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Protein

Trace amine-associated receptor 8a

Gene

Taar8a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 8a
Short name:
TaR-8a
Short name:
Trace amine receptor 8a
Alternative name(s):
Trace amine receptor 11
Short name:
TaR-11
Gene namesi
Name:Taar8a
Synonyms:Ta11, Tar11, Trar11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631391. Taar8a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 67CytoplasmicSequence analysisAdd BLAST13
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 102ExtracellularSequence analysisAdd BLAST14
Transmembranei103 – 127Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 196ExtracellularSequence analysisAdd BLAST29
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 260CytoplasmicSequence analysisAdd BLAST43
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 291ExtracellularSequence analysis10
Transmembranei292 – 314Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini315 – 344CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701761 – 344Trace amine-associated receptor 8aAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923X9.
PRIDEiQ923X9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044110.

Structurei

3D structure databases

ProteinModelPortaliQ923X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923X9.
KOiK05051.
PhylomeDBiQ923X9.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNFSQAPL QLCYENVNAS CIKTPYSPGL RVLLYMVFGF GAVLAVCGNL
60 70 80 90 100
LVVISVLHFK QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG
110 120 130 140 150
DTFCSLHSCC DAAFCYSSLF HLCFISVDRY IAVTDPLVYP TKFTVSVSGI
160 170 180 190 200
CISISWILPL VYSSAVFYTG ISATGIENLV SALNCVGGCQ IVVNQDWVLI
210 220 230 240 250
DFLLFLIPTL VMIILYSKIF LVAKQQAVKI ETSISGSKGE SSLESHKARV
260 270 280 290 300
AKRERKAAKT LGVTVVAFMV SWLPYTIDTL IDAFMGFITP AYVYEICCWS
310 320 330 340
AYYNSAMNPL IYAFFYPWFR KAIKLILSGE ILKSHSSTMS LFSE
Length:344
Mass (Da):38,065
Last modified:November 7, 2003 - v2
Checksum:iCC75FFAC392A637A
GO

Sequence cautioni

The sequence AAK71250 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380199 Genomic DNA. Translation: AAK71250.1. Different initiation.
RefSeqiNP_783189.1. NM_175599.1.
XP_017445356.1. XM_017589867.1.
XP_017445965.1. XM_017590476.1.
UniGeneiRn.138160.

Genome annotation databases

GeneIDi108348200.
319104.
KEGGirno:100910174.
rno:319104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380199 Genomic DNA. Translation: AAK71250.1. Different initiation.
RefSeqiNP_783189.1. NM_175599.1.
XP_017445356.1. XM_017589867.1.
XP_017445965.1. XM_017590476.1.
UniGeneiRn.138160.

3D structure databases

ProteinModelPortaliQ923X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044110.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923X9.
PRIDEiQ923X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi108348200.
319104.
KEGGirno:100910174.
rno:319104.

Organism-specific databases

CTDi215859.
RGDi631391. Taar8a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923X9.
KOiK05051.
PhylomeDBiQ923X9.
TreeFamiTF343107.

Miscellaneous databases

PROiQ923X9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAA8A_RAT
AccessioniPrimary (citable) accession number: Q923X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.