Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

  • cellular response to heat Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to heat Source: CGD
  • pathogenesis Source: CGD
  • trehalose biosynthetic process Source: CGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processStress response

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
Ordered Locus Names:CAALFM_CR05720WA
ORF Names:CaO19.13961, CaO19.6640
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000182821. TPS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224961 – 478Alpha,alpha-trehalose-phosphate synthase [UDP-forming]Add BLAST478

Proteomic databases

PRIDEiQ92410.

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

BioGridi1229305. 1 interactor.

Structurei

Secondary structure

1478
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Beta strandi14 – 19Combined sources6
Beta strandi21 – 23Combined sources3
Beta strandi25 – 29Combined sources5
Helixi33 – 37Combined sources5
Helixi39 – 42Combined sources4
Beta strandi47 – 52Combined sources6
Helixi59 – 61Combined sources3
Helixi62 – 73Combined sources12
Beta strandi74 – 77Combined sources4
Helixi82 – 89Combined sources8
Helixi90 – 96Combined sources7
Helixi97 – 101Combined sources5
Helixi105 – 107Combined sources3
Helixi112 – 130Combined sources19
Beta strandi138 – 143Combined sources6
Helixi144 – 146Combined sources3
Helixi149 – 157Combined sources9
Beta strandi160 – 163Combined sources4
Beta strandi165 – 169Combined sources5
Helixi177 – 180Combined sources4
Helixi186 – 193Combined sources8
Beta strandi197 – 203Combined sources7
Helixi204 – 217Combined sources14
Beta strandi221 – 224Combined sources4
Beta strandi227 – 230Combined sources4
Beta strandi233 – 239Combined sources7
Helixi246 – 252Combined sources7
Helixi256 – 268Combined sources13
Turni269 – 271Combined sources3
Beta strandi272 – 281Combined sources10
Helixi283 – 285Combined sources3
Helixi287 – 300Combined sources14
Helixi302 – 304Combined sources3
Turni305 – 307Combined sources3
Beta strandi308 – 315Combined sources8
Helixi322 – 342Combined sources21
Beta strandi349 – 353Combined sources5
Helixi359 – 368Combined sources10
Beta strandi370 – 374Combined sources5
Beta strandi377 – 381Combined sources5
Helixi384 – 390Combined sources7
Turni393 – 395Combined sources3
Beta strandi398 – 402Combined sources5
Helixi406 – 409Combined sources4
Beta strandi414 – 417Combined sources4
Helixi422 – 434Combined sources13
Helixi437 – 453Combined sources17
Helixi456 – 469Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HUTX-ray1.90A/B1-478[»]
5HUUX-ray2.37A/B1-478[»]
5HUVX-ray2.00A/B1-478[»]
5HVLX-ray1.80A/B1-478[»]
ProteinModelPortaliQ92410.
SMRiQ92410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

InParanoidiQ92410.
KOiK00697.
OrthoDBiEOG092C0LDC.

Family and domain databases

CDDicd03788. GT1_TPS. 1 hit.
InterProiView protein in InterPro
IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
PfamiView protein in Pfam
PF00982. Glyco_transf_20. 1 hit.
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQGKVLVVS NRIPVTIKRL DNGSYDYSMS SGGLVTALQG LKKTTEFQWY
60 70 80 90 100
GWPGLEIPED EQTKVNDELK SKFNCTAIFL SDTIADLHYN GFSNSILWPL
110 120 130 140 150
FHYHPGEMNF DENAWAAYIE ANKKFALEIV KQVNDDDMIW VHDYHLMLLP
160 170 180 190 200
EMLRQEIGNK KKNIKIGFFL HTPFPSSEIY RILPVRKEIL EGVLSCDLIG
210 220 230 240 250
FHTYDYARHF ISSVSRIVPN VSTLPNGIKY QGRSISIGAF PIGIDVDNFI
260 270 280 290 300
DGLKKDSVVE RIKQLKSKFK DVKVIVGVDR LDYIKGVPQK LHAFEVFLNE
310 320 330 340 350
NPEWIGKVVL VQVAVPSRGD VEEYQSLRST VSELVGRING EFGTVEFVPI
360 370 380 390 400
HYLHKSIPFD ELISLYNISD VCLVSSTRDG MNLVSYEYIA CQQDRKGVLI
410 420 430 440 450
LSEFAGAAQS LNGALIVNPW NTEDLSEAIK ESLTLPEEKR EFNFKKLFTY
460 470
ISKYTSGFWG ESFVKELYKC NPQKSLRD
Length:478
Mass (Da):54,457
Last modified:February 1, 1997 - v1
Checksum:i86CD64FB5AD7E86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07918 Genomic DNA. Translation: CAA69223.1.
CP017630 Genomic DNA. Translation: AOW31288.1.
RefSeqiXP_711706.1. XM_706614.2.

Genome annotation databases

GeneIDi3646699.
KEGGical:CAALFM_CR05720WA.

Similar proteinsi

Entry informationi

Entry nameiTPS1_CANAL
AccessioniPrimary (citable) accession number: Q92410
Secondary accession number(s): A0A1D8PT23, Q59PS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families