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Protein

NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial

Gene

NUO51

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Protein has several cofactor binding sites:
  • FMNCuratedNote: Binds 1 FMN.Curated
  • [4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi393Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi396Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi399Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi439Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 107NADBy similarity10
Nucleotide bindingi214 – 261FMNBy similarityAdd BLAST48

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-51kD
Short name:
CI-51kD
Gene namesi
Name:NUO51
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000001997931 – 496NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrialAdd BLAST466

Proteomic databases

PaxDbiQ92406.

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

STRINGi5061.CADANGAP00004183.

Structurei

3D structure databases

ProteinModelPortaliQ92406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2658. Eukaryota.
COG1894. LUCA.

Family and domain databases

InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. Nuo51_FMN-bd.
IPR019575. Nuop51_4Fe4S-bd.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamiPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTiSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRAAAPSS SIASLSSRSL RAQAPAARSF ATVQDNAPPV KHYGGLKDQD
60 70 80 90 100
RIFTNLYGHH GADLKSAMKY GDWHRTKDIV LKGHDWLISE LKASGLRGRG
110 120 130 140 150
GAGFPSGLKY SFMNFKDWDK DPRPRYLVVN ADEGEPGTCK DREIMRKDPQ
160 170 180 190 200
KLIEGCLVVG RAMNANAAYM YIRGEFYQEA TVLQRAINEA YEAGLIGKNA
210 220 230 240 250
CGTGYDFDVY IHRGMGAYVC GEETSLIESI EGKAGKPRLK PPFPAAVGLF
260 270 280 290 300
GCPSTVTNVE TVAVTPTIMR RGASWFSSFG RERNAGTKLF CISGHVNNPC
310 320 330 340 350
TVEEEMSISL RDVIDRHCGG VRGGWDNLLA VIPGGSSTPV LPKTICDDQL
360 370 380 390 400
MDFDALKDSQ SGLGTAAVIV MDKSTDIVRA ISRLSTFYKH ESCGQCTPCR
410 420 430 440 450
EGSKWTMHMM QRMEKGQARE REIDMLQELT KQVEGHTICA LGEAFAWPIQ
460 470 480 490
GLIRHFRPEL EARIREYSKE VGGNGPYAGG WHPEARAEGK LISPGM
Length:496
Mass (Da):54,452
Last modified:February 1, 1997 - v1
Checksum:iDE64F00A8E32B42A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64402 Genomic DNA. Translation: CAA45744.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64402 Genomic DNA. Translation: CAA45744.1.

3D structure databases

ProteinModelPortaliQ92406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00004183.

Proteomic databases

PaxDbiQ92406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2658. Eukaryota.
COG1894. LUCA.

Family and domain databases

InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. Nuo51_FMN-bd.
IPR019575. Nuop51_4Fe4S-bd.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamiPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTiSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUV1_ASPNG
AccessioniPrimary (citable) accession number: Q92406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: December 9, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.