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Protein

Trace amine-associated receptor 1

Gene

Taar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 1
Short name:
TaR-1
Short name:
Trace amine receptor 1
Gene namesi
Name:Taar1
Synonyms:Ta1, Tar1, Trar1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621621. Taar1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 58CytoplasmicSequence analysisAdd BLAST13
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 97ExtracellularSequence analysisAdd BLAST18
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 187ExtracellularSequence analysisAdd BLAST28
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 249CytoplasmicSequence analysisAdd BLAST41
Transmembranei250 – 270Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini271 – 287ExtracellularSequence analysisAdd BLAST17
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 332CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3833.
GuidetoPHARMACOLOGYi364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701451 – 332Trace amine-associated receptor 1Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 181PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923Y9.
PRIDEiQ923Y9.

PTM databases

PhosphoSitePlusiQ923Y9.

Expressioni

Tissue specificityi

Widely distributed, but in low abundance, throughout the brain. Highest levels detected in the olfactory bulb, nucleus accumbens/olfactory tubercle, prefrontal cortex and other cortical regions, midbrain regions consisting of substantia nigra and ventral tegmentum, cerebellum, and pons/medulla. Among peripheral tissues, highest level observed in the liver, less expression in kidney, gastrointestinal tract, spleen, pancreas, and heart.

Gene expression databases

BgeeiENSRNOG00000016073.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021510.

Chemistry databases

BindingDBiQ923Y9.

Structurei

3D structure databases

ProteinModelPortaliQ923Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y9.
KOiK05051.
PhylomeDBiQ923Y9.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLCHNSANI SHTNSNWSRD VRASLYSLIS LIILTTLVGN LIVIISISHF
60 70 80 90 100
KQLHTPTNWL LHSMAVVDFL LGCLVMPYSM VRTVEHCWYF GELFCKLHTS
110 120 130 140 150
TDIMLSSASI LHLAFISIDR YYAVCDPLRY KAKINLAAIF VMILISWSLP
160 170 180 190 200
AVFAFGMIFL ELNLEGVEEL YHNQVFCLRG CFPFFSKVSG VLAFMTSFYI
210 220 230 240 250
PGSVMLFVYY RIYFIAKGQA RSINRANLQV GLEGESRAPQ SKETKAAKTL
260 270 280 290 300
GIMVGVFLLC WCPFFFCMVL DPFLGYVIPP TLNDTLNWFG YLNSAFNPMV
310 320 330
YAFFYPWFRR ALKMVLFGKI FQKDSSRSKL FL
Length:332
Mass (Da):38,021
Last modified:December 1, 2001 - v1
Checksum:iAD7F3A728C77B246
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti170L → Q.2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380186 Genomic DNA. Translation: AAK71237.1.
AF421352 mRNA. Translation: AAL65137.1.
AY702315 Genomic DNA. Translation: AAV70127.1.
RefSeqiNP_599155.1. NM_134328.1.
UniGeneiRn.81209.

Genome annotation databases

GeneIDi113914.
KEGGirno:113914.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380186 Genomic DNA. Translation: AAK71237.1.
AF421352 mRNA. Translation: AAL65137.1.
AY702315 Genomic DNA. Translation: AAV70127.1.
RefSeqiNP_599155.1. NM_134328.1.
UniGeneiRn.81209.

3D structure databases

ProteinModelPortaliQ923Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021510.

Chemistry databases

BindingDBiQ923Y9.
ChEMBLiCHEMBL3833.
GuidetoPHARMACOLOGYi364.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ923Y9.

Proteomic databases

PaxDbiQ923Y9.
PRIDEiQ923Y9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113914.
KEGGirno:113914.

Organism-specific databases

CTDi134864.
RGDi621621. Taar1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y9.
KOiK05051.
PhylomeDBiQ923Y9.
TreeFamiTF343107.

Miscellaneous databases

PROiQ923Y9.

Gene expression databases

BgeeiENSRNOG00000016073.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR1_RAT
AccessioniPrimary (citable) accession number: Q923Y9
Secondary accession number(s): Q5QD26, Q8VHQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.