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Protein

Trace amine-associated receptor 9

Gene

Taar9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 9
Short name:
TaR-9
Short name:
Trace amine receptor 9
Alternative name(s):
Trace amine receptor 3
Short name:
TaR-3
Gene namesi
Name:Taar9
Synonyms:Ta3, Tar3, Trar3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi631383. Taar9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 5814CytoplasmicSequence analysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 9718ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 18729ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini209 – 24941CytoplasmicSequence analysisAdd
BLAST
Transmembranei250 – 27021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini271 – 28414ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini306 – 33833CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Trace amine-associated receptor 9PRO_0000070183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923Y6.
PRIDEiQ923Y6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037691.

Structurei

3D structure databases

ProteinModelPortaliQ923Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y6.
KOiK05051.
OMAiCIALSWF.
OrthoDBiEOG7966GS.
PhylomeDBiQ923Y6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELCYENVNG SCIKSSYSPW PRAILYAVLG LGALLAVFGN LLVITAILHF
60 70 80 90 100
KQLHTPTNFL VASLACADFL VGVTVMPFST VRSVEGCWYF GDTYCKFHTC
110 120 130 140 150
FDTSFCFASL FHLCCISIDR YVAVTDPLTY PTKFTISVSG VCIALSWFFS
160 170 180 190 200
VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL LCFLLFFLPT
210 220 230 240 250
VVMVFLYGRI FLVAKQQARK IEGSANQPQA SSESYKERVA RRERKAAKTL
260 270 280 290 300
GIAMAAFLVS WLPYIIDAVI DAYMNFITPA YVYEILVWCV YYNSAMNPLI
310 320 330
YAFFYPWFRK AIKLIVSGKV FRADSSRTNL FSEEAGAG
Length:338
Mass (Da):37,846
Last modified:December 1, 2001 - v1
Checksum:iF8BC058A21664EA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380190 Genomic DNA. Translation: AAK71241.1.
RefSeqiNP_783192.1. NM_175602.1.
UniGeneiRn.138162.

Genome annotation databases

EnsembliENSRNOT00000038523; ENSRNOP00000037691; ENSRNOG00000026096.
GeneIDi319107.
KEGGirno:319107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380190 Genomic DNA. Translation: AAK71241.1.
RefSeqiNP_783192.1. NM_175602.1.
UniGeneiRn.138162.

3D structure databases

ProteinModelPortaliQ923Y6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037691.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923Y6.
PRIDEiQ923Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038523; ENSRNOP00000037691; ENSRNOG00000026096.
GeneIDi319107.
KEGGirno:319107.

Organism-specific databases

CTDi134860.
RGDi631383. Taar9.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y6.
KOiK05051.
OMAiCIALSWF.
OrthoDBiEOG7966GS.
PhylomeDBiQ923Y6.

Miscellaneous databases

NextBioi672095.
PROiQ923Y6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiTAAR9_RAT
AccessioniPrimary (citable) accession number: Q923Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.