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Q92410

- TPS1_CANAL

UniProt

Q92410 - TPS1_CANAL

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Protein
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Gene
TPS1, CaO19.13961, CaO19.6640
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: CGD
  2. trehalose-phosphatase activity Source: CGD

GO - Biological processi

  1. cellular response to heat Source: CGD
  2. cellular response to osmotic stress Source: CGD
  3. cellular response to oxidative stress Source: CGD
  4. cellular response to starvation Source: CGD
  5. dephosphorylation Source: GOC
  6. filamentous growth Source: CGD
  7. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  8. filamentous growth of a population of unicellular organisms in response to heat Source: CGD
  9. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  10. negative regulation of flocculation Source: CGD
  11. pathogenesis Source: CGD
  12. trehalose biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Stress response

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
ORF Names:CaO19.13961, CaO19.6640
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004028. TPS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000122496Add
BLAST

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi1229792. 1 interaction.
STRINGi5476.CAL0004028.

Structurei

3D structure databases

ProteinModelPortaliQ92410.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0380.
KOiK00697.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92410-1 [UniParc]FASTAAdd to Basket

« Hide

MVQGKVLVVS NRIPVTIKRL DNGSYDYSMS SGGLVTALQG LKKTTEFQWY    50
GWPGLEIPED EQTKVNDELK SKFNCTAIFL SDTIADLHYN GFSNSILWPL 100
FHYHPGEMNF DENAWAAYIE ANKKFALEIV KQVNDDDMIW VHDYHLMLLP 150
EMLRQEIGNK KKNIKIGFFL HTPFPSSEIY RILPVRKEIL EGVLSCDLIG 200
FHTYDYARHF ISSVSRIVPN VSTLPNGIKY QGRSISIGAF PIGIDVDNFI 250
DGLKKDSVVE RIKQLKSKFK DVKVIVGVDR LDYIKGVPQK LHAFEVFLNE 300
NPEWIGKVVL VQVAVPSRGD VEEYQSLRST VSELVGRING EFGTVEFVPI 350
HYLHKSIPFD ELISLYNISD VCLVSSTRDG MNLVSYEYIA CQQDRKGVLI 400
LSEFAGAAQS LNGALIVNPW NTEDLSEAIK ESLTLPEEKR EFNFKKLFTY 450
ISKYTSGFWG ESFVKELYKC NPQKSLRD 478
Length:478
Mass (Da):54,457
Last modified:February 1, 1997 - v1
Checksum:i86CD64FB5AD7E86F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07918 Genomic DNA. Translation: CAA69223.1.
AACQ01000186 Genomic DNA. Translation: EAK92484.1.
AACQ01000165 Genomic DNA. Translation: EAK92987.1.
RefSeqiXP_711706.1. XM_706614.1.
XP_712180.1. XM_707087.1.

Genome annotation databases

GeneIDi3646212.
3646699.
KEGGical:CaO19.13961.
cal:CaO19.6640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07918 Genomic DNA. Translation: CAA69223.1 .
AACQ01000186 Genomic DNA. Translation: EAK92484.1 .
AACQ01000165 Genomic DNA. Translation: EAK92987.1 .
RefSeqi XP_711706.1. XM_706614.1.
XP_712180.1. XM_707087.1.

3D structure databases

ProteinModelPortali Q92410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1229792. 1 interaction.
STRINGi 5476.CAL0004028.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646212.
3646699.
KEGGi cal:CaO19.13961.
cal:CaO19.6640.

Organism-specific databases

CGDi CAL0004028. TPS1.

Phylogenomic databases

eggNOGi COG0380.
KOi K00697.
OrthoDBi EOG76QFS6.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity."
    Zaragoza O., Blazquez M.A., Gancedo C.
    J. Bacteriol. 180:3809-3815(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTPS1_CANAL
AccessioniPrimary (citable) accession number: Q92410
Secondary accession number(s): Q59PS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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