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Q92410 (TPS1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene names
Name:TPS1
ORF Names:CaO19.13961, CaO19.6640
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Induction

By heat shock.

Sequence similarities

Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
   Biological processStress response
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to heat

Inferred from mutant phenotype PubMed 19231283Ref.1. Source: CGD

cellular response to osmotic stress

Inferred from mutant phenotype PubMed 6792910. Source: CGD

cellular response to oxidative stress

Inferred from mutant phenotype PubMed 19231283. Source: CGD

cellular response to starvation

Inferred from mutant phenotype PubMed 11988502. Source: CGD

dephosphorylation

Inferred from mutant phenotype PubMed 11895938. Source: GOC

filamentous growth

Inferred from mutant phenotype PubMed 11988502Ref.1. Source: CGD

filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype Ref.1. Source: CGD

filamentous growth of a population of unicellular organisms in response to heat

Inferred from mutant phenotype PubMed 10577485Ref.1. Source: CGD

filamentous growth of a population of unicellular organisms in response to starvation

Inferred from mutant phenotype PubMed 11988502. Source: CGD

negative regulation of flocculation

Inferred from mutant phenotype PubMed 11988502. Source: CGD

pathogenesis

Inferred from mutant phenotype PubMed 11988502PubMed 19231283Ref.1. Source: CGD

trehalose biosynthetic process

Inferred from mutant phenotype PubMed 10577485PubMed 11895938Ref.1. Source: CGD

   Molecular_functionalpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Inferred from genetic interaction Ref.1. Source: CGD

trehalose-phosphatase activity

Inferred from mutant phenotype PubMed 11895938. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000122496

Sequences

Sequence LengthMass (Da)Tools
Q92410 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 86CD64FB5AD7E86F

FASTA47854,457
        10         20         30         40         50         60 
MVQGKVLVVS NRIPVTIKRL DNGSYDYSMS SGGLVTALQG LKKTTEFQWY GWPGLEIPED 

        70         80         90        100        110        120 
EQTKVNDELK SKFNCTAIFL SDTIADLHYN GFSNSILWPL FHYHPGEMNF DENAWAAYIE 

       130        140        150        160        170        180 
ANKKFALEIV KQVNDDDMIW VHDYHLMLLP EMLRQEIGNK KKNIKIGFFL HTPFPSSEIY 

       190        200        210        220        230        240 
RILPVRKEIL EGVLSCDLIG FHTYDYARHF ISSVSRIVPN VSTLPNGIKY QGRSISIGAF 

       250        260        270        280        290        300 
PIGIDVDNFI DGLKKDSVVE RIKQLKSKFK DVKVIVGVDR LDYIKGVPQK LHAFEVFLNE 

       310        320        330        340        350        360 
NPEWIGKVVL VQVAVPSRGD VEEYQSLRST VSELVGRING EFGTVEFVPI HYLHKSIPFD 

       370        380        390        400        410        420 
ELISLYNISD VCLVSSTRDG MNLVSYEYIA CQQDRKGVLI LSEFAGAAQS LNGALIVNPW 

       430        440        450        460        470 
NTEDLSEAIK ESLTLPEEKR EFNFKKLFTY ISKYTSGFWG ESFVKELYKC NPQKSLRD 

« Hide

References

« Hide 'large scale' references
[1]"Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity."
Zaragoza O., Blazquez M.A., Gancedo C.
J. Bacteriol. 180:3809-3815(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07918 Genomic DNA. Translation: CAA69223.1.
AACQ01000186 Genomic DNA. Translation: EAK92484.1.
AACQ01000165 Genomic DNA. Translation: EAK92987.1.
RefSeqXP_711706.1. XM_706614.1.
XP_712180.1. XM_707087.1.

3D structure databases

ProteinModelPortalQ92410.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1229792. 1 interaction.
STRING5476.CAL0004028.

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646212.
3646699.
KEGGcal:CaO19.13961.
cal:CaO19.6640.

Organism-specific databases

CGDCAL0004028. TPS1.

Phylogenomic databases

eggNOGCOG0380.
KOK00697.
OrthoDBEOG76QFS6.

Family and domain databases

InterProIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsTIGR02400. trehalose_OtsA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPS1_CANAL
AccessionPrimary (citable) accession number: Q92410
Secondary accession number(s): Q59PS4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names