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Protein

Trace amine-associated receptor 1

Gene

Taar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

GO - Molecular functioni

  • G-protein coupled amine receptor activity Source: MGI
  • trace-amine receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375280. Amine ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 1
Short name:
TaR-1
Short name:
Trace amine receptor 1
Gene namesi
Name:Taar1
Synonyms:Ta1, Tar1, Trar1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2148258. Taar1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 58CytoplasmicSequence analysisAdd BLAST13
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 97ExtracellularSequence analysisAdd BLAST18
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 187ExtracellularSequence analysisAdd BLAST28
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 249CytoplasmicSequence analysisAdd BLAST41
Transmembranei250 – 270Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini271 – 287ExtracellularSequence analysisAdd BLAST17
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 332CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4908.
GuidetoPHARMACOLOGYi364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701431 – 332Trace amine-associated receptor 1Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923Y8.
PRIDEiQ923Y8.

PTM databases

PhosphoSitePlusiQ923Y8.

Expressioni

Tissue specificityi

Widely distributed throughout the brain. Strongly expressed in the mitral cell layer of the olfactory bulb, piriform cortex, the arcuate, motor, and mesencephalic trigeminal nuclei, lateral reticular and hypoglossal nuclei, cerebellar Purkinje cells, and ventral horn of the spinal cord. Moderately expressed in the frontal, entorhinal, and agranular cortices, the ventral pallidum, thalamus, hippocampus, several hypothalamic nuclei, ambiguus, dorsal raphe, and gigantocellular reticular nuclei. Weakly expressed in the septum, basal ganglia, amygdala, myelencephalon, and spinal cord dorsal horn. Particularly interesting is the moderate expression in several monoaminergic cell groups, namely the dorsal raphe, the locus coeruleus, and the ventral tegmental area.

Gene expression databases

BgeeiENSMUSG00000056379.
CleanExiMM_TAAR1.
GenevisibleiQ923Y8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049527.

Chemistry databases

BindingDBiQ923Y8.

Structurei

3D structure databases

ProteinModelPortaliQ923Y8.
SMRiQ923Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139340.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y8.
KOiK05051.
OMAiMVYAFFY.
OrthoDBiEOG091G06VI.
PhylomeDBiQ923Y8.
TreeFamiTF343107.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q923Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLCHAITNI SHRNSDWSRE VQASLYSLMS LIILATLVGN LIVIISISHF
60 70 80 90 100
KQLHTPTNWL LHSMAIVDFL LGCLIMPCSM VRTVERCWYF GEILCKVHTS
110 120 130 140 150
TDIMLSSASI FHLAFISIDR YCAVCDPLRY KAKINISTIL VMILVSWSLP
160 170 180 190 200
AVYAFGMIFL ELNLKGVEEL YRSQVSDLGG CSPFFSKVSG VLAFMTSFYI
210 220 230 240 250
PGSVMLFVYY RIYFIAKGQA RSINRTNVQV GLEGKSQAPQ SKETKAAKTL
260 270 280 290 300
GIMVGVFLVC WCPFFLCTVL DPFLGYVIPP SLNDALYWFG YLNSALNPMV
310 320 330
YAFFYPWFRR ALKMVLLGKI FQKDSSRSKL FL
Length:332
Mass (Da):37,621
Last modified:December 1, 2001 - v1
Checksum:i680BE692B1892264
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380187 Genomic DNA. Translation: AAK71238.1.
BC125368 mRNA. Translation: AAI25369.1.
BC125370 mRNA. Translation: AAI25371.1.
CCDSiCCDS23735.1.
RefSeqiNP_444435.1. NM_053205.1.
UniGeneiMm.377141.

Genome annotation databases

EnsembliENSMUST00000051532; ENSMUSP00000049527; ENSMUSG00000056379.
GeneIDi111174.
KEGGimmu:111174.
UCSCiuc007eqd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTAAR1_MOUSE
AccessioniPrimary (citable) accession number: Q923Y8
Secondary accession number(s): Q05A85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families