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Protein

Trace amine-associated receptor 7h

Gene

Taar7h

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 7h
Short name:
TaR-7h
Short name:
Trace amine receptor 7h
Alternative name(s):
Trace amine receptor 6
Short name:
TaR-6
Gene namesi
Name:Taar7h
Synonyms:Ta6, Tar6, Trar6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi631385. Taar7h.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 83CytoplasmicSequence analysisAdd BLAST15
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 125ExtracellularSequence analysisAdd BLAST21
Transmembranei126 – 143Helical; Name=3Sequence analysisAdd BLAST18
Topological domaini144 – 166CytoplasmicSequence analysisAdd BLAST23
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 217ExtracellularSequence analysisAdd BLAST30
Transmembranei218 – 238Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini239 – 274CytoplasmicSequence analysisAdd BLAST36
Transmembranei275 – 295Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini296 – 309ExtracellularSequence analysisAdd BLAST14
Transmembranei310 – 333Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini334 – 358CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701731 – 358Trace amine-associated receptor 7hAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 205PROSITE-ProRule annotation
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923Y4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044226.

Structurei

3D structure databases

ProteinModelPortaliQ923Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y4.
KOiK05051.
OMAiDDESFPW.
OrthoDBiEOG091G06VI.
PhylomeDBiQ923Y4.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDDESFPW DQDSILSRDL LSALSPQLCY ENLNRSCVRS PYSPGPRLIL
60 70 80 90 100
YAVFGFGAVL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADLLVGLTV
110 120 130 140 150
MPFSMVRSVE GCWYFGDSYC KLHTSFDMSF CCSSLLHLCF ISVDRYIAVS
160 170 180 190 200
DPLIYPIRFT ASVSGKCITF SWFLSIIYGF SLIYTGASEA GLKDLVSALS
210 220 230 240 250
CVGGCQIPMN QSCVLINFLL FLVPTLVMMT VYSKIFLIAK QQAQNMEKMS
260 270 280 290 300
KQTTRASDSY KDRVAKRERK AAKTLGIAVA AFLLSWLPYL IDSIIDAFLG
310 320 330 340 350
FITPSYVYEI LVWIVYYNSA MNPLIYAFFY PWFRNAIKLI VTGKILKQNS

STTNLFSE
Length:358
Mass (Da):40,074
Last modified:December 1, 2001 - v1
Checksum:iCAE028CF89943DCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380194 Genomic DNA. Translation: AAK71245.1.
RefSeqiNP_783177.1. NM_175587.1.
UniGeneiRn.138142.

Genome annotation databases

EnsembliENSRNOT00000043436; ENSRNOP00000044226; ENSRNOG00000048072.
GeneIDi294130.
KEGGirno:294130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380194 Genomic DNA. Translation: AAK71245.1.
RefSeqiNP_783177.1. NM_175587.1.
UniGeneiRn.138142.

3D structure databases

ProteinModelPortaliQ923Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044226.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923Y4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043436; ENSRNOP00000044226; ENSRNOG00000048072.
GeneIDi294130.
KEGGirno:294130.

Organism-specific databases

CTDi294130.
RGDi631385. Taar7h.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y4.
KOiK05051.
OMAiDDESFPW.
OrthoDBiEOG091G06VI.
PhylomeDBiQ923Y4.
TreeFamiTF343107.

Miscellaneous databases

PROiQ923Y4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAA7H_RAT
AccessioniPrimary (citable) accession number: Q923Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.