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Protein

Trace amine-associated receptor 8c

Gene

Taar8c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 8c
Short name:
TaR-8c
Short name:
Trace amine receptor 8c
Alternative name(s):
Trace amine receptor 10
Short name:
TaR-10
Gene namesi
Name:Taar8c
Synonyms:Ta10, Tar10, Trar10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631390. Taar8c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 6710CytoplasmicSequence analysis
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10214ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12725Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 14619CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 19629ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 26043CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 29514ExtracellularSequence analysisAdd
BLAST
Transmembranei296 – 31924Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 34425CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Trace amine-associated receptor 8cPRO_0000070180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923Y0.
PRIDEiQ923Y0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044937.

Structurei

3D structure databases

ProteinModelPortaliQ923Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y0.
KOiK05051.
PhylomeDBiQ923Y0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNFSQATL QLCYENVNAS CIKTPYSPGL RVLLYMVFGF GAVLAVCGNL
60 70 80 90 100
LVVISVLHFK QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG
110 120 130 140 150
DTFCSLHSCC DVAFCYSSAL HLCFISVDRY IAVTDPLVYP TKFTVSVSGI
160 170 180 190 200
CISISWILPL VYSSAVFYTG ISAMGIENLV SALNCVGGCQ VVVNQDWVLI
210 220 230 240 250
SFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSGSKGE SSLESHKARV
260 270 280 290 300
AKRERKAAKT LGVTVLAFIV SWLPYTIDTL IDAFMGFITP AYVYEFCCWS
310 320 330 340
AYYNSAMNPL IYAFFYPWFR KAMKLILSGK ILKGHSSTTS LFSE
Length:344
Mass (Da):38,016
Last modified:December 1, 2001 - v1
Checksum:i6AB7A52CE3BEB692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380198 Genomic DNA. Translation: AAK71249.1.
RefSeqiNP_783190.1. NM_175600.1.
UniGeneiRn.138161.

Genome annotation databases

GeneIDi319105.
KEGGirno:319105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380198 Genomic DNA. Translation: AAK71249.1.
RefSeqiNP_783190.1. NM_175600.1.
UniGeneiRn.138161.

3D structure databases

ProteinModelPortaliQ923Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044937.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923Y0.
PRIDEiQ923Y0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi319105.
KEGGirno:319105.

Organism-specific databases

CTDi494546.
RGDi631390. Taar8c.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923Y0.
KOiK05051.
PhylomeDBiQ923Y0.

Miscellaneous databases

PROiQ923Y0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAA8C_RAT
AccessioniPrimary (citable) accession number: Q923Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.