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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: CGD
  2. trehalose-phosphatase activity Source: CGD

GO - Biological processi

  1. cellular response to heat Source: CGD
  2. cellular response to osmotic stress Source: CGD
  3. cellular response to oxidative stress Source: CGD
  4. cellular response to starvation Source: CGD
  5. dephosphorylation Source: GOC
  6. filamentous growth Source: CGD
  7. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  8. filamentous growth of a population of unicellular organisms in response to heat Source: CGD
  9. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  10. negative regulation of flocculation Source: CGD
  11. pathogenesis Source: CGD
  12. trehalose biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Stress response

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
ORF Names:CaO19.13961, CaO19.6640
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004028. TPS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000122496Add
BLAST

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi1229792. 1 interaction.
STRINGi5476.CAL0004028.

Structurei

3D structure databases

ProteinModelPortaliQ92410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

eggNOGiCOG0380.
InParanoidiQ92410.
KOiK00697.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQGKVLVVS NRIPVTIKRL DNGSYDYSMS SGGLVTALQG LKKTTEFQWY
60 70 80 90 100
GWPGLEIPED EQTKVNDELK SKFNCTAIFL SDTIADLHYN GFSNSILWPL
110 120 130 140 150
FHYHPGEMNF DENAWAAYIE ANKKFALEIV KQVNDDDMIW VHDYHLMLLP
160 170 180 190 200
EMLRQEIGNK KKNIKIGFFL HTPFPSSEIY RILPVRKEIL EGVLSCDLIG
210 220 230 240 250
FHTYDYARHF ISSVSRIVPN VSTLPNGIKY QGRSISIGAF PIGIDVDNFI
260 270 280 290 300
DGLKKDSVVE RIKQLKSKFK DVKVIVGVDR LDYIKGVPQK LHAFEVFLNE
310 320 330 340 350
NPEWIGKVVL VQVAVPSRGD VEEYQSLRST VSELVGRING EFGTVEFVPI
360 370 380 390 400
HYLHKSIPFD ELISLYNISD VCLVSSTRDG MNLVSYEYIA CQQDRKGVLI
410 420 430 440 450
LSEFAGAAQS LNGALIVNPW NTEDLSEAIK ESLTLPEEKR EFNFKKLFTY
460 470
ISKYTSGFWG ESFVKELYKC NPQKSLRD
Length:478
Mass (Da):54,457
Last modified:February 1, 1997 - v1
Checksum:i86CD64FB5AD7E86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07918 Genomic DNA. Translation: CAA69223.1.
AACQ01000186 Genomic DNA. Translation: EAK92484.1.
AACQ01000165 Genomic DNA. Translation: EAK92987.1.
RefSeqiXP_711706.1. XM_706614.1.
XP_712180.1. XM_707087.1.

Genome annotation databases

GeneIDi3646212.
3646699.
KEGGical:CaO19.13961.
cal:CaO19.6640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07918 Genomic DNA. Translation: CAA69223.1.
AACQ01000186 Genomic DNA. Translation: EAK92484.1.
AACQ01000165 Genomic DNA. Translation: EAK92987.1.
RefSeqiXP_711706.1. XM_706614.1.
XP_712180.1. XM_707087.1.

3D structure databases

ProteinModelPortaliQ92410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1229792. 1 interaction.
STRINGi5476.CAL0004028.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3646212.
3646699.
KEGGical:CaO19.13961.
cal:CaO19.6640.

Organism-specific databases

CGDiCAL0004028. TPS1.

Phylogenomic databases

eggNOGiCOG0380.
InParanoidiQ92410.
KOiK00697.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity."
    Zaragoza O., Blazquez M.A., Gancedo C.
    J. Bacteriol. 180:3809-3815(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTPS1_CANAL
AccessioniPrimary (citable) accession number: Q92410
Secondary accession number(s): Q59PS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.