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Q92410

- TPS1_CANAL

UniProt

Q92410 - TPS1_CANAL

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: CGD
    2. trehalose-phosphatase activity Source: CGD

    GO - Biological processi

    1. cellular response to heat Source: CGD
    2. cellular response to osmotic stress Source: CGD
    3. cellular response to oxidative stress Source: CGD
    4. cellular response to starvation Source: CGD
    5. dephosphorylation Source: GOC
    6. filamentous growth Source: CGD
    7. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    8. filamentous growth of a population of unicellular organisms in response to heat Source: CGD
    9. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    10. negative regulation of flocculation Source: CGD
    11. pathogenesis Source: CGD
    12. trehalose biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Stress response

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase
    UDP-glucose-glucosephosphate glucosyltransferase
    Gene namesi
    Name:TPS1
    ORF Names:CaO19.13961, CaO19.6640
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004028. TPS1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000122496Add
    BLAST

    Expressioni

    Inductioni

    By heat shock.

    Interactioni

    Protein-protein interaction databases

    BioGridi1229792. 1 interaction.
    STRINGi5476.CAL0004028.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 20 family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    KOiK00697.
    OrthoDBiEOG76QFS6.

    Family and domain databases

    InterProiIPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQGKVLVVS NRIPVTIKRL DNGSYDYSMS SGGLVTALQG LKKTTEFQWY    50
    GWPGLEIPED EQTKVNDELK SKFNCTAIFL SDTIADLHYN GFSNSILWPL 100
    FHYHPGEMNF DENAWAAYIE ANKKFALEIV KQVNDDDMIW VHDYHLMLLP 150
    EMLRQEIGNK KKNIKIGFFL HTPFPSSEIY RILPVRKEIL EGVLSCDLIG 200
    FHTYDYARHF ISSVSRIVPN VSTLPNGIKY QGRSISIGAF PIGIDVDNFI 250
    DGLKKDSVVE RIKQLKSKFK DVKVIVGVDR LDYIKGVPQK LHAFEVFLNE 300
    NPEWIGKVVL VQVAVPSRGD VEEYQSLRST VSELVGRING EFGTVEFVPI 350
    HYLHKSIPFD ELISLYNISD VCLVSSTRDG MNLVSYEYIA CQQDRKGVLI 400
    LSEFAGAAQS LNGALIVNPW NTEDLSEAIK ESLTLPEEKR EFNFKKLFTY 450
    ISKYTSGFWG ESFVKELYKC NPQKSLRD 478
    Length:478
    Mass (Da):54,457
    Last modified:February 1, 1997 - v1
    Checksum:i86CD64FB5AD7E86F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07918 Genomic DNA. Translation: CAA69223.1.
    AACQ01000186 Genomic DNA. Translation: EAK92484.1.
    AACQ01000165 Genomic DNA. Translation: EAK92987.1.
    RefSeqiXP_711706.1. XM_706614.1.
    XP_712180.1. XM_707087.1.

    Genome annotation databases

    GeneIDi3646212.
    3646699.
    KEGGical:CaO19.13961.
    cal:CaO19.6640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07918 Genomic DNA. Translation: CAA69223.1 .
    AACQ01000186 Genomic DNA. Translation: EAK92484.1 .
    AACQ01000165 Genomic DNA. Translation: EAK92987.1 .
    RefSeqi XP_711706.1. XM_706614.1.
    XP_712180.1. XM_707087.1.

    3D structure databases

    ProteinModelPortali Q92410.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1229792. 1 interaction.
    STRINGi 5476.CAL0004028.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646212.
    3646699.
    KEGGi cal:CaO19.13961.
    cal:CaO19.6640.

    Organism-specific databases

    CGDi CAL0004028. TPS1.

    Phylogenomic databases

    eggNOGi COG0380.
    KOi K00697.
    OrthoDBi EOG76QFS6.

    Family and domain databases

    InterProi IPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity."
      Zaragoza O., Blazquez M.A., Gancedo C.
      J. Bacteriol. 180:3809-3815(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiTPS1_CANAL
    AccessioniPrimary (citable) accession number: Q92410
    Secondary accession number(s): Q59PS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3