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Q92406 (NDUV1_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-51kD
Short name=CI-51kD
Gene names
Name:NUO51
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 FMN Potential.

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion By similarity
Chain31 – 496466NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial
PRO_0000019979

Regions

Nucleotide binding98 – 10710NAD By similarity
Nucleotide binding214 – 26148FMN By similarity

Sites

Metal binding3931Iron-sulfur (4Fe-4S) Potential
Metal binding3961Iron-sulfur (4Fe-4S) Potential
Metal binding3991Iron-sulfur (4Fe-4S) Potential
Metal binding4391Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q92406 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: DE64F00A8E32B42A

FASTA49654,452
        10         20         30         40         50         60 
MISRAAAPSS SIASLSSRSL RAQAPAARSF ATVQDNAPPV KHYGGLKDQD RIFTNLYGHH 

        70         80         90        100        110        120 
GADLKSAMKY GDWHRTKDIV LKGHDWLISE LKASGLRGRG GAGFPSGLKY SFMNFKDWDK 

       130        140        150        160        170        180 
DPRPRYLVVN ADEGEPGTCK DREIMRKDPQ KLIEGCLVVG RAMNANAAYM YIRGEFYQEA 

       190        200        210        220        230        240 
TVLQRAINEA YEAGLIGKNA CGTGYDFDVY IHRGMGAYVC GEETSLIESI EGKAGKPRLK 

       250        260        270        280        290        300 
PPFPAAVGLF GCPSTVTNVE TVAVTPTIMR RGASWFSSFG RERNAGTKLF CISGHVNNPC 

       310        320        330        340        350        360 
TVEEEMSISL RDVIDRHCGG VRGGWDNLLA VIPGGSSTPV LPKTICDDQL MDFDALKDSQ 

       370        380        390        400        410        420 
SGLGTAAVIV MDKSTDIVRA ISRLSTFYKH ESCGQCTPCR EGSKWTMHMM QRMEKGQARE 

       430        440        450        460        470        480 
REIDMLQELT KQVEGHTICA LGEAFAWPIQ GLIRHFRPEL EARIREYSKE VGGNGPYAGG 

       490 
WHPEARAEGK LISPGM 

« Hide

References

[1]"The role of the proton-pumping and alternative respiratory chain NADH:ubiquinone oxidoreductases in overflow catabolism of Aspergillus niger."
Proemper C., Schneider R., Weiss H.
Eur. J. Biochem. 216:223-230(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FGSC 732.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64402 Genomic DNA. Translation: CAA45744.1.

3D structure databases

ProteinModelPortalQ92406.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1894.

Family and domain databases

InterProIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsTIGR01959. nuoF_fam. 1 hit.
PROSITEPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUV1_ASPNG
AccessionPrimary (citable) accession number: Q92406
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 13, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families