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Protein

Trace amine-associated receptor 7e

Gene

Taar7e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 7e
Short name:
TaR-7e
Short name:
Trace amine receptor 7e
Alternative name(s):
Trace amine receptor 14
Short name:
TaR-14
Gene namesi
Name:Taar7e
Synonyms:Ta14, Tar14, Trar14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631394. Taar7e.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 83CytoplasmicSequence analysisAdd BLAST15
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 121ExtracellularSequence analysisAdd BLAST17
Transmembranei122 – 143Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini144 – 166CytoplasmicSequence analysisAdd BLAST23
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 212ExtracellularSequence analysisAdd BLAST25
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 274CytoplasmicSequence analysisAdd BLAST41
Transmembranei275 – 295Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini296 – 309ExtracellularSequence analysisAdd BLAST14
Transmembranei310 – 333Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini334 – 358CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701701 – 358Trace amine-associated receptor 7eAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 205PROSITE-ProRule annotation
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ923X6.

Structurei

3D structure databases

ProteinModelPortaliQ923X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923X6.
PhylomeDBiQ923X6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDDASFPW DQDSILSRDL LSALSSQLCY ENLNRSCIRS PYSPGPRLIL
60 70 80 90 100
HAVFGFSAVL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADLLVGLTV
110 120 130 140 150
MPFSMVRSVE GCWYFGDIYC KFHSSFDVSF CYSSIFHLCF ISVDRYIAVS
160 170 180 190 200
DPLIYLTRFT ASVSGKCITF SWFLSIIYSF SLLYTGASEA GLEDLVSALT
210 220 230 240 250
CVGGCQLAVN QSWVFINFLL FLVPTLVMMT VYSKVFLIAK QQAQNIEKIG
260 270 280 290 300
KQTARASESY KDRVAKRERK AAKTLGITVA AFLLSWLPYF IDSIIDAFLG
310 320 330 340 350
FITPTYVYEI LVWIAYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS

SATNLFPE
Length:358
Mass (Da):40,217
Last modified:December 1, 2001 - v1
Checksum:i516414E0EF0FDF00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380202 Genomic DNA. Translation: AAK71253.1.
UniGeneiRn.138144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380202 Genomic DNA. Translation: AAK71253.1.
UniGeneiRn.138144.

3D structure databases

ProteinModelPortaliQ923X6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923X6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi631394. Taar7e.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ923X6.
PhylomeDBiQ923X6.

Miscellaneous databases

PROiQ923X6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAA7E_RAT
AccessioniPrimary (citable) accession number: Q923X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.