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Protein

Fer3-like protein

Gene

Ferd3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell development Source: MGI
  • floor plate development Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of neurogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fer3-like protein
Alternative name(s):
Basic helix-loop-helix protein N-twist
Nephew of atonal 3
Neuronal twist
Gene namesi
Name:Ferd3l
Synonyms:Nato, Ntwist
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2150010. Ferd3l.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Fer3-like proteinPRO_0000328683Add
BLAST

Proteomic databases

PaxDbiQ923Z4.
PRIDEiQ923Z4.

PTM databases

iPTMnetiQ923Z4.
PhosphoSiteiQ923Z4.

Expressioni

Tissue specificityi

Detected in the developing central nervous system, in particular in embryonic ventral neural tube, brain, and spinal cord. Detected in embryonic intestine. Detected in embryonic and adult thalamus, hypothalamus, midbrain, pons and medulla.2 Publications

Gene expression databases

BgeeiENSMUSG00000046518.
GenevisibleiQ923Z4. MM.

Interactioni

Subunit structurei

Heterodimer with TCF3/E12. Interacts with the bHLH domain of TCF3/E12.1 Publication

Protein-protein interaction databases

BioGridi227826. 1 interaction.
STRINGi10090.ENSMUSP00000058994.

Structurei

3D structure databases

ProteinModelPortaliQ923Z4.
SMRiQ923Z4. Positions 103-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 15553bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 828Poly-Glu

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00730000110958.
HOGENOMiHOG000046685.
HOVERGENiHBG094853.
InParanoidiQ923Z4.
OMAiRHPLLCD.
OrthoDBiEOG091G0YNB.
PhylomeDBiQ923Z4.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYPESCLD ATVLNFVADL SLASPRHPLL CEFPPGVPFG DRTLGYREGR
60 70 80 90 100
PGRLSQFDER YQEVEGDEVE YEDPEEEEEE GEGRGRVASL LGRPKRKRVI
110 120 130 140 150
TYAQRQAANI RERKRMFNLN EAFDQLRRKV PTFAYEKRLS RIETLRLAIV
160
YISFMTELLQ SKEEKEAS
Length:168
Mass (Da):19,463
Last modified:December 1, 2001 - v1
Checksum:i960BA60C19E7237B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369896 Genomic DNA. Translation: AAK72955.1.
AF517121 mRNA. Translation: AAN04085.1.
BC111576 mRNA. Translation: AAI11577.1.
CCDSiCCDS25878.1.
RefSeqiNP_277057.1. NM_033522.2.
UniGeneiMm.204643.

Genome annotation databases

EnsembliENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518.
GeneIDi114712.
KEGGimmu:114712.
UCSCiuc007niv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369896 Genomic DNA. Translation: AAK72955.1.
AF517121 mRNA. Translation: AAN04085.1.
BC111576 mRNA. Translation: AAI11577.1.
CCDSiCCDS25878.1.
RefSeqiNP_277057.1. NM_033522.2.
UniGeneiMm.204643.

3D structure databases

ProteinModelPortaliQ923Z4.
SMRiQ923Z4. Positions 103-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227826. 1 interaction.
STRINGi10090.ENSMUSP00000058994.

PTM databases

iPTMnetiQ923Z4.
PhosphoSiteiQ923Z4.

Proteomic databases

PaxDbiQ923Z4.
PRIDEiQ923Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518.
GeneIDi114712.
KEGGimmu:114712.
UCSCiuc007niv.1. mouse.

Organism-specific databases

CTDi222894.
MGIiMGI:2150010. Ferd3l.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00730000110958.
HOGENOMiHOG000046685.
HOVERGENiHBG094853.
InParanoidiQ923Z4.
OMAiRHPLLCD.
OrthoDBiEOG091G0YNB.
PhylomeDBiQ923Z4.

Miscellaneous databases

PROiQ923Z4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046518.
GenevisibleiQ923Z4. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFER3L_MOUSE
AccessioniPrimary (citable) accession number: Q923Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.