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Protein

Trace amine-associated receptor 7a

Gene

Taar7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 7a
Short name:
TaR-7a
Short name:
Trace amine receptor 7a
Alternative name(s):
Trace amine receptor 8
Short name:
TaR-8
Gene namesi
Name:Taar7a
Synonyms:Ta8, Tar8, Trar8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631387. Taar7a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini69 – 8315CytoplasmicSequence analysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini105 – 12117ExtracellularSequence analysisAdd
BLAST
Transmembranei122 – 14322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini144 – 16623CytoplasmicSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini188 – 21225ExtracellularSequence analysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini234 – 27441CytoplasmicSequence analysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini296 – 30914ExtracellularSequence analysisAdd
BLAST
Transmembranei310 – 33324Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini334 – 35825CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Trace amine-associated receptor 7aPRO_0000070163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 205PROSITE-ProRule annotation
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ923Y2.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997925.

Structurei

3D structure databases

ProteinModelPortaliQ923Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y2.
KOiK05051.
PhylomeDBiQ923Y2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLVDNFLS GQSRTMSEDL LSASSPQLCY ENLNGSCIRS PYSPGPRLIL
60 70 80 90 100
YAVFGFGAVL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV
110 120 130 140 150
MPFSTVRSVE GCWYFGDTYC KFHSCFEGSF CYSSIFHLCF ISVDRYIAVS
160 170 180 190 200
DPLIYPTRFT ASVSGKCITF SWLLSIIYSF SLLYTGANEA GLEDLVSALT
210 220 230 240 250
CVGGCQIAVN QSWVFINFLL FLVPTLVMMT VYSKIFLIAK QQAQNIEKMS
260 270 280 290 300
KQTTRASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
310 320 330 340 350
FITPTYVYEI LVWIAYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRQNS

SVTNLFPE
Length:358
Mass (Da):40,147
Last modified:December 1, 2001 - v1
Checksum:iE136ADA32C1A268B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380196 Genomic DNA. Translation: AAK71247.1.
RefSeqiNP_783175.1. NM_175585.1.
UniGeneiRn.138140.

Genome annotation databases

GeneIDi294125.
KEGGirno:294125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380196 Genomic DNA. Translation: AAK71247.1.
RefSeqiNP_783175.1. NM_175585.1.
UniGeneiRn.138140.

3D structure databases

ProteinModelPortaliQ923Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997925.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ923Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi294125.
KEGGirno:294125.

Organism-specific databases

CTDi215856.
RGDi631387. Taar7a.

Phylogenomic databases

HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y2.
KOiK05051.
PhylomeDBiQ923Y2.

Miscellaneous databases

NextBioi637621.
PROiQ923Y2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiTAA7A_RAT
AccessioniPrimary (citable) accession number: Q923Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.