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Q92411

- TRPG_COCHE

UniProt

Q92411 - TRPG_COCHE

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Protein

Multifunctional tryptophan biosynthesis protein

Gene
TRP1
Organism
Cochliobolus heterostrophus (Southern corn leaf blight fungus) (Bipolaris maydis)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei103 – 1031For GATase activity By similarity
Active sitei199 – 1991For GATase activity By similarity
Active sitei201 – 2011For GATase activity By similarity

GO - Molecular functioni

  1. anthranilate synthase activity Source: UniProtKB-EC
  2. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  3. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
  4. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiCochliobolus heterostrophus (Southern corn leaf blight fungus) (Bipolaris maydis)
Taxonomic identifieri5016 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 768768Multifunctional tryptophan biosynthesis proteinUniRule annotationPRO_0000056856Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92411.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 225201Glutamine amidotransferase type-1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 520265Indole-3-glycerol phosphate synthaseUniRule annotationAdd
BLAST
Regioni535 – 768234N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotationAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92411-1 [UniParc]FASTAAdd to Basket

« Hide

MPSSTLIDHS PRNPNPSPPR ITASNVILID NYDSFTWNVY QYLVFEGAFV    50
TVYRNDEITL DELIAKKPTQ LVISQVPDTR KEDVALAIEP LRTSVAKSPF 100
SACAWESCIF YSYGGTVDVT GQILHGKTCP LKHDGKGVFA GVPQDVPVTR 150
YHSLAGTHGT LPDCLEISAT IPANADAEIK EVIMGVRHKE YVIEGVQFHP 200
ESILTEHGRL MMRNFLKMQG GTWAENERLQ KEAHAQAIGA AFSESAMVQR 250
TDSRTHLQKI YDHRRAAVAE QKKIPSNRPV DLQAAYDSNL APPQINFPER 300
LRQSPFKLSL MSEIKRASPS KGIISLSTCA PAQARLYAKA GARPISVLTE 350
PEWFKGSIED LRAVRQSIEG MANRPALLRK EFIFDEYQIL EGRLAGADTV 400
LVIVKMLETE LLERLLGLSD SVGMEPLVEV QNTDEMKIAV KLGAQVIGVN 450
NRNLVNFEVD IGTTNRLIQM VPKETILCAL SGIAGPKDVE AYIKDGVGAV 500
LVGEALMRAS DMSQFISELL GGPYKEVRAS SSSPIVKISG TRSEAAVAAV 550
EAGADLIGII LAPGLKRTVT AETALSISEA VHKTKKPNVS KSGLLADSKT 600
ASDFFDHGAS RLLETISRAL LVGVFRNQSL EYVLEQQRLL NLDVVQLHGQ 650
EPIEWAKLVP VPVLKAFNPQ DHGIGTRGYH ALPLLDAGSG GSGKQLGLSD 700
VKAAFTKDDG IKIILGRGLE PDNVQTTLAG LDEYRDRVYA VDVSSGVEED 750
GQQSLDKIRS FVKAAKSL 768
Length:768
Mass (Da):83,655
Last modified:February 1, 1997 - v1
Checksum:iB2F215AA304B8B00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70035 Genomic DNA. Translation: CAA49629.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70035 Genomic DNA. Translation: CAA49629.1 .

3D structure databases

ProteinModelPortali Q92411.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
UPA00035 ; UER00042 .
UPA00035 ; UER00043 .

Family and domain databases

Gene3Di 3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMi SSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complementation of Cochliobolus heterostrophus trp-mutants produced by gene replacement."
    Mullin P.G., Turgeon B.G., Yoder O.C.
    Fungal Genet. Newsl. 40:51-53(1993)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 48330 / C3.

Entry informationi

Entry nameiTRPG_COCHE
AccessioniPrimary (citable) accession number: Q92411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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