Reviewed, UniProtKB/Swiss-Prot Q92442 (AGLU_MUCJA)

Names and origin

Protein names	Recommended name:     Alpha-glucosidase     EC=3.2.1.20 Alternative name(s):     Maltase
Organism	Mucor javanicus
Taxonomic identifier	51122 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Mucor

Protein attributes

Sequence length	864 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Hydrolyzes not only malto-oligosaccharides but also soluble starch.
Catalytic activity	Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 31 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alpha-glucosidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 864	842	Alpha-glucosidase		PRO_0000018580
Sites
	Active site	430	1	Nucleophile By similarity
	Active site	433	1	By similarity
	Active site	567	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Glycosylation	364	1	N-linked (GlcNAc...) Potential
	Glycosylation	406	1	N-linked (GlcNAc...) Potential
	Glycosylation	466	1	N-linked (GlcNAc...) Potential
	Glycosylation	500	1	N-linked (GlcNAc...) Potential
	Glycosylation	568	1	N-linked (GlcNAc...) Potential
	Glycosylation	734	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92442-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: CFAB4759DC431403	FASTA	864	98,761
	10 20 30 40 50 60 MAKVSFIFVA IALITGNVLC QTDATYAVSS SAPGYKIDGH VRKTEAGLHI PLTLNSRGNK 70 80 90 100 110 120 KTGIDTFGKT IKDITVDVEY ETEERLHVKI SDKAKKQYLV PDSPLGFERP QIKHYVSPKH 130 140 150 160 170 180 SNLDFQYTAK PFSFKVVRKD DKTTIFDTTN MPLVFEDQYL ELSTKVPEDA NIYGIGEVTA 190 200 210 220 230 240 PFRRTHNVTT LWARDNPDDF YRNIYGAHPY YQEVRDGKAH GALLMNAHGM DVITTEGRIT 250 260 270 280 290 300 YKVIGGILDF YFFAPKSGKP NDLSIAYTDL IGKPMMPSHW MLGWHHCRYG YPNIDKVETV 310 320 330 340 350 360 KRKYKEANIP LQTVWVDIDY MEETKDFTFD KVNFPQDRMI GLGEQLHKDG QNYVVMVDPA 370 380 390 400 410 420 ISANTTYEPY VRGTEMDVWI KNADGSDFIG SVWPGFTTFP DWWHPNATKY WNKEIIDFVD 430 440 450 460 470 480 MLGVDGLWID MNEPASFCLG SCGSGKVDAG NQPYRWTYTE EEQAANHTRW EKELKAMGNP 490 500 510 520 530 540 PGEERNLLYP KYAINNGAGN LSEFTVATTA LHYGNIPHYD IHNLYGHAES HITRQALIKH 550 560 570 580 590 600 KNKIRPFVLT RSSFPGSGKS VGHWTGDNHS FWPYLKNSIA NILNFQMFGV SYSGADVCGF 610 620 630 640 650 660 NSDTTEELCT RWMEIGAFYP FARNHNNNAA KDQEPYLWES TAEASRIAIN TRYEMLPYFY 670 680 690 700 710 720 TLFEESNRLG LGVWRPLIFE YPAYEELVSN DVQTLVGSDI LLSPVLDEGK TSVKAQFPGG 730 740 750 760 770 780 QWYDWYTHEL TVDNKSNKKV KTVTLDAPLT HIPIHIRGGA IIPTKTPKYT VGETFATPYN 790 800 810 820 830 840 LVIALDKKGQ ASGRLYIDDG ESLEVKSSSG YHFHLQEWSP QGFWQVWLQE GRKDWLHHHY 850 860 WQARQQVAKG SRWQEDYQID PWQE

References

[1]	"Molecular cloning, sequencing, and expression of a cDNA encoding alpha-glucosidase from Mucor javanicus." Sugimoto M., Suzuki Y. J. Biochem. 119:500-505(1996) [PubMed: 8830045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: IFO 4570 / NRRL 13035.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D67034 mRNA. Translation: BAA11053.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GH31. Glycoside Hydrolase Family 31.
Enzyme and pathway databases
BRENDA	3.2.1.20. 21384.
Family and domain databases
InterPro	IPR000322. Glyco_hydro_31. [Graphical view]
PANTHER	PTHR22762. Glyco_hydro_31. 1 hit.
Pfam	PF01055. Glyco_hydro_31. 1 hit. [Graphical view]
PROSITE	PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit. PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGLU_MUCJA

Accession

Primary (citable) accession number: Q92442

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	April 14, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)