Q92410 (TPS1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
EC=2.4.1.15

Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase

Gene names

Name:	TPS1
ORF Names:	CaO19.6640, CaO19.13961

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.
Induction	By heat shock.
Sequence similarities	Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
Biological process	Stress response
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular response to stress Inferred from mutant phenotype. Source: CGD hyphal growth Inferred from mutant phenotype Ref.1. Source: CGD pathogenesis Inferred from mutant phenotype Ref.1. Source: CGD trehalose biosynthetic process Inferred from mutant phenotype Ref.1. Source: CGD
Molecular function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from genetic interaction Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]		PRO_0000122496

Sequences

	Sequence		Length	Mass (Da)
	Q92410 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 86CD64FB5AD7E86F	FASTA	478	54,457
	10 20 30 40 50 60 MVQGKVLVVS NRIPVTIKRL DNGSYDYSMS SGGLVTALQG LKKTTEFQWY GWPGLEIPED 70 80 90 100 110 120 EQTKVNDELK SKFNCTAIFL SDTIADLHYN GFSNSILWPL FHYHPGEMNF DENAWAAYIE 130 140 150 160 170 180 ANKKFALEIV KQVNDDDMIW VHDYHLMLLP EMLRQEIGNK KKNIKIGFFL HTPFPSSEIY 190 200 210 220 230 240 RILPVRKEIL EGVLSCDLIG FHTYDYARHF ISSVSRIVPN VSTLPNGIKY QGRSISIGAF 250 260 270 280 290 300 PIGIDVDNFI DGLKKDSVVE RIKQLKSKFK DVKVIVGVDR LDYIKGVPQK LHAFEVFLNE 310 320 330 340 350 360 NPEWIGKVVL VQVAVPSRGD VEEYQSLRST VSELVGRING EFGTVEFVPI HYLHKSIPFD 370 380 390 400 410 420 ELISLYNISD VCLVSSTRDG MNLVSYEYIA CQQDRKGVLI LSEFAGAAQS LNGALIVNPW 430 440 450 460 470 NTEDLSEAIK ESLTLPEEKR EFNFKKLFTY ISKYTSGFWG ESFVKELYKC NPQKSLRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity." Zaragoza O., Blazquez M.A., Gancedo C. J. Bacteriol. 180:3809-3815(1998) [PubMed: 9683476] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y07918 Genomic DNA. Translation: CAA69223.1. AACQ01000186 Genomic DNA. Translation: EAK92484.1. AACQ01000165 Genomic DNA. Translation: EAK92987.1.
RefSeq	XP_711706.1. XM_706614.1. XP_712180.1. XM_707087.1.
3D structure databases
ProteinModelPortal	Q92410.
ModBase	Search...
Protein-protein interaction databases
STRING	Q92410.
Protein family/group databases
CAZy	GT20. Glycosyltransferase Family 20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646212. 3646699.
KEGG	cal:CaO19.13961. cal:CaO19.6640.
Organism-specific databases
CGD	CAL0004028. TPS1.
Phylogenomic databases
OMA	EYGRKEM.
PhylomeDB	Q92410.
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR012766. Trehalose_OtsA. [Graphical view]
KO	K00697.
Pfam	PF00982. Glyco_transf_20. 1 hit. [Graphical view]
TIGRFAMs	TIGR02400. Trehalose_OtsA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPS1_CANAL

Accession

Primary (citable) accession number: Q92410
Secondary accession number(s): Q59PS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program