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Protein

Plasma membrane ATPase

Gene

PCA1

Organism
Pneumocystis carinii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPaseUniRule annotation (EC:3.6.3.6UniRule annotation)
Gene namesi
Name:PCA1Imported
OrganismiPneumocystis cariniiImported
Taxonomic identifieri4754 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaPneumocystidomycetesPneumocystidaceaePneumocystis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei117 – 13620HelicalUniRule annotationAdd
BLAST
Transmembranei142 – 16120HelicalUniRule annotationAdd
BLAST
Transmembranei294 – 31522HelicalUniRule annotationAdd
BLAST
Transmembranei327 – 35529HelicalUniRule annotationAdd
BLAST
Transmembranei689 – 71325HelicalUniRule annotationAdd
BLAST
Transmembranei719 – 73921HelicalUniRule annotationAdd
BLAST
Transmembranei759 – 78022HelicalUniRule annotationAdd
BLAST
Transmembranei826 – 84924HelicalUniRule annotationAdd
BLAST
Transmembranei861 – 88525HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ92446.
SMRiQ92446. Positions 49-927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 14174Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]SAAS annotation
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEGKALIH ETVYYKHTST FEISETTKDL EKGGEEECLL DDEDNDIEAL
60 70 80 90 100
IDELESQGGD QEDNIEDTEF QSQRQVPEEL LATDTRIGLT SQEVVNRRKK
110 120 130 140 150
YGLNKMKEEK ENMIIKFLMY FVGPIQFVME AAAILAASLQ DWVDFGVICA
160 170 180 190 200
LLLLNAFVGF IQEFQAGSIV DELKKTLALK ATVLRDGRLI DIEAEEVVPG
210 220 230 240 250
DILQLEEGSI VPADGRIVTE EAYIQVDQSS ITGESLAVDK HKGDNIYSSS
260 270 280 290 300
VVKRGETFMV VTATGDGTFV GHAASLVNKA SCGTGHFTDV LNRIGTILLV
310 320 330 340 350
LVVFTLFVVY ISAFYRSSTT ITILKYTLAI TIIGVPVGLP AVVTTTMAVG
360 370 380 390 400
AAYLAKKKAI VQKLSAIESL AGVEILCSDK TGTLTKNDLS LAEPYTVEGI
410 420 430 440 450
SCDELMLTAC LAASRKKKGL DAIDKAFLKA LRNYPVVRSA ISKYNLVEFH
460 470 480 490 500
PFDPVSKKVT AIVESPSGER IACVKGAPLF VLRTVEEDQP VPEDIQNAYK
510 520 530 540 550
DKVAEFASRG YRSLGIARKT GNSNWEILGI MPCSDPPRCD TARTISEAIR
560 570 580 590 600
LGLRIKMLTG DAVGIAKETA RQLGMGTNVY NAERLGLGGG GDMPGSEVYD
610 620 630 640 650
FVEAADGFAE VFPQHKYNVV EILQQRGYLV AMTGDGVNDA PSLKKADTGI
660 670 680 690 700
AVEGASDAAR SAADIVFLAP GLSAIIDALK TSRQIFHRMY AYVVYRIALS
710 720 730 740 750
LHLEIFLGLW IVIFNHLMIL ELVVFIAIFA DIATLAIAYD NAPYSLLPTK
760 770 780 790 800
WNLPKLWGIS LLLGAALAIG SWIALTTIYI NDNTFGIVQG YGNVDAVMFL
810 820 830 840 850
EISLTENWLI FITRANGPFW SSLPSWQLFG AVFLVDVIAT IFCIFGWFTG
860 870 880 890 900
TKEHGLERTS IITVVRVWLF SLGVFCIMAG IYYLLSDSVA FDNIMHGKSV
910 920
KKNSKQRSLE DFVVALQRMS TKHEKGE
Length:927
Mass (Da):101,518
Last modified:February 1, 1997 - v1
Checksum:i372B0466540B278A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65004 Genomic DNA. Translation: AAB06958.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65004 Genomic DNA. Translation: AAB06958.1.

3D structure databases

ProteinModelPortaliQ92446.
SMRiQ92446. Positions 49-927.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "PCR amplification of DNA sequences from the transcription factor IID and cation transporting ATPase genes in Pneumocystis carinii."
    Meade J.C., Stringer J.R.
    J. Protozool. 38:66S-68S(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning and characterization of an ATPase gene from Pneumocystis carinii which closely resembles fungal H+ ATPases."
    Meade J.C., Stringer J.R.
    J. Eukaryot. Microbiol. 42:298-307(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Meade J.C., Stringer J.R.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ92446_PNECA
AccessioniPrimary (citable) accession number: Q92446
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.