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Protein

Adhesion G protein-coupled receptor L4

Gene

Adgrl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endothelial orphan receptor that acts as a key regulator of angiogenesis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandCalcium

Protein family/group databases

MEROPSiP02.013

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L4
Alternative name(s):
EGF, latrophilin seven transmembrane domain-containing protein 1
Gene namesi
Name:Adgrl4
Synonyms:Eltd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2655562 Adgrl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 481ExtracellularCuratedAdd BLAST462
Transmembranei482 – 502Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini503 – 513CytoplasmicCuratedAdd BLAST11
Transmembranei514 – 534Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini535 – 548ExtracellularCuratedAdd BLAST14
Transmembranei549 – 569Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini570 – 581CytoplasmicCuratedAdd BLAST12
Transmembranei582 – 602Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini603 – 622ExtracellularCuratedAdd BLAST20
Transmembranei623 – 643Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini644 – 667CytoplasmicCuratedAdd BLAST24
Transmembranei668 – 688Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini689 – 695ExtracellularCurated7
Transmembranei696 – 716Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini717 – 739CytoplasmicCuratedAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype but deficient mice present increased cardiac hypertrophy in response to pressure overload.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001287120 – 739Adhesion G protein-coupled receptor L4Add BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi22 ↔ 33PROSITE-ProRule annotation
Disulfide bondi27 ↔ 42PROSITE-ProRule annotation
Disulfide bondi44 ↔ 56PROSITE-ProRule annotation
Disulfide bondi62 ↔ 74PROSITE-ProRule annotation
Disulfide bondi68 ↔ 83PROSITE-ProRule annotation
Disulfide bondi85 ↔ 106PROSITE-ProRule annotation
Disulfide bondi112 ↔ 124PROSITE-ProRule annotation
Disulfide bondi118 ↔ 133PROSITE-ProRule annotation
Disulfide bondi135 ↔ 156PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei455 – 456CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ923X1
PaxDbiQ923X1
PRIDEiQ923X1

PTM databases

PhosphoSitePlusiQ923X1

Expressioni

Inductioni

Induced by VEGF and FGF2.1 Publication

Gene expression databases

BgeeiENSMUSG00000039167
ExpressionAtlasiQ923X1 baseline and differential
GenevisibleiQ923X1 MM

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041939

Structurei

3D structure databases

ProteinModelPortaliQ923X1
SMRiQ923X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 57EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini58 – 107EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST50
Domaini108 – 157EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST50
Domaini415 – 467GPSPROSITE-ProRule annotationAdd BLAST53

Domaini

The transmembrane domain is not required for cleavage, but it is required for dimer formation.By similarity

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
KOG4291 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00900000140800
HOGENOMiHOG000112361
HOVERGENiHBG101117
InParanoidiQ923X1
KOiK04595
OMAiYKVFRHT
OrthoDBiEOG091G00GJ
TreeFamiTF316380

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q923X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLPLLVGF STLLNCSYTQ NCSKTTCLPN AKCEVHNGVE ACFCSQGYSG
60 70 80 90 100
NGVTICEDID ECSESSVCGD HAVCENVNGG FSCFCREGYQ TATGKSQFTP
110 120 130 140 150
NDGSYCQDID ECSESSVCGD HAVCENVNGG FSCFCREGYQ TATGKSQFTP
160 170 180 190 200
NDGSYCQESM NSNCHLEHAC IAANINKTLK RIGPITEQTT LLQEIYRNSE
210 220 230 240 250
AELSLMDIVT YIEILTESSS LLGHPNSTTS YKDAHFNSTL TEFGETINNF
260 270 280 290 300
VERSTHKMWD QLPTNHRRLH LTKLMHTAEL VTLQIAQNTQ KNSQFDMNST
310 320 330 340 350
DLALKVFAFD STHMKHAHPH MNVDGGYVKI SPRRKAAHGT TGNVVVAFLC
360 370 380 390 400
YKSIGPLLSS SDNFLLDTQN DNSEGKEKVI SSVISASISS NPPTLYELEK
410 420 430 440 450
ITFTLSHVKL SDKHRTQCAF WNYSVDAMNN GSWSTEGCEL THSNDTHTSC
460 470 480 490 500
RCSHLTHFAI LMSSTSSIGI KDYNILTRIT QLGIIISLIC LAICIFTFWF
510 520 530 540 550
FSEIQSTRTT IHKNLCCSLF LAELVFLIGI NINTNKLVCS IIAGLLHYFF
560 570 580 590 600
LAAFAWMCIE GIHLYLIVVG VIYNKGFLHK NFYIFGYLSP AVVVGFSASL
610 620 630 640 650
GYRYYGTTKV CWLSTENNFI WSFIGPACLI ILVNLLAFGV IIYKVFRHTA
660 670 680 690 700
GLKPEVSCYE NIRSCARGAL ALLFLLGTTW IFGVLHVVHA SVVTAYLFTV
710 720 730
SNAFQGMFIF LFLCVLSRKI QEEYYRLFKN VPCCFGCLR
Length:739
Mass (Da):82,246
Last modified:July 27, 2011 - v3
Checksum:i1AEB95CCCB73B095
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289T → I in AAK62363 (PubMed:11438738).Curated1
Sequence conflicti313Missing in AAH17134 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385682 mRNA Translation: AAK62363.1
AC127233 Genomic DNA No translation available.
BC017134 mRNA Translation: AAH17134.1
CCDSiCCDS17910.1
RefSeqiNP_573485.2, NM_133222.3
UniGeneiMm.317261

Genome annotation databases

EnsembliENSMUST00000046977; ENSMUSP00000041939; ENSMUSG00000039167
GeneIDi170757
KEGGimmu:170757
UCSCiuc008rsj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAGRL4_MOUSE
AccessioniPrimary (citable) accession number: Q923X1
Secondary accession number(s): E9QLT4, Q91W44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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