Q923Y8 (TAAR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 1
Short name=TaR-1
Short name=Trace amine receptor 1

Gene names

Name:	Taar1
Synonyms:	Ta1, Tar1, Trar1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Widely distributed throughout the brain. Strongly expressed in the mitral cell layer of the olfactory bulb, piriform cortex, the arcuate, motor, and mesencephalic trigeminal nuclei, lateral reticular and hypoglossal nuclei, cerebellar Purkinje cells, and ventral horn of the spinal cord. Moderately expressed in the frontal, entorhinal, and agranular cortices, the ventral pallidum, thalamus, hippocampus, several hypothalamic nuclei, ambiguus, dorsal raphe, and gigantocellular reticular nuclei. Weakly expressed in the septum, basal ganglia, amygdala, myelencephalon, and spinal cord dorsal horn. Particularly interesting is the moderate expression in several monoaminergic cell groups, namely the dorsal raphe, the locus coeruleus, and the ventral tegmental area.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred by curator Ref.1. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	trace-amine receptor activity Inferred from direct assay Ref.3. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Trace amine-associated receptor 1		PRO_0000070143
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 45	21	Helical; Name=1; Potential
	Topological domain	46 – 58	13	Cytoplasmic Potential
	Transmembrane	59 – 79	21	Helical; Name=2; Potential
	Topological domain	80 – 97	18	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 138	20	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Name=4; Potential
	Topological domain	160 – 187	28	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 249	41	Cytoplasmic Potential
	Transmembrane	250 – 270	21	Helical; Name=6; Potential
	Topological domain	271 – 287	17	Extracellular Potential
	Transmembrane	288 – 308	21	Helical; Name=7; Potential
	Topological domain	309 – 332	24	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 181		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q923Y8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 680BE692B1892264	FASTA	332	37,621
	10 20 30 40 50 60 MHLCHAITNI SHRNSDWSRE VQASLYSLMS LIILATLVGN LIVIISISHF KQLHTPTNWL 70 80 90 100 110 120 LHSMAIVDFL LGCLIMPCSM VRTVERCWYF GEILCKVHTS TDIMLSSASI FHLAFISIDR 130 140 150 160 170 180 YCAVCDPLRY KAKINISTIL VMILVSWSLP AVYAFGMIFL ELNLKGVEEL YRSQVSDLGG 190 200 210 220 230 240 CSPFFSKVSG VLAFMTSFYI PGSVMLFVYY RIYFIAKGQA RSINRTNVQV GLEGKSQAPQ 250 260 270 280 290 300 SKETKAAKTL GIMVGVFLVC WCPFFLCTVL DPFLGYVIPP SLNDALYWFG YLNSALNPMV 310 320 330 YAFFYPWFRR ALKMVLLGKI FQKDSSRSKL FL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Trace amines: identification of a family of mammalian G protein-coupled receptors." Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C. Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed: 11459929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF380187 Genomic DNA. Translation: AAK71238.1. BC125368 mRNA. Translation: AAI25369.1. BC125370 mRNA. Translation: AAI25371.1.
IPI	IPI00124857.
RefSeq	NP_444435.1. NM_053205.1.
UniGene	Mm.377141.
3D structure databases
ProteinModelPortal	Q923Y8.
SMR	Q923Y8. Positions 17-316.
ModBase	Search...
Protein-protein interaction databases
STRING	Q923Y8.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q923Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000051532; ENSMUSP00000049527; ENSMUSG00000056379.
GeneID	111174.
KEGG	mmu:111174.
UCSC	uc007eqd.1. mouse.
Organism-specific databases
CTD	134864.
MGI	MGI:2148258. Taar1.
Phylogenomic databases
GeneTree	ENSGT00550000074214.
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
InParanoid	Q923Y8.
OMA	HLAFISI.
OrthoDB	EOG4RV2RT.
PhylomeDB	Q923Y8.
Gene expression databases
ArrayExpress	Q923Y8.
Bgee	Q923Y8.
CleanEx	MM_TAAR1.
Genevestigator	Q923Y8.
GermOnline	ENSMUSG00000056379. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009133. Trac_amin_rcpt_1. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01831. TRACEAMINE1R. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	365457.
SOURCE	Search...

Entry information

Entry name

TAAR1_MOUSE

Accession

Primary (citable) accession number: Q923Y8
Secondary accession number(s): Q05A85

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program