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Q92407

- HXKG_ASPNG

UniProt

Q92407 - HXKG_ASPNG

Protein

Glucokinase

Gene

glkA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    • Comment

    Functioni

    The enzyme has great affinity for glucose. Mannose, 2-deoxyglucose and glucosamine can serve as substrates.

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    pH dependencei

    Activity is relatively constant from pH 7.5 to 9.0. Below pH 7.5, activity decreases with pH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei93 – 931ATPSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi472 – 4776ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glucokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Short name:
    GLK
    Gene namesi
    Name:glkA
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495GlucokinasePRO_0000197611Add
    BLAST

    Proteomic databases

    PRIDEiQ92407.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ92407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 220213Hexokinase type-1Add
    BLAST
    Domaini226 – 487262Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni149 – 17527Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Phylogenomic databases

    eggNOGiCOG5026.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92407-1 [UniParc]FASTAAdd to Basket

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    MSSALLDEAA RIARQFDYPA AEVQRGVTEY IREIDEGLSK EHTTLSQIPT    50
    YVTAVPNGTE KGLYLAVDLG GTNFRVCSID LHGDTTFSLT QSKIMIPRET 100
    MASGTAKDLF LFLARQIESF LRIHHNDHFE AHLRRRNEKN GNCEEDLFDL 150
    GFTFSFPVRQ LGINKGTLIR WTKGFNIPDA VGKDVCALLQ NAIDDLGLPV 200
    RVAALVNDTV GTLMARSYTS PGETGTFLGA IFGTGTNGAY VEKLDRITKL 250
    QTIEHSEYDK TTGEMIINAE WGSFDNHLSV LPNTIYDQQL DADSNNPGIQ 300
    MFEKRVSGMF LGEILRRVML DMQRNESLGF LRAGGASTVS VPQESSLYRQ 350
    WGIDTSLLSL VEADKTENME QIKVALKDHL KIERPTTDDC KAIQTVVHAI 400
    GKRAARLSAV PLAAILLSTG KLQKDDLVDI GVDGSLVEFY PNFEGYMRDA 450
    LREVPEVGEA GNKKIRIGIS KDGSGVGAAL IALVASKEET RRKSQ 495
    Length:495
    Mass (Da):54,537
    Last modified:February 1, 1997 - v1
    Checksum:i02C94EF07D1809F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99626 Genomic DNA. Translation: CAA67949.1.
    PIRiS74210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99626 Genomic DNA. Translation: CAA67949.1 .
    PIRi S74210.

    3D structure databases

    ProteinModelPortali Q92407.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q92407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5026.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and biochemical characterisation of an Aspergillus niger glucokinase. Evidence for the presence of separate glucokinase and hexokinase enzymes."
      Panneman H., Ruijter G.J.G., van den Broeck H.C., Driever E.T.M., Visser J.
      Eur. J. Biochem. 240:518-525(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

    Entry informationi

    Entry nameiHXKG_ASPNG
    AccessioniPrimary (citable) accession number: Q92407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3