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Protein

Trace amine-associated receptor 7b

Gene

Taar7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 7b
Short name:
TaR-7b
Short name:
Trace amine receptor 7b
Alternative name(s):
Trace amine receptor 12
Short name:
TaR-12
Gene namesi
Name:Taar7b
Synonyms:Ta12, Tar12, Trar12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi631392. Taar7b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini69 – 8315CytoplasmicSequence analysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini105 – 12521ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 14722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 16619CytoplasmicSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini188 – 21124ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 27442CytoplasmicSequence analysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini296 – 30914ExtracellularSequence analysisAdd
BLAST
Transmembranei310 – 33223Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini333 – 35826CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Trace amine-associated receptor 7bPRO_0000070165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 205PROSITE-ProRule annotation
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923X8.
PRIDEiQ923X8.

Interactioni

Chemistry

BindingDBiQ923X8.

Structurei

3D structure databases

ProteinModelPortaliQ923X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923X8.
KOiK05051.
OMAiHLCFISA.
OrthoDBiEOG7966GS.
PhylomeDBiQ923X8.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDDDRFPW DQDSILSRDL LSASSMQLCY EKLNRSCVRS PYSPGPRLIL
60 70 80 90 100
YAVFGFGAVL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV
110 120 130 140 150
MPFSMVRSVE GCWYFGDIYC KFHSSFDGSF CYSSIFHLCF ISADRYIAVS
160 170 180 190 200
DPLIYPTRFT ASVSGKCITF SWLLSIIYSF SLFYTGVNEA GLEDLVSALT
210 220 230 240 250
CVGGCQIAVN QSWVFINFLL FLVPALVMMT VYSKIFLIAK QQAQNIEKMG
260 270 280 290 300
KQTARASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
310 320 330 340 350
FVTPTYVYEI LVWIGYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS

SATNLFPE
Length:358
Mass (Da):40,291
Last modified:November 22, 2005 - v2
Checksum:iB73ADC0A748F9A2F
GO

Sequence cautioni

The sequence AAK71251.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380200 Genomic DNA. Translation: AAK71251.1. Different initiation.
AY702319 Genomic DNA. Translation: AAV70131.1.
RefSeqiNP_783176.2. NM_175586.2.
UniGeneiRn.138141.

Genome annotation databases

EnsembliENSRNOT00000021559; ENSRNOP00000021559; ENSRNOG00000046302.
GeneIDi294126.
KEGGirno:294126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380200 Genomic DNA. Translation: AAK71251.1. Different initiation.
AY702319 Genomic DNA. Translation: AAV70131.1.
RefSeqiNP_783176.2. NM_175586.2.
UniGeneiRn.138141.

3D structure databases

ProteinModelPortaliQ923X8.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ923X8.
ChEMBLiCHEMBL2176813.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923X8.
PRIDEiQ923X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021559; ENSRNOP00000021559; ENSRNOG00000046302.
GeneIDi294126.
KEGGirno:294126.

Organism-specific databases

CTDi209517.
RGDi631392. Taar7b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923X8.
KOiK05051.
OMAiHLCFISA.
OrthoDBiEOG7966GS.
PhylomeDBiQ923X8.
TreeFamiTF343107.

Miscellaneous databases

NextBioi637625.
PROiQ923X8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  2. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WIST/Crl.

Entry informationi

Entry nameiTAA7B_RAT
AccessioniPrimary (citable) accession number: Q923X8
Secondary accession number(s): Q5QD22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 22, 2005
Last modified: May 11, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.