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Protein

Trace amine-associated receptor 4

Gene

Taar4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).By similarity

GO - Molecular functioni

  • 2-phenylethylamine receptor activity Source: GO_Central
  • G-protein coupled amine receptor activity Source: MGI
  • trace-amine receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 4
Short name:
TaR-4
Short name:
Trace amine receptor 4
Alternative name(s):
2-phenylethylamine receptor
Trace amine receptor 2
Short name:
TaR-2
Gene namesi
Name:Taar4
Synonyms:Ta2, Tar2, Trar2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi631382. Taar4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini59 – 69CytoplasmicSequence analysisAdd BLAST11
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 110ExtracellularSequence analysisAdd BLAST20
Transmembranei111 – 129Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 197ExtracellularSequence analysisAdd BLAST27
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 260CytoplasmicSequence analysisAdd BLAST42
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 296ExtracellularSequence analysisAdd BLAST15
Transmembranei297 – 317Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini318 – 347CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701531 – 347Trace amine-associated receptor 4Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923Y7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029877.
ExpressionAtlasiQ923Y7. differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050289.

Structurei

3D structure databases

ProteinModelPortaliQ923Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y7.
KOiK05051.
OMAiGMIFHPD.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ923Y7.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPDLWYSP ETQFCFAAAN NSCPRKARPA LVVCAMYLVM IGAIVMTMLG
60 70 80 90 100
NMVVIISIAH FKQLHSPTNF LILSMATTDF LLSCVVMPFS MVRSIESCWY
110 120 130 140 150
FGDLFCKVHS CCDIMLCTTS IFHLCFISVD RHYAVCDPLH YVTQITVGVV
160 170 180 190 200
GVFLLISWSV PILFAFGLVF SELNLIGAED FVAAIDCTGL CVLIFNKLWG
210 220 230 240 250
VLASFIAFFL PGAIMVGIYI HIFTVARKHA RKIGPGPRTK RALSESKMKA
260 270 280 290 300
TSGKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIGFTT PEDLYNVFLW
310 320 330 340
LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP
Length:347
Mass (Da):38,783
Last modified:December 1, 2001 - v1
Checksum:iB6294B2876618DB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380188 Genomic DNA. Translation: AAK71239.1.
RefSeqiNP_783173.1. NM_175583.1.
UniGeneiRn.138138.

Genome annotation databases

EnsembliENSRNOT00000047810; ENSRNOP00000050289; ENSRNOG00000029877.
GeneIDi294122.
KEGGirno:294122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380188 Genomic DNA. Translation: AAK71239.1.
RefSeqiNP_783173.1. NM_175583.1.
UniGeneiRn.138138.

3D structure databases

ProteinModelPortaliQ923Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050289.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047810; ENSRNOP00000050289; ENSRNOG00000029877.
GeneIDi294122.
KEGGirno:294122.

Organism-specific databases

CTDi209513.
RGDi631382. Taar4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y7.
KOiK05051.
OMAiGMIFHPD.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ923Y7.
TreeFamiTF343107.

Miscellaneous databases

PROiQ923Y7.

Gene expression databases

BgeeiENSRNOG00000029877.
ExpressionAtlasiQ923Y7. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR4_RAT
AccessioniPrimary (citable) accession number: Q923Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.