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Protein

G-protein coupled receptor family C group 5 member B

Gene

Gprc5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • glucose homeostasis Source: MGI
  • locomotory behavior Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of inflammatory response Source: UniProtKB
  • positive regulation of macrophage cytokine production Source: UniProtKB
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of neuron projection development Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of protein tyrosine kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member B
Alternative name(s):
Retinoic acid-induced gene 2 protein
Short name:
RAIG-2
Gene namesi
Name:Gprc5b
Synonyms:Raig2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1927596. Gprc5b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 56ExtracellularSequence analysisAdd BLAST28
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 94CytoplasmicSequence analysisAdd BLAST17
Transmembranei95 – 115Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini116 – 126ExtracellularSequence analysisAdd BLAST11
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 164CytoplasmicSequence analysisAdd BLAST17
Transmembranei165 – 185Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini186 – 199ExtracellularSequence analysisAdd BLAST14
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 234CytoplasmicSequence analysisAdd BLAST14
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 271ExtracellularSequence analysisAdd BLAST16
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 410CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: MGI
  • membrane raft Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001296629 – 410G-protein coupled receptor family C group 5 member BAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ923Z0.
PaxDbiQ923Z0.
PeptideAtlasiQ923Z0.
PRIDEiQ923Z0.

PTM databases

iPTMnetiQ923Z0.
PhosphoSitePlusiQ923Z0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008734.
ExpressionAtlasiQ923Z0. baseline and differential.
GenevisibleiQ923Z0. MM.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008878.

Structurei

3D structure databases

ProteinModelPortaliQ923Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE42. Eukaryota.
ENOG410Y0Z8. LUCA.
GeneTreeiENSGT00520000055551.
HOVERGENiHBG051794.
InParanoidiQ923Z0.
KOiK04619.
OrthoDBiEOG091G0DAG.
PhylomeDBiQ923Z0.
TreeFamiTF321410.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q923Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLVLERKMR THQVFPLPLL LVIASVASEN ASTSRGCGLD LLPQYVSLCD
60 70 80 90 100
LDAIWGIVVE AVAGAGALIT LLLMLILLVR LPFIKDKERK RPVCLHFLFL
110 120 130 140 150
LGTLGLFGLT FAFIIQMDET ICSIRRFLWG VLFALCFSCL LSQAWRVRRL
160 170 180 190 200
VRQGTSPASW QLVSLALCLM LVQVIIATEW LVLTVLRDTK PACAYEPMDF
210 220 230 240 250
VMALIYDMVL LAITLAQSLF TLCGKFKRWK VNGAFILVTT FLSALIWVVW
260 270 280 290 300
MTMYLFGNSL IKQGDAWSDP TLAITLAASG WVFVIFHAIP EIHYTLLPPL
310 320 330 340 350
QENPPNYFDT SQPRMRETAF DEEMHLPRAY MENKAFSMDE HNAALRSAVG
360 370 380 390 400
FSNGSLEQRS SSLGKKPSSL GNRPSAPFRS NVYQPTEMAV VLNGGTIPTA
410
PPSHTGRHHW
Length:410
Mass (Da):45,899
Last modified:December 1, 2001 - v1
Checksum:iE1DA5283270FFF34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118D → G in BAC27669 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378831 mRNA. Translation: AAK58076.1.
AK032047 mRNA. Translation: BAC27669.1.
BC020004 mRNA. Translation: AAH20004.1.
CCDSiCCDS21777.1.
RefSeqiNP_071865.1. NM_022420.2.
UniGeneiMm.103439.

Genome annotation databases

EnsembliENSMUST00000008878; ENSMUSP00000008878; ENSMUSG00000008734.
GeneIDi64297.
KEGGimmu:64297.
UCSCiuc009jkx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378831 mRNA. Translation: AAK58076.1.
AK032047 mRNA. Translation: BAC27669.1.
BC020004 mRNA. Translation: AAH20004.1.
CCDSiCCDS21777.1.
RefSeqiNP_071865.1. NM_022420.2.
UniGeneiMm.103439.

3D structure databases

ProteinModelPortaliQ923Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008878.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ923Z0.
PhosphoSitePlusiQ923Z0.

Proteomic databases

MaxQBiQ923Z0.
PaxDbiQ923Z0.
PeptideAtlasiQ923Z0.
PRIDEiQ923Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008878; ENSMUSP00000008878; ENSMUSG00000008734.
GeneIDi64297.
KEGGimmu:64297.
UCSCiuc009jkx.2. mouse.

Organism-specific databases

CTDi51704.
MGIiMGI:1927596. Gprc5b.

Phylogenomic databases

eggNOGiENOG410IE42. Eukaryota.
ENOG410Y0Z8. LUCA.
GeneTreeiENSGT00520000055551.
HOVERGENiHBG051794.
InParanoidiQ923Z0.
KOiK04619.
OrthoDBiEOG091G0DAG.
PhylomeDBiQ923Z0.
TreeFamiTF321410.

Miscellaneous databases

PROiQ923Z0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008734.
ExpressionAtlasiQ923Z0. baseline and differential.
GenevisibleiQ923Z0. MM.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC5B_MOUSE
AccessioniPrimary (citable) accession number: Q923Z0
Secondary accession number(s): Q8CCV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.