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Protein

Multifunctional tryptophan biosynthesis protein

Gene

TRP1

Organism
Cochliobolus heterostrophus (Southern corn leaf blight fungus) (Bipolaris maydis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1, 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (TRP1)
  2. no protein annotated in this organism
  3. Multifunctional tryptophan biosynthesis protein (TRP1)
  4. Multifunctional tryptophan biosynthesis protein (TRP1)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103Nucleophile; for GATase activityBy similarity1
Active sitei199For GATase activityBy similarity1
Active sitei201For GATase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040
UPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiCochliobolus heterostrophus (Southern corn leaf blight fungus) (Bipolaris maydis)
Taxonomic identifieri5016 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568561 – 768Multifunctional tryptophan biosynthesis proteinAdd BLAST768

Proteomic databases

PRIDEiQ92411

Structurei

3D structure databases

ProteinModelPortaliQ92411
SMRiQ92411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 225Glutamine amidotransferase type-1Add BLAST201

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 78Glutamine bindingBy similarity3
Regioni153 – 154Glutamine bindingBy similarity2
Regioni256 – 520Indole-3-glycerol phosphate synthaseAdd BLAST265
Regioni535 – 768N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST234

Keywords - Domaini

Glutamine amidotransferase

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 3 hits
3.40.50.880, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR016302 Anthranilate_synth_II
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
IPR006221 TrpG/PapA_dom
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
PIRSFiPIRSF001382 TrpG-trpC-trpF, 1 hit
SUPFAMiSSF51366 SSF51366, 3 hits
SSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR00566 trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

Q92411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSTLIDHS PRNPNPSPPR ITASNVILID NYDSFTWNVY QYLVFEGAFV
60 70 80 90 100
TVYRNDEITL DELIAKKPTQ LVISQVPDTR KEDVALAIEP LRTSVAKSPF
110 120 130 140 150
SACAWESCIF YSYGGTVDVT GQILHGKTCP LKHDGKGVFA GVPQDVPVTR
160 170 180 190 200
YHSLAGTHGT LPDCLEISAT IPANADAEIK EVIMGVRHKE YVIEGVQFHP
210 220 230 240 250
ESILTEHGRL MMRNFLKMQG GTWAENERLQ KEAHAQAIGA AFSESAMVQR
260 270 280 290 300
TDSRTHLQKI YDHRRAAVAE QKKIPSNRPV DLQAAYDSNL APPQINFPER
310 320 330 340 350
LRQSPFKLSL MSEIKRASPS KGIISLSTCA PAQARLYAKA GARPISVLTE
360 370 380 390 400
PEWFKGSIED LRAVRQSIEG MANRPALLRK EFIFDEYQIL EGRLAGADTV
410 420 430 440 450
LVIVKMLETE LLERLLGLSD SVGMEPLVEV QNTDEMKIAV KLGAQVIGVN
460 470 480 490 500
NRNLVNFEVD IGTTNRLIQM VPKETILCAL SGIAGPKDVE AYIKDGVGAV
510 520 530 540 550
LVGEALMRAS DMSQFISELL GGPYKEVRAS SSSPIVKISG TRSEAAVAAV
560 570 580 590 600
EAGADLIGII LAPGLKRTVT AETALSISEA VHKTKKPNVS KSGLLADSKT
610 620 630 640 650
ASDFFDHGAS RLLETISRAL LVGVFRNQSL EYVLEQQRLL NLDVVQLHGQ
660 670 680 690 700
EPIEWAKLVP VPVLKAFNPQ DHGIGTRGYH ALPLLDAGSG GSGKQLGLSD
710 720 730 740 750
VKAAFTKDDG IKIILGRGLE PDNVQTTLAG LDEYRDRVYA VDVSSGVEED
760
GQQSLDKIRS FVKAAKSL
Length:768
Mass (Da):83,655
Last modified:February 1, 1997 - v1
Checksum:iB2F215AA304B8B00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70035 Genomic DNA Translation: CAA49629.1

Similar proteinsi

Entry informationi

Entry nameiTRPG_COCHE
AccessioniPrimary (citable) accession number: Q92411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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