.1. Different initiation.
AAHF01000004 Genomic DNA. Translation: EAL90786.1.
RefSeqiXP_752824.1. XM_747731.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKCX-ray2.00A/B/X/Y1-210[»]
ProteinModelPortaliQ92450.
SMRiQ92450.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3124. Asp f 6.0101.
76. Asp f 6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00007458; CADAFUAP00007458; CADAFUAG00007458.
GeneIDi3509846.
KEGGiafm:AFUA_1G14550.

Organism-specific databases

EuPathDBiFungiDB:Afu1g14550.

Phylogenomic databases

HOGENOMiHOG000013583.
InParanoidiQ92450.
KOiK04564.
OMAiKAAYVDN.
OrthoDBiEOG092C4NQ6.

Miscellaneous databases

EvolutionaryTraceiQ92450.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_ASPFU
AccessioniPrimary (citable) accession number: Q92450
Secondary accession number(s): Q4WRZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.