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Protein

Trace amine-associated receptor 6

Gene

Taar6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 6
Short name:
TaR-6
Short name:
Trace amine receptor 6
Alternative name(s):
Trace amine receptor 4
Short name:
TaR-4
Gene namesi
Name:Taar6
Synonyms:Ta4, Tar4, Trar4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi631384. Taar6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 68CytoplasmicSequence analysisAdd BLAST15
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 107ExtracellularSequence analysisAdd BLAST18
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 147CytoplasmicSequence analysisAdd BLAST19
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 202ExtracellularSequence analysisAdd BLAST34
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 259CytoplasmicSequence analysisAdd BLAST36
Transmembranei260 – 276Helical; Name=6Sequence analysisAdd BLAST17
Topological domaini277 – 282ExtracellularSequence analysis6
Transmembranei283 – 302Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini303 – 345CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701611 – 345Trace amine-associated receptor 6Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ923Y5.

PTM databases

PhosphoSitePlusiQ923Y5.

Structurei

3D structure databases

ProteinModelPortaliQ923Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiQ923Y5.
KOiK05051.
OMAiICVWCAY.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ923Y5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSSPPAV LQLCYENVNG SCVKTPYSPG PRVLLYAVFG FGAVLAVFGN
60 70 80 90 100
LLVMISILHF KQLHSPTNFL IASLACADFW VGVSVMPFSM VRSIESCWYF
110 120 130 140 150
GRSFCTFHTC CDVAFCYSSL FHLSFISIDR YIAVTDPLVY PTKFTVSVSG
160 170 180 190 200
ICISISWILP LAYSGAVFYT GVYADGLEEV SDAVNCVGGC QVVVNQNWVL
210 220 230 240 250
IDFLSFLIPT LVMIILYGNI FLVARQQAKK IETVGNKAES SSESYKARVA
260 270 280 290 300
RRERKAAKTL GITVVAFMIS WLPYSIDSLV DAFMGFITPA YIYEICVWCA
310 320 330 340
YYNSAMNPLI YALFYPWFKK AIKVIMSGQV FKNSSATMNL FSEQI
Length:345
Mass (Da):38,311
Last modified:December 1, 2001 - v1
Checksum:iDC904127D5B406EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380191 Genomic DNA. Translation: AAK71242.1.
RefSeqiNP_783174.1. NM_175584.1.
UniGeneiRn.138139.

Genome annotation databases

EnsembliENSRNOT00000021529; ENSRNOP00000070620; ENSRNOG00000016089.
GeneIDi294124.
KEGGirno:294124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380191 Genomic DNA. Translation: AAK71242.1.
RefSeqiNP_783174.1. NM_175584.1.
UniGeneiRn.138139.

3D structure databases

ProteinModelPortaliQ923Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ923Y5.

Proteomic databases

PRIDEiQ923Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021529; ENSRNOP00000070620; ENSRNOG00000016089.
GeneIDi294124.
KEGGirno:294124.

Organism-specific databases

CTDi319100.
RGDi631384. Taar6.

Phylogenomic databases

GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiQ923Y5.
KOiK05051.
OMAiICVWCAY.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ923Y5.

Miscellaneous databases

PROiQ923Y5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR6_RAT
AccessioniPrimary (citable) accession number: Q923Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.